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M. Pandapotan Nasution
Program Studi Farmasi, Fakultas Farmasi, Universitas Muslim Nusantara Al-Washliyah, Medan, Sumatera Utara, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Analisis cemaran bakteri Staphylococcus aureus pada daging ayam krispy pinggir jalan dan fast food di daerah Teladan kota Medan Adelia Ramadani; Yayuk Putri Rahayu; M. Pandapotan Nasution; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.205

Abstract

Chicken meat is a highly nutritious food containing protein, fat, minerals and other substances. Chicken meat is easily contaminated with the pathogen Staphylococcus aureus which can cause Staph Food Poisoning (SFP) or food poisoning due to contamination from unhygienic traders, processing, and the environment. The purpose of this study was to identify the presence of S. aureus pathogenic bacteria in roadside crispy fried chicken meat and well-known fast food brands in the Teladan area of Medan city and to analyze the contamination value of S. aureus bacteria whether it meets the Indonesian National Standard (SNI) < 1X102 CFU/ml. The research method was to determine the presence of S. aureus in the sample using Baird Parker Agar Base (BPA) and Egg Yolk media. Specific identification using Gram stain test, coagulase test, and catalase test. Calculation of contamination value of S. aureus with Total Plate Count (TPC). The results on roadside crispy fried chicken were positive for the presence of S. aureus with a contamination value exceeding the threshold above 1X102 CFU/ml so it did not meet SNI standards. Fast food crispy fried chicken meat is known to be negative in the absence of S. aureus pathogenic bacteria so that it meets SNI standards.
Penetapan kadar flavonoid total ekstrak etanol, fraksi etil asetat dan n-heksan pada daun kakao (Theobroma cacao L.) dengan metode spektrofotometri uv-vis Zikra Maqfirah; Muhammad Amin Nasution; M. Pandapotan Nasution; Haris Munandar Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.43

Abstract

Cocoa (Theobroma cacao L.)  is a plant that is cultivated on plantations in Indonesia. One part of the cacao plant that has the potential to be developed as a traditional medicine is the cacao leaf because it contains secondary metabolites of flavonoids. Flavonoids have many properties, including acting as antioxidants, protecting cell structures, anti-inflammatories, preventing osteophoresis, and antibiotics. The purpose of this study is to determine the content of secondary metabolites and total flavonoid levels in ethanol extract, ethyl acetate fraction and n-hexane in cocoa leaves. In this study, the initial steps taken are sample collection, sample processing into simplicia, simplicia characterization test then preparation of cocoa leaf ethanol extract by maceration method using 70% ethanol solvent, followed by partitioning process with liquid-liquid extraction method to obtain ethyl acetate fraction and n-hexane and phytochemical screening is carried out. Determination of total flavonoid levels using the UV-vis spectrophotometric method at a wavelength of 437 nm with quercetin as a comparison.The results of this study showed that a cocoa leaf ethanol extract contains alkaloid compounds, flavonoids, tannins, saponins, steroids and glycosides, the ethyl acetate fraction contains alkaloid compounds, flavonoids, tannins, steroids and glycosides, while the n-hexan fraction contains alkaloid compounds, flavonoids and steroids. Total flavonoid levels in cocoa leaves from an ethanol extract amounted to 39.1422±0.0540 mg QE/g, ethyl acetate fraction 45.274±0.0629 mg QE/g and n-hexane fraction 21.4812±0.7048 mg QE/g. The highest flavonoid levels are obtained in the ethyl acetate fraction.
Uji aktivitas antioksidan ekstrak etanol daun bunga melati (Jasminum sambac (L.) Sol. ex Aiton) dengan metode DPPH Selfiani Selfiani; M. Pandapotan Nasution; Anny Sartika. D; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.200

