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All Journal Nusantara Hasana Journal Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Riana Putri Rahmawati
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Agriculture, Biological Sciences & Forestry Humanities Economics, Econometrics & Finance Education Health Professions Nursing Public Health

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FORMULASI DAN UJI EFEKTIVITAS SEDIAAN ROLL ON AROMATERAPI BERBAHAN AKTIF MINYAK ATSIRI DAUN JERUK NIPIS (Citrus aurantifolia) SEBAGAI RELAKSASI PADA KELINCI ANGGORA (Oryctolagus cuniculus domesticus) Ferliano Miko Fachriansyah; Riana Putri Rahmawati; Fahrudin Arif
Nusantara Hasana Journal Vol. 5 No. 2 (2025): Nusantara Hasana Journal, July 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i2.1550

Abstract

Anxiety disorder is a mental condition characterized by excessive feelings of fear and worry. Individuals experiencing this disorder may feel anxious almost constantly, which can interfere with their daily lives. Aromatherapy is a therapeutic practice that utilizes essential oils extracted from plant parts—typically through distillation—to enhance physical and emotional well-being. The development of aromatherapy as a treatment can be applied to roll-on formulations due to their convenient and practical use, aligning with public preference. This study aims to evaluate the physical quality and effectiveness of an aromatherapy roll-on preparation containing lime leaf (Citrus aurantifolia) essential oil for relaxation in Angora rabbits (Oryctolagus cuniculus domesticus). Physical quality assessments included homogeneity test, organoleptic evaluation, pH measurement, user preference test, and skin irritation test. Effectiveness testing was conducted based on varying concentrations (3%, 4%, 5%) and a control group. The collected data were processed using SPSS software, applying a one-way ANOVA. The findings revealed that all preparations were yellow liquids with the distinctive citrus aroma of lime essential oil. Homogeneity and pH tests confirmed that all formulations met the criteria for topical application. In terms of effectiveness, the 5% concentration yielded the most optimal results. Normality and homogeneity tests indicated that all data sets had normal and homogeneous distributions (p>0,05), fulfilling requirements for ANOVA. The ANOVA results showed a significant difference among the five treatment groups (p<0,05). Post Hoc analysis identified a significant difference between the negative control group and all other treatment groups (p<0,05).
Pengaruh Antibakteri Kombinasi Ekstrak Kulit Jeruk Manis (Citrus Sinensis (L.) Osbeck) dan Daun Pepaya (Carica Papaya L.) Terhadap Bakteri Escherichia Coli Regitha Adiba Fayza Purwoko; Riana Putri Rahmawati; Muhammad Khudzaifi
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.6079

Abstract

Sweet orange peel and papaya leaves have been used by the community to prevent and treat various diseases caused by bacterial, fungal, and viral infections. Sweet orange peel contains flavonoids, alkaloids, saponins, tannins, and terpenoids that can inhibit bacterial growth. While papaya leaves contain active compounds such as alkaloids, flavonoids, steroids, tannins, and terpenoids that can inhibit bacterial growth. Escherichia coli bacteria are gram-negative, facultative anaerobic bacteria that can cause intestinal infections, causing diarrhea. The combination of extracts from several plants has greater inhibitory power so that it has greater antibacterial activity than a single plant. The purpose of this study was to determine whether the combination of sweet orange peel and papaya leaf extracts has an effect on the growth of Escherichia coli bacteria. The test method used was the disc diffusion method on TSA agar media. Sweet orange peel and papaya leaf extracts in this study were obtained by the maceration method with 96% ethanol solvent. The ratio of extracts used was sweet orange peel and papaya leaves 1:3; 2:2; 3:1. The positive control used was ciprofloxacin. The negative control used was 10% dimethyl sulfoxide (DMSO). The results of this study indicate that the combination of sweet orange peel extract (Citrus sinensis L. Osbeck) and papaya leaves (Carica papaya L.) has an effect on the growth of Escherichia coli bacteria because it produces an inhibition zone around the disc paper. All comparisons, namely 1: 3; 2: 2; 3: 1 are optimal in inhibiting the growth of Escherichia coli bacteria with a diameter of the inhibition zone in sequence of 17.78 mm (strong category), 22.14 mm (very strong category), and 26.28 mm (very strong category). Likewise, the positive control produces an inhibition zone of 34.25 (very strong category). The most optimum antibacterial combination shows the diameter of the inhibition zone against Escherichia coli bacteria, namely at a ratio of 3: 1.
Co-Authors Fahrudin Arif Ferliano Miko Fachriansyah Muhammad Khudzaifi Regitha Adiba Fayza Purwoko