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All Journal Jurnal Riset Kesehatan Jurnal Biosains Pascasarjana Jurnal Surya Medika Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Klinikal Sains (Jurnal Analis Kesehatan) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JURNAL MEDIA KESEHATAN Poltekita : Jurnal Ilmu Kesehatan JURNAL ANALIS LABORATORIUM MEDIK Jaringan Laboratorium Medis Journal of Applied Health Management and Technology Jurnal Ners Borneo Journal of Medical Laboratory Technology Borneo Community Health Sevice Journal Jurnal Sehat Indonesia (JUSINDO) Jurnal Pengabdian Pada Masyarakat Abdi Reksa E-Amal: Jurnal Pengabdian Kepada Masyarakat Jurnal Sains dan Kesehatan
Roni Afriansya
Poltekkes Kemenkes Semarang
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UJI SENSITIVITAS EKSTRAK BAWANG PUTIH (ALLIUM SATIVUM) TERHADAP PERTUMBUHAN BAKTERI ESCHERICHIA COLI Afriansya, Roni
JURNAL MEDIA KESEHATAN Vol 7 No 2 (2014): Jurnal Media Kesehatan Poltekkes Kemenkes Bengkulu Volume 7 Nomor 2 Agustus Tahun
Publisher : Politeknik Kesehatan Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jmk.v7i2.234

Abstract

An Escherichia coli bacterium is normal flora bacteria in human body. The excess of bacteria can cause diseases. Garlic has allicin compound, which known as antimicrobial compound.. The research a purpose to determine the antibacterial activity of garlic against the bacteria Escherichia coli at a concentration of garlic and what was the most powerful (effective) hinders the growth of the bacterium Escherichia coli. The research was a laboratory experiment with antimicrobial testing using paper disc diffusion method. Garlic extract was made by the process of maceration. Maceration process conducted over 5 days. Garlic extracted and then tested on the growth of Escherichia coli with three repetitions. Observation was made after 1x24 hours. Then observed a clear zone was formed, the zone was measured by using a ruler. Results of the research noted that garlic extract has the ability to inhibit the growth of bacteria Escherichia coli and seen a proportional relation-ship in each other, concentration of garlic extract become greater as inhibiting the growth of the bacterium Escherichia coli does so. The most effective concentration to inhibit the growth of Escherichia coli bacteria was garlic extract concentration of 75 % with an average diameter of 10.66 mm zone of inhibition and concentration of 100% with an average inhibition zone diameter of 13.33 mm. Garlic can be used as medicine of natural materials dan consume garlic regularly can prevent the growth of escherichia coli bacteria that can not controlled in the body.
Hubungan Kadar Hemoglobin dan Kadar Kreatinin Darah pada Pasien Gagal Ginjal Kronik Pasca Transfusi Berulang Eko Naning Sofyanita; Roni Afriansya; Nur Indah Palupi
Jaringan Laboratorium Medis Vol 2, No 2 (2020): November 2020
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v2i2.7030

Abstract

Kidneys are part of the body that has an important role. One of the functions of the kidney is the production of erythropoietin. Erythropoietin stimulates the production of red blood cells. People or patients who have kidney problems can cause anemia. This study aims to determine the relationship between hemoglobin levels and blood creatinine levels in patients with chronic kidney disease after receiving a transfusion. Blood creatinine levels in this study were used as an index to measure kidney function. The study was conducted at the Wira Tamtama Hospital Semarang by taking data on 20 patients in 2020 with chronic kidney disease and taking data on hemoglobin (cut-off 12 g/dL) and serum creatinine (cut-off 1.5 mg/dL). The relationship between the two was calculated by chi-square test and found 80% of patients with low hemoglobin in patients with high creatinine levels and 0% of patients with low hemoglobin in patients with normal creatinine levels (p=0.040). There is a risk of decreased hemoglobin levels (OR = 3,442) in patients with high creatinine levels. It was concluded that there was a significant relationship between hemoglobin levels and blood creatinine levels and patients with high creatinine levels tended to be at risk of anemia.
Gambaran Ureum dan Kreatinin pada Pasien Penyakit Ginjal Kronik yang Menjalani Hemodialisis Roni Roni Afriansya; Eko Naning Sofyanita; Suwarsi Suwarsi
Jaringan Laboratorium Medis Vol 2, No 1 (2020): May 2020
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v2i1.5813

