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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Keperawatan Muhammadiyah
Isyti'aroh
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Determination of Phenolic Total, Flavonoid Total, Antioxidant Assay and Inhibition of Xanthine Oxidase Enzyme Activity Kemloko Fruits Extract (Phyllanthus Embilica. L) Wirasti Wirasti; Khusna Santika Rahmasari; Isyti'aroh
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 9 No. 1 (2024)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v9i1.33737

Abstract

People use Kemloko Fruits as sweets and some also use it as a herbal medicine to reduce uric acid. The sour-tasting Kemloko fruit contains a lot of ascorbic acid. Ascorbic acid and ingredients contained in it have the effect of preventing or reducing uric acid levels. The aim of this research was to treat the antioxidant effect and inhibitory of the xanthine oxidase enzyme Kemloko Fruit extract, as well as determine the phenolic total and flavonoid total levels. The method used to make Kemloko fruit extract uses maceration with ethanol 96% solvent. The phytochemical screening method uses an in-tube reaction for flavonoid content using the Shinoda test, alkaloids using the Dregendorf reagent, saponins using the foam test and terpenoids/steroids using the Liebermann Burchard reagent. Meanwhile, the methods for determining phenolics and flavonoids total are the colorimetric used spectrophotometry UV-Vis, the DPPH methods for antioxidant assay, and measurenment of inhibiting xanthin oxidase activity using a microplate at a wavelength of 375 nm. Qualitative data produced by the ethanol extract of Kemloko fruit contains tannins, flavonoids, alkaloids, terpenoids, saponins and glycosides. Meanwhile, Quantitative data showed that the phenolic and flavonoid total levels were 1465.63±0.003 mgGAE/g extract and 9.52±0.001 µg/mL, respectively, as well as the IC50 for xanthin oxidase enzyme inhibition of 20.65 µg/mL and the IC50 antioxidant power of 9.49 ±0.0007 µg/mL. Kemloko fruit ethanol extract contains tannins, flavonoids, alkaloids, terpenoids, saponins and glycosides has inhibitor activity against xanthine oxidase and antioxidant is a strong.
Analisis Kemandirian Terhadap Depresi Lansia Dengan Riwayat Diabetes Mellitus Di Keluarga Di Kabupaten Pekalongan Fijianto, Dwi; Rejeki, Herni; Prasojo, Sigit; Faradisi, Firman; Isyti'aroh; Pratiwi, Yuni Sandra
Jurnal Keperawatan Muhammadiyah Vol 9 No 1 (2024): JURNAL KEPERAWATAN MUHAMMADIYAH
Publisher : UNIVERSITAS MUHAMMADIYAH SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jkm.v9i1.20059

Abstract

Objective: The Process of getting old in the elderly certainly experiences many problems both physical and mentally, socio-economically, and biologically. One of the mental and emotional problems that is often found in the elderly is depression. Factors that increase the risk of depression in the elderly include genetic susceptibility, chronic disease and disability, pain, and frustration with limitations in carrying out daily activities. Independence in the elderly can also influenced by the presence of diabetes mellitus (DM) which effects the elderly in the family. This study aims to analyze the independence of elderly people who suffer from diabetes mellitus on the incidence of depression in the Pekalongan Regency.Methods: The research method that will be used is descriptive with a cross-sectional design. Place of research in the Region of Pekalongan Regency. The sampling technique used purposive sampling. Analysis using the Spearman Rho test.Results: The results showed that the value of p = 0.04 if α = 0.05 then p <α and H1 are accepted, which means there is a relationship between the level of depression and independence in Activity of Daily Living (ADL) in elderly with diabetes mellitus in Pekalongan Regency. Nurses continue to strive to increase independence and control depression in the elderly with DM so that the quality of life of the elderly becomes more optimal.Conclusion: The conclusion of the study is a significant correlation between the  level of depression and independence in Activity of Daily Living (ADL) in elderly with diabetes mellitus.
Co-Authors Fijianto, Dwi Firman Faradisi Herni Rejeki Khusna Santika Rahmasari sigit prasojo Wirasti Yuni Sandra Pratiwi