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All Journal Indonesian Journal of Pharmaceutical Science and Technology Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan) Jurnal Buana Farma Journal of Noncommunicable Diseases (JOND) Journal of Pharmaceutical and Sciences. Journal of Pharmaceutical Science and Clinical Pharmacy (PSCP)
Yunita Al-Azzahra
Akademi Farmasi Bumi Siliwangi, Bandung, Jawa Barat, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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UJI AKTIVITAS ANTIINFLAMASI EKSTRAK BATANG AKAR KUNING (Arcangelisia flava (L.) Merr.) SECARA IN VITRO Syumillah Saepudin; Taufik Septiyan Hidayat; Yunita Al-Azzahra; Ade Cahyati
Jurnal Buana Farma Vol. 4 No. 1 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i1.934

Abstract

Inflammation is a natural response that occurs in tissue damage caused by oxidative stress. Yellow root plant is one of the plants from the Menispermaceae family that contains bioactive compounds with several potential pharmacological activities, including as anti-inflammatory. The purpose of this study was to test the effect of administration of n-hexane, ethyl acetate, and 70% ethanol extract of yellow root on anti-inflammatory activity and test the most optimal anti-inflammatory activity on the type of solvent of yellow root extract (Arcangelisia flava (L.) Merr.). This study used a method of stabilizing red blood cell membranes in vitro which was measured using a UV-Vis spectrophotometer. Stabilization was observed through the inhibitory ability of yellow root extract against red blood cell lysis due to the induction of a hypotonic solution which was then compared with a positive control (Ibuprofen). Results showed that n-hexane, ethyl acetate, and 70% ethanol extracts of yellow root can stabilize red blood cell membranes. Data analysis showed significant significance that there was a significant percent difference in red blood cell membrane stabilization in the four test groups. The most optimal anti-inflammatory activity was found in yellow root n-hexane extract at a concentration of 250 ppm which was 48.76% comparable to the positive control (Ibuprofen) at a concentration of 50 ppm of 59.09%.
UJI AKTIVITAS ANALGESIK FRAKSI DAUN SENGGANI (Clidemia hirta [L] D.Don) PADA MENCIT PUTIH GALUR SWISS WEBSTER Taufik Septiyan Hidayat; Dadan Rohdiana; Syumillah Saepudin; Dini Febrianty; Yunita Al Azzahra
Jurnal Buana Farma Vol. 4 No. 1 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i1.935

Abstract

Pain is a sensation that can interfere with activities and reduce the quality of life of the sufferer if left untreated and left prolonged. Senggani is one of the plants that contains flavonoid compounds and steroids that have analgesic activity. This study aimed to test the analgesic activity of senggani leaf fraction (Clidemia hirta [L] D.Don) in white mice swiss webster strain induced acetic acid and determine the fraction that most effectively produces analgesic activity. The type of research conducted is true experimental design based on Complete Randomized Design (RAL). The test animals used were 25 heads divided into 5 groups with 5 replications, namely negative control (CMC 1%), positive control (dexamethasone) and the test group of senggani leaf fraction, namely n-hexane, ethyl acetate, and ethanol fractions. The data obtained were analyzed using an alternative test from One Way ANOVA namely Kruskal Wallis with a follow-up test post hoc Mann Whitney test. The results showed that the fraction of senggani leaves in all types of solvents had analgesic activity compared to negative controls (CMC 1%) with a significant difference (p0.05). From these results it is concluded that the senggani leaf fraction can be used as an analgesic.
PENAMBATAN MOLEKUL SENYAWA AKTIF SIRIH (Piper betle L) TERHADAP RESEPTOR HSV-1 SEBAGAI KANDIDAT ANTI HERPES Al Azzahra, Yunita; Taufik Septiyan Hidayat; Syumillah Saepudin
Pharmaceutical Science and Clinical Pharmacy Vol 2 No 1 (2024)
Publisher : Akademi Farmasi Bumi Siliwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61329/pscp.v2i1.22

