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All Journal International Journal of Public Health Science (IJPHS) Global Medical and Health Communication Biomedika Universa Medicina Jurnal Keperawatan Padjadjaran Cermin Dunia Kedokteran Magna Neurologica Cermin Dunia Kedokteran
Rivan Danuaji
Departemen Neurologi, Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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PERBEDAAN OPTIC NERVE SHEATH DIAMETER (ONSD) PADA RESPONDEN NORMAL DAN NYERI KEPALA Sulistyani Sulistyani; Rivan Danuaji
Biomedika Vol 11, No 2 (2019): Biomedika Agustus 2019
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v11i2.8466

Abstract

Nyeri kepala merupakan salah satu tanda adanya peningkatan tekanan intrakranial. Nervus optikus merupakan saraf kranialis yang mudah dipengaruhi langsung oleh adanya peningkatan tekanan intrakranial. Kelainan nervus optikus dapat diketahui dengan adanya pelebaran optic nerve sheath diameter (ONSD). ONSD dapat diukur dengan transorbital sonografi yang bersifat noninvasif. Tujuan penelitian ini adalah untuk mengetahui perbedaan nilai ONSD pada responden normal dan nyeri kepala. Penelitian ini menggunakan pendekatan observasional analitik dengan metode cross sectional. Responden diambil dari pasien rawat inap dan responden normal. Hasil penelitian didapatkan Rata – rata nilai ONSD pada pasien nyeri kepala adalah 0,52 ± 0,86 dan pada responden normal adalah 0,40 ± 0,57 (p 0,05). Terdapat perbedaan signifikan nilai ONSD pada pasien normal dan nyeri kepala. Pasien nyeri kepala akibat peningkatan intrakranial dapat dideteksi dengan pemeriksaan ONSD yang bersifat non invasif.Kata Kunci: Optic Nerve Sheath Diameter (ONSD), Responden Normal, Nyeri KepalaHeadache is one of the symptoms of increased intracranial pressure. The optic nerve is part of the cranial nerve can be affected directly by the increased intracranial pressure. Opticus nerve can be examined from ONSD dilatation examination by non invasif sonography transorbital. The research aimed to defferentiate the optic nerve sheath diameter (ONSD) on the normal volunteer and headache. Analysis observational with cross sectional method was conducted in ward patients with headache at RSDM in April-May 2015. Mean ONSD in headache patient is 0,52 ± 0,86 and normal volunteers 0,40 ± 0,57 (p 0,05). The significant different ONSD value between headache and normal volunteers. Headache with intracranial increased can be detected with non invasif ONSD examination.Keyword: Optic nerve sheath diameter , headache , normal volunteer 
PENGARUH JENIS KELAMIN TERHADAP BESARAN MOTOR TRESHOLD (MT) MENGGUNAKAN TRANSCRANIAL MAGNETIC STIMULATION (TMS) Yetty Hambarsari; Rivan Danuaji; Baarid Luqman Hamidi; Priyanka Ganesa Utami; Befrie Mahaztra Sudarman
Biomedika Vol 13, No 2 (2021): Biomedika Agustus 2021
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v13i2.11950

