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All Journal Jurnal Gizi dan Pangan Prosiding Seminar Biologi Majalah Obat Tradisional The Indonesian Biomedical Journal PREPOTIF : Jurnal Kesehatan Masyarakat Bioscientist : Jurnal Ilmiah Biologi
Larasati Sekar Kinasih
Program Studi Pendidikan Dokter, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Islam Maulana Malik Ibrahim Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Potensi makanan fermentasi khas Indonesia sebagai imunomodulator Tias Pramesti Griana; Larasati Sekar Kinasih
Prosiding Seminar Biologi Vol 6 No 1 (2020): PROSIDING SEMINAR NASIONAL BIOLOGI DI ERA PANDEMI COVID-19 (OKTOBER 2020)
Publisher : Jurusan Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/psb.v6i1.15939

Abstract

Indonesia merupakan negara kepulauan dengan berbagai suku dan budaya. Perbedaan budaya menyebabkan berbeda jenis makanan khas yang ada di Indonesia. Makanan hasil pengolahan dengan fermentasi dapat dijumpai hampir di setiap daerah. Pengolahan makanan dengan bioteknologi konvensional yang berupa fermentasi melibatkan berbagai mikroorganisme. Senyawa hasil metabolisme mikroba yang hidup pada bahan baku pangan merupakan prebiotik yang memiliki manfaat bagi kesehatan. Begitu pula mikroba yang hidup pada makanan terfermentasi yang masuk ke dalam tubuh, disebut sebagai probiotik, mampu meningkatkan fungsi imun. Sehingga makanan terfermentasi memiliki potensi sebagai pengatur sistem imun (imunomodulator) di dalam tubuh manusia. Artikel ini mengulas potensi bahan makanan dengan pengolahan fermentasi yang berasal dari berbagai daerah di Indonesia sebagai agen imunomodulator.
Compound Molecules of Network Pharmacology-Based of Tamarillo (Cyphomandra betacea Cav.) and the Potential as Noodle for Type 2 Diabetes Mellitus Treatment Fitriyani, Fitriyani; Ningrum, Salsabila E.S.; Mutiah, Rohiatul; Kinasih, Larasati Sekar
Majalah Obat Tradisional Vol 28, No 3 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.84655

Abstract

Consuming noodles excessively is not good for health because it contains high trans fat, which can cause diabetes mellitus (DM) as a disease with a high prevalence, especially type 2 DM, as much as 95% in Indonesia. Tamarillo (Chypomandra betacea Cav.) can potentially reduce blood glucose levels and restore adipokine regulation to prevent insulin resistance in type 2 DM. This study aims to determine the formulation and potential of tamarillo compounds into noodle products named "Chypotes (Chypomandra Antidiabetes) Noodle" as an alternative food for type 2 DM patients.  The methods used are noodle formulation, organoleptic test, hedonic test, and network pharmacology.  Based on the results of an organoleptic test, Chypotes Noodle has a chewy texture, a distinctive smell, yellow colour, and a slightly sour tasteless taste typical of Tamarillo. Based on the results of the hedonic test, 30 respondents chose the like and very like options in filling out the questionnaire with a percentage of 80-90%. Based on the Network Pharmacology of Tamarillo shows that 150 of the 365 target proteins of Tamarillo are involved in the biological processes and signaling pathways of type 2 diabetes mellitus, with 75 target proteins locking and interacting. Compound Molecules of Tamarillo, such as six bioactive components of the hydroxycinnamic acids group, have activity in type 2 DM and affect the biological processes and signaling pathways of type 2 DM against ADIPOQ, TNF, and INS. Therefore, Tamarillo can potentially be used as an alternative food product in the form of noodles for type 2 DM treatment.
HUBUNGAN USIA DAN JENIS KELAMIN TERHADAP ANGKA KEJADIAN DIABETES MELITUS TIPE 2 BERDASARKAN 4 KRITERIA DIAGNOSIS DI POLIKLINIK PENYAKIT DALAM RSUD KARSA HUSADA KOTA BATU Rohmatulloh, Vanda Rizky; Riskiyah, Riskiyah; Pardjianto, Bambang; Kinasih, Larasati Sekar
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 1 (2024): APRIL 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i1.27198

