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All Journal Jurnal Penelitian Kesehatan Suara Forikes Jurnal Biologi Tropis Dinamisia: Jurnal Pengabdian Kepada Masyarakat Innovative: Journal Of Social Science Research
Marvel Reuben Suwitono
Universitas Advent Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Formulasi Tablet Effervescent Penurunan Berat Badan dari Ekstrak Daun Jati Belanda, Daun Kumis Kucing, Daun Sirih, Herba Meniran dan Rimpang Kunyit Joana Rachel Marlitha Santoso; Titin Sulastri; Marvel Reuben Suwitono
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 15, No 4 (2024): Oktober-Desember 2024
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf15437

Abstract

Herbal medicine is widely recognized as a plant-based extract that has been effective for generations in Indonesia to treat various diseases. The purpose of this study was to evaluate the physical properties of effervescent tablets from a combination of extracts of jati belanda leaves, kumis kucing leaves, sirih leaves, meniran herbs, and turmeric rhizomes, with various sweeteners, namely cane sugar, stevia, and maltodextrin. This study was an descriptive study. The researchers assessed the physical parameters, namely flow rate, angle of repose, and compressibility for granules; while tablet analysis included weight uniformity, size uniformity, friability, hardness, dissolution time, and pH. The results showed that the formulations with stevia and maltodextrin met most of the test criteria effectively. There was a wider variability in the stevia formulation (3%), indicating challenges in achieving consistent tablet weight due to variations in water content. Friability was 0.66% for maltodextrin indicating good structural integrity. It was concluded that the combination tablet of herbal extracts of Guazuma ulmifolia leaves, Orthosiphon aristatus leaves, Piper betle leaves, Phyllanthus niruri herbs, and Curcuma domestica rhizomes showed a successful formulation into effervescent tablets through wet granules, with the use of cane sugar, stevia, and maltodextrin as sweeteners.Keywords: herbal medicine; weight loss; effervescent tablets ABSTRAK Obat herbal diakui secara luas karena ekstrak berbasis tanaman yang telah efektif selama beberapa generasi di Indonesia untuk mengobati berbagai penyakit. Tujuan penelitian ini adalah mengevaluasi sifat fisik tablet effervescent dari kombinasi ekstrak daun jati belanda, daun kumis kucing, daun sirih, herba meniran, dan rimpang kunyit, dengan berbagai pemanis, yaitu gula tebu, stevia, dan maltodekstrin. Penelitian ini merupakan studi deskriptif. Peneliti menilai parameter fisik yaitu kecepatan alir, sudut diam, dan kompresibilitas untuk granul; sedangkan analisis tablet mencakup keseragaman bobot, keseragaman ukuran, kerapuhan, kekerasan, waktu larut, dan pH. Hasil penelitian menunjukkan bahwa formulasi dengan stevia dan maltodekstrin memenuhi sebagian besar kriteria pengujian secara efektif. Tampak adanya variabilitas yang lebih luas dalam formulasi stevia (3%), yang menunjukkan tantangan dalam mencapai bobot tablet yang konsisten akibat variasi kadar air. Kerapuhan adalah 0,66% untuk maltodekstrin yang menunjukkan integritas struktural yang baik. Disimpulkan bahwa tablet kombinasi ekstrak herbal daun Guazuma ulmifolia, daun Orthosiphon aristatus, daun Piper betle, herba Phyllanthus niruri, dan rimpang Curcuma domestica menunjukkan formulasi yang berhasil menjadi tablet effervescent melalui granulsi basah, dengan penggunaan gula tebu, stevia, dan maltodekstrin sebagai pemanis.Kata kunci: obat herbal; penurunan berat badan; tablet effervescent
Formulasi Tablet Effervescent Penurunan Berat Badan dari Ekstrak Daun Jati Belanda, Daun Kumis Kucing, Daun Sirih, Herba Meniran dan Rimpang Kunyit Joana Rachel Marlitha Santoso; Titin Sulastri; Marvel Reuben Suwitono
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 15, No 4 (2024): Oktober-Desember 2024
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf15437

