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All Journal Jurnal Farmasi Klinik Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian Journal of Innovation Research and Knowledge JK Jurnal Kesehatan
Annafiatuzakiah Annafiatuzakiah
Pharmacy Department, Faculty Of Medicine, Tanjungpura University
Humanities Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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ETHNO PHARMACOLOGY STUDY, ACUTE AND ANALGESIC BAMBOO LEAVES EXTRACT ETHANOL (BAMBUSA VULGARIS) ENDEMIC PLANT WEST KALIMANTAN Annafiatuzakiah Annafiatuzakiah; Inarah Fajriaty; Rafika Sari; Pratiwi Apridamayanti
Jurnal Kesehatan Vol. 1 No. 5 (2023): November
Publisher : CV. ADIBA AISHA AMIRA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Objectives: The purpose of this study was to determine the benefits of bamboo leaves as empirically analgesic drugs is safe to eat. Methods: Ethno pharmacology study was see the benefits of bamboo leaves use empirically in the community and continued test of pharmacology, where bamboo leaves were extracted by maceration using 96% ethanol. The results of the extraction continued with pharmacological trials method toxicity test to determine the level of safety of a drug and continued with analgesic test to determine the effective dose in bamboo leaves. Rat wistar were using orally for toxicity tests consist of a dose of 2000mg/kgbwbw and dose of 500mg/kgbw to see the LD50 and continue with test of analgesics use mice strains Swiss consisting the positive control group (Paracetamol 500mg/kgbw), negative control (CMC-Na) and 1 dose (300mg/kgbw), second dose (600mg/kgbw), the third dose (1200mg/kgbw). Research on analgesic test using stretching to give a 0.6% acetic acid intraperitoneally and observed every 5 minutes for 60 minutes, the next is done with the data analysis. Results: Study Ethno pharmacology bamboo leaves empirically used as a pain medication, but clinical use of traditional medicine is not recognized, if not scientifically proven the test of pharmacology to determine efficacy as an analgesic, because not secure, study was conducted determine the lethal dose (LD50) ethanol extract of bamboo leaves use Wistar rats. In the acute toxicity results obtained LD50>5000mg/kgbw and organ index see no effect between the dose of 2000mg/kgbw and 5000mg/kgbw. Further research on analgesic test to determine whether there is the analgesic effect of the ethanol extract of the leaves of bamboo (Bambusa vulgaris) using mice Swiss strain. This study is divided into 5 in the control group positive control (Paracetamol 500mg / kgbw), Negative control (CMC-Na) and Dose 1 (300 mg/ kgbw), Dose II (600mg/kgbw), Dose III (1200 mg/kgbw), Testing the analgesic effect is done by giving chemical stimulation in the form of a 0.6% acetic acid intraperitoneally. The response of mice were observed amount of stretching, observations were made every 5 minutes for 60 minutes. Data were evaluated with SPSS to compare the results from each dose group exhibited significantly with the controls at a rate of 0.05%. Conclusions: The utilization of bamboo leaves empirically showed that bamboo leaves are consumed safely and effectively as a pain medication. The results of this study are supported on the acute toxicity test LD50> 5000mg/kgbw. The next in analgesic trials showed that the ethanol extract of bamboo leaf has efficacy as an analgesic percent protection stretching on the dose I: 71.08%, dose II: 42.85%, dose III: 28.23%.
Drug-Related Problems pada Pasien Rawat Inap Geriatri dengan Stroke Iskemik di RS Bhayangkara Anton Soedjarwo Pontianak Annafiatuzakiah, Annafiatuzakiah; Rahmawati, Fita
Indonesian Journal of Clinical Pharmacy Vol 12, No 1 (2023)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2023.12.1.31