Abstract

ABSTRAKMotor threshold (MT) adalah intensitas minimal yang dibutuhkan untuk membangkitkan respon otot.  Jenis kelamin diduga mempengaruhi motor threshold (MT). Penelitian ini bertujuan untuk mengetahui pengaruh jenis kelamin  terhadap besaran motor threshold menggunakan TMS. Penelitian ini menggunakan desain kuantitatif analitik observasional. Subyek penelitian sebanyak 32 orang, yang terdiri dari 17 laki-laki dan 15 perempuan. Target otot penelitian ini adalah musculus abductor policis brevis kanan dan kiri, dengan asal stimulasi dari transcranial magnetik stimulation (TMS). Hasil penelitian ini didapatkan rata-rata besaran motor treshold kanan sebesar 45% pada laki-laki dan 53% pada perempuan, dengan nilai p= 0,105. Sedangkan rata-rata besaran motor treshold kiri sebesar 46% pada laki-laki dan 45 % pada perempuan, dengan nilai p= 0,771. Sehingga dapat disimpulkan bahwa tidak ada hubungan antara jenis kelamin dengan besaran motor threshold dengan menggunakan TMS.  Kata Kunci: Jenis Kelamin, Ambang Motorik, Transcranial Magnetic Stimulation  ABSTRACTThe motor threshold (MT) is the minimum intensity required to evoke a muscle response. Gender is thought to affect the motor threshold (MT). This study aims to determine the effect of gender on the magnitude of the motor threshold using TMS. This study uses an observational analytic quantitative design. The research subjects were 32 people, consisting of 17 men and 15 women. The muscles target in this study were the right and left abductor policis brevis muscles, with the origin of stimulation from transcranial magnetic stimulation (TMS). The results of this study obtained an average right motor treshold magnitude were 45% in men and 53% in women, with p value = 0.105. While the average left motor treshold magnitude were 46% for men and 45% for women, with p value = 0.771. It can be concluded that there was no relationship between gender and the magnitude of the motor threshold using TMS.. Keywords: Gender, Motor Threshold, Transcranial Magnetic Stimulation
PATTERNS OF TRANSCRANIAL DOPPLER FLOW VELOCITIES AND CAROTID INTIMA MEDIA THICKNESS (CIMT) IN JAVANESE ISCHEMIC STROKE Rivan Danuaji; Subandi Subandi; Arif Apriyanto; Endang Kusuma Dewi; Suroto Suroto; Diah Kurnia Mirawati; Pepi Budianto; Yetty Hambarsari; Baarid Lukman Hamidi; Hanindya Riani Prabaningtyas; Sulistyani Sulistyani
Biomedika Vol 12, No 1 (2020): Biomedika Februari 2020
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v12i1.9921

Abstract

ABSTRACTIntracranial atherosclerosis is the most common cause of stroke in Asia including Indonesia. Transcranial Doppler (TCD) is a noninvasive tool which able to detect intracranial atherosclerosis. The purpose of this study was to determine the pattern of TCD waves in Javanese ischemic stroke patients and Carotid Intima Media Thickness (CIMT), and its correlation to demographic data. This is a cross-sectional study was conducted at Hospital X Surakarta. All Javanese ischemic stroke treated in stroke unit were examine for flow velocity using TCD and CIMT using ultrasound. Chi square was used to analyzes the relationship between age, gender, stroke type and the thickness of CIMT.  A total of 43 ischemic stroke patients were examined for TCD, consisting of 30 (69.77%) men and 13 (30,23%) women. The results showed that 31 (72.09%) had intracranial abnormalities in the form of stenosis or occlusion on MCA (23.26%), ACA (4.65%), PCA (4.65%), vertebral arteries (6.98 %) and other locations (32.56%). Thickening of CIMT was obtained as much as 22 (51,16%) of the patients. Age was a factor associated with CIMT thickening with (P: 0.041), while gender and type of stroke did not (P0,05)). To sum up Intracranial flow velocity abnormalities often occur in Javanese ischemic stroke patients, while CIMT thickening is not associated with ischemic stroke pathologyKeywords: TCD, Stroke Ischemic, Flow Velocity, CIMT, JavaneseABSTRAKAterosklerosis intrakranial adalah penyebab paling umum dari stroke di Asia termasuk Indonesia. Transcranial Doppler (TCD) adalah alat noninvasif yang mampu mendeteksi aterosklerosis intrakranial. Tujuan dari penelitian ini untuk mengetahui pola gelombang TCD pada pasien stroke iskemik suku Jawa dan Carotid Intima Media Thickness (CIMT), dan korelasinya dengan data demografi. Penelitian cross-sectional ini dilakukan di Rumah Sakit X Surakarta. Semua stroke iskemik suku Jawa yang dirawat di unit stroke diperiksa untuk kecepatan aliran menggunakan TCD dan CIMT menggunakan ultrasound. Chi square digunakan untuk menganalisis hubungan antara usia, jenis kelamin, jenis stroke dan ketebalan CIMT. Sebanyak 43 pasien stroke iskemik diperiksa untuk TCD, terdiri dari 30 (69,77%) pria dan 13 (30,23%) wanita. Hasil penelitian menunjukkan bahwa 31 (72,09%) memiliki kelainan intrakranial dalam bentuk stenosis atau oklusi pada MCA (23,26%), ACA (4,65%), PCA (4,65%), arteri vertebral (6,98%) dan lokasi lain (32,56%). Penebalan CIMT diperoleh sebanyak 22 (51,16%) dari pasien. Usia adalah faktor yang terkait dengan penebalan CIMT dengan (p= 0,041), sedangkan jenis kelamin dan jenis stroke tidak (p 0,05), sehingga ditarik kesimpulan bahwa kelainan kecepatan aliran intrakranial sering terjadi pada pasien stroke iskemik Jawa, sedangkan penebalan CIMT tidak berhubungan dengan patologi stroke iskemik.Kata Kunci: TCD, Stroke Iskemik, Flow Velocity, CIMT, Suku Jawa
Relationship between Tension-Type Headache and Quality of Sleep, Excessive Daytime Sleepiness, and Fatigue Syndrome among Healthcare Workers during COVID-19 Pepi Budianto; Stefanus Erdana Putra; Muhammad Hafizhan; Fauzi Novia Isnaening Tyas; Astrida Fesky Febrianty; Hanindia Riani Prabaningtyas; Diah Kurnia Mirawati; Rivan Danuaji; Subandi Subandi
Global Medical & Health Communication (GMHC) Vol 9, No 3 (2021)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (124.598 KB) | DOI: 10.29313/gmhc.v9i3.8530

