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Uji Aktivitas Antioksidan Ekstrak Etanol Sabut Buah Pinang (Areca catechu L.) Pratiwi, Indah; Hasnaeni, Hasnaeni; Handayani, Selpida
Jurnal Pharmascience Vol 11, No 1 (2024): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i1.16811

Penelitian ekstrak etanol buah pinang (Areca catechu L.) telah dilakukan. Penelitian ini untuk mengetahui nilai IC50 antioksidan optimal buah pinang (A. catechu L.) menggunakan metode DPPH. Sampel buah pinang (A. catechu L.) diekstraksi dengan etanol 96% menggunakan metode ekstraksi maserasi. Ekstrak diuapkan untuk mendapatkan ekstrak etanol kental menggunakan rotary evaporator. Skrining fitokimia dilakukan untuk mengetahui kandungan metabolit sekunder. Hasil skrining menunjukkan adanya senyawa flavonoid dan alkaloid dalam ekstrak etanol buah pinang. Pengujian aktivitas antioksidan dilakukan dengan menggunakan DPPH dan menggunakan quercetin sebagai senyawa standar. Nilai IC50 ekstrak etanol diketahui sebesar 69,979 µg/mL. Hasil penelitian menunjukkan adanya potensi ekstrak etanol buah pinang sebagai antioksidan kuat. Kata Kunci: 2,2-Diphenyl-1-Picrylhydrazyl (DPPH), Flavanoid, Nilai IC50, Maserasi, Kuersetin The purpose of this study was to determine the optimal antioxidant IC50 value of Areca catechu L. using the DPPH method. Areca fruit extract (Areca catechu L.) with 96% ethanol using maceration procedure. The extract was evaporated using a rotary evaporator to obtain concentrated ethanol extract, after which a phytochemical screening was carried out to determine the content of secondary metabolites. Screening results showed that flavonoids and alkaloids were found in the ethanol extract of areca nut coconut shells. In addition, antioxidant activity was also tested with DPPH and uses quercetin as a standard. The IC50 of 96% ethanol extract is 69,979 µg/mL. In this review, IC50 results were obtained which showed the potential of A.catechu ethanol extract as a strong antioxidant

Antibacterial Activity of Ethanol Extract of Purple Kencana Leaves (Ruellia tuberosa L.) Using TLC-Bioautography and Agar Diffusion Methods Sari, Felisa Ananda; Herwin, Herwin; Handayani, Selpida
Journal Microbiology Science Vol 3, No 2 (2023)
Publisher : Fakultas Farmasi, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jms.v3i2.982

Kencana Ungu Leaf (Ruellia tuberosa L.) is a traditional plant that has antibacterial activity. The purpose of this study was to determine the antibacterial activity of the ethanol extract of Kencana Ungu leaves (Ruellia tuberosa L.) using TLC-Bioautography and Agar Diffusion methods. Simplisia from Kencana Ungu leaves (Ruellia tuberosa L.) was extracted by maceration method and then evaporated to obtain a thick extract. Preliminary testing, namely the antibacterial screening test, active extract at a concentration of 0.5% against Escherichia coli, Shigella dysenteriae, and Salmonella thypi. The results of the antibacterial activity test using the TLC-Bioautography method using chloroform: methanol (7:1) as an eluent showed results with an Rf value of 0.89 which inhibited the growth of Escherichia coli, Shigella dysenteriae, and Salmonella thypi bacteria. While the results of testing the antibacterial activity using the Agar Diffusion method obtained the largest diameter of the inhibition zone at a concentration of 20% for Escherichia coli bacteria with an inhibition zone diameter of 12.15 mm, Shigella dysenteriae with an inhibition zone diameter of 11.72 mm, and Salmonella thypi with an inhibition zone diameter of 12.67 mm

Pemberdayaan Kader Putri Karangtaruna Desa Pucak, Maros Melalui Pelatihan Pengolahan Singkong Menjadi Produk Pangan Sehat Effendi, Nurmaya; Nurlina, Nurlina; Handayani, Selpida; Amran, Farizah Dhaifina
Abdimas Galuh Vol 6, No 2 (2024): September 2024
Publisher : Universitas Galuh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25157/ag.v6i2.14318