Abstract

Tanaman sirih secara tradisional telah digunakan untuk pengobatan beberapa penyakit seperti bau mulut, penyembuhan luka, anti radang, batuk pilek, gangguan pencernaan. Sebagian besar manfaat sirih untuk kesehatan berasal dari senyawa bioaktif fenolik yang terdapat pada tanaman sirih, senyawa polifenol juga diketahui memiliki berpotensi sebagai antivirus. Herpes Simplex Virus (HSV) adalah patogen yang sangat menular yang menyebabkan infeksi berulang. Infeksi herpes disebabkan oleh masuknya virus ke dalam sel hingga mencapai lapisan membran atau gabungan sel. Penelitian ini bertujuan untuk mengetahui sifat ADMET dan memprediksi ikatan senyawa bioaktif yang terkandung dalam sirih terhadap reseptor HSV-1 dengan kode protein 2KI5 sebagai kandidat obat antiherpes. Metode yang digunakan pada penelitian ini secara in silico yaitu penambatan molekul menggunakan aplikasi AutodockTools dengan visualiasi menggunakan aplikasi Discovery Studio. Dari hasil penelitian ini diketahui bahwa senyawa bioaktif dari tanaman sirih mempunyai aktivitas pengikatan terhadap reseptor HSV-1, senyawa 4-Allylphenol dengan nilai ΔG -7.79 Kkal/Mol dan Ki 1.96 µM dan 4 kemiripan asam amino dengan senyawa pembanding diprediksi dapat dijadikan sebagai kandidat obat antiherpes karena memiliki sifat absorbsi, distribusi, metabolisme, eksresi dan toksisitas yang baik.
Antiviral Activity of Various Glycoside Compounds Al Azzahra, Yunita; Muchtaridi, Muchtaridi; Yusuf, muhammad
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.44496

Abstract

Glycoside compounds consist of several groups of important compounds, such as flavonoids and alkaloids. Sometimes the glycosidic residues in glycoside compounds have an important role in their activity, but some can only increase their pharmacokinetic parameters. However, recent developments in molecular glycobiology have gained a greater understanding of the activity of aglycones vs. glycosides. Several glycoside compounds, such as flavonoid glycosides and Cardiac glycosides, have been known to have antiviral activity, including against Herpes Simplex Virus, Influenza, and Human Immunodeficiency Virus. Still, until now, the potential for various Glycoside compounds as antivirals have not been widely studied, although many biologically active compounds are in the form of glycosides. Further studies regarding the antiviral activity of this glycoside compound are needed to determine the possibility of this compound as an alternative for treating diseases caused by viruses.Keyword : flavonoid glikosida, cardiac glikosida, HSV, Influenza, HIV
ANALISIS KADAR ALKALOID DAN FLAVONOID SEDUHAN RAMBUT JAGUNG (Zea mays L. ) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Al Azzahra, Yunita; Hidayat, Taufik Septiyan; Dewi, Lisna; Saepudin, Syumillah; Kartikawati, Endah; Rahayu, Iseu; Ajeng, Nurtina Dwi; Widiyaningrum, Eva Mutba
Jurnal Buana Farma Vol. 4 No. 3 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i3.1126