Abstract

Coronavirus disease 2019 (COVID-19) is an infectious disease that was later declared a pandemic. During a pandemic, excessive workloads cause an increase in physical symptoms, such as tension-type headaches, in medical personnel. Tension-type headache (TTH) is associated with decreased sleep quality which will lead to excessive daytime sleepiness (EDS) and fatigue syndrome. This study aims to determine the relationship between TTH and sleep quality, EDS, and fatigue syndrome in medical personnel during the pandemic. This study is a cross-sectional study conducted on health workers at Sebelas Maret University Hospital, Surakarta, Indonesia in March–August 2020. The relationship between TTH and three other variables was analyzed using the Spearman correlation test. Multiple logistic regression analysis was used to calculate the odds ratio (OR) of headache associated with the covariate. The Kruskal-Wallis test was used to compare sleep quality, EDS, and fatigue syndrome in the TTH, non-TTH headache, and control groups. There were 120 respondents (mean age 30.93±12.48) in this study. The Spearman correlation test found a weak positive correlation between TTH and the three dependent variables. OR sleep quality, EDS, and fatigue syndrome with the incidence of TTH respectively 2.33 (95% CI=1.18–5.11, p<0.001); 2.52 (CI 95%=1.17–4.79, p=0.001), and 4.46 (95% CI=2.71–7.69, p<0.001). The Kruskal-Wallis test showed that the TTH group had poorer sleep quality and more frequent EDS and fatigue syndrome. There is a significant relationship between TTH and sleep quality, EDS, and fatigue syndrome in medical personnel during the pandemic. HUBUNGAN NYERI KEPALA TIPE TEGANG DENGAN KUALITAS TIDUR, RASA KANTUK BERLEBIHAN DI SIANG HARI, DAN SINDROM KELELAHAN PADA TENAGA MEDIS SELAMA COVID-19Coronavirus disease 2019 (COVID-19) merupakan penyakit menular yang kemudian dinyatakan sebagai pandemi. Selama pandemi, beban kerja yang berlebihan menyebabkan peningkatan gejala fisik, seperti nyeri kepala tipe tegang (tension-type headache) pada tenaga medis. Tension-type headache (TTH) dikaitkan dengan penurunan kualitas tidur yang akan menyebabkan rasa kantuk berlebihan di siang hari (excessive daytime sleepiness, EDS) dan sindrom kelelahan. Penelitian ini bertujuan mengetahui hubungan TTH dengan kualitas tidur, EDS, dan sindrom kelelahan pada tenaga medis selama pandemi. Penelitian ini merupakan studi potong lintang yang dilakukan pada petugas kesehatan di RS Universitas Sebelas Maret, Surakarta, Indonesia pada Maret–Agustus 2020. Hubungan antara TTH dan tiga variabel lainnya dianalisis menggunakan uji korelasi Spearman. Analisis regresi logistik ganda digunakan untuk menghitung odds ratio (OR) nyeri kepala yang terkait dengan kovariat. Uji Kruskal-Wallis digunakan untuk membandingkan kualitas tidur, EDS, dan sindrom kelelahan pada kelompok TTH, nyeri kepala non-TTH, dan kontrol. Terdapat 120 responden (rerata usia 30,93±12,48). Uji korelasi Spearman menemukan korelasi positif lemah antara TTH dan tiga variabel terikat. OR kualitas tidur, EDS, dan sindrom kelelahan dengan kejadian TTH secara berurutan 2,33 (IK 95%=1,18–5,11; p<0,001); 2,52 (IK95 %=1,17–4,79; p=0,001); dan 4,46 (IK 95%=2,71–7,69; p<0,001). Uji Kruskal-Wallis menunjukkan bahwa kelompok TTH memiliki kualitas tidur yang lebih buruk dan lebih sering mengalami EDS, serta sindrom kelelahan. Terdapat hubungan yang signifikan TTH dengan kualitas tidur, EDS, dan sindrom kelelahan pada tenaga medis selama pandemi.
Long-COVID neurological symptoms are associated with D-dimer levels in COVID-19 patients Diah Kurnia Mirawati; Pepi Budianto; Rivan Danuaji; Subandi Subandi; Ira Ristinawati; Hanindia Riani Prabaningtyas
Universa Medicina Vol. 41 No. 2 (2022)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2022.v41.169-175