Abstract

Herbal medicine is widely recognized as a plant-based extract that has been effective for generations in Indonesia to treat various diseases. The purpose of this study was to evaluate the physical properties of effervescent tablets from a combination of extracts of jati belanda leaves, kumis kucing leaves, sirih leaves, meniran herbs, and turmeric rhizomes, with various sweeteners, namely cane sugar, stevia, and maltodextrin. This study was an descriptive study. The researchers assessed the physical parameters, namely flow rate, angle of repose, and compressibility for granules; while tablet analysis included weight uniformity, size uniformity, friability, hardness, dissolution time, and pH. The results showed that the formulations with stevia and maltodextrin met most of the test criteria effectively. There was a wider variability in the stevia formulation (3%), indicating challenges in achieving consistent tablet weight due to variations in water content. Friability was 0.66% for maltodextrin indicating good structural integrity. It was concluded that the combination tablet of herbal extracts of Guazuma ulmifolia leaves, Orthosiphon aristatus leaves, Piper betle leaves, Phyllanthus niruri herbs, and Curcuma domestica rhizomes showed a successful formulation into effervescent tablets through wet granules, with the use of cane sugar, stevia, and maltodextrin as sweeteners.Keywords: herbal medicine; weight loss; effervescent tablets ABSTRAK Obat herbal diakui secara luas karena ekstrak berbasis tanaman yang telah efektif selama beberapa generasi di Indonesia untuk mengobati berbagai penyakit. Tujuan penelitian ini adalah mengevaluasi sifat fisik tablet effervescent dari kombinasi ekstrak daun jati belanda, daun kumis kucing, daun sirih, herba meniran, dan rimpang kunyit, dengan berbagai pemanis, yaitu gula tebu, stevia, dan maltodekstrin. Penelitian ini merupakan studi deskriptif. Peneliti menilai parameter fisik yaitu kecepatan alir, sudut diam, dan kompresibilitas untuk granul; sedangkan analisis tablet mencakup keseragaman bobot, keseragaman ukuran, kerapuhan, kekerasan, waktu larut, dan pH. Hasil penelitian menunjukkan bahwa formulasi dengan stevia dan maltodekstrin memenuhi sebagian besar kriteria pengujian secara efektif. Tampak adanya variabilitas yang lebih luas dalam formulasi stevia (3%), yang menunjukkan tantangan dalam mencapai bobot tablet yang konsisten akibat variasi kadar air. Kerapuhan adalah 0,66% untuk maltodekstrin yang menunjukkan integritas struktural yang baik. Disimpulkan bahwa tablet kombinasi ekstrak herbal daun Guazuma ulmifolia, daun Orthosiphon aristatus, daun Piper betle, herba Phyllanthus niruri, dan rimpang Curcuma domestica menunjukkan formulasi yang berhasil menjadi tablet effervescent melalui granulsi basah, dengan penggunaan gula tebu, stevia, dan maltodekstrin sebagai pemanis.Kata kunci: obat herbal; penurunan berat badan; tablet effervescent
Formulasi Liquid Blush On dari Ekstrak Bunga Kertas, Bunga Mawar, dan Bit sebagai Pewarna Alami Happy Sevday Sihotang; Titin Sulastri; Marvel Reuben Suwitono
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 15, No 4 (2024): Oktober-Desember 2024
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf15438

