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All Journal Journal of Food and Pharmaceutical Science METAMORFOSA Journal of Biological Sciences El-Hayah : Jurnal Biologi Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Prosiding Seminar Biologi Journal of Islamic Pharmacy AL QUDS : Jurnal Studi Alquran dan Hadis Jurnal SOLMA Journal of Islamic Medicine JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) Journal of Food and Pharmaceutical Sciences
Tias Pramesti Griana
UNIVERSITAS ISLAM NEGERI MAULANA MALIK IBRAHIM MALANG
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Analisis Fitokimia dan Aktivitas Antioksidan Ekstrak Daun Kesambi (Schleira oleosa) Metode DPPH Holil, Kholifah; Griana, Tias Pramesti
Journal of Islamic Pharmacy Vol 5, No 1 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i1.9387

Abstract

Kesambi (Schleichera oleosa) is one of the forest plants from Indonesia that has potential as medicine. Kesambi has active compounds that act as antioxidants. The purpose of this study was to determine the potential of kesambi leaf as an antioxidant using the DPPH method. Samples of kesambi leaf were extracted in methanol, ethanol, and water solvents by the maceration method. The class of compounds contained in kesambi leaf was tested by the colour reaction test method for alkaloids, flavonoids, triterpenoids, phenols, steroids, saponins, and tannins. Antioxidant activity was tested by the DPPH method to determine IC50 values. Based on the results of the colour reaction test showed that methanol and ethanol solvents were able to bind 6 classes of compounds (alkaloids, flavonoids, triterpenoid, phenols, saponins, and tannins) and water solvents were only able to bind 5 classes of compounds (flavonoids, triterpenoid, phenols, saponins, and tannins) contained in kesambi leaf. The results of antioxidant activity tests using the DPPH method showed the lowest IC50 value was methanol extract (16,12µg/ml) compared to ethanol extract (20,43µg/ml) and water (904,28µg/ml). It was concluded that the leaf extract of kesambi has potential as an antioxidant and which has the best antioxidant ability was extracted in methanol. The class of compounds which were thought to be responsible for the antioxidant activity of the kesambi leaf extract based on the color reaction test were phenols, flavonoids and tannins.Keywords: antioxidant, kesambi, Schleichera oleosa, DPPH
SCABIES : PENYEBAB, PENANGANAN DAN PENCEGAHANNYA Griana, Tias Pramesti
El-Hayah : Jurnal Biologi Vol 4, No 1 (2013): EL-HAYAH (VOL 4, NO 1, September 2013)
Publisher : Department of Biology Science and Technology Faculty UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v4i1.2619

Abstract

Gudik or kudis is a kind of skin disease that could be found in people who living in crowded neighborhood, for examples slums area, Islamic boarding school, prison, military camp and hospital. Gudik could be infect all age, race, and social economic level. Many people do not know that the cause of gudik is mite which named Sarcoptes scabiei. According to Departemen Kesehatan Republik Indonesia, scabies ranked third of the twelve of skin disease that most often arises. Until now, scabies is still neglected, and it becomes to be public health problems worldwide. As the transmission process is fast, misunderstanding of society about this disease makes difficult to eradicate scabies. Sarcoptes scabiei lives in stratum corneum of skin and eat cell fluids. Female mite digs tunnels under skin surfaces and lays its eggs. This mite activities cause rash on the skin and itch at night. Transmission of scabies can through direct or indirect contact with the patient. Drug of choice for scabies is still debatable. Although the results of therapy are effective, sulfur 5%-10%, benzyl benzoate, crotamiton 10%, permethrin 5% and ivermectin give bad side effect for patient. In vitro study showed the effectivity of tea tree 5% (Melaleuca alternifolia), paste of neem leaves (Azadirachta indica) and turmeric (Curcuma longa),  and anise (Pimpinella anisum) as scabicide. Prevention of scabies transmisstion is carried out by hygiene and treatment for all people who have direct contact with the patient.
GAMBARAN HISTOPATOLOGI GASTER MENCIT HIBRID F1 (C3HxAJ) YANG DIINOKULASI TUMOR ADENOCARCINOMA MAMMA SECARA INTRAVENA, INTRAPERITONIAL DAN SUBKUTAN Griana, Tias Pramesti
El-Hayah : Jurnal Biologi Vol 2, No 2 (2012): EL-Hayah (Vol 2, No 2, Maret 2012)
Publisher : Department of Biology Science and Technology Faculty UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v2i2.2211

