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Formulation and Characterization of Sungkai Leaf Extract Nanoemulsion Dista, Rama; Larasati, Cindy; Ayuningsih, Sylvia; Anggraeni, Nurah; Batubara, Irmanida
Al-Kimia Vol 10 No 2 (2022): DECEMBER
Publisher : Study Program of Chemistry - Alauddin State Islamic University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-kimia.v10i2.33482

Sungkai (Peronema canescens Jack) leaves are empirically used for various treatments, and their efficacy can be enhanced using nanoparticle technology, especially nanoemulsions. The purpose was to find the best nanoemulsion formula (NES) containing sungkai leaf extract (EDS). Sungkai leaves were extracted with 70% ethanol, and the compounds were determined by liquid chromatography-mass spectrometry. NES was formed by mixing EDS (260, 400, and 530 mg), VCO, tween80, PEG400, soy lecithin, sodium alginate, and deionized water. The NES formed were characterized by particle size, polydispersity index (PDI), zeta potential, pH, viscosity, percent transmittance, and physical stability test. The results showed that EDS contains at least seven compounds, with eupatilin as a dominant compound. The characterization results obtained NES with a particle size range of 270–520 nm with a PDI value of 0.413–0.608. NES was categorized as stable with a zeta potential value of -45.9 to -48.7 mV and no phase separation based on the centrifugation test. NES has a viscosity of about 1.90–2.03 cP, pH 7, and a percent transmittance of 93–98%. The best formula is the formula with EDS F1 (260 mg). Thus, NES has the potential for the development of multiple treatment targets.

PVSAT Optical strategy to boost glass sales in Sintang City Larasati, Cindy; Sari, Rachi Titi Ramadhani; Astikawati, Yunita
Journal Magister Ilmu Ekonomi Universtas Palangka Raya : GROWTH Vol. 10 No. 1 (2024): June 2024
Publisher : Fakultas Ekonomi dan Bisnis Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52300/grow.v10i1.15303

Pvsat Optics is a private company operating in the eye health sector. Glasses are one of the products at Optik Pvsat. Glasses are a visual aid for someone who suffers from nearsightedness or farsightedness. This research aims to determine Pvsat Optical's strategy for increasing glass sales in Sintang. The research method used in this research is descriptive qualitative research. Data collection techniques in this research were collected by interviewing customers, documentation, and observation. This research shows that Optik Pvsat uses several strategies to increase sales, namely conducting training for employees and implementing marketing strategies by utilizing social media. Promotions implemented by Optik Pvsat include promotions online and in person. Online promotions include social media such as WhatsApp and Instagram, while offline promotions include banners/billboards or direct education to customers. This education conveys the customer's benefits of using glasses.

Phytochemical Screening, Cytotoxicity Test, and Antibacterial Activity Test of Wungu Plant Extract (Graptophyllum pictum L. Griff) Arista, Rini Anggi; Jalloh, Mohammed A.; Insani, Fahma Alifia; Balqis, Putri Azzahara; Larasati, Cindy; Arief, Barieq Farial Putra; Fatriani, Rizka
Jurnal Jamu Indonesia Vol. 8 No. 2 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i2.330

Indonesia boasts a rich array of medicinal herbs, including the wungu (Graptophyllum pictum L. Griff), which is known for its potential as an anticancer and antibacterial agent. Here, we used qualitative phytochemical assays to identify bioactive compounds in various parts of the wungu plant (leaves, stem, and roots) and their efficacy in combating cancer and bacterial infections. The brine shrimp lethality test (BSLT) was used to measure anticancer properties and antibacterial activity against Escherichia coli. We found that the leaves contained flavonoids, triterpenoids, phenols, saponins, and alkaloids, whereas the stem and root contained steroids and alkaloids. Notably, the wungu plant exhibited no toxicity, as shown by the cytotoxicity test, indicating a lack of anticancer potential as all parts showed LC50 values exceeding 1000 ppm. However, the antibacterial assays strikingly showed efficacy against bacteria across all parts of the plants, with varying strengths from weak to strong. This study sheds light on the promising antibacterial properties of the wungu plant and its potential as a therapeutic agent.