Abstract

Natural products for liquid blush beauty formulation from Bougainvillea spectabilis, Rosa damascena Mill., and Beta vulgaris L. open up new perspectives in taking color inspiration from nature. Paper flowers provide varied and bright colors, rose petals are highly sought after not only for their beauty but also for their antioxidant properties. Beetroot provides a deep red color with its nutrients. This study aimed to develop a liquid blush formulation using paper flower extract (Bougainvillea spectabilis), red rose flower (Rosa damascena Mill.) and beetroot (Beta vulgaris L.) as natural dyes, and to find out which natural dye extract is preferred by respondents from the three types of extracts using a careful experimental method. The researchers extracted the pigments with ethanol and studied the obtained liquid blush formulation in terms of pH, homogeneity, and skin compatibility. The results of the analysis showed that the pH value ranged from 4.5 to 6.5, making it suitable for use in cosmetics. No adverse skin reactions were detected. Furthermore, it was concluded that there is a possibility of using natural dyes in the development of cosmetic products, which are safe, effective, environmentally friendly, and reflect their beauty.Keywords: beauty formulation; natural dye; Beta vulgaris; Bougainvillea spectabilis; Rosa damascene ABSTRAK Produk alami untuk formulasi kecantikan liquid blush on dari Bougainvillea spectabilis, Rosa damascena Mill., dan Beta vulgaris L. membuka perspektif baru dalam mengambil inspirasi warna dari alam. Bunga kertas memberikan warna yang bervariasi dan cerah, kelopak mawar yang sangat diminati tidak hanya terkenal karena keindahannya tetapi juga karena sifat antioksidannya. Bit memberikan warna merah tua dengan nutrisinya. Penelitian ini bertujuan untuk mengembangkan formulasi liquid blush on yang menggunakan ekstrak bunga kertas (Bougainvillea spectabilis), bunga mawar merah (Rosa damascena Mill.) dan bit (Beta vulgaris L.) sebagai pewarna alami, serta untuk mengetahui ekstrak pewarna alami mana yang lebih disukai oleh responden dari ketiga jenis ekstrak tersebut dengan menggunakan metode eksperimen yang cermat. Peneliti mengekstrak pigmen dengan etanol dan mempelajari formulasi liquid blush on yang diperoleh terkait dengan pH, homogenitas, dan kompatibilitas kulit. Hasil analisis menunjukkan bahwa nilai pH berkisar antara 4,5 hingga 6,5, sehingga cocok untuk digunakan dalam kosmetik. Tidak ada reaksi merugikan pada kulit yang terdeteksi. Selanjutnya disimpulkan adanya kemungkinan penggunaan pewarna alami dalam pengembangan produk kosmetik, yang aman, efektif, ramah lingkungan, dan mencerminkan keindahannya.Kata kunci: formulasi kecantikan; pewarna alami; Beta vulgaris; Bougainvillea spectabilis; Rosa damascene
Formulation and Evaluation of Transdermal Patch from Extract of Babadotan Leaves Makanoneng, Dawna Stacey Derose; Suwitono, Marvel Reuben; Sulastri, Titin
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.8761

Abstract

The Transdermal Drug Delivery System (TDDS) represents a modality for conveying therapeutic agents across the cutaneous barrieroffering an alternative route to overcome the limitations of oral formulations. This experimental investigation endeavored to formulate and assess a percutaneous patch containing Ageratum conyzoides L. leaf extract, known for its antibacterial and anti-inflammatory properties. The extract was formulated using HPMC polymer and evaluated through organoleptic tests, pH, thickness, weight uniformity, moisture absorption, and folding endurance. The results showed that the patch was a a membranous disk exhibiting a 5 cm caliber, green in color, with a characteristic herbal odor, smooth, flexible, and non-sticky surface. The hydrogen ion concentration spanned from 6.2 to 6.93, accompanied by a caliper between 0.53–0.57 mm. The patch demonstrated good folding endurance (>200 folds) and moisture content ranging from 17% to 23%. The formulation exhibited good physical stability and met the quality criteria for transdermal preparations. This patch has potential as an effective topical therapy derived from natural ingredients for treating skin infections and inflammation, and supports the utilization of local medicinal plants in the innovation of modern pharmaceutical drug delivery systems.
The Preparation and Formulation of Moringa oleifera Lam. Leaf Extract in Transdermal Patch Sarumpaet, Ines Rianty; Sulastri, Titin; Suwitono, Marvel Reuben
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.8823