Abstract

The aim of the current study was to know if adenocarcinoma mamma tumor can be appear at the stomach of F1 hybrid mouse (C3HxAJ) that innoculated adenocarcinoma mamma's tumor via antravenous, intraperitoneal, and subcutaneus. Methods : The study was experimentaly  using  posttest  control  group  design,  to  examine  the  pylorus  mucosa thickness, the number of metaplasia, hyperplasia, and inflammatory cell. Result : There were no metaplasia and hyperplasia but inflammatory cell has been found. Analize of the pylorus mucosa thickness and the number of inflammatory cell by Oneway ANOVA showed there was no significant different of control group and manipulated group (intravenous, intraperitoneal and subcutaneus) (p0.05). Conclution : Adenocarcinoma mamma's tumor has been not found at the stomach of F1 hybrid mouse (C3HxAJ) that innoculated with via intravenous, intraperotoneal and subcutaneus.  
Potensi Daun Kesambi (Schleicera Oleosa) Sebagai Kandidat Agent Anti Jamur Untuk Penyakit Onikomikosis (Infeksi Jamur Pada Kuku) Khoiroh, Zaimatul; Griana, Tias Pramesti
Journal of Islamic Medicine Vol 3, No 2 (2019): Journal of Islamic Medicine
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v3i2.15487

Abstract

Onikomikosis merupakan infeksi jamur pada kuku yang disebabkan oleh jamur golongan dermatofita. Penelitian potensi daun kosambi (Schleicera oleosa) sebagai kandidat agent anti jamur untuk penyakit onikomikosis (infeksi jamur pada kuku) telah dilakukan. Daun kosambi (Schleicera oleosa) diekstrak menggunakan methanol.  Telah diketahui ekstrak methanol daun kosambi berpotensi sebagai antijamur. Penelitian ini bertujuan membuktikan ekstrak daun Kosambi (Schleicera oleosa (Lour.) Oken) mampu menghambat pertumbuhan Trichophyton spp dan membuktikan daya hambat ekstrak daun Kosambi (Schleicera oleosa (Lour.) Oken) terhadap pertumbuhan Trichophyton spp. lebih baik daripada daya hambat obat ketokonazol sebagai drug of choice penyakit Onikomikosis. Pengujian dilakukan dengan metode cakram dengan perlakuan konsentrasi 5%, 10%, 15%, 20%, 25%, control negatif dengan DMSO 1% dan control positi ketokonazol 2%. Hasil menunjukkan bahwa ekstrak methanol daun kosambi mampu menghambat pertumbuhan Trichophyton spp dengan diameter zona hambat terbesar pada konsentrasi 25% yaitu 9,7mm. Key word: Trichophyton spp, Onikomikosi, Schleicera oleosa, agent anti jamur
Potensi makanan fermentasi khas Indonesia sebagai imunomodulator Tias Pramesti Griana; Larasati Sekar Kinasih
Prosiding Seminar Biologi Vol 6 No 1 (2020): PROSIDING SEMINAR NASIONAL BIOLOGI DI ERA PANDEMI COVID-19 (OKTOBER 2020)
Publisher : Jurusan Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/psb.v6i1.15939

Abstract

Indonesia merupakan negara kepulauan dengan berbagai suku dan budaya. Perbedaan budaya menyebabkan berbeda jenis makanan khas yang ada di Indonesia. Makanan hasil pengolahan dengan fermentasi dapat dijumpai hampir di setiap daerah. Pengolahan makanan dengan bioteknologi konvensional yang berupa fermentasi melibatkan berbagai mikroorganisme. Senyawa hasil metabolisme mikroba yang hidup pada bahan baku pangan merupakan prebiotik yang memiliki manfaat bagi kesehatan. Begitu pula mikroba yang hidup pada makanan terfermentasi yang masuk ke dalam tubuh, disebut sebagai probiotik, mampu meningkatkan fungsi imun. Sehingga makanan terfermentasi memiliki potensi sebagai pengatur sistem imun (imunomodulator) di dalam tubuh manusia. Artikel ini mengulas potensi bahan makanan dengan pengolahan fermentasi yang berasal dari berbagai daerah di Indonesia sebagai agen imunomodulator.
Potential Effect of Pegagan (Centella asiatica (L.) Urban) and Widuri (Calotropis gigantea (L.)) as Immunomodulator Tias Pramesti Griana
Journal of Food and Pharmaceutical Sciences Vol 7, No 2 (2019): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.723

