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All Journal JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kefarmasian AKFARINDO Archives of The Medicine and Case Reports
Khamdiyah Indah Kurniasih
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Comparative Effectiveness of Single Versus Combination Antihypertensive Therapy in PROLANIS Hypertension Patients: A Retrospective Study in Purbalingga Regency Khamdiyah Indah Kurniasih; Nanang Munif Yasin; Utami, Pri Iswati
Archives of The Medicine and Case Reports Vol. 5 No. 4 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i4.625

Abstract

The PROLANIS program in Indonesia aims to manage chronic diseases like hypertension. While combination antihypertensive therapy is recommended for many patients, evidence on its effectiveness in the PROLANIS setting remains limited. This study investigated the comparative effectiveness of single versus combination antihypertensive therapy in achieving blood pressure control among PROLANIS hypertension patients in Purbalingga Regency. A retrospective cohort study was conducted using data from PROLANIS hypertension patients in Purbalingga Regency from January-December 2023. Patients were categorized into two groups: those receiving single antihypertensive therapy and those receiving combination therapy. The primary outcome was the proportion of patients achieving blood pressure control (<140/90 mmHg). Secondary outcomes included changes in blood pressure, medication adherence, and adverse events. Multivariable logistic regression was used to adjust for potential confounders. A total of 1,250 patients were included, with 680 receiving single therapy and 570 receiving combination therapy. The proportion of patients achieving blood pressure control was significantly higher in the combination therapy group (65%) compared to the single therapy group (52%) (adjusted odds ratio [OR] 1.72, 95% confidence interval [CI] 1.35-2.20). Combination therapy was also associated with greater reductions in systolic and diastolic blood pressure. No significant differences were observed in medication adherence or adverse events between the two groups. Combination antihypertensive therapy is more effective than single therapy in achieving blood pressure control among PROLANIS hypertension patients in Purbalingga Regency. These findings support the use of combination therapy as the preferred approach for managing hypertension in this population.
Impact of mRNA COVID-19 Vaccines on Blood Pressure in Hypertensive Patients: A Retrospective Observational Study Raysyifa, Mugi Rahma; Khamdiyah Indah Kurniasih; Siti Setianingsih
Archives of The Medicine and Case Reports Vol. 5 No. 4 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i4.628

Abstract

The COVID-19 pandemic necessitated rapid vaccine development, with mRNA vaccines (Moderna or Pfizer) emerging as frontrunners. While effective, concerns arose regarding their impact on blood pressure (BP), particularly in hypertensive individuals, a population already at increased cardiovascular risk. The study aimed to investigate the effects of mRNA COVID-19 vaccines on BP in hypertensive patients. A retrospective observational study was conducted at the Mrebet Community Health Center. Data from hypertensive patients receiving the second dose of either Moderna or Pfizer vaccine were analyzed. Pre- and post-vaccination BP readings, patient demographics, medication profiles, and hypertension severity were assessed. Statistical analysis was performed to evaluate changes in BP and identify potential associations. The study included 33 hypertensive patients (mean age: 55.2 years, 84.8% female). The majority (84.8%) received the Moderna vaccine. Pre- and post-vaccination BP readings showed a slight increase in systolic BP (133 mmHg to 137 mmHg) and a minor decrease in diastolic BP (85 mmHg to 84 mmHg). Statistical analysis revealed a significant association between vaccination and changes in diastolic BP (p < 0.05), but not systolic BP (p > 0.05). In conclusion, mRNA COVID-19 vaccines may have a modest impact on BP in hypertensive patients, particularly on diastolic BP. The clinical significance of these changes warrants further investigation. Close monitoring of BP in hypertensive individuals post-vaccination is recommended.
ANALISIS PENGGUNAAN ANTIBIOTIK PASIEN DEMAM TIFOID DI RSUD dr. R. GOETENG TAROENADIBRATA PURBALINGGA TAHUN 2022 MENGGUNAKAN METODE ATC/DDD DAN DU 90% Alifia Kurniati; Sunarti; Khamdiyah Indah Kurniasih
Jurnal Kefarmasian Akfarindo Vol 9 No 1 (2024)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.283

