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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Nusantara Hasana Journal JPKM Cahaya Negeriku Jurnal Farmasi Ikifa Joseph
Wahyu Purwanjani
Universitas An Nuur
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Other

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Uji Aktivitas Serum Anti Aging Ekstrak Daun Salam (Syzygium polyanthum) Wahyu Purwanjani
Joseph: Journal of Science and Pharmacy Vol 3 No 1 (2023): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background : Skin aging is a natural process characterized by a decrease in skin elasticity, firmness, and moisture, as well as the appearance of wrinkles caused by both intrinsic and extrinsic factors such as UV exposure and free radicals. The use of natural ingredients as anti-aging agents is increasingly being explored, one of which is bay leaf (Syzygium polyanthum), known to contain active compounds such as flavonoids, tannins, and antioxidants that can combat free radicals and slow down the skin aging process. Objective : To evaluate the anti-aging activity of a serum formulation containing bay leaf extract as the main ingredient. Method : Bay leaf extract was obtained through a maceration process and then formulated into a serum with various concentrations. The effectiveness test was conducted on rabbits using a Skin Analyzer device to measure skin parameters such as moisture, elasticity, and wrinkle depth before and after serum application. Results : The study showed that the serum containing 4.5% extract concentration provided the most significant improvement in skin condition, with notable increases in moisture and elasticity and a marked reduction in wrinkle depth. Therefore, bay leaf extract has potential as an active agent in anti-aging skincare products.  
UJI AKTIVITAS ANTIBAKTERI SEDIAAN FACE TONER EKSTRAK ETANOL 70% DAUN SALAM (Syzygium polyanthum) TERHADAP BAKTERIStaphylococcus aureus Sony Hartono; Wahyu Purwanjani; Maulita Saraswati
Joseph: Journal of Science and Pharmacy Vol 4 No 1 (2024): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Salam leaves contain several chemical compounds including alkaloids, flavonoids, saponins, triterpenoids and tannins which are active compounds that are effective as drugs that can cure infectious diseases caused by bacteria. Purpose: The purpose of this study was to determine the antibacterial activity of bay leaf extract face toner preparations against Staphylococcus aureus bacteria. Method: Bay leaves are extracted with 70% ethanol by maceration. The ethanol extract of bay leaves is formulated into a facial toner preparation and then tested for antibacterial activity using the disc diffusion method or the Kirby Bauer method. Results: The results of the research show that the face toner preparation with 70% ethanol extract of salam (Syzygium polyanthum) contains alkaloid compounds, flavonoids, saponins, triterpenoids and tannins. Ethanol extract of salam leaf has antibacterial activity against Staphylococcus aureus with the inhibition zone diameter of F1 of 10.28 mm, F2 of 11.24 mm, and F3 of 12.24 mm. Conclusion: Facial toner preparation of bay leaf extract (Syzygium polyanthum) provides the strongest antibacterial activity in F3 against the growth of Staphylococcus aureus bacteria with an inhibitory zone diameter of 12.24 mm  
UJI AKTIVITAS ANTI JAMUR SEDIAAN GEL EKSTRAK DAUN TURI PUTIH (Sesbania grandiflora L.) TERHADAP JAMUR Candida albicans Sinta ardani; Supriyanto; Wahyu Purwanjani
Joseph: Journal of Science and Pharmacy Vol 4 No 1 (2024): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: One of the plants that has anti-fungal potential is the white Turi Plant (Sesbania grandriflora) white turi leaf extract (Sesbania grandiflora) which is suspected to be able to inhibit the growth of Candida albicans, one of the fungi that cause candidiasis. Purpose: This study aims to determine the antifungal activity of Sesbania grandriflora white turi leaf extract gel against the fungus Candida albicans, determine the minimum inhibitory concentration (KHM) and determine the content of secondary metabolite compounds. Method: The leaves (Sesbania grandriflora) are extracted by maceration with a 70% ethanol solvent. The extracts obtained were subjected to phytochemical screening tests. The antifungal activity test of turi leaf extract gel was carried out by the well method against Candida albicans. The positive control used was the 2% dandruff gel while the negative control used was the gel preparation without the extract. Results: White turi leaf extract gel (Sesbania grandriflora) has antifungal activity against Candida albicans. Conclusion: Based on the results of the research on the Antifungal Activity Test of Sesbania glandriflora White Turi Leaf Extract Gel Preparation against Candida albicans Fungus, it can be concluded as follows: 1. Sesbania glandriflora (L.) white turquoise leaf extracthas the content of Saponins, flavonoids, and tannins  2.  Sesbania glandriflora (L.) white turquoise leaf extractgel preparation has the activity of inhibiting the fungusCandida albicans   The most effective formulation of Sesbania glandriflora (L.) white turi extract gel preparation against the growth of Candida albicans fungus is Formulation 3 with a concentration of 8% of 20.65 mm, included in the very strong group    
Analisis Zat Pengawet Boraks pada Cilok dan Pentol Bakso yang Dijual di Kabupaten Grobogan Salma Ellya Sayidina; Wahyu Purwanjani; Estuningtyas Ayu Hapsari
Joseph: Journal of Science and Pharmacy Vol 5 No 1 (2025): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: The increasing use of borax as an unauthorized preservative in foodssuch as cilok and pentol bakso sold in Grobogan Regency poses a threat to public health. Purpose: to examine the presence and concentration of borax in cilok and pentol bakso samples circulating in the area. Method: Qualitative analysis using boric acid test kits and quantitative analysis using Spectrophotometry UV-Vis to measure boric acid levels in the samples. Samples were collected from various street vendors, prepared and then analyzed in the laboratory. Results: The study results showed that borax was detected in one cilok sample with a the highest concentration reaching 112.22 μg/kg.  Conclusion: The study results indicate that some food vendors are still adding borax to their products. Therefore, further supervision and increased awareness regarding the risks of using borax in food are necessary.
