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All Journal E-Jurnal Medika Udayana Bali Journal of Anesthesiology Syntax Literate: Jurnal Ilmiah Indonesia PREPOTIF : Jurnal Kesehatan Masyarakat Neurologico Spinale Medico Chirurgico Journal of Anesthesiology and Clinical Research Jurnal Neuroanestesi Indonesia Journal of Global Pharma Technology Jurnal Anestesi dan Terapi Intensif Udayana Jurnal Anestesiologi dan Terapi Intensif
Christopher Ryalino
Departemen Anestesiologi Dan Terapi Intensif, Fakultas Kedokteran, Universitas Udayana, Denpasar, Bali
Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Journal : Journal of Global Pharma Technology

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Ethanolic Extracts of Young Papaya Seed (Carica papaya, Linn) Decrease Spermatocytes, Leydig Cells, and Androgen Receptor of Leydig Cells of Adult Mice (Mus musculus) Christopher Ryalino
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Uncontrolled population growth is one of the problems in Indonesia. Among the various types of wild plants that can be used as anti-fertility drugs are papaya plants. This study aims to determine the effect of extracts on the number of spermatozoa, Leydig cells and androgen receptor (AR) expression on Leydig cells as an anti-fertility mechanism.  Materials and Methods: This was an experimental, randomized posttest-only controlled group study. We used a total of 36 Wistar rats as the subjects of this study. The rats were classified equally into two groups by simple random sampling method. Group E rats received 0.5 mL ethanol extract of papaya seeds for 50 days (orally), and the rats in Group C (control) received 0.5 cc aquabidest for 50 days. Results: The treatment group showed a decrease in the number of spermatozoa (201.86 vs. 94.3, p <0.001), a decrease in the number of Leydig cells (7.61 vs. 3.32, p <0.001), and decreased AR expression of Leydig cells (46.19 vs. 18.48, p <0.001) compared to the control group. Conclusion: ethanol extracts of young papaya seeds significantly reduce the number of spermatocytes, Leydig cells, and the AR expression of the Leydig cells.Keywords: Young papaya seed, Male anti-fertility, Androgen receptor, Leydig cells.
Co-Authors Adinda Putra Pradhana Agung Senapathi, Tjokorda Gede Agustina, Mona Anak Agung Gde Oka Cristy, Nadia Assecia Cynthia Dewi Sinardja Desy Permatasari Desy Permatasari Dewi, Christina Angelia Maharani Elizeus Hanindito Estrada, Ronald Farha, Nabilla Gatot Triwono Haithami, Guntur Mu Ammar Heryana, Kadek Agus I Gde Raka Widiana I Gede Budiarta I Gusti Agung Gede Utara Hartawan I Gusti Ngurah Mahaalit Aribawa I Ketut Sinardja I Ketut Suyasa I Made Gede Widnyana I Made Subagiartha I Nyoman Semadi I Putu Agus Surya Panji I Wayan Aryabiantara, I Wayan I Wayan Suranadi Ida Bagus Krisna Jaya Sutawan Junaedi, I Made Darma Junaedi, Made Darma Labobar, Otniel Adrians Leton, Yohanes PT Made Wiryana Mahaalit, I Gusti Ngurah Narakusuma, I Putu Fajar Ngakan Gede Dwija Hermawan Ni Nyoman Sri Budayanti Pontisomaya Parami Pradnyani, Ni Putu Novita Pranoto, Theodorus Pascalis Yullie Putu Agus Surya Panji Putu Diah Virayanti, Luh Putu Kurniyanta Putu Pramana Suarjaya Raka-Sudewi A. A. Saputra, Darmawan Jaya Sidemen, I Gusti Ayu Eka Para Santi Suwardana, Muhammad Bayu Tjahya Aryasa Tjokorda Gde Agung Senapathi Utariani, Arie Virayanti, Luh Putu Diah Wanda, Aprilia