Abstract

Diabetes melitus tipe 2 terjadi karena terganggunya metabolisme kronis yang ditandai dengan kenaikan kadar gula darah akibat resistensi insulin. Prevalensi diabetes melitus tipe 2 mengalami kenaikan tiap tahunnya, di RSUD Karsa Husada kota Batu terjadi peningkatan pasien rawat inap pada tahun 2022 dari tahun 2021. Faktor risiko terjadinya diabetes melitus tipe 2 adalah usia dan jenis kelamin. Penelitian ini bertujuan untuk mengetahui hubungan usia dan jenis kelamin terhadap angka kejadian penderita diabetes melitus tipe 2 di RSUD Karsa Husada Kota Batu. Desain penelitian ini berupa observasional cross sectional kuantitatif dengan teknik total sampling. Responden merupakan pasien rawat inap penderita diabetes melitus tipe 2 di Poli Penyakit Dalam RSUD Karsa Husada Kota Batu yang berjumlah 87 pasien. Penelitian ini menggunakan data rekam medis. Data yang diperoleh dianalisis menggunakan uji chi-square. Hasil penelitian ini menunjukkan sebagian besar penderita diabetes melitus tipe 2 adalah wanita dan berusia lebih dari 45 tahun. Berdasarkan analisis uji chi-square didapatkan p value >0,05 dan nilai korelasi sebesar 0,397 dan 0,470. Hal ini dapat disimpulkan bahwa tidak ada hubungan antara usia dan jenis kelamin terhadap angka kejadian diabetes melitus tipe 2 di RSUD Karsa Husada Kota Batu.
Vegetables Spices Fermentation Extract Inhibit NAFLD Development by Attenuation of Steatosis through Suppression of C/EBPα and TNFα mRNA Expression Rachmawati, Ermin; Machdaniar, Maulidya; Kinasih, Larasati Sekar; Sargowo, Djanggan; Syarifuddin, Brillian Putra; Putri, Fayza Cinta Rahmadina; Ismail, Mahrus
The Indonesian Biomedical Journal Vol 16, No 2 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i2.2934

Abstract

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD), characterized by inflammation and steatosis, is one of the metabolic problems that trigger serious complications. Statin is usually used for NAFLD therapy, however, statin intolerance and resistance reduce the effectiveness of NAFLD treatment. Therefore, this study was conducted to develop the phytopharmaca against NAFLD by elucidating the anti-inflammatory and steatosis suppression of vegetable spices fermentation extract (VSFE) in rabbits induced with high-fat diet (HFD).METHODS: Twenty New Zealand White rabbits were determined into 4 groups; which were groups receiving standard diet (SD), HFD, HFD and 100 mg/kgBW VSFE, as well as HFD and 200 mg/kgBW VSFE. mRNA expressions of tumor necrosis factor alpha (TNFα) and CCAAT/enhancer-binding protein alpha (C/EBPα) were evaluated. The TNFα concentration was quantified after protein and RNA isolation. Inflammation and steatosis were observed in liver hematoxylin-eosin-stained preparate using microscope.RESULTS: Macrophage cells and hepatic steatosis showed significant decrease in a drug dependent manner. An effective dose of 200 mg/kgBW decreased C/EBPα and TNFα expression to 0.45±0.32 and 0.72±0.29 (p=0.013 and p=0.002, compared to the HFD group), respectively. TNFα inflammatory cytokine concentrations also responded to the administration of 100 mg/kgBW and 200 mg/kgBW doses, with the value of 31.72±10.40 mg/dL and 48.35±7.15 mg/dL (p=0.009 and p=0.002, compared to the HFD group), respectively.CONCLUSION: VSFE might prevent NAFLD by inhibit steatosis and inflammation through suppression of C/EBPα expression and TNFα expression.KEYWORDS: C/EBPα, TNFα, fermentation, steatosis, NAFLD
Combination of Red Betel (Piper crocatum) Leaf and Sambiloto (Andrographis paniculata Ness) Herb Extract on Reduction of Lipid Profile in Diabetic Rats Tjahjono, Kusmiyati; Rahmawati, Nesti; Afifah, Diana Nur; Kinasih, Larasati Sekar
Bioscientist : Jurnal Ilmiah Biologi Vol. 13 No. 2 (2025): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v13i2.15828

