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All Journal JURNAL MAHKAMAH Jurnal Surya Medika JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik Narra J World Psychology
Ika Trisnawati, Ika
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Cost Effectiveness Analysis of Anticoagulants as The Therapy of Corona Virus Disease 19 (Covid-19) Saputra, Andy Kurniawan; Andayani, Tri Murti; Trisnawati, Ika
Majalah Farmaseutik Vol 20, No 4 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i4.86807

Abstract

Hypercoagulation is a condition characterized by increased thrombosis and is caused by various factors, one of which is SARS-CoV-2 virus infection. Anticoagulants are the main therapeutic options such as heparin and enoxaparin. The administration of these two drugs can reduce coagulation parameters such as D-dimer, PT, and fibrinogen values. The purpose of this study was to analyze the cost-effectiveness comparison of heparin and enoxaparin as anticoagulants in severe and critical COVID-19 patients. This study is an analytical observational study with a retrospective cohort design from a provider perspective. The research subjects were severe and critical COVID-19 patients who met the inclusion and exclusion criteria at Dr. Sardjito General Hospital in the period January 2021 - January 2022. The effectiveness of anticoagulants was seen through a decrease in the D-dimer value to a value of < 500 ug/ml on day 14 in medical records, safety was assessed from the incidence of bleeding recorded in medical records, while the average direct cost data during the patient's hospitalization was studied to determine cost-effectiveness with the Incremental Cost-Effectiveness Ratio (ICER). The achievement of D-dimer value < 500 μg/ml for the heparin group was 39.5% while the enoxaparin group was 48.4%, the result showed no significant difference (p=0.293). All subjects did not experience bleeding. The average direct medical cost of the heparin group was Rp. 31,296,577 and enoxaparin was Rp. 55,205,810. The ACER calculation of heparin and enoxaparin was Rp. 79,233,841 and Rp. 114,061,591 with an ICER of Rp. 2,686,431 for a decrease in D-dimer value reaching < 500 ug/ml. This shows that enoxaparin is better at reducing D-dimer values despite having a higher cost than heparin. 
Pencegahan Pembiayaan Bermasalah Melalui Komite Pembiayaan Susilo, Agus; Trisnawati, Ika
Jurnal Mahkamah : Kajian Ilmu Hukum dan Hukum Islam Vol. 3 No. 2 December (2018)
Publisher : Institut Agama Islam Ma'arif NU (IAIMNU) Metro Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25217/jm.v3i2.379

Abstract

One source of BMT income is the distribution of funds through Murabahah financing. Murabahah financing is a contract of sale and purchase with prices and profits notified at the beginning. And the total amount of financing available must be managed professionally so as not to become a problematic financing. At BMT Assyafi'iyah Berkah Nasional, this professionalism is realized in the form of a Financing Committee. This research is a field research which is qualitative descriptive. Data collection techniques using observation, interviews and documentation. The subjects in this study were the Business Director and Head of the Financing Division of KSPPS BMT Assyafi'iyah Berkah Nasional, while the object of this study was all activities related to the Financing Committee in the KSPPS BMT Assyafi'iyah Berkah Nasional. The results of the study explain that problematic financing at BMT Assyafi'iyah is caused by 3 factors, namely financing members, BMT internal factors, and external factors. Its function is to minimize problem financing by analyzing the feasibility of providing financing through the 5C principle approach which includes Character, Capacity, Capital, and Colleteral.
Spectrum of rare EGFR mutations in Indonesian lung adenocarcinoma: Findings from an 8-year analysis of 4,778 cases highlighting the need for advanced targeted therapies Heriyanto, Didik S.; Trisnawati, Ika; Rachmadi, Lisnawati; Tenggara, Jeffry B.; Lau, Vincent; Gunawan, Andrew N.; Halim, Brigitta N.; Yuliani, Fara S.; Laiman, Vincent; Gondhowiardjo, Soehartati; Chuang, Hsiao-Chi
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1721