Abstract

The anti-fibrotic, anti-inflammatory, and antimicrobial qualities of moringa leaf extracts, which are high in saponins, flavonoids, steroids, and phenols, can aid in tissue regeneration and wound healing. The aim of this study was to prepare and formulate a transdermal patch of Moringa oleifera Lam. leaf extract with hydroxypropyl methylcellulose (HPMC) and polyvinyl pyrrolidone (PVP) as the polymers. The study was aimed at investigating the effect of various concentrations of the extract (20%, 40%, and 80%) on the physical properties of the patch, including organoleptic properties, weight uniformity, thickness, folding endurance, pH, and water absorption. Extract was made by maceration with 96% ethanol, and patches were cast by the solvent casting method. Results showed that all formulations met the required pH range (6.62–6.68), folding endurance (>300 folds), and thickness (<1 mm). However, weight uniformity and moisture absorption exceeded desired optimum values and ranged between 17% to 23%. The 20% concentration of extract exhibited the maximum physical stability. This study highlights the potential of Moringa oleifera leaf extract in transdermal patch preparations, although it needs to be optimized to improve weight consistency and water absorption.
Effervescent Tablet Formulation for Appetite Stimulation with Extracts of Temulawak, Pegagan, Lempuyang Wangi, and Sweet Fennel Sugito, Esther Shirley; Sulastri, Titin; Suwitono, Marvel Reuben
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7894

Abstract

The study develops an effervescent tablet formulation with a combination of extracts from temulawak, pegagan, lempuyang wangi, and sweet fennel to increase appetite. Such underweight conditions always lead to a lot of health burdens, like a poor immune system and stunted growth, which makes it highly relevant to have an effective appetite stimulant. The aim of this study is to test the acceptability and effectiveness of the sweeteners (i.e., cane sugar, stevia, and maltodextrin) used in the tablets. The results indicate that all tablet formulations (F1, F2, and F3) passed the granule and physical tablet tests, demonstrating that all variants are of good quality. Moreover, the well-structured formulation process and selection of ingredients in their natural form make the product safe for consumption and effective, hence a really good alternative for improving one's appetite naturally. The present study provides evidence for the role that potentially existing herbal remedies from traditional knowledge may play in their modern applications, nutraceuticals, and improved public health via a simple and effortless means of stimulating appetite.
Development of Conventional Tablets from Herbal Extracts of Jati Belanda, Kumis Kucing, Meniran, Sirih, and Turmeric for Body Weight Reduction Tampubolon, Stephanie Angelica Rinjani; Suwitono, Marvel Reuben; Sulastri, Titin
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.8020

Abstract

Health problems that occur today are diverse and varied, one of which is being overweight. This study focuses on the formulation of herbal extracts in conventional tablet preparations using Jati Belanda, Kumis Kucing, Meniran, Sirih, and Kunyit which have the potential as weight loss agents. Extraction is carried out using the maceration method, then the extract is made into conventional tablets with additional ingredients: magnesium stearate, talc, PVP, Avicel pH 102, and aerosil. Evaluation of physical properties such as uniformity of size, uniformity of weight, hardness, and disintegration time has been carried out. The results of the study showed that conventional tablet preparations from various spices with 3 different formulations were successful. However, the results of the tablet hardness test have not met existing standards. The danger is the lack of PVP (Polyvinylpyrrolidone) excipients in the granules which cause the tablets to become brittle. To improve the formulation, the addition of the moisturizing agent can be done.
Formulation of Conventional Herbal Tablets Based on Lempuyang Wangi, Daun Pegagan, Adas Manis and Temulawak for Weight Gain Ratu, Renike Lyana Monalisa; Suwitono, Marvel Reuben; Sulastri, Titin
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.8111

Abstract

There are many medicinal plants in Indonesia and people have used these medicinal plants to overcome health problems. Tablets are usually made by mixing these ingredients, then pressing the mixture into a solid and easy-to-take form. This study aims to develop a conventional tablet formulation from herbal extracts of Lempuyang Wangi, Pegagan Leaves, Sweet Fennel and Temulawak to increase weight gain. Data were analyzed by conducting granule testing. The results showed that the developed tablet formulation met the requirements for weight uniformity and disintegration time. However, the hardness of the tablet was still below standard. This study shows the potential for further development of this herbal tablet formulation by optimizing the amount and type of binder. The conclusion is that herbal tablets can increase body weight, but optimization of the formulation is still needed.
The Effect of HPMC and PVP Bases on the Formulation of Physical Properties and Transdermal Stability of Patch Estrak leaves of Jarak Pagar (Jatropha curcas L.) Makkayu, Juand Valentino; Suwitono, Marvel Reuben; Sulastri, Titin
Jurnal Biologi Tropis Vol. 25 No. 1 (2025): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i1.8783

