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All Journal Jurnal Kesehatan Bakti Tunas Husada Medical Sains : Jurnal Ilmiah Kefarmasian
Rafiastiana Capritasari
Universitas Muhammadiyah Magelang
Chemistry Health Professions Medicine & Pharmacology Nursing Public Health

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IDENTIFIKASI VARIAN GENETIK TERKAIT KEJADIAN INFARK MIOKARD MELALUI PENDEKATAN BIOINFORMATIK Rafiastiana Capritasari; Muhammad Irham; Fara Azzahra; Davit Nugraha; Anna Lesmanasari Yusuf; Febriana Astuti; Zulkifli Zulkifli; Anggoro Wicaksono; Andhika Nor Hendryawan; Tiyas Putri Nurgraheni; Kusmini Kusmini; Ilham Alifiar; Dona Suzana
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 23, No 1 (2023)
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v23i1.1307

Abstract

Faktor risiko terjadinya penyakit kardiovaskuler selain faktor risiko konvensional (perokok, hipertensi, dislipidemia, diabetes militus dan obesitas) terdapat juga faktor genetik serta faktor risiko non-konvensional seperti kecemasan, stres dan depresi. Tujuan dari penelitian ini yaitu mengidentifikasi variasi genetik yang terkait dengan patogenesis infark miokard pada berbagai populasi dengan menggunakan basis data genom dan pendekatan bioinformatika. Hasil terdapat tiga varian genetik  yaitu gen APOE, ZC3HC1 dan ALDH2  yang memiliki potensi kerusakan terhadap protein DNA sehingga dapat menyebabkan kejadian infark miokard. SNP dengan kode rs7412, rs11556924 dan rs671 merupakan SNP yang paling kuat dikaitkan dengan kejadian infark miokard sehingga dapat direkomendasikan sebagai risiko genetik.
REVIEW: THE ROLE OF HERBAL AS A THERAPY FOR ENDOTHELIAL DYSFUNCTION IN CARDIOVASCULAR DISEASES: NARRATIVE REVIEW Febriana Astuti; Akrom; Rafiastiana Capritasari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1238

Abstract

Atherosclerosis, diabetes mellitus, hypertension, and aging are examples of cardiovascular illnesses, the pathogenesis of which is affected by endothelial dysfunction. Many patients with cardiovascular disease already use herbs or combine herbs with medications prescribed by doctors. Herbs have emerged as alternative treatments for health maintenance. Herbs are in increasing demand by patients and health professionals. An overview of the role of herbal plants, their active substances, and their mechanisms of action as therapies for endothelial dysfunction to prevent the worsening of cardiovascular disease is presented in this review. The research was carried out by reviewing published scientific papers using online sources, such as PubMed and Google Scholar. Herbs can be used as a therapy for endothelial dysfunction to prevent the worsening of cardiovascular disease through various mechanisms, including inhibition of oxidative stress through the COX-2 and NOX2 pathways, inhibition of NADPH oxidase, inhibition of ROS formation through Src/EGFR/Akt, and increasing nitric oxide (NO) production by activating eNOS. The benefits and potential of herbal plants in dysfunction therapy to prevent cardiovascular disease need to be further developed for plants that grow widely in Indonesia. Furthermore, it is necessary to develop mechanisms for other targets, such as immunomodulatory therapy, to prevent cardiovascular disease from worsening. Keywords: Herbals, Endothelial Dysfunction, Cardiovascular Disease
Co-Authors Akrom Andhika Nor Hendryawan Anggoro Wicaksono Anna Lesmanasari Yusuf Davit Nugraha Dona Suzana Fara Azzahra Febriana Astuti Febriana Astuti Ilham Alifiar Kusmini Kusmini Muhammad Irham Tiyas Putri Nurgraheni Zulkifli Halid