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All Journal Farmaka Pharmacology and Clinical Pharmacy Research
Setyowati, Lulu Alya
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Studi In Silico Senyawa Bioaktif Daun Sirih (Piper betle L.) Sebagai Anti Kolesterol pada Reseptor Hmg Co-A Reductase Djamaluddin, Muhammad Ilham; Suryanto, Rajwa Dwifauza; Salsabila, Salma; Aziz, Calista Sasikirana Finola; Setyowati, Lulu Alya; Muchtaridi, Muchtaridi; Mardisanutomo, Harsoning Tyas; Rusdin, Agus
Farmaka Vol 22, No 1 (2024): Farmaka (Maret)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v22i1.48866

Abstract

Daun sirih (Piper betle L.) adalah tanaman yang memiliki potensi efek farmakologis dalam mengatasi kolesterol. Penelitian ini bertujuan untuk melakukan analisis potensi senyawa (eucalyptol, cadinene, estragole, pinene, limonene, chavicol, hydroxychavicol, carvacrol, safrole, dan eugenol) sebagai antikolesterol dengan pembanding kontrol positif obat Simvastatin. Tahapan penelitian analisis potensi senyawa pada daun sirih (Piper betle L.)  secara in silico terdiri dari prediksi Lipinski, penentuan ADMET, skrining farmakofor, dan molecular docking. Analisis ini menggunakan website PubChem, PreADMET dan perangkat lunak  Discovery studio client 4.1, Ligandscout dan Autodock Tools. Senyawa Hydroxychavicol dan Eugenol menunjukkan hasil molecular docking terbaik untuk menjadi Lead Compound. Menilai dari energi Gibbs (ΔG), konstanta inhibisi dan kemiripan interaksi senyawa dengan kontrol positif, meliputi interaksi ikatan hidrogen ARGD590, ASPD690, ASNC755 dan ikatan residu asam amino. Hydroxychavicol dan Eugenol  dapat dilakukan penelitian lebih lanjut sebagai potensi antikolesterol dilihat dari seluruh pengujian pada penelitian yang menunjukkan kemiripan dengan kontrol positif Simvastatin.
Effectiveness of Cognitive-behavioral Therapy for Generalized-Anxiety Disorders in Adolescents: A Systematic Review Using PICO Framework Suryanto, Rajwa Dwifauza; Gaharani, Prodio Efa; Salsabila, Salma; Finola Aziz, Calista Sasikirana; Khaerani, Fitri Azlia; Athaya, Salsabila; Setyowati, Lulu Alya; Kartadikaria, Elisya; Djamaluddin, Muhammad Ilham; Soewahju, Renata Bella Aprilana; Pitaloka, Dian Ayu Eka
Pharmacology and Clinical Pharmacy Research Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i2.53373

Abstract

A number of teenagers experience various levels of mental disorders, ranging from mild stress to Generalized Anxiety Disorder (GAD). According to the World Health Organization (WHO), approximately 264 million people suffer from anxiety disorders, including GAD, and this condition is a significant leading cause of suicide incidents, ranking sixth among serious mental health issues. From a societal perspective, Cognitive Behavioral Therapy (CBT) has the advantage of cost-effectiveness by minimizing the use of medications and enhancing productivity in education for adolescents receiving CBT. This study aims to conduct a systematic review of the existing literature on GAD in adolescents, using the PICO format method and formulating relevant research questions (RQ). Based on research that has been done, CBT has a relevant effect on some cases of GAD experienced by adolescents, although in some conditions CBT needs to be combined with antidepressants.
Co-Authors Athaya, Salsabila Aziz, Calista Sasikirana Finola Djamaluddin, Muhammad Ilham Finola Aziz, Calista Sasikirana Gaharani, Prodio Efa Kartadikaria, Elisya Khaerani, Fitri Azlia Mardisanutomo, Harsoning Tyas Muchtaridi Muchtaridi Pitaloka, Dian Ayu Eka Rusdin, Agus Salsabila, Salma Soewahju, Renata Bella Aprilana Suryanto, Rajwa Dwifauza