Abstract

Stroke iskemik terjadi ketika arteri otak terhambat sehingga aliran darah berkurang menuju otak. Stroke iskemik membutuhkan perawatan yang lama dan pemakaian regimen obat yang komplek sehingga berpotensi terjadi Drug Related Problems (DRPs), kejadian yang tidak diharapkan berkaitan dengan terapi obat yang dapat menggangu keberhasilan dalam proses penyembuhan. Penelitian bertujuan mengidentifikasi penyebab terjadinya DRPs pada pasien geriatri yang didiagnosa penyakit stroke iskemik. Studi ini merupakan observasional dengan menggunakan desain penelitian cross sectional. Pengumpulan data dilakukan secara retrospektif melalui rekam medis tahun 2020 di Rumah sakit Bhayangkara Anton Soedjarwo, Kota Pontianak. Sejumlah 94 pasien memenuhi kriteria inklusi meliputi pasien dengan diagnosa stroke iskemik berumur 60 tahun atau lebih dan rekam medis lengkap. DRPs diklasifikasikan berdasarkan penyebabnya menggunakan PCNE (Pharmaceutical Care Network Europe) ver 9.0. Analisis deskriptif dilakukan untuk mendiskripsikan jumlah dan jenis DRPs. DRPs ditemukan pada 28 pasien (29,78%) dengan total kejadian DRPs sebanyak 44 kejadian. DRPs diklasifikasikan dalam penyebab yang berkaitan dengan pemilihan obat yang tidak tepat sebanyak 24 pasien (25,53%) dan dosis tidak tepat sebanyak 20 pasien (21,26%). Jenis obat yang banyak menimbulkan DRPs adalah Amlodipin, dan ditemukan sebanyak 14 (23,33%). Adanya DRPs pasien geriatri stroke iskemik menjadi tantangan bagi farmasis untuk dapat menyelesaikan masalah terkait obat sehingga meningkatkan optimasi terapi pasien stroke iskemik.
FAKTOR FAKTOR YANG MEMPENGARUHI PADA PASIEN GERIATRI DENGAN STROKE ISKEMIK DI RS BHAYANGKARA ANTON SOEDJARWO PONTIANAK Annafiatuzakiah, Annafiatuzakiah; Fita Rahmawati
Journal of Innovation Research and Knowledge Vol. 4 No. 9: Februari 2025
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53625/jirk.v4i9.9691

Abstract

Ischemic stroke occurs when the arteries of the brain are blocked so that blood flow is reduced to the brain. Ischemic stroke requires long treatment and the use of multiple drug regimens so that there is the potential for Drug Related Problems (DRPs), unexpected events related to drug therapy that can interfere with the success of the healing process. This study aims to identify the causes of DRPs in geriatric patients diagnosed with ischemic stroke. This study used observational crosssectional design. Data collection was carried out retrospectively through medical records in 2020 at the Bhayangkara Anton Soedjarwo Hospital, Pontianak City. A total of 94 patients met the inclusion criteria including patients with a diagnosis of ischemic stroke aged 60 years or older and complete medical records. Data collection method using questionnaires and analyzed bivariately using Chi Square. The results of the study showed a relationship between risk factors age and LOS (length of Stay) with the occurrence of DRPs. At age has a p value = 0.041 and LOS has a p value = 0.031 the value is <0.05, the test using chi square confidence level used 5% with OR and CI values respectively of 2.489 (1.043-5.937) and 0.456 (0.254-0.820).
Profil Penggunaan Antibiotik di Apotek Best Pontianak Periode Oktober 2024 - Februari 2025 Wahdaningsih, Sri; Annafiatuzakiah, Annafiatuzakiah; Andres, Andres; Kamil, Insan; Wijaya, Anisa; Imania, Imania; Faujiah, Nurul; Goneril, Aldo
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 6, No 2 (2025): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v6i2.31584

Abstract

Penyakit infeksi dapat disebabkan oleh  mikroorganisme seperti bakteri, parasit, fungi dan virus. Infeksi terjadi karena adanya mikroorganisme yang masuk kedalam tubuh dan menyebabkan suatu penyakit. Pilihan pengobatan pertama  pada terapi infeksi adalah antibiotik. Pengendalian antibiotik di Provinsi Kalimantan Barat diatur dalam Surat Edaran Gubernur Kalimantan Barat Nomor 442/245/SDK-A/DINKES yang menyatakan bahwa antibiotik hanya dapat diperoleh melalui resep dokter. Oleh karena itu, penelitian ini bertujuan untuk mengetahui pola pengguaan antibiotik di Apotek Best Pontianak periode Oktober 2024 hingga Februari 2025 berdasarkan resep dokter. Penelitian ini merupakan penelitian deskriptif dengan observasi langsung ke Apotek. Pengambilan data dilakukan dengan metode non probability sampling. Hasil yang diperoleh menunjukkan pola penggunaan antibiotik yang paling banyak diresepkan yaitu cefixime (48,11%) dengan dosis 200 mg (31,06%) sediaan tablet (25,31%). Karakteristik pasien yang mendapat peresepan antibiotik berdasarkan jenis kelamin yaitu paling banyak diresepkan pada perempuan (50,13%) dibandingkan laki-laki (49,87%), dan paling banyak terjadi pada kelompok usia dewasa pada rentang 19-59 tahun (56,5%).
Co-Authors Andres Andres Faujiah, Nurul Fita Rahmawati Fita Rahmawati Fita Rahmawati Goneril, Aldo Imania, Imania Inarah Fajriaty Kamil, Insan Pratiwi Apridamayanti Rafika Sari Sri Wahdaningsih Wijaya, Anisa