Abstract

Corn silk is generally a waste of sweet corn plants after being harvested and is rarely used, however, on the other hand, corn silk is also used by the community as herbal medicine and is believed to reduce the risk of hypertension and other types of chronic diseases such as kidney infections. Corn silk is thought to contain metabolite compounds such as flavonoids, essential oils, steroids, and alkaloids. Alkaloid compounds can function as drugs and strong activators for immune cells that can destroy bacteria, viruses, fungi, and cancer cells. Flavonoid compounds are compounds that have various bioactive effects such as anti-inflammatory, antiviral, cardioprotective, anti-diabetic, anti-cancer, anti-aging, and antioxidants. it is necessary to measure the levels of alkaloids and flavonoids from corn silk infusion to determine the levels of alkaloid and flavonoid compounds in corn silk infusion. The method used in this study is the Uv-Vis spectrophotometry method. The alkaloid content was calculated using the regression formula y = 0.0895x - 0.3046, the results obtained in the corn hair infusion extract were 46.36 mg / g extract, and the flavonoid content was calculated using the regression formula y = 0.0144 x - 0.025 and the results obtained in the corn hair infusion extract were 85.42 mg / g extract. So it can be concluded that corn hair infusion contains more flavonoid compounds, namely with alkaloid compound levels of 46.36 mg / g extract and flavonoid compounds of 85.42 mg / g extract.
Formulasi dan evaluasi fisik sediaan spray gel ekstrak daun bandotan (Ageratum conyzoides l.) sebagai pengobatan luka bakar Hartono, Kusdi; Hidayat, Taufik Septiyan; Azzahra, Yunita Al; Azmiyanti, Isfina
Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan) Vol. 8 No. 2 (2024): Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan)
Publisher : Sekolah Tinggi Ilmu Kesehatan Holistik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51873/jhhs.v8i2.337

Abstract

Latar belakang: Daun bandotan (Ageratum conyzoides L.) mengandung berbagai jenis senyawa metabolit sekunder didalamnya yaitu senyawa flavonoid, alkaloid, saponin, tanin, steroid, terpenoid, kumarin dan minyak atsiri yang secara tradisional tanaman daun bandotan dapat digunakan untuk mengobati luka bakar, luka memar, memiliki khasiat sebagai analgetik, antiinflamasi, bakteriosida yang barvariasi di berbagai daerah. Tujuan penelitian: Penelitian ini bertujuan untuk merumuskan sediaan spray gel yang optimal yang mengandung daun bandotan (Ageratum conyzoides L.) dengan kemampuan untuk mengobati luka bakar. Metode penelitian: Penelitian ini dilakukan dengan metode eksperimental yaitu dengan menggunakan variasi konsentrasi HPMC 0,1%, 0,3%, 0,5% dan ekstrak sebanyak 5%. Ekstrak daun bandotan diperoleh melalui proses maserasi menggunakan pelarut etanol 70%, diikuti dengan pengentalan menggunakan rotary evaporator. Selanjutnya, ekstrak tersebut diformulasikan menjadi sediaan spray gel. Sediaan dengan hasil terbaik kemudian diujikan pada kelinci yang telah diinduksi luka bakar. Hasil: Formulasi terbaik sediaan spray gel ekstrak daun bandotan adalah formula F2 dengan konsentrasi HPMC sebanyak 0,3%. Formula terbaik dipilih berdasarkan hasil evaluasi pH sediaan yang stabil, formulasi F2 yang lebih banyak disukai dari segi tekstur dan warna berdasarkan hasil pengujian hedonik dan tidak mengiritasi kulit. Formulasi terbaik spray gel ekstrak daun bandotan yaitu formula F2 juga memberikan pengaruh terhadap luka bakar pada hewan percobaan kelinci dengan berkurangnya luas diameter luka bakar seiring bertambahnya waktu. Simpulan: Formulasi terbaik spray gel ekstrak daun bandotan (F2) karena menunjukkan hasil evaluasi fisik yang baik, tidak menyebabkan iritasi dan berdasarkan uji hedonik lebih disukai oleh responden, formula ini juga memberikan pengaruh lebih baik terhadap luka bakar pada hewan percobaan kelinci dengan berkurangnya diameter luas luka bakar seiring bertambahnya waktu.
Uji aktivitas antibakteri dan analisis KLT - bioautografi ekstrak etanol 70% daun Peperomia obtusifolia (L.) A. Dietr terhadap bakteri Escherichia coli ATCC 2305 Kartikawati, Endah; Saepudin, Syumillah; Marni, Aulia; Hidayat, Taufik Septiyan; Azzahra, Yunita Al
Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan) Vol. 8 No. 2 (2024): Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan)
Publisher : Sekolah Tinggi Ilmu Kesehatan Holistik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51873/jhhs.v8i2.343