Optimization of D-limonene and phenolic compounds extraction from local Indonesian orange peel using ultrasound-assisted extraction Wa Ode Cakra Nirwana; Dewi, Luthfi Kurnia; Larasati, Cindy; Anggraini, Oktavia; Hapsari, Safrina
Jurnal Rekayasa Proses Vol 19 No 1 (2025): Volume 19, Number 1, 2025
Publisher : Jurnal Rekayasa Proses

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jrekpros.17479

Malang Regency is one of the orange plantation centers in East Java, Indonesia, and has been named Indonesia’s orange agrotourism area. Orange peel waste in Indonesia has not been utilized, even though orange peel contains valuable compounds, such as D-limonene and polyphenols. To date, studies on the extraction of D-limonene and total phenolic compounds (TPC) from Baby Java Pacitan orange (Citrus sinensis L.) and Keprok Batu 55 oranges (Citrus reticulata Blanco) has not been investigated. In this work, several factors affecting the extraction of D-limonene and total phenolic compounds from local Indonesian orange peels with ultrasonic assistance were investigated and optimized. The results showed that drying using a vacuum oven and agitation significantly increased the yield of D-limonene and TPC. The optimum condition for extracting D-limonene was a solid-solvent ratio (SSR) of 1:10 with an ethanol concentration of 96% for 40 minutes. Meanwhile, the optimum condition for extracting polyphenol compounds was a solid-solvent ratio of 1:10 with an ethanol concentration of 96% for 80 minutes. Under optimum conditions, Baby Java Pacitan orange peel produced D-limonene of 130.5 mg/g dry biomass, which was 2.8 times higher than Keprok Batu 55 orange peel. Meanwhile, the TPC for Baby Java Pacitan orange peel and Keprok Batu 55 orange peel were 46.1 mgGAE/g dry biomass and 43.9 mgGAE/g dry biomass, respectively.

ANALISIS KINERJA KEUANGAN PEMERINTAH KOTA GORONTALO DALAM PENGELOLAAN ANGGARAN PENDAPATAN DAN BELANJA DAERAH TAHUN 2019-2023 Larasati, Cindy; Ali, Yuwin; Ariesta Iyonu, Mentari
Jurnal Akuntansi, Keuangan dan Teknologi Informasi Akuntansi Vol. 6 No. 1 (2025): Edisi Juni 2025
Publisher : Universitas Muhammadiyah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36085/jakta.v6i1.8306

This study aims to analyze the financial performance of the Gorontalo City Government in the 2019–2023 period using a mixed methods sequential explanatory model approach. Quantitative data were obtained from the City Budget Realization Report (LRA), balance sheet, and CAKL, analyzed using seven financial ratios: independence, degree of decentralization, dependence, PAD effectiveness, efficiency, spending activity, and PAD growth. The qualitative stage involved semi-structured interviews with informants from the City Finance Agency and taxpayers. The results showed that the average independence ratio was 40.87% (low category), the degree of decentralization was 25.97% (sufficient), financial dependence was 64.29% (very high), and PAD effectiveness was sufficient (94.34%), but efficiency decreased (104.65%) and operating expenses dominated (87.72%) compared to capital expenditures (11.99%). PAD growth fluctuated with a low average (15.35%). Qualitative analysis revealed the main factors: suboptimal financial management, low PAD due to tax and policy awareness, and a small portion of capital expenditure. In conclusion, the financial performance of Gorontalo City is not yet independent and efficient, still highly dependent on central transfers, needs to improve management, increase PAD, and increase the portion of capital expenditure to strengthen fiscal independence and regional development. Keywords: Financial Performance, Regional Financial, Independence Ratio

Phytochemical Screening, Cytotoxicity Test, and Antibacterial Activity Test of Wungu Plant Extract (Graptophyllum pictum L. Griff) Arista, Rini Anggi; Jalloh, Mohammed A.; Insani, Fahma Alifia; Balqis, Putri Azzahara; Larasati, Cindy; Arief, Barieq Farial Putra; Fatriani, Rizka
Jurnal Jamu Indonesia Vol. 8 No. 2 (2023): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v8i2.330

Indonesia boasts a rich array of medicinal herbs, including the wungu (Graptophyllum pictum L. Griff), which is known for its potential as an anticancer and antibacterial agent. Here, we used qualitative phytochemical assays to identify bioactive compounds in various parts of the wungu plant (leaves, stem, and roots) and their efficacy in combating cancer and bacterial infections. The brine shrimp lethality test (BSLT) was used to measure anticancer properties and antibacterial activity against Escherichia coli. We found that the leaves contained flavonoids, triterpenoids, phenols, saponins, and alkaloids, whereas the stem and root contained steroids and alkaloids. Notably, the wungu plant exhibited no toxicity, as shown by the cytotoxicity test, indicating a lack of anticancer potential as all parts showed LC50 values exceeding 1000 ppm. However, the antibacterial assays strikingly showed efficacy against bacteria across all parts of the plants, with varying strengths from weak to strong. This study sheds light on the promising antibacterial properties of the wungu plant and its potential as a therapeutic agent.

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