Modified-cassava flour (mocaf) merupakan produk tepung dari singkong termodifikasi melalui proses fermentasi yang melibatkan bakteri asam laktat. Mocaf merupakan produk olahan singkong yang bebas protein gluten sehingga aman dikonsumsi oleh kalangan masyarakat yang intoleran dengan jenis protein ini. Hasil panen singkong yang sangat melimpah di Desa Pucak setiap tahunnya yang mencapai 68 ton per tahun tentunya dapat menjadi salah satu peluang bisnis yang tentunya bisa menaikkan nilai ekonomi komoditi unggul tersebut melalui produksi mocaf dan pengolahannya menjadi produk bernilai ekonomi lain seperti kue kering dan brownies. Kegiatan pengabdian kami ini bertujuan untuk meningkatkan pengetahuan, sikap, dan keterampilan kader putri karang taruna Bukit Kemuning, Desa Pucak, Maros dalam membuat produk pangan sehat, dalam hal ini kue kering dan brownies berbahan mocaf. Dalam mencapai tujuan ini, digunakan metode penyuluhan, diskusi interaktif, serta pelatihan untuk meningkatkan pengetahuan kelompok mitra dalam membuat cookies dan brownies berbahan dasar mocaf. Untuk mengamati dan mengevaluasi perubahan pengetahuan, sikap, dan keterampilan kader putri karang taruna sebagai mitra, kami menggunakan kuesioner pre-post tes baik sebelum dan sesudah kegiatan. Hasil kegiatan menunjukkan bahwa telah terjadi peningkatan pengetahuan, sikap, dan keterampilan mitra dalam membuat cookies dan brownies berbahan dasar mocaf. Selanjutnya, kami berharap kader putri karang taruna Bukit Kemuning, Desa Pucak, Maros dapat menerapkan dan menyebarluaskan pengetahuan dan keterampilan mereka dalam membuat cookies dan brownies berbahan dasar mocaf sehingga dapat membantu meningkatkan diversifikasi produk olahan singkong desa mereka dan menjadikannya peluang usaha yang dapat meningkatkan taraf ekonomi mereka.

Toxicity of Standardized Ethanolic Extracts from Duchesnea indica (Jacks.) Focke Plants Using the BSLT Method Waris, Risda; Handayani, Selpida; Wisdawati; Hossani, Rahni
Window of Health : Jurnal Kesehatan Vol 7 No 3 (July 2024)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.v7i2.1328

Duchesnea indica (jacks. ) focke., known as a medical plant that is used as raw ingredients for traditional medicines and herbs to increase the immune system because plants have the properties to cure and prevent various diseases. The objective of this study is to examine the quality of the duchesnea indica leaves extract by standardization method of specific and non specific parameters as well as the toxicity assay using using the Brine Shrimp Letality Test (BSLT). The results of specific parameter research include the identity of extracting duchesnea indica, Organoptic tests form extract samples that are used to extract thick, It's brown, Typical smell, astringent taste. The content of water soluble compounds is 18.67%, the content of ethanol soluble compounds is 0.03%, based in phytochemical screening test, the duchesnea indica leaves extract contain phenolic, flavonoid, tannin, Saponin and terpenoid. Non-specific parameters carried out include loss on drying of grounded Duchesne indica leaves at 0.029%, loss on drying of DuchesneA indica leaves extract at 0.026%, specific gravity determination at 0.83%, extract water content determination of 2.15%, total ash content is 3.70%, non-soluble acid of ash content is 1.32%. Thus, from these results, we can conclude that Duchesne indica leaf extract meets quality standards for extracting raw materials that can be used for traditional medicine. Research results: The standardized ethanol extract of duchesnea indica leaves is toxic to Artemia salina leach larvae.

Identification of Medicinal Chemicals (BKO) Piroxicam in Jamu Pegal Linu Preparations in Makassar City Hasnaeni, Hasnaeni; Handayani, Selpida; Andina, Velda
Hydrogen: Jurnal Kependidikan Kimia Vol 12, No 1 (2024): February 2024
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v12i1.10576

The aim of the research was to identify Piroxicam in herbal medicine for rheumatic pain circulating in Makassar. There are several traditional medicines that contain medicinal chemicals. Research has been conducted on the identification of medicinal chemicals (BKO) on several rheumatic herbs preparations in herbs shops in Makassar. The BKO which is often included in rheumatic herbs is the NSAID group, one of which is piroxicam. This inspection was conducted to know the presence of the chemical drug piroxicam contained within rheumatic herbs preparations and the samples used were 5 samples. The method used was a qualitative test using thin layer chromatography (TLC) consisting of a mobile phase mixed with n-hexane and acetone (7:3) and a stationary phase using Silica Gel GF254. The results of the TLC examination from 5 samples of herbal medicine added BKO piroxicam contained 3 samples including herbs A, B, and C because they had the same stain color at the same Rf value as the piroxicam. Some of the rheumatic herbs circulating in Makassar contain medicinal chemicals in the form of piroxicam.

