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All Journal International Journal of Evaluation and Research in Education (IJERE) Medicina E-Jurnal Medika Udayana WMJ (Warmadewa Medical Journal) MNJ (Malang Neurology Journal) Jurnal Kesehatan Husada Mahakam: Jurnal Kesehatan Majalah Kedokteran Neurosains Kumawula: Jurnal Pengabdian Kepada Masyarakat Jurnal Locus Penelitian dan Pengabdian MEDICINUS Journal of Global Pharma Technology
Desak Ketut Indrasari Utami
Department Of Neurology, Faculty Of Medicine, Universitas Udayana, Sanglah Hospital, Bali, Indonesia
Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Kadar Asam Urat Serum Fase Akut Stroke Iskemik Sebagai Prediktor Kualitas Tidur Pasca Stroke Iskemik: Sebuah Kajian Literatur Sistematis Triana, Rossy; Tini, Kumara; Utami, Desak Ketut Indrasari
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 11 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i11.5076

Abstract

Stroke iskemik akut merupakan bentuk stroke yang paling umum terjadi secara global dan sering kali disertai gangguan tidur pada fase pasca serangan. Kualitas tidur yang buruk setelah stroke diketahui dapat memperlambat proses pemulihan neurologis. Salah satu faktor biologis yang diduga berperan dalam gangguan tidur pasca stroke adalah kadar asam urat, mengingat keterkaitannya dengan stres oksidatif dan proses inflamasi. Tinjauan sistematis ini disusun untuk mengevaluasi hubungan antara kadar asam urat pada fase akut stroke iskemik dan kualitas tidur pasien pasca stroke. Tinjauan ini disusun berdasarkan pedoman PRISMA dengan pencarian literatur melalui basis data PubMed, Scopus, dan Cochrane Library hingga Mei 2025. Kata kunci yang digunakan antara lain: "uric acid", "ischemic stroke", "sleep quality", dan "insomnia". Studi yang diikutsertakan merupakan studi yang menilai kadar asam urat serum dan kualitas tidur (diukur menggunakan PSQI). Sebanyak dua studi memenuhi kriteria inklusi dengan total 2.040 pasien, mayoritas berasal dari Asia Timur. Beberapa studi menunjukkan bahwa kadar asam urat yang tinggi berhubungan dengan risiko lebih rendah terhadap gangguan tidur, sedangkan studi lainnya menunjukkan hasil yang kontradiktif. Terdapat perbedaan metode pengukuran dan ambang batas kadar asam urat antar studi, serta heterogenitas dalam definisi “kualitas tidur buruk”. Kadar asam urat tinggi pada fase akut stroke iskemik dapat berasosiasi dengan kualitas tidur yang lebih baik, namun juga berpotensi berdampak negatif terhadap fungsi kognitif. Oleh karena itu, diperlukan penelitian lanjutan dengan metodologi yang lebih seragam untuk menentukan batas optimal kadar asam urat yang bermanfaat tanpa meningkatkan risiko efek samping neurologis lainnya.
Kurang Tidur dan Regulasi Nafsu Makan: Tinjauan Mekanisme Hormonal dan Metabolik Rossy Triana; Desak Ketut Indrasari Utami
MEDICINUS Vol. 39 No. 4 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/wt0v0274

Abstract

Sleep deprivation has become an increasingly prevalent global health issue in the modern era. This condition not only affects cognitive function and quality of life but is also closely associated with the regulation of appetite and metabolic processes. Numerous studies have demonstrated that sleep insufficiency triggers hormonal changes, including increased ghrelin level, decreased leptin level, and alterations in other hormones involved in hunger and satiety regulation. These physiological changes promote increased energy intake, particularly from calorie-dense foods, while weakening cognitivecontrol over eating impulses. Moreover, sleep deprivation has been shown to reduce insulin sensitivity, increase insulin resistance, and disrupt glucose homeostasis, thereby contributing to the risk of obesity, type 2 diabetes, and metabolicsyndrome. Therefore, adequate and good-quality sleep plays a crucial role in maintaining metabolic balance and preventing long-term health complications.
The Correlation Between Serum Vitamin D Levels with Sleep Quality and Fatigue in Neurology and Psychiatry Trainees Doctors Putri Rossyana Dewi; Desak Ketut Indrasari Utami; Ida Bagus Kusuma Putra; Anak Agung Ayu Meidiary; I Komang Arimbawa; I Putu Eka Widyadharma
WMJ (Warmadewa Medical Journal) Vol 10 No 1 (2025): May 2025
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.10.1.12454.28-33

Abstract

Health workers, including resident physicians, are integral to delivering healthcare services. Engagement in both physical and non-physical tasks under rotating shift schedules may adversely impact sleep quality and precipitate fatigue among this cohort. Given the existing evidence, this study aims to examine the correlation between serum vitamin D levels, sleep quality, and fatigue among resident doctors. An analytical cross-sectional study was performed at Ngoerah Hospital from May to June 2022. Serum 25-hydroxy vitamin D [25(OH)D] concentrations were quantified to ascertain vitamin D status. Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI), and fatigue severity was measured via the Fatigue Severity Scale (FSS). Serum 25(OH) D levels demonstrated a strong and statistically significant negative correlation with PSQI scores (r = -0.664, p<0.001) and with FSS scores (r = -0.734, p<0.001). Regression analysis revealed that each one-unit increase in serum vitamin D was associated with a 65.7% reduction in PSQI score and a 68.2% reduction in FSS score. Most participants exhibited insufficient to deficient vitamin D status, likely attributable to limited occupational sun exposure. Monitoring and management of vitamin D status, including education on adequate sunlight exposure and consideration of vitamin D supplementation, are critically important for healthcare professionals, who are at elevated risk for deficiency, to support optimal sleep quality and minimize fatigue that may adversely affect clinical performance.
Co-Authors Amaze Morato Anak Agung Ayu Meidiary Anna Marita Gelgel Desak Ketut Ernawati Faldi Yaputra I Komang Arimbawa I Made Oka Adnyana I Putu Eka Widyadharma I Putu Eka Widyadharma Ida Ayu Sri Wijayanti Ida Bagus Kusuma Putra Mahadewi, Ni Putu Ayu Putri Morato, Amaze Grace Davidz Ni Kadek Dwita Hening Tias Ni Luh Putu Eka Diarthini Ni Luh Putu Wulan Budyawati Ni Made Oka Suliani, Ni Made Oka Putri Rossyana Dewi Rossy Triana Susilawathi, Ni Made Tini, Kumara Triana, Rossy Widyastuti, Ketut