Abstract

Background Coronavirus disease 2019 (COVID-19) is a disease designated as a global pandemic by the WHO that can manifest clinically as neurological disorders that can occur in the acute phase or after the acute phase (long COVID-19), such as headache, myalgia, anosmia, and cognitive impairment. These neurological disorders as symptoms of long COVID-19 are presumably caused by hypercoagulable conditions characterized by an increase in D-dimer level. This study aims to determine the correlation of long COVID-19 neurological symptoms with hypercoagulable conditions and the role of D-dimer as a biomarker of long COVID-19 neurological symptoms. MethodsThis was a cross-sectional study involving 31 patients with long COVID-19 symptoms. Admitted long COVID-19 cases with recorded D-dimer levels and definitive outcomes were included consecutively. Long COVID-19 neurological symptoms were collected. D-dimer level was measured using immunofluorescence assay and reported in fibrinogen equivalent units (ìg/mL). The correlation between D-dimer levels and neurological clinical manifestations was assessed by using ordinal regression analysis. The p-value of <0.05 was considered statistically significant. ResultsThe mean age of the subjects was 38.81 ± 11.58 years and 18 (58.06%) were female. Long COVID neurological symptoms comprised myalgia, anosmia and cephalgia, and most subjects complained of myalgia (80.65%). On multivariable analysis, long-COVID-19 neurological symptoms were significantly correlated with D-dimer [odds ratio (OR) = 1.05; p=0.020]. ConclusionThe number of neurological long COVID symptoms were significantly correlated with level of D-Dimer. Ultimately, more clarity is needed on the neurological impact of COVID-19, its diagnosis, and its treatment.
A rare case of Fahr's syndrome with dissociative amnesia Faizal Muhammad; Wilson Arpin; Yeremia Suryo Pratama; Cynthia Hanny Lestari; Pepi Budianto; Rivan Danuaji; Ervina Arta Jayanti Hutabarat; Stefanus Erdana Putra; Muhammad Hafizhan
Jurnal Keperawatan Padjadjaran Vol. 10 No. 3 (2022): Jurnal Keperawatan Padjadjaran
Publisher : Faculty of Nursing Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkp.v10i3.2134

Abstract

Background: Fahr's syndrome (FS) is a movement and psychiatric disorder characterized by symmetrical and bilateral calcification of the basal ganglia. Dissociative amnesia is a rare psychiatric disorder that occurs after stressful events and is classified as a dissociative disorder. In addition, dissociation is the process by which the mind conceals stressful events from consciousness. Several neuropsychiatric manifestations in FS have been reported. However, due to their rarity, FS and dissociative amnesia can be misdiagnosed. Case: A 43-year-old female presented with Parkinsonian symptoms and an inability to recall important personal information. FS and dissociative amnesia were diagnosed after a thorough medical, psychiatric, and diagnostic investigation. Subsequently, correction of calcium and phosphate levels by α-hydroxy-vitamin-73 D3 and psychotherapy were administered for two-months until there were no neuropsychiatric symptoms reported. Conclusion: This research highlights a rare case of FS with dissociative amnesia which pathophysiology is not completely understood due to limited research.
Evaluation of cerebrovascular disease risk with carotid ultrasonography imaging in artificial intelligence framework Rivan Danuaji; Subandi Subandi; Stefanus Erdana Putra; Muhammad Hafizhan
International Journal of Public Health Science (IJPHS) Vol 12, No 2: June 2023
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v12i2.22285