Irritation Assessment of Herbal Deodorant from Essential Oil of Pomelo (Citrus maxima) Peel on Rabbit Skin Wisdawati, Wisdawati; Handayani, Selpida; Pratama, Mamat
Journal of Food and Pharmaceutical Sciences Vol 12, No 3 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.12139

A deodorant manages an unpleasant body odor through both reducing and suppressing antibacterial activity and it is formulated generally using antibacterial agents and fragrances. Nowadays, quaternary ammonium compounds like triclosan, aluminum salts, and odor eliminators are used as antibacterial agents and fragrance in deodorant products. A nature-based deodorant potentially replace the synthetic deodorant with less irritating effect. Pomelo (Citrus maxima) is one of the Indonesian plants which has some bioactive compounds, including limonene. Essential oil of Pomelo peel (EOPP) exhibits an antibacterial activity as well as fragrance. The aim of this research is to observe the irritation effect of EOPP deodorant on rabbit skin. The irritation assay of herbal deodorant of EOPP with various concentrations (F1: 1.25%; F2: 2.5% and F3: 5%) was carried out based on protocol for dermal acute irritation test on rabbit skin. All the formulations performed the same grades (negligible criteria) with the irritation index of F1, F2 and F3: 0; 0.037 and 0.148, respectively. The herbal deodorants with various concentrations of EOPP did not show an irritating effect on rabbit skin.

INOVASI PERMEN ANTIOKSIDAN TOMAKUMA DI DESA PUCAK MAROS SULAWESI SELATAN Faradiba; Syarif, Rezki Amriati; Handayani, Selpida; Amaliah Dahlia, Andi
Mejuajua: Jurnal Pengabdian pada Masyarakat Vol. 4 No. 2 (2024): Desember 2024
Publisher : Yayasan Penelitian dan Inovasi Sumatera (YPIS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/mejuajuajabdimas.v4i2.174

Desa Pucak merupakan salah satu desa yang berada di kabupaten Maros Sulawesi Selatan. Permasalahan pada desa tersebut adalah banyaknya buah tomat pada masa panen yang tidak bisa disimpan lama, sehingga banyak buah tomat yang membusuk. Selain itu masih kurangnya pengetahuan masyarakat tentang kegunaan buah tomat yang mengandung likopen sebagai antioksidan. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan keterampilan dalam mengolah buah tomat yang matang dibuat menjadi permen tomat dengan rasa kurma yang dikenal sebagai tomakuma yang dikemas dalam kemasan yang higienis dan menarik sehingga dapat disimpan dalam waktu yang lama dan dapat dijual untuk sumber pendapatan tambahan bagi masyarakat, selain itu memberikan pengetahuan tentang buah tomat yang mengandung senyawa likopen sebagai antioksidan. Metode yang digunakan adalah pelatihan dan pendampingan dalam pembuatan permen antioksidan tomakuma dan diskusi dalam bentuk penyuluhan tentang manfaat buah tomat yang mengandung likopen sebagai antioksidan. Peningkatan pengetahuan tentang buah tomat dan produk tomakuma dapat diukur dari hasil kuisioner yang diberikan kepada masyarakat sebelum dan sesudah kegiatan pelatihan dan penyuluhan. Hasil yang diperoleh menunjukkan adanya peningkatan pengetahuan tentang buah tomat dan antioksidan yang ditunjukkan pada nilai presentase menjawab pertanyaan benar dan salah sebelum dan sesudah pelatihan berturut-turut 7% menjadi 93% dan 86% menjadi 14%. Selain itu diperoleh hasil tingkat kesukaan masyarakat masing-masing untuk pendapat netral, setuju, dan sangat setuju berturut-turut terhadap produk tomakuma sebesar 10,72% ; 80,95% ; 8,33%. Kegiatan pengabdian kepada masyarakat ini menunjukkan dampak yang positif kepada masyarakat desa pucak karena ada perubahan peningkatan pengetahuan tentang buah tomat, antioksidan dan produk tomakuma.