Abstract

Latar belakang: Peperomia obtusifolia (L.) A. Dietr merupakan tanaman dari keluarga Piperaceae. Peperomia obtusifolia (L.) A. Dietr secara empiris dapat digunakan untuk menyembuhkan berbagai jenis penyakit seperti pengobatan asma, sakit maag, nyeri, peradangan dan infeksi bakteri. Tujuan penelitian: Mengetahui daya hambat dari ekstrak ekstrak etanol 70% daun Peperomia obtusifolia (L.) A. Dietr terhadap pertumbuhan bakteri Escherichia coli. Metode penelitian: Pengujian aktivitas antibakteri ekstrak etanol 70% daun Peperomia obtusifolia (L.) A. Dietr dengan metode difusi secara in vitro (Kirby-Bauer) menggunakan kertas cakram dengan konsentrasi 6,25; 12,5; 25; dan 50%. Pengujian dengan metode KLT-Bioautografi menggunakan Bioautografi kontak langsung. Aktivitas antibakteri terhadap ekstrak daun Peperomia obtusifolia dilakukan dengan uji KLT-Bioautografi menggunakan fase gerak metanol : n-heksan (8:2). Hasil: Berdasarkan hasil uji Duncan, konsentrasi terbaik ekstrak etanol 70% daun Peperomia obtusifolia (L.) A. Dietr yang paling efektif dalam menghambat pertumbuhan bakteri Escherichia coli yaitu konsentrasi 50% dengan rata-rata zona hambat sebesar 7,08 ± 0,18 mm. Hasil pengujian menggunakan metode KLT-Bioautografi menunjukkan bahwa tidak adanya zona hambat pada bercak noda kromatografi lapis tipis. Simpulan: Konsentrasi terbaik dari semua konsentrasi ekstrak etanol 70% daun Peperomia obtusifolia (L.) A. Dietr terdapat pada konsentrasi 50% dengan rata-rata zona hambat sebesar 7,08 ± 0,18 mm. Pada metode KLT-Bioautografi ekstrak daun Peperomia obtusifolia (L.) A. Dietr, pada profil kromatografi terdapat tiga bercak noda dengan nilai Rf 1: 0,71, Rf 2: 0,65, dan Rf 3: 0,57, dan Bioautografi kontak tidak mampu memberikan zona hambat.
Analisis Molecular Docking Senyawa Aktif Tanaman Kumis Kucing (Orthosiphon stamineus B.) terhadap Reseptor Carbonic Anhydrase II sebagai Kandidat Obat Antihipertensi Hadisoebroto, Ginayanti; Effendi, Syulastri; Al Azzahra, Yunita
JOURNAL OF NONCOMMUNICABLE DISEASES Vol 5, No 1 (2025): April 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jond.v5i1.1349