Abstract

Antioxidant compounds are substances that can absorb or neutralize free molecules so they can prevent degenerative diseases such as heart disease and cancer. Antioxidants are able to donate electrons to stop free radical chain reactions that can damage the body. Jasmine flower leaves contain bioactive substances such as flavonoids, alkaloids, and tannins which are potential ingredients as natural antioxidants. One method to measure or determine free radical scavenging antioxidants is the DPPH (1,1-Diphenyl-2-Picrylhidrazyl) method. This study aims to determine the antioxidant activity of the ethanol extract of jasmine leaves based on the IC value50. The methods used in this study included examination of simplicia characteristics, phytochemical screening and antioxidant activity tests using the DPPH method (1,1-Diphenyl-2-picrylhidrazyl) using a UV-Vis spectrophotometer. The results of this study revealed that the ethanol extract of jasmine flower leaves (Jasminum sambac (L.) Sol. ex Aiton) showed that the extract contained chemical compounds of alkaloids, flavonoids, saponins, tannins, and steroids. In addition, this study also revealed that the ethanol extract of jasmine leaves has antioxidant activity with an IC value50 namely 56.05 µg/mL and for vitamin C the IC value was obtained50 3.70 µg/mL. This shows that the ethanol extract of jasmine leaves positively contains secondary metabolites and has the potential as an antioxidant with a strong classification compared to vitamin C, which is an antioxidant with a very strong classification.
Penetapan kadar flavonoid total ekstrak etanol daun bunga melati (Jasminum sambac (L.) Sol. ex Aiton) dengan spektrofotometri Uv-Vis Hastri Kholifah; M. Pandapotan Nasution; Anny Sartika Daulay; Haris Munandar Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.201

Abstract

Traditional medicine uses plants with a natural ingredient content as its raw material. The bioactive compounds found in plants are secondary metabolites such as alkaloids, flavonoids, tannins, glycosides, steroids, and saponins. One of the plants containing secondary metabolite compounds is jasmine. This study aims to determine the chemical compounds contained in the ethanol extract and the total flavonoid content of the ethanol extract of jasmine leaves using the UV-Vis spectrophotometric method. The stages of this research included processing plant simplicia, making ethanol extract, examining characteristics, screening phytochemicals, and determining the total flavonoid content of the ethanol extract of jasmine leaves using the UV-Vis spectrophotometric method. Extract jasmine flower leaves by maceration method using 96% ethanol solvent; the extract obtained was concentrated using a rotary evaporator; then the total flavonoid content was determined using the UV-Vis spectrophotometry method. The research shows that the ethanol extract of jasmine flower leaves (Jasminum sambac (L.) Sol. ex Aiton) contains several secondary metabolite compounds, such as flavonoids, glycosides, alkaloids, saponins, steroids, and tannins. A number of steps were taken to find out how many flavonoids were in the ethanol extract as a whole. These included finding the maximum wavelength of quercetin, the operational time, making a quercetin calibration curve, and using UV-Vis spectrophotometry to determine how many flavonoids were in the extract. The analysis results reveal that the total flavonoid content in the ethanol extract of jasmine flower leaves is approximately 40.10911 ± 0.5878 mg QE/g.
Efektivitas antibakteri ekstrak etanol daun bisbul (Diospyros discolor Willd) terhadap bakteri Propionibacterium acnes Nanda Nadia; D. Elysa Putri Mambang; M. Pandapotan Nasution; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.240

Abstract

The bisbul plant (Dyospiros discolor Willd) is a plant whose fruit is often consumed by the public. Bisbul leaves are known to have antibacterial and antifungal activity. The purpose of this study was to determine whether the ethanol extract of bisbul leaves (Diospyros discolor Willd) has antibacterial effectiveness against Propionibacterium acnes bacteria. This research was conducted using experimental methods which included sample collection, macroscopic examination, microscopic examination, simplex preparation, characteristic examination, phytochemical screening, preparation of ethanol extract, and testing of antibacterial effectiveness against Propionibacterium acnes bacteria using the agar diffusion method. The results of the macroscopic examination conducted on the bisbul leaf simplex were brownish-green leaves, flat edges, 5 cm long leaves, 4 cm wide leaves, had a distinctive odor and a slightly bitter taste. The simplex characteristic results obtained water content of 4%, water-soluble essence content of 21%, 23% ethanol-soluble extract content, 4.8% total ash content and 0.3% acid-insoluble ash content. Phytochemical screening of simplex powder and ethanol extract of bisbul leaves showed the presence of alkaloids, tannins, flavonoids, steroids/triterpenoids, saponins and glycosides. The results of the antibacterial effectiveness test of the ethanol extract of bisbul leaves showed that the diameter of the inhibition zone was larger at a concentration of 80%, namely 15.98 mm, compared to concentrations of 70% and 60%, namely 15.43 mm and 14.18 mm. From the results of the study it can be concluded that the ethanol extract of bisbul leaves can provide antibacterial effectiveness against Propionibacterium acnes bacteria.
Skrining fitokimia dan uji aktivitas antibakteri ekstrak etanol daun kayu Jawa ((Lannea coromandelica) (Houtt) Merr terhadap bakteri Propionibacterium acnes dan Staphylococcus epidermidis Munaziatul Jannah; Haris Munandar Nasution; M. Pandapotan Nasution; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.241