Abstract

This study aims to determine the antihyperlipidemic effect of a combination of red betel extract and sambiloto herb in an experimental animal model of Type 2 Diabetes Mellitus (T2DM). This study was a randomized pre-post-test experiment with a control group design on 25 male Sprague-Dawley rats. Rats experienced T2DM with a high-fat diet for 14 days and Streptozotocin (STZ) induction of 55 mg/kgBW preceded by nicotinamide (NA) 100 mg/kgBW. We confirmed T2DM if the rats' fasting glucose levels were less than 200 mg/dl. The rats were randomly divided into 5 groups: negative control (K1), positive control (K2), combination of red betel leaf and sambiloto herb extract 75:25 (P1), 50:50 (P2), and 25:75 (P3). The combination of red betel leaf and sambiloto herb extract at any dose was able to significantly reduce total cholesterol, LDL cholesterol, and triglyceride levels (p<0.05). The combined extract of red betel leaf and sambiloto herb at a ratio of 75:25 yielded the effective dose for reducing total cholesterol, triglyceride levels, and LDL. In T2DM rats, the combination of these extracts has the potential to increase total cholesterol, LDL, and triglyceride levels.
Golden Berry (Physalis peruviana) Juice for Reduction of Blood Glucose and Amelioration of Insulin Resistance in Diabetic Rats Kinasih, Larasati Sekar; Djamiatun, Kis; Al-Baarri, Ahmad Ni’matullah
Jurnal Gizi dan Pangan Vol. 15 No. 1 (2020)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (264.108 KB) | DOI: 10.25182/jgp.2020.15.1.37-44

Abstract

The study aimed to gather evidence on the potential of golden berry (GB) juice in improving blood glucose level, insulin level, and insulin resistance in type-2 diabetes mellitus (T2DM) in comparison to quercetin supplement in animal model. This study used true experimental pre-post-test study with control group design. Twenty five Wistar male rats were divided into five groups: healthy group (K-), T2DM positive control group (K+), T2DM group with 1 ml/200 g BW/day of GB juice (X1), T2DM group with 5 ml/200 g BW/day of GB juice (X2), and T2DM group with 6 mg/200 g BW/day of quercetin (X3). The T2DM rasts were obtained from healthy rats induced by high-fat feed and Streptozotocin (STZ). The result showed that various dosages of GB juice (X1 and X2) were able to lower blood glucose level (-79.15; -110.44; -108.20) and HOMA-IR (-2.40; -2.92; -3.02). In addition, it was also able to increase insulin level (0.26; 1.99; 1.42) compared to (K+) group (p<0.05). In conclusion, GB juice was able to lower blood glucose level, insulin resistance, and increase insulin level in T2DM rats. The GB juice dosage of 1 ml/200 g BW/day and 5 ml/200 g BW/day were better in lowering the blood glucose level and improving insulin resistance compared to quercetin supplement.
Co-Authors Al-Baarri, Ahmad Ni’matullah Bambang Pardjianto Diana Nur Afifah, Diana Nur Djanggan Sargowo Ermin Rachmawati Fitriyani Fitriyani Ismail, Mahrus Kis Djamiatun Kusmiyati Tjahjono Machdaniar, Maulidya Mutiah, Rohiatul Ningrum, Salsabila E.S. Putri, Fayza Cinta Rahmadina Rahmawati, Nesti riskiyah, Riskiyah - Rohmatulloh, Vanda Rizky Syarifuddin, Brillian Putra Tias Pramesti Griana