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All Journal Media Penelitian dan Pengembangan Kesehatan Laboratory Journal of Infectious Diseases
Aditia Aditia
Poltekkes Kemenkes Pontianak
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Environmental Science Immunology & microbiology Medicine & Pharmacology

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Antimicrobial Activity of Endophytic Bacteria Isolated from the Roots of Avicennia marina (Forssk.) Against Escherichia coli Ari Nuswantoro; Diana Novita; Aditia Aditia
Laboratory Journal of Infectious Diseases Vol. 2 No. 1 (2026): Laboratory Journal of Infectious Diseases
Publisher : Poltekkes Kemenkes Kupang

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Abstract

Endophytic bacteria are beneficial microorganisms that interact with the host plant without causing damage. This study aimed to determine the antimicrobial activity of endophytic bacteria from the roots of Avicennia marina (Forssk.) against Escherichia coli. Samples were collected using a purposive sampling approach with 9 repetitions. Endophytic bacteria were isolated from root tissues and identified using Gram staining and biochemical tests (Simmons citrate, SIM, TSIA, methyl red, catalase, BAP, and MCA). The antimicrobial activity test used the disc diffusion method with a 100% concentration of endophytic bacterial suspension adjusted to 0,5 McFarland standard; ampicillin served as the positive control. Three bacterial isolates were obtained: Aeromonas sp., Enterobacter sp., and Bacillus sp. The average inhibition zones were 18,78 mm (Aeromonas sp.), 15,1 mm (Enterobacter sp.), and 16,66 mm (Bacillus sp.). Based on the standard for interpreting inhibition zones (≥20 mm = very strong; 10–20 mm = strong), all isolates demonstrated strong antibacterial potential. One-way ANOVA revealed a significant difference among the three isolates (p < 0,001), with Aeromonas sp. showing the highest activity. This study is novel in providing the first comparative evidence that Aeromonas sp. from Avicennia marina (Forssk.) roots exhibits superior antibacterial activity against Escherichia coli growth.
PERBEDAAN HASIL HITUNG BERBAGAI JENIS LEUKOSIT PADA PASIEN COVID-19 YANG ISOLASI MANDIRI DENGAN ISOLASI DI RSUD KABUPATEN MELAWI Nur Reza; Edi Santoso; Ari Nuswantoro; Ratih Indrawati; Etiek Nurhayati; Aditia Aditia
Media Penelitian dan Pengembangan Kesehatan Vol. 32 No. 3 (2022): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v32i3.1886

Abstract

COVID-19 infection causes various clinical manifestations so the treatment method is also different for each individual. Patient isolation is one of the treatments to break the chain of transmission of COVID-19. Asymptomatic to moderate symptomatic patients are usually asked to self-isolate, while those with severe and critical symptoms are isolated in hospital. Leukocyte examination is an important parameter and plays a role in determining patient follow-up. The aim of this study was to find out whether there were differences in leukocyte differential-counts in COVID-19 patients who were self-isolating and those isolated at Melawi Regional Hospital. This study had a cross-sectional design by taking data from medical records of COVID-19 patients at Melawi Regional Hospital during October 2021 to July 2022. The data taken were from 399 COVID-19 patients, consisting of 182 patients are self-isolating and 217 patients are isolating at Melawi Regional Hospital. In self-isolated patients, the average value of leukocyte count was 7.04 x 10³ cells/µL, and the leukocyte differential-counts was neutrophils 58.45%, lymphocytes 21.81%, monocytes 13.84%, eosinophils 1.52%, and basophils 4.38%. In isolated patients at Melawi Regional Hospital, the average value of leukocyte count was 9.89 x 10³ cells/µL, and the leukocyte differential-counts was neutrophils 75.09%, lymphocytes 12.97%, monocytes 8.38%, eosinophils 0.46%, and basophils 3.11%. The Mann-Whitney U test obtained a significance value of 0.000 (p < 0.05), which means there is a significant difference in the results of leukocyte counts between self-isolated patients and those isolated at Melawi Regional Hospital.
KORELASI JUMLAH MONOSIT DENGAN KADAR C-REACTIVE PROTEIN PADA PENDERITA TUBERKULOSIS Ari Nuswantoro; Fitri Mega Astuti; Fitri Ulya Hartati; Aditia Aditia
Media Penelitian dan Pengembangan Kesehatan Vol. 32 No. 3 (2022): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v32i3.2027

Abstract

Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is still a public health problem throughout the world, including in Indonesia. Monocytes play a role in cellular reactions against MTB bacteria and are considered a marker of active TB spread. C-Reactive Protein (CRP) examination is very useful for diagnosing inflammation or infectious diseases. This study aimed to determine the correlation between monocyte counts and CRP levels in TB patients in North Putussibau. This research was observational analytic with cross-sectional approach and the sampling technique was accidental nonprobability sampling. The sample was TB patients in North Putussibau who were undergoing treatment for 0, 2, and 6 months in 2022, resulting in 36 patients. Monocyte counts were examined using the fluorescence method and CRP levels were examined using the latex agglutination method. At 0 months of treatment, the monocyte count was obtained with an average of 1.096.88cells/µL and average CRP level of 55.13mg/L, at 2 months of treatment the average monocyte count was 742.31 cells/µL and CRP levels were obtained an average of 10.62mg/L, and after 6 months of treatment an average monocyte count was 414.29cells/µL and an average CRP level of 0mg/L. The Kendall's Tau-b test showed a significant value 0.000 (<0.05), which means there was a significant correlation between the number of monocytes and CRP levels in TB patients with a correlation coefficient 0.645 which shows the strength of  strong relationship. This shows that the decrease in the number of monocytes and CRP levels is in line with the length of the TB treatment period.
Co-Authors Affifatuzahara Affifatuzahara Anisya Nur Shafitri Ari Nuswantoro Bagus Muhammad Ihsan Benedikta Anjelica Diana Novita Edi Santoso Etiek Nurhayati Fahma Ajeng Al-qorifah Fitri Mega Astuti Fitri Ulya Hartati Herlinda Djohan Indrawati, Ratih Nur Reza Nurul Uq'ma