Abstract

Jawa wood (Lannea coromandelica) (Houtt.) Merr. is a tropical plant that has potential as a medicinal plant. Almost all parts of this plant can be used in traditional medicine. This wild plant can be found easily in various locations such as home gardens, roadsides and community gardens. This study aims to evaluate the potential antibacterial activity of ethanol extract from the leaves of Kayu Jawa (Lannea coromandelica) (Houtt.) Merr. Against the growth of Propionibacterium acnes and Staphylococcus epidermidis bacteria. This research used experimental methods involving sample collection, macroscopic examination, microscopic examination, simplicia making, characteristic examination, Phytochemical Screening, and Antibacterial Activity Test using ethanol extract from Kayu Jawa ((Lannea coromandelica) (Houtt) Merr) against the bacteria Propionibacterium acnes and Staphylococcus epidermidis, using the agar diffusion method. Macroscopic examination results show that the leaves of Kayu Jawa have a tapered shape with a total of 7-11 strands. The flowers produced are single and yellowish-green in color, while the fruit has seeds of a certain length. Microscopic examination reveals the upper epidermis, palisade fragments, coral flowers, and wooden vessels with thickened spirals and stairs. The characteristics of simplicia show a water content of 4%, soluble essence content in water 21%, soluble essence content in ethanol 23%, total ash content of 4.8%, and insoluble ash content of 0.4% acid. The results of phytochemical screening on simplicia powder and ethanol extract of Kayu Jawa leaves showed contents such as alkaloids, tannins, flavonoids, steroids/triterpenoids, saponins and glycosides. The antibacterial activity test showed that Jawa wood showed potential as an antibacterial agent, with different inhibitory abilities depending on the concentration used. At a concentration of 20%, an inhibition zone of 6.85 mm was observed against Propionibacterium acnes and 5.75 mm against Staphylococcus epidermidis. Meanwhile, at a concentration of 80%, the area of inhibition increased to 14.15 mm against Propionibacterium acnes and 11.75 mm against Staphylococcus epidermidis.
Skrining fitokimia dan isolasi senyawa flavonoid dari ekstrak etanol kulit buah menteng (Baccaurea racemosa (Reinw.) Müll.Arg) Muhammad Ari Mukhtizar; Haris Munandar Nasution; M. Pandapotan Nasution; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.299

Abstract

The menteng plant, which belongs to the Euphorbiaceae family, is a subtropical plant worldwide. Flavonoids are one of the groups of phenolic compounds found in plant tissues that can act as antioxidants. This research aimed to determine the class of chemical compounds found in the Menteng fruit peel and determine the characteristics of fruit peel flavonoids by UV Spectrophotometry and IR Spectrophotometry. %. Phytochemical screening showed positive for alkaloids, flavonoids, and steroids/triterpenoids, while tannins, saponins, and glycosides were negative from 400 grams of simplisia produced 39.1 grams of viscous extract. Characterization of crystal isolates of UV spectrophotometry showed a wavelength of 280 nm, inferred to be a flavanoid. The results of IR spectrophotometry show the O-H, C-H aliphatic, C=C aromatic, C=O, C-H, and C-O groups.
Co-Authors Adelia Ramadani Anny Sartika Daulay Anny Sartika. D D. Elysa Putri Mambang Haris Munandar Nasution Hastri Kholifah Muhammad Amin Nasution Muhammad Ari Mukhtizar Munaziatul Jannah Nanda Nadia Rafita Yuniarti Selfiani Selfiani Yayuk Putri Rahayu Zikra Maqfirah