Abstract

Chronic Kidney Disease is evident if the blood urea level is more than 200 mg/dl. Uremia causes a malfunction in almost all organ systems such as; fluid and electrolyte disorders, metabolic endocrine, neuromuscular, cardiovascular and pulmonary, skin, gastrointestinal, hematological, and immunological. Hemodialysis is an attempt to reduce the symptoms of uremia so that the patient's clinical condition can also improve. The purpose of this study was to determine the description of Ureum and Creatinine in CKD Patients undergoing Hemodialysis. This type of research is observational descriptive. The sample included all CKD patients undergoing hemodialysis at the Ir Sukarno Sukoharjo Regional Hospital in 2019 who met the inclusion criteria, so as many as 83 samples were obtained. The type of data is secondary data obtained from medical records. The results showed that most patients were in the 40-60 years age group of 72% and the majority of the male sex were 51 patients (61%). Urea and creatinine appearance in patients undergoing hemodialysis has increased very high. In 83 patients with CKD increased serum creatinine levels ( 100%) with a mean creatinine level in men of 11.80 mg / dL and women of 9.73 mg / dL and an increase in ureum levels with a mean of 167 men, 09 mg / dL and women of 164.39 mg / dL. This study concludes that all patients with CKD have increased levels of urea and creatinine by more than 100%.
DIFFERENCES OF INHIBITION ZONE FOREST PURE HONEY AND CINNAMON (Cinnamomum burmani) AS ANTIBACTERIAL BACTERIAL COMPOUNDS OF MEMBERS OF THE Enterobacteriaceae FAMILY Eko Naning Sofyanita; Roni Afriansya
Jurnal Riset Kesehatan Vol 10, No 1 (2021): MAY 2021
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (450.538 KB) | DOI: 10.31983/jrk.v10i1.6424

Abstract

Honey and cinnamon are plant products that have many properties, one of which is used as an antibacterial agent for various diseases. The effectiveness of the two active substances against bacteria in the Enterobacteriaeae family is unclear. The study was conducted to determine the differences in the effectiveness of forest honey and cinnamon in inhibiting the growth of bacteria in the Enterobacteriaceae family. This research method is an experimental study with a combination method of diffusion and wells using samples of the bacteria Klebsiella pneumoniae, Esherichia coli, Salmonella typhi, Serratia marcescens, and Enterobacter cloacae. Forest pure honey and cinnamon were prepared as test solutions with concentrations of 25%, 40%, 55%, 70%, 85% and 100%. The results obtained were the inhibition zone formed on Nutrient Agar Plate (NAP) media, in forest pure honey the inhibition zone formed in S. typhi, E. coli, Klebsiella pneumoniae, Serratia marcescens, and Enterobacter cloacae was greater at 100% concentration, namely 30.5mm, 32.5mm, 38mm, 29.5mm, 26mm, while the 100% concentration of cinnamon showed results, namely 12mm, 10mm, 8.5mm, 11mm, and 11mm. Conclusion is Forest pure honey was more effective at inhibiting bacteria from the Enterobacteriaceae family than cinnamon.
The Effect of Light Exposure to Bilirubine Levels on Serum Jaundice Infant in Hospital of Islamic NU Demak Eko Naning Sofyanita; Endang Susilowaty; Roni Afriansya
Borneo Journal of Medical Laboratory Technology Vol 3 No 1 (2020): Borneo Journal of Medical Laboratory Technology
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjmlt.v3i1.1766

Abstract

Bilirubin is a substance formed from the normal breakdown of erythrocytes in the body so that it gives a yellow color to the stool and urine. The test of bilirubin in the laboratory must avoid exposure to light, which can cause decreased serum bilirubin levels by up to 50% in 1 hour due to disruption of the bilirubin's stability. This study is a cross-sectional analytic study of primary data using 30 samples of jaundice baby serum and direct and total bilirubin test. Data collection was conducted from the primary data by a direct test using 40 samples of infant jaundice and test of direct bilirubin and total bilirubin using methods Dichlorophenyl Diazonium. The results of the tests of 40 samples can result in the mean levels of total bilirubin were exposed to the light of 8.58 mg/dl and were not exposed to light 12,67mg /dl. Direct bilirubin levels mean that exposure to light is 3.98 mg/dl. In contrast, the unexposed light of 8.71 mg/dl, so that it can be concluded that the levels of total and direct bilirubin in serum jaundice infants exposed to lower light compared with those not exposed to light.
Hubungan Jumlah Eritrosit dan Hitung Jenis Leukosit pada Masyarakat dengan Paparan Polutan Tinggi di Desa Tambak Mulyo Kota Semarang Eko Naning Sofyanita; Hendra Adistia Bangkit; Roni Afriansya
Borneo Journal of Medical Laboratory Technology Vol 3 No 2 (2021): Borneo Journal of Medical Laboratory Technology
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjmlt.v3i2.2230

