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All Journal International Journal of Public Health Science (IJPHS) Global Medical and Health Communication Biomedika Universa Medicina Jurnal Keperawatan Padjadjaran Cermin Dunia Kedokteran Magna Neurologica Cermin Dunia Kedokteran
Rivan Danuaji
Departemen Neurologi, Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Efek Terapi Citicoline terhadap Pemulihan Kognitif dan Motorik Pasien Stroke Iskemik Akut dengan Polimorfisme ApoE4 rs429358 dan rs7412 Faizal Muhammad; Afifah Syifaul Ummah; Farida Aisyah; Rivan Danuaji; Subandi; Diah Kurnia Mirawati
Cermin Dunia Kedokteran Vol 50 No 11 (2023): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i11.1016

Abstract

Citicoline has a neuroprotectant effect, especially in mild-to-moderate stroke. The presence of the ε4 allele in the ApoE gene is associated with a severe acute ischemic stroke (AIS) phenotype, in addition to neurodegenerative risk This study aims to determine the effect of citicoline on cognitive and motoric recovery in severe AIS biomolecularly, such as ApoE4 rs429358 and rs7412 polymorphisms. A 64-year-old woman was diagnosed with AIS with a 6-hour onset and with a NIHSS score of 25 and MMSE score of 21. The patient’s AIS was biomolecularly severe as proven by PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) ApoE4 which yielded 482 bp at rs429358 (codon 112) and 249 bp 167 bp at rs7412 (codon 158) on electrophoretic visualization. The patient received 3x 500 mg intravenous citicoline for 4 days followed by another 1000 mg of citicoline intravenous during polyclinic control for 5 consecutive days. On the 9th day, the patient experienced improvement in cognitive function with an MMSE score of 29 and superior (4/5) and inferior (5/5) motoric strength. Citicoline is a neuroprotectant agent that is beneficial for the recovery of cognitive and motoric function in biomolecularly severe SIA (ApoE4, C/C, Arg112/Arg158) because it can save the penumbra area from infarction.
ACUTE ISCHEMIC STROKE RISK FACTORS STRATIFICATION MODEL IN ISOLATED VERTIGO PATIENTS: TWO-YEARS COHORT RETROSPECTIVE STUDY Faizal Muhammad; Rivan Danuaji
Magna Neurologica Vol. 4 No. 2 (2026): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v4i2.3271

Abstract

Background: Vertigo is a common complaint in medical settings, with the most important differential diagnosis to exclude being vertebrobasilar ischemic stroke. However, there have been no cohort studies evaluating the risk of stroke following hospitalization for acute vertigo without other neurological symptoms (isolated vertigo). Objective: To assess the long-term risk of stroke in patients with a history of hospitalization due to isolated vertigo. Methods: This retrospective cohort study was conducted at Dr. Moewardi Hospital in Surakarta, utilizing secondary data from electronic medical records for the years 2024–2025. A total of 268 patients hospitalized for vertigo and 223 control patients (elective gastrointestinal endoscopy patients) were selected based on similar age distribution. Stroke incidence data were analyzed using Kaplan-Meier methods and Cox regression, with adjustments for demographic variables and vascular risk factors. Results: Over a 2-year period, stroke occurred in 16 vertigo patients (5.8%) and 2 control patients (1.1%). After adjustment, vertigo patients had a 3.25-fold higher risk of stroke compared to the control group (HR: 3.25; 95% CI: 2.18–4.15; p = 0.002). Stroke risk significantly increased in patients with ≥3 vascular risk factors (HR: 5.01). Approximately 68% of strokes occurred within the first year. Conclusion: Isolated vertigo significantly increases the risk of ischemic stroke, particularly in patients with risk factors during the first year following the initial symptoms of isolated vertigo.
Co-Authors ., Subandi Afifah Syifaul Ummah Arif Apriyanto Astrida Fesky Febrianty Baarid Lukman Hamidi Baarid Luqman Hamidi Baarid Luqman Hamidi Befrie Mahaztra Sudarman Benedictus Benedictus Bhisma Murti Brilliandi, Immanuel Billy Budianto, Pepi Cynthia Hanny Lestari Diah Kurnia Mirawati Endang Kusuma Dewi Ervina Arta Jayanti Hutabarat Faizal Muhammad Faizal Muhammad Farida Aisyah Fauzi Novia Isnaening Tyas Hanindia Riani Prabaningtyas Hanindia Riani Prabaningtyas Hanindia Riani Prabaningtyas Hanindya Riani Prabaningtyas Ira Ristinawati Kenneth Tan Lawly Arrel Dionnie Greatalya Muhammad Hafizhan Muhammad Hafizhan Priyanka Ganesa Utami Raden Andi Ario Tedjo Stefanus Erdana Putra Sulistyani Sulistyani Suroto Suroto Suroto Suroto Teddy Tejomukti Vivienne Tjung Wilson Arpin Yeremia Suryo Pratama Yetty Hambarsari Yetty Hambarsari Yetty Hambarsari