Abstract

Demam tifoid termasuk salah satu permasalahan kesehatan yang signifikan terutama di negara-negara berkembang, salah satunya indonesia. Penggunaan antibiotik secara berlebihan dapat membahayakan pasien dan menimbulkan resistensi obat terhadap bakteri. Upaya untuk mengetahui kuantitas pemakaian antibiotik perlu dilakukan menggunakan metode kuantitatif yseperti metode ATC (Anatomic Therapeutic Chemical) dan DDD (Defined Daily Dose) serta DU 90% (Drug Utilization). Penelitian ini dilakukan untuk menilai penggunaan antibiotik pada pasien dewasa yang menderita demam tifoid sesuai ATC/DDD dan DU 90% yang dirawat di RSUD dr. R. Goeteng Taroenadibrata Purbalingga tahun 2022. Jenis penelitian ini yaitu deskriptif melalui pengumpulan data retrospektif berdasarkan rekam medis, pengumpulan sampel dengan metode purposive sampling berjumlah 302 sampel. Data yang dikumpulkan meliputi nomor rekam medis, lama rawat inap, identitas pasien, diagnosis, dan profil pengobatan (nama antibiotik, jumlah antibiotik, cara pemberian, aturan pakai, dosis obat). Organisasi Kesehatan Dunia (WHO) menerapkan ATC (Anatomical Therapeutic Chemical) dan DDD (Defined Daily Dose) sebagai standar global dalam penelitian tentang penggunaan obat. Salah satu contoh penggunaannya adalah dalam mengukur pemakaian antibiotik dengan metode ATC/DDD. Hasil penelitian menunjukkan total nilai DDD yaitu 120,31 DDD/100 patient days dengan 1210 hari total rawat inap. Antibiotik dengan nilai DDD tertinggi per 100 hari pasien hingga terendah yaitu cefixime (63,26), ceftriaxon (45,62), ciprofloxacin p.o (5,33), ciprofloxacin i.v (0,91), amoxicillin p.o (1,4), amoxicillin i.v (0,21), cefotaxime (0,41) dan azithromycin (3.17). Antibiotik yang termasuk dalam kategori DU 90% yaitu cefixime (52,58) serta ceftriaxon (37,92%).
Analisis Biaya Hemodialisis pada Penyakit Ginjal Kronis: Peran Karakteristik Pasien di Rumah Sakit Regional Indonesia Fauziah Fauziah; Ikhwan Yuda Kusuma; Bella Aisya Putri; Khamdiyah Indah Kurniasih; Gamaliel Agung Nugroho; Fiqih Nurkholis
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 3 (2025): J Sains Farm Klin 12(3), December 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.3.192-198.2025

Abstract

Haemodialysis (HD) is the primary treatment for end-stage renal disease in Indonesia and heavily strains the national health insurance. This study examined how patient characteristics influence the direct medical costs of CKD patients receiving HD at Dr. R. Goeteng Taroenadibrata Regional General Hospital. A retrospective cross-sectional analysis was conducted using secondary data from medical, pharmacy, and financial records between July and December 2023. The study included 85 patients who met the inclusion criteria. Statistical analyses were performed using IBM SPSS Statistics, and cost differences across patient characteristics were analysed using nonparametric tests. The total cost over six months reached IDR 2.64 billion, averaging IDR 654,758 per HD visit. While no significant cost differences were observed across patient characteristics such as age, gender, comorbidities, or HD frequency (p > 0.05 for all), descriptive data indicated higher average costs in older patients, in patients receiving HD weekly, and in patients with CKD due to non-hypertensive etiologies. These findings suggest that standard reimbursement rates may overlook variations in resource utilization, highlighting observed cost variations that suggest the need for more tailored health financing approaches. Broader, multicenter studies are recommended to improve resource allocation in CKD management.
Co-Authors Alifia Kurniati Bella Aisya Putri Fauziah Fauziah Fiqih Nurkholis Gamaliel Agung Nugroho Ikhwan Yuda Kusuma Nanang Munif Yasin Pri Iswati Utami Raysyifa, Mugi Rahma Siti Setianingsih Sunarti