Abstract

Lung cancer patients in Indonesia exhibit a high prevalence of epidermal growth factor receptor (EGFR) mutations, with a substantial proportion attributed to rare or uncommon variants. The clinical significance of rare EGFR mutations lies in their differential sensitivity to tyrosine kinase inhibitors (TKIs). While they are frequently resistant to first- and second- generation TKIs, they often respond to third-generation TKIs, necessitating tailored treatment options. The need for improving access to advanced targeted therapies in Indonesia also highlights the importance of conducting research on rare EGFR mutations. The aim of this study was to identify the spectrum and frequency of EGFR mutations in patients with lung adenocarcinoma in Indonesia. A cross-sectional observational study with total sampling was conducted from January 2016 to April 2024 to investigate EGFR mutation profiles in lung adenocarcinoma patients. Samples were acquired from patients with a confirmed anatomical pathology diagnosis from various healthcare centers across Indonesia. A total of 4,778 samples were analyzed using real-time quantitative polymerase chain reaction (RT-qPCR) on various specimen types to determine EGFR mutation prevalence and patterns. Associations between demographic data and EGFR mutation status were assessed. EGFR mutations were detected in 54.6% of samples, with common mutations (exon 19 deletions/insertions and point mutation L858R) comprising 76.2% of positive cases and rare mutations (exon 20 insertions, point mutation G719X, S768I, T790M, and L861Q) accounted for 20.3%. Significant associations were found between geographic origin, age, and sex with EGFR mutation status. This study confirms substantial genetic variability and geographical differences in EGFR mutations among Indonesian lung adenocarcinoma patients, emphasizing the urgent need for further research to prompt enhanced molecular diagnostics and targeted therapies in the region.
Literatur Review: Pengaruh Pemberian Terapi ACEI/ARB Terhadap Mortalitas dan Adverse Outcome pada Pasien COVID-19: Literature Review: Impact of ACEI/ARB Therapy on Mortalities and Adverse Outcame in Patients with Covid-19 Murni, Siti Olega Adawiyah; Andayani, Tri Murti; Trisnawati, Ika
Jurnal Surya Medika (JSM) Vol. 11 No. 2 (2025): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v11i2.7649

Abstract

Severe acute respiratory syndrome coronavirus 2 merupakan virus pembawa corona virus disease 2019, yang terkait dengan tingginya insiden disfungsi multiorgan dan kematian menginfeksi manusia bergantung pada angiotensin converting enzyme 2 (ACE2) sehingga keamanan penggunaan pengobatan yang bekerja untuk meningkatkan ekspresi reseptor ACE2 seperti ACEI/ARB masih diperlukan pembuktian. Literature review ini dilakukan untuk mengetahui pengaruh ACEI/ARB terhadap kejadian mortalitas dan adverse outcome pada pasien COVID-19. Penelitian menggunakan literatur dari database Scopus, PubMed dan Science Direct. Pencarian literatur dengan kata kunci COVID-19, ACEI/ARB, Antihipertensi, Mortality dan outcome. Hasil penyaringan literatur diperoleh 19 artikel studi yang masuk kriteria inklusi. Ulasan ini menunjukkan hasil yang beragam terkait pengaruh ACEI/ARB terhadap perburukan klinis pasien COVID-19. Namun berdasarkan sejumlah artikel sistematik review dan meta-analisis dengan jumlah sampel yang cukup besar menunjukkan penggunaan ACEI/ARB tidak terkait dengan mortalitas dan perburukan klinis pasien (tidak dikaitkan dengan resiko admisi ke ICU, resiko penggunaan ventilasi mekanis invasif maupun non-invasif, peningkatan resiko rawat inap, serta resiko terinfeksi virus COVID-19). Kesimpulan: Penggunaan ACEI/ARB tidak berhubungan dan tidak mempengaruhi mortalitas serta perburukan luaran klinis pasien COVID-19, penggunaan ACEI/ARB sebelum terinfeksi direkomendasikan untuk dilanjutkan pada pasien COVID-19 untuk efek perbaikan pada kondisi pasien.
Clinical Outcomes for Severe COVID-19 Patients with Comorbid Type 2 DM through Dexamethasone Therapy at RSUP Dr. Sardjito Yogyakarta Dewi, Novia Ariani; Andayani, Tri Murti; Trisnawati, Ika
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 15, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.96954