Abstract

Open wounds are tissue damage that increases the risk of infection and requires proper treatment. Castor leaves (Jatropha curcas L.) contain flavonoids, saponins, and tannins, which have anti-inflammatory and antiseptic properties, aiding in tissue regeneration and infection prevention. To enhance its effectiveness, the extract is formulated into a transdermal patch, allowing direct drug absorption through the skin with stable release and convenient application. This study aims to determine the best formulation and optimal concentration of Hydroxypropyl Methylcellulose (HPMC) and Polyvinylpyrrolidone (PVP) in transdermal patches to improve stability and release effectiveness of the active compounds from castor leaf extract while evaluating their potential in accelerating wound healing. The transdermal patches were prepared using three variations of HPMC and PVP concentrations: F1 (HPMC 1 g : PVP 0.5 g), F2 (HPMC 0.75 g : PVP 0.75 g), and F3 (HPMC 0.5 g : PVP 1 g). Evaluations included organoleptic tests, pH, thickness, folding endurance, and moisture absorption. The results showed that F1 was the optimal formulation, exhibiting favorable physical characteristics and meeting the required standards, as it had the best mechanical properties with higher folding endurance, optimal thickness, and uniform weight distribution, ensuring better flexibility, durability, and stability. These findings indicate that variations in HPMC and PVP concentrations significantly affect the formulation and stability of transdermal patches, with F1 being the most effective formulation for potential wound healing applications.
Analisis Efektivitas Biaya (Cost Effectiveness Analysis) Penggunaan Antibiotik Pada Pasien Pneumonia Di Rumah Sakit X Bandung Nabuasa, Merry; Allo, Duma Turu; Suwitono, Marvel Reuben
Innovative: Journal Of Social Science Research Vol. 4 No. 2 (2024): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v4i2.10179

Abstract

Pneumonia adalah infeksi paru-paru yang bisa disebabkan oleh bakteri, virus, atau jamur, dengan gejala seperti demam tinggi, batuk produktif, sesak napas, nyeri dada, dan kelelahan. Berbagai usia rentan terhadap kondisi ini, dengan risiko lebih tinggi pada anak-anak dan lansia. Untuk mengobati pneumonia dengan efektif, penting untuk memilih antibiotik yang tepat dengan efek samping minimal dan biaya yang terjangkau. Oleh karena itu, kajian analisis efektivitas biaya diperlukan untuk memfasilitasi pemilihan pengobatan yang hemat biaya bagi pasien pneumonia. Tujuan dari penelitian ini adalah untuk melihat efektivitas biaya penggunaan antibiotik pada pasien pneumonia berdasarkan hasil dari ACER & ICER. Desain dari penelitian ini adalah observasional dengan analisis deskriptif. Pengumpulan data dilakukan secara retrospektif selama periode Desember 2023-Februari 2024, dengan teknik pengambilan sampel total sampling dan pengumpulan data menggunakan rekam medis. Hasil akhir dari penelitian ini menyatakan bahwa obat antibiotik yang efektif dan harganya terjangkau adalah antibiotik Cefotaxime 1 gr (JK), Azithromycin 500 mg tablet (JK) + Cefixime 200 mg tablet (JK). Dimana bisa kita lihat dari hasil LOS yaitu 3 hari dan juga di buktikan dengan nilai dari ACER Rp. 1.977.959. Berdasarkan kuadran nilai ACER dan efektivitas biaya, antibiotik di atas merupakan pilihan terapi yang lebih hemat biaya karena memiliki nilai ACER yang lebih rendah dan menempati posisi kolom dominan dalam analisis data.
Co-Authors Allo, Duma Turu Anggelia, Anggelia Happy Sevday Sihotang Mailani, Senfia Liberti Makanoneng, Dawna Stacey Derose Makkayu, Juand Valentino Nabuasa, Merry Oktavia, Maria Maulina Ratu, Renike Lyana Monalisa Sarumpaet, Ines Rianty Sinambela, Romisna Wati Sugito, Esther Shirley Sundari, Vivin Tampubolon, Stephanie Angelica Rinjani Taryono, Ribka Mutiara Titin Sulastri Turuallo, Duma Yanti, Rut Damai