Abstract

Lead (Pb) and carbon monoxide (CO) are gas components in airborne pollutants due to vehicle fumes or industrial exhaust gases that affect the blood, namely shortening the life span of erythrocytes produced in erythropoiesis. In addition, small pollutants can be inhaled and enter the alveoli and then phagocytosis and trigger the release of mediators, namely leukocyte cells, which can cause inflammation. This study aims to determine the correlation between the erythrocytes count and differential leucocyte count of the Tambak Mulyo village community, Semarang City. This research was a cross-sectional analytic study of primary data using 20 blood samples, carried out by the erythrocytes count and differential leucocyte count tests. The examination results showed that the average erythrocytes count in all samples was 5.25 million cells/mm3 with a percentage of the normal erythrocytes count is 45.00%, and a high of erythrocytes count is 55.0%. On the test of the differential leucocyte count, 4 samples are obtained with specific values. Normal leukocytes and as many as 16 samples experienced an increase and decrease in the differential leucocyte count. The chi-square test shows Asymp.Sig> 0.05, which means there is no correlation between variables, so it can be concluded that there is no significant correlation between the erythrocytes count and differential leucocyte count (lymphocytes, basophils, eosinophils, neutrophils, and monocytes) in the community with exposure to high pollutants in Tambak Mulyo village, Semarang City.
Ekspresi mRNA LMP2A Epstein-Barr Virus dari Biopsi Jaringan dalam Blok Parafin Berpotensi sebagai Biomarka dalam Diagnosis Karsinoma Nasofaring Roni Afriansya; Hendro Pramono; Hidayat Sulistyo; Daniel Joko Wahyono
Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Vol 33, No 3 (2016)
Publisher : Fakultas Biologi | Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mib.2016.33.3.323

Abstract

Karsinoma nasofaring (KNF) merupakan tumor epitel yang terletak di nasofaring dan merupakan penyakit genetik multifaktor yang endemik. Penyebab utama KNF adalah infeksi oleh Virus Epstein-Barr (EBV). Keberadaan EBV pada penderita KNF dapat diketahui dengan ditemukannya DNA EBV dalam spesimen biopsi jaringan penderita KNF. Genom EBV dan ekspresi sebagian dari produk gen laten virus secara konsisten terdeteksi hampir di setiap sel dalam kanker ini, salah satunya adalah gen Latent Membrant Protein (LMP). Aktivitas mRNA EBV lebih mencerminkan patogenesis KNF yang  sesungguhnya dari pada diagnosis serologi dan pengukuran DNA EBV di sirkulasi. Penelitian dilakukan di Laboratorium PA RSUD Margono Seokarjo, Purwokerto/Lab PA Fakultas Kedokteran dan laboratorium genetika/molekuler Universitas Jenderal Soedirman Purwokerto. Analisis Ekspresi mRNA LMP2A EBV dengan teknik one step RT-PCR dan produk RT-PCR (amplikon cDNA) divisualisasi dengan elektroforesis gel agarosa 1%. Hasil ekspresi mRNA LMP2A EBV adalah 27,3% (6 dari 22 sampel). Kesimpulan, metode one step RT-PCR dapat digunakan untuk menganalisis ekspresi mRNA LMP2A EBV dari sampel biopsi jaringan KNF dalam blok paraffin dan hasil positivitas ekspresi mRNA LMP2A EBV sedang, sehingga berpotensi digunakan sebagai petanda biologi molekul diagnosis KNF.
Deteksi Karsinoma Nasofaring Mengunakan Rapid Test Uji Imunokromatografi pada Petugas SPBU Roni Afriansya; Umi Rosidah; Eko Naning Sofyanita
Jaringan Laboratorium Medis Vol 5, No 1 (2023): May 2023
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v5i1.9337

Abstract

Nasopharyngeal cancer (NPC) is the 4th most common malignancy in Indonesia, after breast, cervical and lung cancer. The risk factors for this cancer are Epstein-Barr virus, gender, race, adult age 30-50 years, family history, drinking alcohol and smoking. The prevalence of NPC in Indonesia is 6.2/100,000, with nearly 13,000 new cases, but this is a small proportion that has been documented. Adham et al (2012) reported that NPC is the most common head and neck cancer (28.4%), with a male-female ratio of 2:4 and is endemic to the island of Java. The existence of knowledge about NPC starting from prevention, early detection, appropriate treatment will be able to help overcome problems caused by nasopharyngeal cancer. Early detection is very important. If NPC is found at an early stage, the cure rate is quite high, reaching 90%. The purpose of this study was to find out whether there were gas station workers in Semarang City who experienced NPC. This study used an analytic survey method with a cross-sectional approach. The results of the study of 20 Semarang City Gas Station officers found that the characteristics based on age were the most in the range 31-50, namely 70%. Characteristics based on gender of the 20 gas station attendants are all male (100%). Characteristics based on length of service are 1 - 10 years (35%), 11 - 20 years (35%) and 21 - 30 years (30%) respectively. Characteristics based on smoking history, 55% of respondents smoked and 45% did not smoke. And the NPC examination results of all respondents (100%) were NPC negative.
Profile of Lymposites in New Tuberculosis (TB) Patients in Semarang City Roni Afriansya; Nurul Qomariyah; Anung Sugihartono; Eko Naning Sofyanita
Jurnal Surya Medika (JSM) Vol. 8 No. 3 (2022): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v8i3.3681