Abstract

Abstract: The immune system functions to protect the body from pathogens and cure disease. Even a mild infection will have a bad effect if the host's immune system is not working properly. Modification of the immune response functions to increase and decrease the immune response to overcome disease known as immunomodulation. Immunomodulators are used either as a prevention or treatment of various diseases related to immune disorders. Immunomodulatory drugs change the immune system response by increasing (immunostimulating) or decreasing (immunosuppressive) antibody production. Immunostimulators are given to increase the immune response to infectious diseases, immunodeficiency (e.g. AIDS) and cancer. Immunosuppressive drugs are used to reduce the immune response to transplanted organs and treat autoimmune diseases. The use of medicinal plants to treat various diseases has shown minimal side effects. Natural compounds that are produced from the metabolism of medicinal plants are known to affect the immune system, both the function and production of immune cells, as well as antibody secretion. Indonesia is one of the countries that has used plants as traditional medicine since ancient times. Indonesia 7,000 species of medicinal plants that have been studied to address health problems. Among the medicinal plants that have been studied are Centella asiatica (L.) Urban and Calotropis gigantea (L.) which have been shown to cure various diseases. This review article describes the potential of native Indonesian medicinal plants, namely Centella asiatica (L.) Urban and Calotropis gigantea (L.) as immunomodulators.
Aplikasi Topikal Ekstrak Daun Kesambi Meningkatkan Penyembuhan Luka Pada Mencit Tias Pramesti Griana; Achmad Tri Sugiarto Kharisul Islam Fazri; Pardjianto Bambang
JURNAL KEDOKTERAN DAN KESEHATAN Vol 8, No 1 (2021)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/V8I1.11741

Abstract

Proses penyembuhan luka pada kulit akibat injuri terdiri dari 3 fase, fase inflamasi, fase proliferasi dan fase remodeling. Schleichera oleosa memiliki senyawa aktif yang mampu menghambat proses inflamasi. penelitian ini bertujuan untuk mengetahui efek aplikasi topikal ekstrak daun kesambi untuk penyembuhan luka pada mencit. 30 mencit jantan yang dieksisi kulit punggungnya, dibagi menjadi 5 kelompok, kontrol negatif (K-) yang tidak diberi apa-apa, kelompok perlakuan yang diberi salep ekstrak daun kesambi dengan konsentrasi 0% (P0), 5% (P1), 10% (P2) dan 15% (P3). Sebelum diaplikasikan, salep di evaluasi organoleptik, homogenitas, pH dan viskositasnya. Setelah diaplikasikan ke luka kulit pada mencit, diamati eritema yang terjadi di kulit yang sehat sekitar luka, adanya krusta dan granulasi pada hari ke-28. Pengukuran persentase konstriksi dan intensitas warna eritema dilakukan pada hari ke-1, ke-7, ke-14, ke-21 dan ke-28. Hasil penelitian menunjukkan bahwa semua sediaan salep memiliki bentuk fisik yang baik, pH sesuai untuk kulit, sedangkan berdasarkan SNI, hanya salep dengan ekstrak daun kesambi 15% yang memiliki viskositas baik. Aplikasi sediaan salep ekstrak daun kesambi tidak menimbulkan iritasi pada kulit mencit yang sehat, dan tidak ditemukan krusta atau granulasi pada luka. Persentase konstriksi luka yang tertinggi adalah pada kelompok P3, sedangkan instensitas warna eritema tidak memiliki perbedaan pada semua kelompok mencit. 
Pembentukan dan Pelatihan Kader Posbindu PTM Berbasis Masjid di Kecamatan Turen Kabupaten Malang Tias Pramesti Griana; Lailia Nur Rachma; Herry Darsim Gaffar
JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat) VOL. 5 NOMOR 2 SEPTEMBER 2021 JPPM (Jurnal Pengabdian dan Pemberdayaan Masyarakat)
Publisher : Lembaga Publikasi Ilmiah dan Penerbitan (LPIP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.335 KB) | DOI: 10.30595/jppm.v5i2.7473