Abstract

Carotid plaque is a biomarker of generalized atherosclerosis, and may predict ischemic stroke. Carotid intima-media thickness (C-IMT) measurement with ultrasonography imaging could capture the condition of carotid plaque. However, manual measurement of C-IMT is observer- dependent, resulting in observer bias and low reproducibility. In this study, we develop artificial intelligence (AI) framework that could automatically measure the C-IMT, and compared it with C-IMT measured by board of expert. This is a retrospective study done in Dr. Moewardi General Hospital, Surakarta, Indonesia. Carotid B-mode ultrasonography images were measured by panel of expert and by AI. After annotation process on Neurabot platform, AI could detect region of interest (ROI), and would do segmentation on the area to measure C-IMT autonomously. Dependent T-test was used to evaluate validity, and Cronbach’s alpha was used to find the reliability of C-IMT measured by panel of expert and AI. There was strong correlation (r=0.874; p=0.014) on dependent t-test for C-IMT measured by AI with C-IMT measured by board of expert. The internal consistency reliability coefficients (Cronbach’s alpha) were 0.938 and 0.909, for pretest and posttest, respectively. We also analyzed the test-retest reliability by comparing pretest and posttest score with dependent t-test, and we observed strong correlation with r=0.871 (p=0.000). AI developed on Neurabot platform are valid and reliable to measure C-IMT.
Efek Terapi Citicoline terhadap Pemulihan Kognitif dan Motorik Pasien Stroke Iskemik Akut dengan Polimorfisme ApoE4 rs429358 dan rs7412 Faizal Muhammad; Afifah Syifaul Ummah; Farida Aisyah; Rivan Danuaji; Subandi; Diah Kurnia Mirawati
Cermin Dunia Kedokteran Vol 50 No 11 (2023): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i11.1016

Abstract

Citicoline has a neuroprotectant effect, especially in mild-to-moderate stroke. The presence of the ε4 allele in the ApoE gene is associated with a severe acute ischemic stroke (AIS) phenotype, in addition to neurodegenerative risk This study aims to determine the effect of citicoline on cognitive and motoric recovery in severe AIS biomolecularly, such as ApoE4 rs429358 and rs7412 polymorphisms. A 64-year-old woman was diagnosed with AIS with a 6-hour onset and with a NIHSS score of 25 and MMSE score of 21. The patient’s AIS was biomolecularly severe as proven by PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) ApoE4 which yielded 482 bp at rs429358 (codon 112) and 249 bp 167 bp at rs7412 (codon 158) on electrophoretic visualization. The patient received 3x 500 mg intravenous citicoline for 4 days followed by another 1000 mg of citicoline intravenous during polyclinic control for 5 consecutive days. On the 9th day, the patient experienced improvement in cognitive function with an MMSE score of 29 and superior (4/5) and inferior (5/5) motoric strength. Citicoline is a neuroprotectant agent that is beneficial for the recovery of cognitive and motoric function in biomolecularly severe SIA (ApoE4, C/C, Arg112/Arg158) because it can save the penumbra area from infarction.
Hematomyelia Akibat Traumatic Lumbar yang Menyebabkan Syok Spinal: Sebuah Laporan Kasus Raden Andi Ario Tedjo; Lawly Arrel Dionnie Greatalya; Vivienne Tjung; Muhammad Hafizhan; Stefanus Erdana Putra; Suroto Suroto; Diah Kurnia Mirawati; Subandi Subandi; Rivan Danuaji; Pepi Budianto; Yetty Hambarsari; Baarid Luqman Hamidi; Hanindia Riani Prabaningtyas; Ervina Arta Jayanti Hutabarat; Ira Ristinawati; Teddy Tejomukti
Jurnal Keperawatan Padjadjaran Vol. 11 No. 3 (2023): Jurnal Keperawatan Padjadjaran
Publisher : Faculty of Nursing Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkp.v11i3.2352