Irritation Assessment of Herbal Deodorant from Essential Oil of Pomelo (Citrus maxima) Peel on Rabbit Skin Wisdawati, Wisdawati; Handayani, Selpida; Pratama, Mamat
Journal of Food and Pharmaceutical Sciences Vol 12, No 3 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.12139

A deodorant manages an unpleasant body odor through both reducing and suppressing antibacterial activity and it is formulated generally using antibacterial agents and fragrances. Nowadays, quaternary ammonium compounds like triclosan, aluminum salts, and odor eliminators are used as antibacterial agents and fragrance in deodorant products. A nature-based deodorant potentially replace the synthetic deodorant with less irritating effect. Pomelo (Citrus maxima) is one of the Indonesian plants which has some bioactive compounds, including limonene. Essential oil of Pomelo peel (EOPP) exhibits an antibacterial activity as well as fragrance. The aim of this research is to observe the irritation effect of EOPP deodorant on rabbit skin. The irritation assay of herbal deodorant of EOPP with various concentrations (F1: 1.25%; F2: 2.5% and F3: 5%) was carried out based on protocol for dermal acute irritation test on rabbit skin. All the formulations performed the same grades (negligible criteria) with the irritation index of F1, F2 and F3: 0; 0.037 and 0.148, respectively. The herbal deodorants with various concentrations of EOPP did not show an irritating effect on rabbit skin.

Wound Healing Ointment Formulation from Essential Oil of Lemongrass (Cymbopogon citratus) Wisdawati, Wisdawati; Razak, Rais; Handayani, Selpida
Jurnal Jamu Indonesia Vol. 10 No. 1 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i1.337

Untreated wound may lead to the infection. In some countries, plants are used to cure wound traditionally. Lemongrass (Cymbopogon citratus) has various bioactive compounds, including citronellol, limonene and geraniol that perform some pharmacological activities. In this study, the essential oil of lemongrass was designed into ointment formulation since lemongrass has been reported to have a wound healing effect in mice. The wound healing ointment made from different concentration of the essential oil of Cymbopogon citratus (F1: EOCC 5%, F2: EOCC 10% and F3: EOCC 15%) using a water-removable base and the characteristic as well as the stability (texture, color, smell, homogeneity, and pH) after been stored for 14 days was also evaluated. The result showed that all formulation (F1, F2, and F3) of wound healing formulation revealed good texture, consistency, odor, color, homogeneity and compatible to the skin until 14 days of storage. However, F3 (EOCC 15%) has a strong lemongrass smell compare to the other formulations.

Determination of Flavonoids Content of Gringsingan Stems (Mesosphaerum suaveolens (L) Kuntze) Extracted by Microwave Assisted Extraction Handayani, Selpida; Aminah, Aminah; Badu, Nurul Fadillah
Pharmaceutical Reports Vol 4, No 1 (2025): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharmrep.v4i1.357

Gringsingan plant (Mesosphaerum suaveolens (L) kuntze) is an plant belonging to the lamiaceae family originating from Sinjai district, South Sulawesi. This plant is empirically used by the people of Sinjai district as a medicine to relieve stomach aches. The modern extraction method used is microwave-assisted extraction, which is an extraction method that uses microwave radiation to speed up extraction by heating the solvent quickly and efficiently. The aim of this research was to determine the value of total flavonoid content in Gringsingan (Mesosphaerum suaveolens (L) kuntze) stems extract based on microwave-assisted extraction. This research was carried out experimentally in the laboratory. The stages of this research began with preparing test samples, testing the quality of flavonoid compounds, and ended with determining the total flavonoid content of gringsingan stems, which then measured their absorption using a UV – Vis spectrophotometer. In this study, the results were obtained that the Gringsingan stem extract was positive for containing flavonoids based on identification results using the Wilstater reagent. This sample was also declared positive for containing flavonoids based on the thin layer chromathography (TLC) test using the AICI3 specific reagent. Determination of the total flavonoid content of Gringsingan stem extract based on microwave assisted extraction. Obtained was 17.949 mgQE/g.

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