ANALISIS NATRIUM SIKLAMAT PADA TEH JUMBO DI KABUPATEN GROBOGAN DENGAN METODE KUALITATIF DAN KUANTITATIF iman cahyani_putri; Maulita Saraswati; Wahyu Purwanjani
Joseph: Journal of Science and Pharmacy Vol 5 No 1 (2025): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Jumbo tea is a popular drink because it is practical and affordable. However, manufacturers often add sodium cyclamate, an artificial sweetener that is 30 times as sweet as sucrose and is known to be cheap, to reduce production costs. Excessive use of sodium cyclamate can cause health problems. Purpose: This research aims to analyze the presence and levels of sodium cyclamate in jumbo tea drinks circulating in Grobogan Regency. Method: This research used 10 jumbo tea samples taken from 5 sub-districts in Grobogan Regency using a purposive sampling method, namely samples that had an excessively sweet taste. Analysis was carried out qualitatively using the deposition method and quantitatively using the UV-Vis Spectrophotometry method. Results: Of the 10 samples tested, the qualitative test results showed that 3 samples were positive for containing sodium cyclamate (samples C2, E1, and E2) which were characterized by the formation of a white precipitate. The quantitative test results on the three positive samples showed the following sodium cyclamate levels: sample C2 was 0.08104 g/kg, sample E1 was 0.04693 g/kg, and sample E2 was 0.06242 g/kg. Conclusion: There were 3 out of 10 jumbo tea samples in Grobogan Regency that tested positive for sodium cyclamate15. However, the sodium cyclamate levels found in the three samples were still below the maximum limit permitted by BPOM (3 g/kg).
UJI STABILITAS FISIK SEDIAAN KRIM EKSTRAK ETANOL 96% DAUN BELIMBING WULUH (Averrhoa bilimbi L.) DENGAN VARIASI KONSENTRASI GLISERIN Nike Wijayanti; Wahyu Purwanjani; Supriyanto
Joseph: Journal of Science and Pharmacy Vol 6 No 1 (2026): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Background: Bilimbi leaves (Averrhoa bilimbi L.) contain secondary metabolites that have potential as antioxidants. The development of cream preparations requires evaluation of physical stability, Glycerine as a humectant plays a role in influencing the physical stability of the preparation. Purpose: This study aimed to evaluate the effect of varying glycerine concentrations on the physical stability of 96% ethanol extract creams from starfruit leaves. Method: The extract was obtained by maceration using 96% ethanol and formulated into three cream formulations with glycerine concentrations of 10%, 15%, and 20%. Accelerated stability testing was conducted using the cycling test method for 6 cycles (12 days). Qualitative analysis included the identification of secondary metabolite compounds using thin-layer chromatography (TLC) as well as descriptive evaluation of organoleptic properties, homogeneity, and cream type. Quantitative analysis included pH, spreadability, adhesion, and viscosity tests, which were statistically analysed using the One Way ANOVA test if the data were normally distributed and homogeneous (p ≥ 0.05), while data that did not meet the requirements were analysed using the Kruskal–Wallis and Mann–Whitney tests. Results: Starfruit leaf extract was found to contain flavonoids, saponins, alkaloids, and tannins. All cream formulations showed good physical stability with pH suitable for skin, spreadability and adhesion meeting requirements, viscosity in accordance with SNI standards, and an oil-in-water (O/W) type. Conclusion: The 96% ethanol extract cream of starfruit leaves with varying glycerin concentrations showed good organoleptic characteristics, was homogeneous, had an oil-in-water (O/W) type, and met the requirements for pH, viscosity, spreadability, and adhesion before and after stability testing in all formulations. Varying glycerin concentrations affected the physical stability of the preparation. Formulation III with a glycerin concentration variation of 20% showed more optimal and stable physical stability compared to other formulations.
