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Anny Sartika Daulay
Program Studi Farmasi, Fakultas Farmasi, Universitas Muslim Nusantara Al-Washliyah, Medan, Sumatera Utara, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Penetapan kadar flavonoid total ekstrak etanol daun bunga melati (Jasminum sambac (L.) Sol. ex Aiton) dengan spektrofotometri Uv-Vis Hastri Kholifah; M. Pandapotan Nasution; Anny Sartika Daulay; Haris Munandar Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.201

Abstract

Traditional medicine uses plants with a natural ingredient content as its raw material. The bioactive compounds found in plants are secondary metabolites such as alkaloids, flavonoids, tannins, glycosides, steroids, and saponins. One of the plants containing secondary metabolite compounds is jasmine. This study aims to determine the chemical compounds contained in the ethanol extract and the total flavonoid content of the ethanol extract of jasmine leaves using the UV-Vis spectrophotometric method. The stages of this research included processing plant simplicia, making ethanol extract, examining characteristics, screening phytochemicals, and determining the total flavonoid content of the ethanol extract of jasmine leaves using the UV-Vis spectrophotometric method. Extract jasmine flower leaves by maceration method using 96% ethanol solvent; the extract obtained was concentrated using a rotary evaporator; then the total flavonoid content was determined using the UV-Vis spectrophotometry method. The research shows that the ethanol extract of jasmine flower leaves (Jasminum sambac (L.) Sol. ex Aiton) contains several secondary metabolite compounds, such as flavonoids, glycosides, alkaloids, saponins, steroids, and tannins. A number of steps were taken to find out how many flavonoids were in the ethanol extract as a whole. These included finding the maximum wavelength of quercetin, the operational time, making a quercetin calibration curve, and using UV-Vis spectrophotometry to determine how many flavonoids were in the extract. The analysis results reveal that the total flavonoid content in the ethanol extract of jasmine flower leaves is approximately 40.10911 ± 0.5878 mg QE/g.
Analisis kadar natrium benzoat pada kecap pedas yang beredar di pasaran dengan metode kromatografi lapis tipis (KLT) dan spektrofotometri Uv-Vis Tamara Army; Ainil Fithri Pulungan; Ridwanto Ridwanto; Anny Sartika Daulay
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.266

Abstract

Sodium benzoate is one of the preservatives allowed in food and beverages. The objective of this research was to determine the level of sodium benzoate found in spicy soy sauce. Qualitative tests are first carried out on samples with the Thin Layer Chromatography (KLT) method, and quantitative tests are carried out using the spectrophotometry Uv-Vis method to determine the preservative level of sodium benzoate. Qualitative tests on KLT plates were carried out by optimising eluents (N-Butanol: Ethyl Acetate: Ammonia, Methanol: Ethyl Acetate: Ammonia, and Isopropanol: Ammonia), where the results of the three eluents showed that the Isopropanol: Ammonia eluents had Rf values from three samples that were close to each other with the comparison Rf values. The results of quantitative analysis on spectrophotometry Uv-Vis showed the total levels of Spicy Soy Sauce A 264.16±12.3206 mcg/g, Spicy Soy Sauce B 317.8±21.8643 mcg/g and Spicy Soy Sauce C 110.2±23.5356 mcg/g. Based on these results, it can be concluded that sodium benzoate levels in samples A, B, and C meet the requirements of the maximum usage limit standard, which is not more than 600 mg/kg.  
Penetapan kadar fenolik total ekstrak etanol, fraksi etil asetat dan n-heksan daun kopi robusta (Coffea canephora Pierre ex A. Froehner) dengan metode spektrofotometri Uv-Vis Yulia Nanda Putri; Muhammad Amin Nasution; Ridwanto Ridwanto; Anny Sartika Daulay
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.301

Abstract

Phenolic compounds have various biological effects, such as antioxidant activity, can reduce the risk of cancer, coronary heart disease, stroke and other neurodegenerative diseases. Robusta coffee leaves (Coffea canephora Pierre ex A. Froehner) have activity as antioxidants because they contain abundant phenolic compounds. This study aims to determine the ratio of total phenolic levels between ethanol extract, ethyl acetate fraction and n-hexane fraction from robusta coffee leaves. In this study, the first step taken was a characterization test on simplicial powder and robusta coffee leaves macerated with 70% ethanol solvent. The maserat obtained is further fractionated with n-hexane and ethyl acetate. Followed by phytochemical screening on coffee leaf samples. Furthermore, the extract, n-hexane fraction and ethyl acetate determined total phenolic levels using visible spectrophotometry at a wavelength of 749 nm. Determination of total phenolic levels using the Folin-Ciocalteu method with gallic acid standards. Total phenolic levels are expressed in mg gallic acid equivalent (GAE) per gram of simplicial. The results showed that 70% ethanol extract of robusta coffee leaves had a total phenolic content of 25.9438± 0.0889 mg GAE/g. From the fractionation results show that the ethyl acetate fraction of robusta coffee leaves has a greater total phenolic content compared to the n-hexan fraction of 28.048 ± 0.3692 mg GAE / g and followed by the n-hexane fraction of 15.5231 ± 0.7213mg GAE / g. This is because the fractionation method can increase the desired compound content by removing or separating unwanted compounds, thus making the compound results in the use of fractions purer.
Penetapan kadar fenolik total ekstrak kayu bajakah (Spatholobus littolaris Hassk.) berdasarkan perbedaan konsentrasi etanol dengan metode spektrofotometri Uv-Vis Indah Triutami Harahap; Anny Sartika Daulay; Fathur Rahman; Haris Munandar Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.302