Abstract

Hipertensi merupakan kondisi patologis yang ditandai oleh peningkatan tekanan darah melebihi batas normal, yaitu tekanan sistolik ≥ 140 mmHg dan diastolik ≥ 90 mmHg. Salah satu mekanisme yang dapat digunakan untuk menurunkan tekanan darah adalah dengan menghambat enzim carbonic anhydrase II (CA-II). Penelitian ini bertujuan untuk mengeksplorasi potensi senyawa aktif dalam tanaman kumis kucing (Orthosiphon stamineus B.) sebagai kandidat obat antihipertensi melalui pendekatan in silico menggunakan metode molecular docking. Proses docking dilakukan melalui beberapa tahapan, meliputi preparasi ligan dan reseptor CA-II, validasi metode, docking antara senyawa uji dan reseptor, serta visualisasi interaksi molekuler. Parameter yang dianalisis dari hasil docking mencakup energi ikatan, konstanta inhibisi (Ki), dan interaksi residu asam amino aktif. Hasil studi menunjukkan bahwa senyawa Damascenone memiliki potensi tertinggi sebagai kandidat antihipertensi, dengan nilai energi ikatan sebesar -6,91 kcal/mol dan Ki sebesar 8,57 µM, yang mendekati nilai dari ligan native, yaitu furosemid. Selain itu, Damascenone menunjukkan profil farmakokinetik dan toksikologi yang baik berdasarkan analisis ADMET (Absorpsi, Distribusi, Metabolisme, Ekskresi, dan Toksisitas). Kemiripan pola interaksi hidrogen Damascenone dengan furosemid mendukung prediksi bahwa senyawa ini berpotensi menghasilkan efek antihipertensi yang sebanding melalui penghambatan terhadap reseptor CA-II.Hypertension is a pathological condition characterized by elevated blood pressure exceeding normal limits, specifically systolic pressure ≥ 140 mmHg and diastolic pressure ≥ 90 mmHg. One mechanism to reduce blood pressure is through the inhibition of the enzyme carbonic anhydrase II (CA-II). This study aims to explore the potential of active compounds in the medicinal plant Orthosiphon stamineus B. as antihypertensive drug candidates using an in silico approach through molecular docking methods.cThe docking process involved several stages, including ligand and CA-II receptor preparation, method validation, docking of the test compounds with the receptor, and visualization of molecular interactions. Parameters analyzed from the docking results included binding energy, inhibition constant (Ki), and interactions with active site amino acid residues. The results indicated that Damascenone demonstrated the highest potential as an antihypertensive candidate, with a binding energy of -6.91 kcal/mol and an inhibition constant (Ki) of 8.57 µM, values comparable to the native ligand, furosemide. Furthermore, Damascenone exhibited favorable pharmacokinetic and toxicological properties based on ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis. The similarity in hydrogen bonding patterns between Damascenone and furosemide supports the prediction that Damascenone may exert a comparable antihypertensive effect through CA-II receptor inhibition.
Analisis Kadar Alkaloid Ekstrak Dan Fraksi Biji Trembesi (Samanea saman Merr.) Berdasarkan Kepolaran Pelarut Menggunakan Spektrofotometri UV-Vis Qolbi, Raihan Ahista; Al Azzahra, Yunita
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1101

Abstract

Samanea saman (Merr.) seeds are plant parts that have not been extensively studied, despite their potential as a source of bioactive compounds, particularly alkaloids. Alkaloid compounds are known to possess various pharmacological activities, such as antimicrobial, anticancer, and analgesic effects, making them promising candidates for the development of natural medicines. This study aimed to analyze the alkaloid content in the extract and fractions of S. saman seeds using solvents with different polarity levels,namely n-hexane (non-polar), ethyl acetate (semi-polar), and distilled water (polar). Extraction was carried out using the Ultrasound Assisted Extraction (UAE) method, while quantitative analysis of alkaloid content was performed using UV-Vis spectrophotometry with caffeine as the standard solution. Qualitative testing showed that the ethyl acetate and aqueous fractions were positive for alkaloids. Quantitative analysis of the extract revealed that S. saman seed extract contained alkaloids at a concentration of 142.59 mgCE/g extract. Further analysis of the fractions indicated that the ethyl acetate fraction had the highest alkaloid content 77.34 mgCE/g fraction, compared to the aqueous fraction 24.65 mgCE/g fraction and the n-hexane fraction 45.7 mgCE/g fraction. These findings suggest that semi-polar solvents are the most effective for extracting alkaloid compounds from S. saman seeds, thereby highlighting their potential for further development as raw materials for phytopharmaceuticals or natural-based herbal preparations.
Co-Authors Ade Cahyati Ajeng, Nurtina Dwi Azmiyanti, Isfina Dadan Rohdiana Dewi, Lisna Dini Febrianty Effendi, Syulastri Hadisoebroto, Ginayanti Hidayat, Taufik Septiyan Kartikawati, Endah Kusdi Hartono, Kusdi Marni, Aulia Muchtaridi Muchtaridi Muhammad Yusuf Qolbi, Raihan Ahista Rahayu, Iseu Syumillah Saepudin Widiyaningrum, Eva Mutba