Garuda - Garba Rujukan Digital

Achmad Hussein Sundawa Kartamihardja

Unknown Affiliation

Author-ID : 2809279

Biochemistry, Genetics & Molecular Biology Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Physics

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BIODISTRIBUSI 177LUTETIUM-(R)-NODAGA-PSMA PADA GINJAL DAN KANDUNG KEMIH TIKUS GALUR WISTAR JANTAN Brigitta Silalahi; Achmad Hussein Sundawa Kartamihardja; N. Elly Rosilawati; Rini Shintawati; Nur Rahmah Hidayati
Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) Vol 20, No 1 (2019): Februari 2019
Publisher : BATAN

177Lutetium (Lu) –(R)-NODAGA-PSMA merupakan perkembangan terapi radionuklida yang dapat digunakan untuk terapi metastasized castration-resistant prostate cancer (mCRPC). Penelitian ini dilakukan untuk mengetahui biodistribusi 177Lu–(R)-NODAGA-PSMA pada ginjal dan kandung kemih hewan coba berupa tikus galur wistar jantan. Penelitian eksperimental laboratorik ini dilakukan di laboratorium Departemen Ilmu Kedokeran Nuklir dan Pencitraan Molekuler RSUP Dr. Hasan Sadikin Bandung. Subjek penelitian adalah 10 tikus galur wistar jantan dengan usia 8-12 minggu; berat 200-250 gram; dalam keadaan sehat. Tikus akan ditidurkan dengan agen anestesi ketamin, lalu dilakukan injeksi 1,3-1,7 mCi radiofarmaka 177Lu–(R)-NODAGA-PSMA pada vena bagian ekor. Perhitungan cacahan organ total dilakukan pada menit ke 60,90, dan 120, pasca injeksi radiofarmaka 177Lu–(R)-NODAGA-PSMA sebesar 1.300-1.700 mCi pada vena bagian ekor. Hasil yang diperoleh dari uji adalah tangkapan ginjal dan kandung kemih.Rata-rata persentase tangkapan radiofarmaka pada menit ke-60 adalah ginjal kanan sebesar 4,35%, ginjal kiri 5,91%, kandung kemih 6,54%; pada menit ke-90 adalah ginjal kanan sebesar 6,31%, ginjal kiri 7,6%, kandung kemih 7,95%; serta pada menit ke-120 adalah ginjal kanan sebesar 6,89%, ginjal kiri 8,48%, kandung kemih 9,60%. Hasil persentase tangkapan organ target akan disajikan dalam tabel dan grafik.Biodistribusi radiofarmaka 177Lu–(R)-NODAGA-PSMA pada tikus galur wistar jantan ditangkap oleh ginjal kanan dan kiri serta kandung kemih. Peningkatan radioaktivitas tangkapan organ target tercatat seiring dengan berjalannya waktu penelitian. Hal ini disebabkan karena ginjal berperan sebagai organ ekskresi dari radiofarmaka.

Hyperthyroidism-Induced Myocardial Ischemia: Quantification and Correlation with fT4 via 99mTc-Sestamibi Scintigraphy Daniel Chung; Achmad Hussein Sundawa Kartamihardja; Raden Erwin Affandi Soeriadi Koesoemah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1336

Background: Hyperthyroidism exerts significant detrimental effects on the cardiovascular system, increasing the risk of major adverse cardiac events (MACE). While associations with atrial fibrillation and cardiomyopathy are well-documented, the incidence and characteristics of myocardial ischemia, particularly assessed by functional imaging, remain less explored. This study aimed to investigate the incidence of myocardial ischemia in hyperthyroid patients using Technetium-99m Sestamibi (⁹⁹ᵐTc-Sestamibi) myocardial perfusion scintigraphy (MPS) and correlate findings with thyroid hormone levels. Methods: This prospective preliminary study enrolled fifteen consecutive patients with confirmed hyperthyroidism and no prior history of ischemic heart disease between January and April 2024. All subjects underwent thyroid function tests (TSH, fT4, T3) and a one-day rest/adenosine-stress ⁹⁹ᵐTc-Sestamibi MPS protocol. Myocardial ischemia presence, reversibility, severity (Summed Stress Score, SSS), and extent (total ischemic segments) were assessed using the AHA 17-segment model. Spearman correlation was used to analyze the relationship between hormone levels and MPS parameters. Results: Fifteen subjects (93.3% female, mean age 34 ± 11 years) were included. Myocardial ischemia was detected in 14/15 subjects (93.3%). Among those with ischemia, 12 (80% of total subjects, 85.7% of ischemic subjects) exhibited reversible defects. Free thyroxine (fT4) levels showed a strong positive correlation with SSS (rs = 0.64, p = 0.01) and the total number of ischemic segments (rs = 0.65, p = 0.01). Conclusion: This preliminary study revealed a high incidence of myocardial ischemia, predominantly reversible, in patients with hyperthyroidism detected by ⁹⁹ᵐTc-Sestamibi MPS. The severity and extent of ischemia demonstrated a significant positive correlation with fT4 levels. These findings underscore the potential utility of MPS in cardiovascular risk assessment and suggest the need for comprehensive cardiac evaluation in hyperthyroid patients, particularly those with higher fT4 levels.

Hyperthyroidism-Induced Myocardial Ischemia: Quantification and Correlation with fT4 via 99mTc-Sestamibi Scintigraphy Daniel Chung; Achmad Hussein Sundawa Kartamihardja; Raden Erwin Affandi Soeriadi Koesoemah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1336

Background: Hyperthyroidism exerts significant detrimental effects on the cardiovascular system, increasing the risk of major adverse cardiac events (MACE). While associations with atrial fibrillation and cardiomyopathy are well-documented, the incidence and characteristics of myocardial ischemia, particularly assessed by functional imaging, remain less explored. This study aimed to investigate the incidence of myocardial ischemia in hyperthyroid patients using Technetium-99m Sestamibi (⁹⁹ᵐTc-Sestamibi) myocardial perfusion scintigraphy (MPS) and correlate findings with thyroid hormone levels. Methods: This prospective preliminary study enrolled fifteen consecutive patients with confirmed hyperthyroidism and no prior history of ischemic heart disease between January and April 2024. All subjects underwent thyroid function tests (TSH, fT4, T3) and a one-day rest/adenosine-stress ⁹⁹ᵐTc-Sestamibi MPS protocol. Myocardial ischemia presence, reversibility, severity (Summed Stress Score, SSS), and extent (total ischemic segments) were assessed using the AHA 17-segment model. Spearman correlation was used to analyze the relationship between hormone levels and MPS parameters. Results: Fifteen subjects (93.3% female, mean age 34 ± 11 years) were included. Myocardial ischemia was detected in 14/15 subjects (93.3%). Among those with ischemia, 12 (80% of total subjects, 85.7% of ischemic subjects) exhibited reversible defects. Free thyroxine (fT4) levels showed a strong positive correlation with SSS (rs = 0.64, p = 0.01) and the total number of ischemic segments (rs = 0.65, p = 0.01). Conclusion: This preliminary study revealed a high incidence of myocardial ischemia, predominantly reversible, in patients with hyperthyroidism detected by ⁹⁹ᵐTc-Sestamibi MPS. The severity and extent of ischemia demonstrated a significant positive correlation with fT4 levels. These findings underscore the potential utility of MPS in cardiovascular risk assessment and suggest the need for comprehensive cardiac evaluation in hyperthyroid patients, particularly those with higher fT4 levels.

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