Abstract

The root of the Bajakah tampala (Spatholobus littolaris Hassk.) is one of the plants that is empirically used by the people of the interior of Central Kalimantan as a traditional medicine. According to the preliminary tests conducted, Bajakah Tampala contains phenolics. Phenolic compounds are compounds that have antioxidant activity. The objective of this research was to determine the class of compounds contained in the macerated extract and the total phenolic content and yield of the macerated extract in Bajakah roots. The stages of this research included the processing of plant materials, preparation of macerated and pirated root extracts, characterization examination, phytochemical screening, and the effect on the yield of total phenolic content of Bajakah roots using the UV-Vis spectrophotometry method. The results showed that the simplicia powder of the root of the Bajakah wood contained alkaloids, glycosides, steroids and triterpenoids, flavonoids, phenolics, saponins, and tannins, while the ethanol extract of the roots of the Bajakah wood showed the presence of alkaloids, steroids and triterpenoids, tannins, saponins, flavonoids, and phenolic compounds. The determination of total phenolic content was carried out by determining the maximum wavelength of gallic acid and calculating the total phenolic content based on the difference in ethanol concentration using the UV-Vis spectrophotometry method. The results for determining total phenolic content in 96% ethanol extract were 33.872 ± 0.0420 mg GAE/g, 70% ethanol extract was 29.345 ± 0.2149 mg GAE/g, and 50% ethanol extract was 18.512 ± 0.1355 mg GAE/g. So it can be concluded that the total phenolic content of 96% ethanol extract is higher than that of 70% ethanol extract and 50% ethanol extract.
Skrining fitokimia dan isolasi senyawa flavonoid dari ekstrak etanol biji buah menteng (Baccaurea racemosa (Reinw.) Müll.Arg). Sarmadansyah Sarmadansyah; Haris Munandar Nasution; Anny Sartika Daulay; Daeng Elysa Putri Mambang
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.304

Abstract

Menteng or kepundung is a fruit-producing tree. At first glance, Menteng or kepundung fruit resembles duku fruit with a variety of tastes (sour) and sweet. Menteng originates from Malaysia, Sumatra, Java and Bali. The purpose of this study was to determine the class of chemical compounds found in Menteng fruit seeds and to determine the characteristics of the fruit seed extract isolates by UV spectrophotometry and IR spectrophotometry. This research includes several processes, namely manufacturing simplicia from menteng fruit seeds, phytochemical screening, and simplicia characterisation. The process of making extracts from menteng fruit seed Simplicia, after that extract analysis using paper chromatography (KKt) method, then separation (isolation) of the extract with preparative paper chromatography (KKt) method, tested the purity of isolates by two-way paper chromatography (KKt), and characterisation of isolate crystals by UV spectrophotometry and IR spectrophotometry. The results of the simplicial characterisation of Menteng fruit seeds (Baccaurea racemose (Reinw.) Müll. Arg) are 4% water content, 36.81% seawater content, 8.79% ethanol soluble extract, 1.26% ash content, 1.26% ash content. Insoluble 0.5% acid. Phytochemical screening showed positive alkaloids, flavonoids, steroids/triterpenoids and glycosides, while tannins and saponins were negative. From 400 grams of simplicia, 93.3 grams of condensed extract was produced. Characterisation of isolate crystals UV spectrophotometry showed a wavelength of 280 nm, which is suspected to be a flavonoid. The results of the IR spectrophotometry showed aliphatic O-H, C-H, C=O, C-H, C-O and C=C groups.
Penetapan kadar flavonoid total ekstrak kayu raru (Cotylelobium lanceolatum Craib) berdasarkan perbedaan konsentrasi etanol dengan metode spektrofotometri Uv-Vis Elma Natasya; Anny Sartika Daulay; Ridwanto Ridwanto; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.305

