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All Journal Journal of Innovative and Creativity Jurnal Siti Rufaidah
Manahan Situmorang
Universitas Sari Mutiara Indonesia
Education Health Professions Languange, Linguistic, Communication & Media Mathematics Nursing Public Health Social Sciences Other

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Pengujian Efek Analgesik Ekstrak Metanol Daun Gaharu (Aquilaria Malaccensis Lam) Pada Tikus Putih Jantan Galur Wistar (Rattus Norvegicus) Monica Suryani; Manahan Situmorang; Dhea Nur Fadhilah
Jurnal Siti Rufaidah Vol. 1 No. 4 (2023): November : Jurnal Siti Rufaidah
Publisher : PPNI UNIMMAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jasira.v1i4.38

Abstract

Medicinal plants have been known and used worldwide for thousands of years. One type of medicinal plant that is often used is gaharu. The efficacy of gaharu leaves provides properties as a fever reducer, increases appetite, launches menstruation, and relieves pain. This study aims to determine whether there is an analgesic effect from the methanol extract of gaharu leaves in male Wistar rats using the heat stimulation method. This study was an experimental study using twenty-five male Wistar rats divided into five groups. Group I (negative control), rats were treated with 1% CMC-Na. Group II (positive control), rats treated with mefenamic acid 45 mg/kg BW. Group III, IV, and V rats were treated with gaharu leaf methanol extract suspension (100; 200, and 400) mg/kg BW. Pain stimulation was carried out by dipping the rat tail into a 40°C water bath. Data on response time to pain, stimuli were analyzed using the One-Way Analysis of Variance (ANNOVA) method with a 95% confidence level followed by a post-hoc Tukey test to determine which group had the same or significantly different effect. The results showed that the normal response time data for mice to painful stimuli ranged from 2.79 to 3.57 seconds. 1% CMC-Na treatment in mice was unable to increase the response time to a significant pain stimulus (p>0.05). Mefenamic acid treatment 45 mg/Kg BW significantly increased the response time to painful stimuli (p<0.05) with the longest average response time to painful stimuli, namely 8.87 seconds. Based on the method used in this research, methanol extract of agarwood leaves 400 mg/kgBW has almost the same analgesic effect as mefenamic acid 45 mg/KgBW.
Effectiveness Test Of The Inhibition Power Of Ethanol Extract Of Salak Pondoh Fruit Skin (Salacca Zalacca (Gaertn.) Voss) Against Eschericia Coli Bacteria And Salmonella Typhi Bacteria Manahan Situmorang; Widya Fitri; Julia Susanti; Enjelina Br Sembiring Kembaren
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.2058

Abstract

Diarrhea is the occurrence of defecation with a more liquid consistency than usual and may be accompanied by liquid mucus or blood with a frequency of three times or more within 24 hours. Salak pondoh contains chemical compounds consisting of flavonoids, saponins, phenols, tannins, alkaloids, chlorogenic acid, ferulic acid, and protocatechuic acid. The bacteria Escherichia coli and Salmonella typhi cause diarrhea and fever due to tissue damage. Based on the above description, this study will test the effectiveness of the inhibitory power of the ethanol extract of salak pondoh fruit skin (Salacca zalacca (Gaertn.) Voss) against Escherichia coli and Salmonella typhi bacteria. This research method uses an experimental agar diffusion method to test the antibacterial activity of salak pondoh fruit skin with concentrations of 20%, 40%, 60%, and 80%. The results of this study show that the concentrations of 20%, 40%, 60%, and 80%, and the positive control (chloramphenicol) of salak pondoh fruit skin have antibacterial inhibitory power against the growth of Escherichia coli bacteria, as indicated by inhibition diameters of 4.81 ± 22.74 mm, 7.81 ± 22.74 mm, 10.15 ± 06.65 mm, 15.07 ± 19.00 mm, and 27.56 ± 48.58 mm, respectively. For Salmonella typhi, the antibacterial inhibitory power was 2.22 ± 18.19 mm, 3.48 ± 23.30 mm, 7.32 ± 67.41 mm, 11.68 ± 112.07 mm, and 24.14 ± 77.77 mm, respectively. The conclusion from the results of this study is that the effectiveness test of the ethanol extract of salak pondoh fruit skin (Salacca zalacca (Gaertn.) Voss) can inhibit the growth of Escherichia coli and Salmonella typhi bacteria, and the concentration that can significantly affect bacterial growth inhibition is 80%.
Anti-Fungal Activity Test Of Cardamom (Amomum Cardamomum L.) Leaf Ethyl Acetate Fraction Against Candida Albicans And Pityrosporum Ovale Nuranti Rumela; Manahan Situmorang; Martin Suhendri; Aditiya Mawarni Zega
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.2061

Abstract

Cardamom leaves (Amomum cardamomum (L.) Cardamom is a plant that is commonly used as a cooking spice and is also believed to have properties for treating various diseases, one of which is disease caused by fungi. The aim of this research is to determine the antifungal activity of ethanol extract of cardamom leaves against fungi Candida albicans and Pythyrovorum ovale to determine the effective inhibitory concentration of the ethanol extract of kitolod leaves in inhibiting it as an antifungal. The samples were extracted by the maceration method using 96% ethanol solvent. The antifungal activity test was carried out by the agar diffusion method using a paper backer. This experiment  consisted of three times Mixtures with respective concentrations of 20%, 40%, 80%, DMSO 10% as a negative control and Ketoconazole as a positive control. The results of the antifungal activity test showed that the ethanol extract of cardamom leaves was against Candida albicans fungi with concentrations of 20%, 40%, 80%. % respectively had an inhibition zone of (16.67 mm), (16.77 mm), (18.09 mm), positive control ketoconazole (21.40 mm), negative control 10% DMSO (0 mm). Meanwhile, the fungus Pythyrovorum ovale with concentrations of 20%, 40%, 80% respectively had an inhibition zone of (13.78 mm), (14.35 mm), (16.18 mm), positive control ketoconazole (19.86 mm), 10% DMSO negative control (0 mm). The results of the study showed that the ethanol extract of cardamom leaves had antifungal activity against Candida albicans and Pythyrovorum ovale.
Co-Authors Aditiya Mawarni Zega Dhea Nur Fadhilah Enjelina Br Sembiring Kembaren Julia Susanti Martin Suhendri Monica Suryani Nuranti Rumela Widya Fitri