Abstract

Background: Spinal cord hemorrhage or hematomyelia can arise from trauma or non-trauma causes, adverse effect of anticoagulation therapy and ruptured vascular malformation. Bleeding in epidural space is common and complications such as acute spinal cord syndrome can arise due to the compression and destruction of the spinal cord. Symptoms of hematomyelia might be varied depending on location of the lesion, often accompanied with acute radicular pain. In this case study, we reported a case of spinal shock after traumatic lumbar hematomyelia. Case: A 13-year-old girl presented to Dr. Moewardi General Hospital with inferior paraparesis, bladder and bowel incontinence, a day after falling on her gluteus. Physical examination revealed reduced motoric and sensory function below 12th thoracal dermatome, with no patellar and reduced Achilles reflexes. Conventional X-ray was unremarkable and further investigation with MRI showed a hematoma on thoracal 10 to 12 vertebrae. Motor and sensory functions were improved after 12 days administration of corticosteroids and further improvement was seen almost immediately after decompression surgery. Objective: To describe a case of spinal shock caused by traumatic lumbar hematomyelia Method: This is a case report study describing spinal shock which improved after administration of corticosteroid and decompression surgery. Conclusion: Spinal shock could be caused by traumatic lumbar hematomyelia, which is characterized by loss of motor, sensory, and bladder function, and decompression surgery improved the prognosis.
Correlation between Neutrophil/Lymphocyte Ratio (NLR), lipid profile, lesion location and vascular cognitive impairment in acute ischemic stroke patients Ira Ristinawati; Kenneth Tan; Benedictus Benedictus; Muhammad Hafizhan; Stefanus Erdana Putra; Suroto Suroto; Diah Kurnia Mirawati; Subandi Subandi; Rivan Danuaji; Pepi Budianto; Yetty Hambarsari; Baarid Luqman Hamidi; Hanindia Riani Prabaningtyas; Ervina Arta Jayanti Hutabarat; Teddy Tejomukti; Raden Andi Ario Tedjo
Jurnal Keperawatan Padjadjaran Vol. 12 No. 2 (2024): Jurnal Keperawatan Padjadjaran
Publisher : Faculty of Nursing Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkp.v12i2.2526

Abstract

Background: Stroke is the leading cause of long-term disability with significant clinical and socioeconomic impact worldwide. Hyperlipidemia and inflammation play major roles in ischemic stroke. This research focuses on the correlation of three factors, namely Neutrophil-Lymphocyte Ratio (NLR), lipid profile, and lesion location, with Vascular Cognitive Impairment (VCI). These factors may serve as potential predictors for VCI. Purpose: This research aims to study the correlation between NLR, lipid profile, and lesion location with vascular cognitive impairment. Besides, this research aims to explore those potential biomarkers as predictors of vascular cognitive impairment. Methods: This was a cross-sectional study which included 107 patients diagnosed with ischemic stroke from February 2022 to January 2023 with a history of admission to the hospital within 72 hours. After signed an informed consent form, every patient had history taking, physical exam, lipid profile, routine blood test, Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment Indonesian Version (MoCA-Ina) on the first hospital day. Statistical tests were done with Spearman correlation method. Results: The data distribution was not normal for INR and MoCA-INA values (p<0.05).  Total cholesterol was insignificantly (p=0.092) correlated with MoCA-INA score with low correlation value (r=-0.293). HDL was significantly (p=0.035) correlated with MoCA-INA score with moderate correlation value (r=0.461). LDL was significantly (p=0.028) correlated with MoCA-INA score with low correlation value (r=-0.387). Triglycerides was insignificantly (p=0.440) correlated with MoCA-INA score with very weak correlation value (r=-0.137). NLR was significantly (p=0.015) correlated with MoCA-INA score with moderate correlation value (r=-0.412). Conclusions: Lipid profile is correlated with cognitive impairment in post stroke patients, with HDL being a protective factor, and LDL as risk factor. NLR was associated with worse cognitive function and LDL was directly proportional to NLR. Lesion location reporting was highly heterogeneous and more uniformed reporting is recommended for future research.
Co-Authors ., Subandi Afifah Syifaul Ummah Arif Apriyanto Astrida Fesky Febrianty Baarid Lukman Hamidi Baarid Luqman Hamidi Baarid Luqman Hamidi Befrie Mahaztra Sudarman Benedictus Benedictus Bhisma Murti Brilliandi, Immanuel Billy Budianto, Pepi Cynthia Hanny Lestari Diah Kurnia Mirawati Endang Kusuma Dewi Ervina Arta Jayanti Hutabarat Faizal Muhammad Faizal Muhammad Farida Aisyah Fauzi Novia Isnaening Tyas Hanindia Riani Prabaningtyas Hanindia Riani Prabaningtyas Hanindia Riani Prabaningtyas Hanindya Riani Prabaningtyas Ira Ristinawati Kenneth Tan Lawly Arrel Dionnie Greatalya Muhammad Hafizhan Muhammad Hafizhan Priyanka Ganesa Utami Raden Andi Ario Tedjo Stefanus Erdana Putra Sulistyani Sulistyani Suroto Suroto Suroto Suroto Teddy Tejomukti Vivienne Tjung Wilson Arpin Yeremia Suryo Pratama Yetty Hambarsari Yetty Hambarsari Yetty Hambarsari