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All Journal Dimas: Jurnal Pemikiran Agama untuk Pemberdayaan Jurnal Kesehatan Bakti Tunas Husada Jurnal Agrotek UMMat Journal of Pharmacopolium Indonesia Natural Research Pharmaceutical Journal (INRPJ) Science Midwifery Journal of Community Development and Disaster Management Bulletin of Chemical Reaction Engineering & Catalysis
Fatmawati, Fenti
Program Studi Farmasi, Sekolah Tinggi Farmasi Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Science Midwifery

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Formula development and characterization of nanostructured lipid carriers (NLC) vitamin E acetate with solid lipids compritol and precirol Salsabilla, Syifa; Jafar, Garnadi; Fatmawati, Fenti
Science Midwifery Vol 12 No 5 (2024): December: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v12i5.1752

Abstract

Vitamin E acetate has antioxidant activity that can prevent premature aging of the skin, but its nature is very lipophilic (log p±12.2) and has the potential to degrade. To overcome the problems of permeability and stability, vitamin E acetate needs to be developed in Nanostructured Lipid Carrier (NLC), which is a nano delivery system based on solid lipids and liquid lipids stabilized by surfactants as a colloidal system. The formulation of vitamin E acetate into NLC was carried out using the heat homogenization method, then sonicated using a probe sonicator. The materials used were 2% vitamin E acetate, 2-6% Compritol® and Precirol® solid lipids, 1% Myritol®, and 1-3% Chremophore and Plantacare® surfactants. The NLC results were then characterized by measuring particle size, zeta potential, polydispersity index, entrapment efficiency, and morphology. The characterization results showed that NLC vitamin E acetate had a particle size of 280-375 nm, a zeta potential of -23 mV to -28 mV, a polydispersity index <0.5, an entrapment efficiency of 92-97%, and a spherical morphology. The results showed that Nanostructured Lipid Carrier vitamin E acetate gave good results.
Formulation and characterization of tretinoin nanosuspension and in silico testing as an anti-inflammatory Ramadhoni, M Ayodia; Jafar, Garnadi; Halizah, Arin Nur; Fatmawati, Fenti
Science Midwifery Vol 13 No 1 (2025): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i1.1892

Abstract

Introduction: Tretinoin is an effective retinoid derivative for acne therapy, but has formulation challenges due to its lipophilic nature and high crystallinity. An appropriate formulation strategy is needed to improve its stability and bioavailability. Objective: This study aims to evaluate the compatibility of tretinoin with excipients in nanosuspension formulations and their physicochemical characterization. Methods: Preliminary tests were carried out using Fourier Transform Infrared Spectroscopy (FTIR), crystallinity was analyzed by X-ray Diffraction (XRD), and thermal analysis by Differential Scanning Calorimetry (DSC). Nanosuspension characterization includes particle size, polydispersity index, zeta potential and entrapment efficiency. In silico test of the potential of tretinoin as a COX-2 inhibitor related to anti-inflammatory effects. Results: FTIR results showed no chemical interaction between tretinoin and excipients. XRD showed a decrease in tretinoin crystallinity after mixing with HPMC and PVP. DSC showed a shift in the melting point of tretinoin, indicating a physical interaction with excipients. Characterization of nanosuspension showed particle size <1000 nm, polydispersity index <0.5, zeta potential ±-20 mV, and entrapment efficiency >80%. In silico tests show that tretinoin has a binding energy of -9.57 kcal/mol against the Cyclooxygenase-2 (COX-2) enzyme with an inhibition constant of 96.03 nM. Conclusion: Tretinoin shows good compatibility and physicochemical characteristics in nanosuspension formulation, as well as potential as an anti-inflammatory agent through COX-2 inhibition.
Co-Authors Algofar, Muhammad Alif Aziz Anggraeni, Vina Juliana Dewi, Alfina Kusuma Dian Nugraheni Garnadi Jafar, Garnadi Halizah, Arin Nur Haryati, Titin Khofiyah, Ikma Nidaul Norman Yoshi Haryono Ramadhoni, M Ayodia Rosmansyah, Hurryatul Fikri Rum, Ira Adiyati Salsabilla, Syifa Soni Muhsinin Syach, Muhammad Zahran Edlian