Abstract

The body's form of defense or natural immune response against intracellular bacteria is phagocytosis. Cells capable of phagocytosing macrophages in natural responses play a role in presenting antigens to lymphocytes in specific immune responses. The number of lymphocytes associated with the incidence of death in TB patients in hospitals. This study aims to determine the lymphocyte profile in pulmonary TB patients with new cases in the city of Semarang in 2020. This study uses a descriptive-analytic research design. The population in this study were new cases of pulmonary TB patients at the Semarang Health Center in 2020. The sample in this study was new cases of pulmonary TB patients at the Semarang Health Center from September to October 2020. The results showed that the newest cases of pulmonary TB were male (59%), and based on age the most were productive age (87.8%), and the lymphocyte profile of 78% of respondents had relative lymphopenia, 19.5% of respondents were normal and 2.4% of respondents experienced relative lymphocytosis. Overall, it can be said that the profile of patients with lymphopenia is 14.63%, and relative lymphopenia is 78%.
Detection of rpoB Gene Mutations in Mycobacterium Tuberculosis widodo widodo; Ahmad Riadi; Devi Etevia Purlinda; Lilik Setyowatiningsih; roni roniafriansya
Journal of Applied Health Management and Technology Vol 5, No 3 (2023): July 2023
Publisher : Politeknik Kesehatan Kementerian Kesehatan Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jahmt.v5i3.10093

Abstract

Perkembangan pengobatan infeksi tuberculosis memberikan harapan kesembuhan total akan tetapi seiring berjalanya waktu pengunaan obat berdampak pada munculnya strain Mycobacterium tuberculosis yang resisten terhadap obat peningkatan kecepatan diaknostik terhadap resistensi perlu dikembangkan salah satunya methode molekuler berbasis PCR penentu mutasi gen yang disebakan resistensi obat salah satu target obat yang digunakan adalah rpoB, pengunaan Primer rpoB sebagai penanda terjadinya mutasi diharapkan mampu memberikan dampak sebagai alternatif deteksi cepat secara molekuler. Panjang pita rpoB 318 bp cocok untuk kelompok Mycobacterium tuberculosis diperoleh hasil menunjukan pada kodon 509 perubagan AGC menjadi AAT terjadi perubahan asam amino dari serin menjadi Apargarin, perubahan nukleotida  CAG menjadi CCG pada kodon 510 mengubah asam amino Glutamin menjadi prolin, kodon 514 perubahan nukleotida TTC menjadi TTG mengubah asam amino Phenylalanine menjadi leucine, kodon 515 terjadi perubahan nukleotida ATG menjadi GTG perubahan ini menyebakan perubahan asam amino Methionine menjadi Valine  . perubahan tersebut menyebabkan terjadinya resistensi terhadap obat Rifampicin
Co-Authors Ahmad Riadi Andini, Dewi Anung Sugihantono Anung Sugihartono Arintina Rahayuni Daniel Joko Wahyono Devi Etevia Purlinda Dina Afrianti1 Duri, Iin Demiany Eko Naning Sofyanita Endang Susilowaty Hadipranoto, Ichsan Hendra Adistia Bangkit Hendro Pramono Hidayat Sulistyo Iin Desmiany Duri Iin Desmiany Duri Kuncara, Rachmad Bayu Lilik Setyowatiningsih Lilik Setyowatiningsih Maulana, Mochamad Rizal Nabila, Jihan Nur Indah Palupi Nurul Qomariyah Palupi, Nur Indah Rachmad Bayu Kuncara Raden Mohamad Herdian Bhakti Riadi , Ahmad Ririh Jatmi Wikandari Rosidah, Umi Salsabilah , Kania Shafa Setyowatiningsih, Lilik Sofyanita, Eko Naning Sulistia Istiqomah Syanubari, Sonnia Pusparindah Teguh Budiharjo, Teguh Umi Rosidah Wagiyo , Wagiyo widodo widodo Widodo Widodo Wiwit Sulistyasmi