Abstract

Background: Dexamethasone is a recommended therapy for severe COVID-19 patients who require hospital treatment. However, its use can affect blood glucose levels in patients, especially patients with diabetes mellitus comorbidity.Objectives: This study aims to determine the clinical outcomes for type 2 diabetes mellitus (DM) patients with Severe COVID-19 comorbidity through dexamethasone as COVID-19 therapy.Methods: This study employed the retrospective cohort an analytical observational research approach. Involving 60 patients as subjects, patients over the age of 18 received dexamethasone at RSUP Dr. Sardjito Yogyakarta between June 2021 and March 2022 and whose RT-PCR results showed severe COVID-19 with comorbidity of type 2 DM were included in the study. The blood glucose profiles derived from the patient's medical record data were the clinical outcome that already checked. The paired t-test was performed to analyze how dexamethasone affected the clinical results of the blood glucose profile.Results: The findings of the study were identified after using dexamethasone for four days, which showed that 78.30% of patients had an increased in blood glucose. Pre and post treatment of dexamethasone for four days had a significant impact on the patient’s blood glucose levels in this study, with an average change in blood glucose levels is 78.32 ± 116.77 (p<0.05).Conclusion: Dexamethasone therapy demonstrates a significant effect on blood glucose levels, resulting in a statistically difference between pre and post values for four days in patients with severe COVID-19 with type 2 DM comorbidity. Consequently, special monitoring needs to be carried out in severe COVID-19 patients with type 2 DM who receive dexamethasone to avoid worsening of the patient’s clinical condition.
Organizational Commitment as A Predictor of Job Performance in Hospital Employees Trisnawati, Ika; Harahap, Farida; Farida, Haniek
World Psychology Vol. 4 No. 1 (2025)
Publisher : Sekolah Tinggi Agama Islam Al-Hikmah Pariangan Batusangkar, West Sumatra, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55849/wp.v4i1.917

Abstract

Low Organizational Commitment has the potential to reduce the level of employee Job Performance in the Hospital environment. This study aims to analyze the effect of Organizational Commitment on employee Job Performance at RSU Kharisma Paramedika. This study uses a quantitative approach with a correlational research type. Participants in this study were 128 employees of RSU Kharisma Paramedika. The data collection technique used a questionnaire with a Likert scale. The instrument used in the Job Performance variable is a modification of the IWPQ Koopmans et al. (2016) and in the Organizational Commitment variable using a modification of the OCQ Mowday et al. (1982). The validity test of the instrument uses the Gregory and Product Moment formulas and the reliability test uses Alpha Cronbach. Data analysis uses simple linear regression analysis with the help of SPSS 25 software. The results of the study show that: (1) Organizational Commitment can be a predictor of Job Performance of employees of RSU Kharisma Paramedika. (2) Organizational Commitment can be a predictor of task performance of employees at Kharisma Paramedika Hospital. (3) Organizational Commitment can be a predictor of contextual performance in employees at Kharisma Paramedika Hospital. (4) Organizational Commitment cannot be a predictor of counterproductive work behavior in employees at Kharisma Paramedika Hospital.
Co-Authors Agus Susilo Andang Setiadi, Andang Chuang, Hsiao-Chi Eko Budiono Farida Harahap Gunawan, Andrew N. Halim, Brigitta N. Haniek Farida Heriyanto, Didik S. Laiman, Vincent Lau, Vincent Lisnawati Rachmadi Murni, Siti Olega Adawiyah Novia Ariani Dewi Saputra, Andy Kurniawan Soehartati Gondhowiardjo Sumardi . Tenggara, Jeffry B. Tri Murti Andayani Yuliani, Fara S.