Abstract

Pos Pembinaan Terpadu (Posbindu) Penyakit Tidak Menular (PTM) merupakan bentuk peran serta masyarakat dalam upaya deteksi dini, pemantauan dan pengendalian faktor risiko PTM yang dilaksanakan secara terpadu, rutin, dan periodik serta mandiri dan berkesinambungan. Dewan Masjid Indonsia (DMI) berkeinginan agar semua masjid di kecamatan Turen memiliki Posbindu PTM untuk memelihara kesehatan masyarakat di sekitarnya. Tujuan pengabdian masyarakat ini untuk menginisiasi pembentukan kader Posbindu PTM berbasis masjid di kecamatan Turen dan meningkatkan kualitas kemampuan kader. Digunakan metode Asset Based Community Development, dengan langkah awal dilakukan survey dan Focus Group Discussion dengan pengurus DMI dan takmir masjid. Dilakukan pengamatan pelaksanaan Posbindu PTM, survei tingkat pengetahuan dengan kuesioner dan pelatihan bagi kader dan calon kader. Hasil penilaian kuesioner tingkat pengetahuan didapatkan 73,13% kader Posbindu PTM dapat menjawab 60% soal yang diberikan dengan benar. Pelatihan yang diberikan membantu menambah kemampuan kader dan calon kader Posbindu PTM berbasis masjid di kecamatan Turen Kabupaten Malang.
Karakter Anatomi KesambiI (Schleichera oleosa (Lour) Oken.,) Pada Ketinggian Yang Berbeda Di Kota Malang Dan Kabupaten Nganjuk Ruri Siti Resmisari; Azizatur Rahmah; Kholifah Holil; Tias Pramesti Griana
Metamorfosa: Journal of Biological Sciences Vol 10 No 2 (2023)
Publisher : Prodi Magister Ilmu Biologi, Fakultas MIPA, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/metamorfosa.2023.v10.i02.p06

Abstract

Indonesia dikenal sebagai negara yang memiliki keanekaragaman hayati yang cukup tinggi, namun data yang ada masih sangat terbatas. Satu diantara kenekaragaman hayati yang dimiliki oleh Indonesia adalah Kesambi (Schleichera oleosa). Tanaman ini memiliki potensi yang cukup besar, karena itu dibutuhkan data yang mendukung untuk pengembangan lebih lanjut baik untuk kepentingan sebagai tanaman obat maupun untuk yang lain. Penelitian identifikasi karakter anatomi bertujuan untuk mengetahui sifat-sifat penting dari spesies tanaman yang berasal dari berbagai habitat tumbuh. Karakter anatomi daun yang diamati meliputi ketebalan xylem dan floem, ketebalan kutikula, ketebalan epidermis, tipe trikoma, rata-rata panjang trikoma, tipe stomata, panjang dan lebar stomata. Berdasarkan hasil penelitian dapat disimpulkan bahwa Pohon Kesambi yang tumbuh baik didataran rendah maupun tinggi di Kota Malang dan di Kabupaten Nganjuk memiliki karakter anatomi yang sama yaitu pada tipe trikoma dan stomata. Sedangkan pada karakter lain menunjukkan perbedaan pada ukuran. Semakin tinggi tempat tumbuh pohon kesambi menunjukkan semakin tipis floem maupun xylem pada batang yang diamati. Sedangkan pada parameter lain tidak menunjukkan pola yang terbentuk pada ukuran karakter yang diamati baik pada daun maupun batang. Kata kunci: Anatomi, Kesambi (Schleichera oleosa), faktor lingkungan
Potential Effect of Pegagan (Centella asiatica (L.) Urban) and Widuri (Calotropis gigantea (L.)) as Immunomodulator Tias Pramesti Griana
Journal of Food and Pharmaceutical Sciences Vol 7, No 2 (2019): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.723

Abstract

Abstract: The immune system functions to protect the body from pathogens and cure disease. Even a mild infection will have a bad effect if the host's immune system is not working properly. Modification of the immune response functions to increase and decrease the immune response to overcome disease known as immunomodulation. Immunomodulators are used either as a prevention or treatment of various diseases related to immune disorders. Immunomodulatory drugs change the immune system response by increasing (immunostimulating) or decreasing (immunosuppressive) antibody production. Immunostimulators are given to increase the immune response to infectious diseases, immunodeficiency (e.g. AIDS) and cancer. Immunosuppressive drugs are used to reduce the immune response to transplanted organs and treat autoimmune diseases. The use of medicinal plants to treat various diseases has shown minimal side effects. Natural compounds that are produced from the metabolism of medicinal plants are known to affect the immune system, both the function and production of immune cells, as well as antibody secretion. Indonesia is one of the countries that has used plants as traditional medicine since ancient times. Indonesia 7,000 species of medicinal plants that have been studied to address health problems. Among the medicinal plants that have been studied are Centella asiatica (L.) Urban and Calotropis gigantea (L.) which have been shown to cure various diseases. This review article describes the potential of native Indonesian medicinal plants, namely Centella asiatica (L.) Urban and Calotropis gigantea (L.) as immunomodulators.
Co-Authors Achmad Tri Sugiarto Kharisul Islam Fazri Achmad Tri Sugiarto Kharisul Islam Fazri Azizatur Rahmah Azizatur Rahmah Bambang Pardjianto Herry Darsim Gaffar Khoiroh, Zaimatul Kholifah Holil Lailia Nur Rachma Larasati Sekar Kinasih Rahmah, Azizatur Ruri Siti Resmisari Umaiyatus Syarifah