Abstract

The utilization of traditional medicinal plants for healing is the oldest form of medicine in the world. One of the plants that have many benefits and contain secondary metabolite compounds is raru bark (Cotylelobium lanceolatum Craib), used as a traditional medicine for diseases such as malaria, diarrhea, and diabetes. This study aims to determine what groups of compounds are contained in raru bark extract and the value of total flavonoid levels contained in raru bark extract in differences in ethanol concentrations (96%, 70%, 50%). The stages of this research include processing plant materials, making ethanol extracts of raru bark extract, characterization examination, phytochemical screening, and determining the total flavonoid content of raru bark ethanol extract. The section of raru bark was made by maceration method using 96%, 70%, and 50% ethanol. Then, the extract obtained was concentrated with a rotary evaporator, and the determination of total flavonoid content was carried out based on differences in ethanol concentration using the UV-Vis spectrophotometric method. The results showed that the ethanol extract of raru bark contained alkaloids, flavonoids, saponins, tannins, and steroid compounds. Determination of total flavonoid content by determining the maximum wavelength of quinine and calculating entire flavonoid content by UV-Vis spectrophotometric method. The results of the decision of complete flavonoid content of raru bark ethanol extract at 96% concentration are 1.9915 ± 0.0139 mg QE/g, 70% is 1.12492 ± 0.01532 mg QE/g, and for 50% is 0.95197 ± 0.01516 mg QE/g. So, the best ethanol concentration to produce flavonoid levels is 96%, which is higher than other ethanol concentrations.
Penetapan kadar fenolik total ekstrak kayu raru (Cotylelobium lanceolatum Craib) berdasarkan perbedaan konsentrasi etanol dengan metode spektrofotometri UV-Vis Lastri Afni; Anny Sartika Daulay; Ridwanto Ridwanto; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.306

Abstract

Many Indonesian people use or use plants as traditional medicine; one plant that has many benefits is raru bark (Cotylelobium lanceolatum Craib), which is used as a traditional medicine in various diseases such as diarrhea, malaria, and diabetes. This study aims to find out what classes of compounds are found in raru bark extract and to determine the value of total phenolic levels contained in raru bark extract in various concentrations (96%, 70%, 50%). The stages of this research include processing plant materials, making raru bark ethanol extract, characterization examination, phytochemical screening, and determining total phenolic levels of raru bark extract based on differences in ethanol concentration by UV-Vis spectrophotometry method. The results showed that raru bark ethanol extract contains compounds, flavonoids, tannins, saponins, steroids, and phenolics. Determination of total phenolic content by determining the maximum wavelength of gallic acid and calculation of entire phenolic content by UV-Vis spectrophotometry method. Results of selecting the whole phenolic content of raru bark ethanol extract at a concentration of 96%; 28,6544±0,1548 mgGAE/g, 70%; 23,9682±0,1270 mgGAE/g, 50%; 20,5825±0,1993 mgGAE/g, then the phenolic content that best produces total phenolic levels is raru bark ethanol extract (Cotylelobium lanceolatum Craib) concentration of 96%.
Prevalensi bakteri Salmonella sp. pada daging ayam potong di pasar tradisional, pasar modern, dan merek terkenal di kota Medan. Lulu Ilma Khoirun Nissa; Yayuk Putri Rahayu; D. Elysa Putri Mambang; Anny Sartika Daulay
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.330

Abstract

Chicken is a source of animal protein for humans. Chicken meat generally contains unsaturated fat; chicken meat also has a compact meat texture and simple protein, so it is easily digested. However, chicken meat can also be contaminated with Salmonella sp. Pathogenic bacteria can cause typhus or typhoid fever, caused by traders' lack of cleanliness and hygiene or their environment. Research was conducted to identify the presence of Salmonella sp. Pathogenic bacteria and analysing the value of Salmonella sp. Pathogenic bacteria contamination that met the Indonesian National Standard (SNI), namely harmful/25g in chicken meat from traditional markets, modern markets, and well-known brands in Medan City, and to determine the prevalence value of Salmonella sp. Bacteria. The method of research uses Total Plate Count (TPC). An identification test is first carried out to calculate and determine the presence of bacteria in a test sample for the existence of Salmonella sp. Pathogenic bacteria and choose the total value of contaminants using a Total Plate Count (TPC), then identify using a gram staining test. These biochemical tests include the indole test, MRVP test, citrate test, urea test, TSIA test, and LIA test. Then, the last one determines the Prevalence value of Salmonella sp. Bacteria. The results showed that the samples of traditional market and modern market chicken meat were positive for the presence of the pathogenic bacteria Salmonella sp. by obtaining Subgenus Salmonella Typhimurium on N2H8 sample code APTL and APTB, N3H15 sample code APTL, APTB, APMI and obtaining Subgenus Salmonella Thypi on N3H15 sample code APMS and the contamination value of the pathogenic bacteria Salmonella sp. Exceeds the threshold and does not meet the Indonesian National Standard (SNI), namely negative/25g. The prevalence value obtained by the pathogenic bacteria Salmonella sp. in broiler meat at Traditional Markets, Modern Markets, and well-known brands is 75%, 50%, and 0%, respectively.
Co-Authors D. Elysa Putri Mambang Daeng Elysa Putri Mambang Elma Natasya Fathur Rahman Fithri Pulungan, Ainil Haris Munandar Nasution Hastri Kholifah Indah Triutami Harahap Lastri Afni Lulu Ilma Khoirun Nissa M. Pandapotan Nasution Muhammad Amin Nasution Ridwanto Ridwanto Sarmadansyah Sarmadansyah Tamara Army Yayuk Putri Rahayu Yulia Nanda Putri