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All Journal Pharmascience Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Pharmaceutical Reports Journal of Pharmaceuticals and Natural Sciences MPSJ
Aulia Wati, Aulia
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Journal : Pharmaceutical Reports

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Evaluation of the Anti-Inflammatory Effect of Ethanol Extract of Porang Tuber (Amorphophallus muelleri Blume) on White Rats (Rattus norvegicus) Amaliah, Annisa; Rahman, Safriani; Wati, Aulia
Pharmaceutical Reports Vol 5, No 1 (2026): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v5i1.395

Abstract

Inflammation is a protective response to tissue injury aimed at neutralizing or eliminating invasive organisms triggered by physical trauma. One of the plants known for its anti-inflammatory properties is the porang tuber, which contains flavonoids. This study aimed to determine the anti-inflammatory effect and effective dosage of ethanol extract of porang tuber (Amorphophallus muelleri Blume) in male rats (Rattus norvegicus). An experimental design was employed, utilizing 20 white rats divided into five treatment groups: a negative control (1% NaCMC), a positive control (sodium diclofenac), and porang tuber ethanol extract at doses of 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW. Test preparations were administered one hour before the induction of 1% carrageenan (0.1 mL, intraplantar). Paw edema volume was measured plethysmographically every 60 minutes for 6 hours. Statistical analysis, performed via one-way ANOVA followed by a Bonferroni post-hoc test, revealed no significant difference between the positive control group and the porang tuber ethanol extract groups. In conclusion, the porang tuber ethanol extract exhibits anti-inflammatory effects, with a dose of 400 mg/kgBW identified as the most effective.
Co-Authors Alani, Fitri Wasto Amaliah, Annisa Arini Arini Aulya, Riska Azhary, Nursyahidah Bayu Putra, Bayu Fira, Alfiah Fitriana Fitriana Hardiyanti, Purnamasari Hasbullah, Nurhijjah Hendra Herman Irma Santi, Irma Meilinda, Mega Mustakim, Putri Dwiyanti Adha Ninsih, Ulfah Ayu Nur Azizah, Rizqi Rachmat Kosman, Rachmat Rahmawati, Junita Eka Rahmawati, Rahmawati Rakhmat, Syahgita Resvani, Syahyu Rian Iryansyah, Rian Iryansyah Safriani Rahman, Safriani Selpida Handayani, Selpida Sitti Amirah sukmawati Sukmawati Sukmawati Zainal Abidin Zulhijja .S, Faradiba