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All Journal Pharmascience Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Journal of Pharmaceuticals and Natural Sciences MPSJ
Aulia Wati, Aulia
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Journal : MPSJ

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UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL BIJI ALPUKAT (Persea americana Mill.) SECARA IN VITRO DENGAN MENGGUNAKAN SPEKTROFOTOMETRI UV-VIS Zulhijja .S, Faradiba; Abidin, Zainal; Wati, Aulia
Makassar Pharmaceutical Science Journal (MPSJ) Vol 1 No 2 (2023)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v1i2.75

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia, which is caused by insulin resistance and dysfunction of insulin secretion. Avocado is used as a traditional medicine to treat various diseases, one of which is the seed of the avocado which contains alkaloids, polyphenols, tannins, flavonoids, triterpenoids, quinones, saponins, monoterpenes and sesquiterpenes and can lower blood glucose levels. The aim of this study was to determine the antidiabetic potential of ethanol extract of avocado seeds (Persea americana Mill.) in vitro using the Nelson Somogyi method. The test began with preparing a series of sample ethanol extract concentrations with concentrations of 40, 50 and 60 ppm using a UV-Vis spectrophotometer measured at a wavelength of 745 nm. The results of testing the anti-diabetic activity by the test samples were able to show the effectiveness of reducing glucose levels in vitro by showing the EC50 value in the ethanol extract sample was 59.1018 μg/mL. From the results of the study it can be concluded that the ethanol extract of avocado seeds (Persea americana Mill) has activity in reducing glucose levels.
Uji Aktivitas Sitotoksik Ekstrak Daun Matoa (Pometia pinnata) dengan Metode BSLT (Brine Shrimp Lethality Test) Rahmawati, Junita Eka; Wati, Aulia; Handayani, Selpida
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 1 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i1.159

Abstract

Matoa plant (Pometia pinnata) is a typical Papuan plant included in the Sapindaceae family which can relieve hypertension and has diuretic, antidiabetic and antioxidant activities. Matoa leaves contain chemical alkaloids, flavonoids, saponins, and steroids. The purpose of this study was to determine the toxic effect and LC50 value of n-hexan extract of matoa leaves against Artemia Salina Leach larvae. Extraction is carried out by maceration method with n-hexane solvent. The n-hexan extract of matoa leaves is prepared in a test solution with concentration variations of 500 ppm, 750 ppm, 1000 ppm, and 1500 ppm. Toxicity testing was carried out using Artemia Salina Leach larvae then the toxic effect of the extract was identified with the percentage of death of Artemia Salina Leach larvae using probit analysis (LC50). The results of this study showed the highest mortality at a concentration of 1500 ppm with the death of 30 larvae. Based on the results of the research conducted, it can be concluded that matoa leaf extract (Pometia pinnata) has a toxic effect on Artemia Salina Leach larvae with a Lethal Concentration value of 50 (LC50) of 509.577 ppm and is included in the toxic category.
Co-Authors Alani, Fitri Wasto Arini Arini Aulya, Riska Azhary, Nursyahidah Bayu Putra, Bayu Fira, Alfiah Fitriana Fitriana Hardiyanti, Purnamasari Hasbullah, Nurhijjah Hendra Herman Irma Santi, Irma Meilinda, Mega Mustakim, Putri Dwiyanti Adha Ninsih, Ulfah Ayu Nur Azizah, Rizqi Rachmat Kosman, Rachmat Rahmawati, Junita Eka Rahmawati, Rahmawati Rakhmat, Syahgita Resvani, Syahyu Rian Iryansyah, Rian Iryansyah Safriani Rahman, Safriani Selpida Handayani, Selpida Sitti Amirah sukmawati Sukmawati Sukmawati Zainal Abidin Zulhijja .S, Faradiba