Analysis of Rhodamine B Levels in Lip Tints Circulating in Tawangharjo District TAWANGHARJO Dhiva Mariska; Renno Ramadhani Ika Baruna; Wahyu Purwanjani
Joseph: Journal of Science and Pharmacy Vol 6 No 1 (2026): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Latar Belakang: Rhodamin B merupakan zat pewarna sintetis yang dilarang penggunaannya dalam kosmetik karena bersifat karsinogenik dan dapat menimbulkan gangguan kesehatan. Tujuan: Penelitian ini bertujuan untuk mengidentifikasi dan menentukan kadar Rhodamin B pada 10 sampel lip tint yang beredar di Kecamatan Tawangharjo. Metode: Penelitian ini menggunakan metode deskriptif kuantitatif dengan teknik pengambilan sampel secara purposive sampling. Identifikasi Rhodamin B dilakukan menggunakan Kromatografi Lapis Tipis (KLT) dengan fase diam silika gel GF254 dan fase gerak n-butanol asetat (10:4:5). Penentuan kadar Rhodamin B dilakukan secara spektrofotometri UV-Vis pada panjang gelombang maksimum 542 nm. Hasil: Hasil identifikasi menggunakan KLT menunjukkan bahwa enam sampel positif mengandung Rhodamin B dengan nilai Rf berkisar antara 0,42–0,60, yang mendekati nilai Rf baku sebesar 0,62, sedangkan empat sampel lainnya menunjukkan hasil negatif. Hasil analisis kuantitatif menunjukkan bahwa seluruh sampel positif mengandung Rhodamin B dengan kadar berkisar antara 0,0188–0,5450 mg/kg atau setara dengan 0,00019%–0,00545%. Kadar Rhodamin B tertinggi ditemukan pada sampel R3, yaitu sebesar 0,5450 mg/kg. Kesimpulan: Berdasarkan hasil penelitian, dapat disimpulkan bahwa produk lip tint yang beredar di Kecamatan Tawangharjo tidak memenuhi persyaratan keamanan kosmetik sesuai dengan ketentuan BPOM karena ditemukan adanya kandungan Rhodamin B yang merupakan zat pewarna yang dilarang penggunaannya dalam kosmetik.   Kata Kunci: Lip Tint, Rhodamin B, KLT, Nilai Rf, Spektrofotometri UV-Vis
UJI KUALITATIF DAN KUANTITATIF BAHAN KIMIA OBAT (BKO)PADA JAMU PEGAL LINU DI WILAYAH KABUPATEN GROBOGAN Alya Iffa Nalia; Wahyu Purwanjani; Renno Ramadhani Ika Baruna
Joseph: Journal of Science and Pharmacy Vol 6 No 1 (2026): Journal of Science and Pharmacy (Joseph)
Publisher : Universitas An Nuur

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Latar Belakang: Banyaknya penambahan bahan Kimia obat (BKO) seperti paracetamol, Dexamethasone, natrium diklofenak pada jamu pegal linu di kabupaten grobogan yang masih beredar luas. Tujuan: untuk mengetahui keberadaan bahan kimia obat pada jamu pegal linu yang beredar luas. Metode: Analisis kualitatif menggunakan uji klt ( kromatografi lapis tipis) dan analisis kuantitatif menggunakan spektrofotometri uv-vis untuk mengukur bahan kimia obat yang terkandung pada sampel jamu pegal linu di lima kecamatan grobogan, dan kemudian dianalisis di laboratorium. Hasil: Hasil penelitian menunjukkan bahwa kadar tertinggi yang di dapat pada masing-masing sampel yaitu Paracetamol terdapat pada sampel C 29,82%; Dexamethasone terdapat pada sampel A 12,50%; dan Natrium Diklofenak terdapat pada sampel C 44,64%. Kesimpulan: Hasil penelitian menunjukkan bahwa beberapa sampel jamu pegal linu masih banyak ditambahkan bahan kimia obat (BKO) seperti paracetamol, Dexamethasone, natrium diklofenak. Oleh karena itu, masih butuh pengawasan lebih lanjut dan peningkatan kesadaran mengenai resiko penggunan bahan kimia obat secara terus menerus.   Keyword: Bahan Kimia Obat ( BKO), Kromatografi Lapis Tipis (KLT), Spektrofotometri UV-Vis 
Co-Authors Alya Iffa Nalia Amanda Risky Damayanti Anisa Eka Pafitri Dhiva Mariska Eka Ammyta PP Estuningtyas Ayu Hapsari Gigih Kenanga Sari iman cahyani_putri Jaka Lepangkari Julia Sita Nur Hidayah Maulita Saraswati Mingle A Pistanty Mingle A Pistanty Muhammad Nur Prasetyo Nike Wijayanti Renno Ramadhani Ika Baruna Rismawati Suci Safitri Salma Ellya Sayidina Sarima Sinta ardani Sony Hartono Supriyanto