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All Journal Althea Medical Journal Universa Medicina Jurnal Kreativitas PKM PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Penelitian dan Karya Ilmiah Lembaga Penelitian Universitas Trisakti Jurnal Abdimas Kesehatan Terpadu Jurnal Kedokteran Meditek
Lie Tanu Merijanti, Lie Tanu
Universitas Trisakti, Jakarta
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Journal : Universa Medicina

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Increased matrix metalloproteinase-9 in male elderly with low 25-hydroxy-vitamin D Pusparini, Pusparini; Merijanti, Lie Tanu; Sudharma, Novia I.
Universa Medicina Vol 35, No 3 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.171-180

Abstract

Background One of the extra-skeletal roles of vitamin D for health is associated with cardiovascular disease. Poor vitamin D status has been associated with vascular endothelial dysfunction. There were controversial results about the association between vitamin D deficiency and matrix metalloproteinase 9 (MMP-9) concentration. The purpose of the present study was to determine the concentrations of 25(OH) vitamin D [25(OH)D] in an elderly population and to find any association between 25(OH)D and MMP-9 concentrations.MethodsThis study was of cross-sectional design involving 160 male and female subjects aged 55–65 years, in South Jakarta, Indonesia. Determination of MMP-9 and 25(OH)D concentrations was done concurrently on subjects who met the inclusion and exclusion criteria after all study subjects had been selected. 25(OH)D and MMP-9 concentrations were assessed by direct competitive chemiluminescence immunoassay (CLIA) and enzyme-linked immunosorbent assay (ELISA) respectively. Statistical analysis used chi square and t tests.ResultsMean 25(OH)D concentration in the study subjects was 14.4 ± 6.4 ng/mL. A total of 68.8% of subjects had a 25(OH)D level of <20 ng/mL, and 31.2 % had a 25(OH)D level of >20 ng/mL.There was an increased MMP-9 concentration in male subjects with a 25(OH)D level of <20 ng/mL compared with subjects with 25(OH)D level of >20 ng/mL (p=0.011), but not among female subjects (p=0.809).ConclusionThe MMP-9 concentration was increased among male subjects with low level of (OH)D. This study confirmed that 25(OH)D concentration may have a potential role in endothelial function.
Decreased adiponectin level in adults with central obesity and low 25-hydroxy vitamin D level Pusparini, Pusparini; Merijanti, Lie Tanu; Lesmana, Alvina; Meiyanti, Meiyanti
Universa Medicina Vol 36, No 3 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.205-213

Abstract

Background Vitamin D insufficiency is associated with obesity and central obesity, which is in turn associated with the accumulation of visceral fat. Visceral fat secretes adiponectin which has a role in the pathogenesis of the metabolic syndrome, diabetes mellitus and cerebrovascular disease. The aim of this study was to determine the relationship between serum 25-hydroxy vitamin D [25(OH)D] level and adiponectin level in adults with central obesity. Methods This study was a cross sectional study with 80 subjects with central obesity and 80 healthy subjects as controls. The age of the subjects ranged from 55 to 65 years. The data collection included anthropometry and blood biochemistry (lipid profile, fasting blood glucose, 25(OH)D, and adiponectin). The data were analyzed using independent t test with p <0.05.Results Mean waist circumference and 25(OH)D level in the central obesity group were 94.9 ± 7.8 cm and 14.3 ± 6.6 ng/mL, respectively, and in the control group 72.4 ± 5.0 cm and 19.2 ± 8.6 ng/mL respectively. There were significant differences in adiponectin level between the central obesity group and the control group at the 25(OH)D level of <20 ng/mL (p=0.001), but no significant differences between the two groups at the 25(OH)D level of ³20 ng/mL (p=0.538).Conclusion The central obesity subgroup with 25(OH)D level of <20 ng/mL have lower adiponectin levels compared with the control group. This study demonstrates the role of adiponectin as a link between insulin resistance and vitamin D status in adults.
Hypoglycemic effect of Phaleria macrocarpa (Scheff.) Boerl dry extract in healthy adults Meiyanti, Meiyanti; Margo, Eveline; Pusparini, Pusparini; Merijanti, Lie Tanu; Lesmana, Alvina
Universa Medicina Vol 37, No 3 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (828.359 KB) | DOI: 10.18051/UnivMed.2018.v37.195-202

Abstract

BackgroundThe prevalence of diabetes in Indonesia continues to increase and causes many complications. Fruits of Phaleria macrocarpa (Scheff.) Boerl. (PM) are used in the traditional health system of the Indonesians, as effective remedy in the management of diabetes mellitus. The aim of this study was to evaluate the effect and magnitude of doses of PM dry fruit extract (PME) on blood glucose levels in healthy adults.MethodsThis research was of pre-posttest design involving 30 healthy volunteer subjects aged 20-55 years receiving glucose loads. At pre-test the subjects were given orally 75 g glucose, and at post-test they were given PME at doses of 125 mg and 250 mg. Data collection included anthropometric examination and blood glucose level. The area under the curve (AUC) of blood glucose levels was measured at 0, 15, 30, 60, 120 and 180 minutes. Data analysis was performed using paired t-test with p <0.05.ResultsThe percentage of reduction in AUC between pre- and post-test after administration of PME 125 mg was 12.1% and significant (p=0.000). But the percentage of reduction in AUC between pre- and post-test after administration of PME 250 mg was 4.07% and not significant (p=0.06). The reduction in AUC between post-test PME 125 mg vs PME 250 mg showed significant results (p=0.011).Conclusion This study demonstrated that a dose of 125 mg Phaleria macrocarpa (Scheff.) Boerl. dry extract has a hypoglycemic effect in healthy adults, and may therefore be suitable for use as traditional anti-diabetic drug.
Co-Authors Alvina Alvina Alvina Lesmana, Alvina Dewi Hastuty Dian Mediana, Dian Eveline Margo, Eveline Ferina, Mutiara Hairunisa, Nany Isahak, Marzuki bin Joice Viladelphia Kalumpiu Kartini Kurniasari Kurniasari Kurniasari Kurniasari Magdalena Wartono Mario Mario Mario Mario Meiyanti Meiyanti, Meiyanti Novia I. Sudharma, Novia I. Prasetyadi, Indiarto Nindyo Purnamawati Tjhin Pusparini Pusparini Pusparini Pusparini Rahmatullah, Ilham Arief Ridwan, Alvin Muhamad Tjahjadi, Muljadi Widia Aina Rohmah Yulizah, Intania