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All Journal Jurnal Berkala Epidemiologi Indonesian Journal of Chemistry Pharmacology and Clinical Pharmacy Research Majalah Farmasetika Jurnal Ilmiah Farmako Bahari Eduvest - Journal of Universal Studies
Dian Ayu Eka Pitaloka
Department Of Pharmacology And Clinical Pharmacy, Faculty Of Pharmacy, Universitas Padjadjaran
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Molecular Docking, Dynamics Simulation, and Scanning Electron Microscopy (SEM) Examination of Clinically Isolated Mycobacterium tuberculosis by Ursolic Acid: A Pentacyclic Triterpenes Dian Ayu Eka Pitaloka; Sophi Damayanti; Aluicia Anita Artarini; Elin Yulinah Sukandar
Indonesian Journal of Chemistry Vol 19, No 2 (2019)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (412.332 KB) | DOI: 10.22146/ijc.33731

Abstract

The purpose of this study was to analyze the inhibitory action of ursolic acid (UA) as an antitubercular agent by computational docking studies and molecular dynamics simulations. The effect of UA on the cell wall of Mycobacterium tuberculosis (MTB) was evaluated by using Scanning Electron Microscopy (SEM). UA was used as a ligand for molecular interaction and investigate its binding activities to a group of proteins involved in the growth of MTB and the biosynthesis of the cell wall. Computational docking analysis was performed by using autodock 4.2.6 based on scoring functions. UA binding was confirmed by 30 ns molecular dynamics simulation using gromacs 5.1.1. H37Rv sensitive strain and isoniazid-resistant strain were used in the SEM study. UA showed to have the optimum binding affinity to inhA (Two-trans-enoyl-ACP reductase enzyme involved in elongation of fatty acid) with the binding energy of -9.2 kcal/mol. The dynamic simulation showed that the UA-inhA complex relatively stable and found to establish hydrogen bond with Thr196 and Ile194. SEM analysis confirms that UA treatment in both sensitive strain and resistant strain affected the morphology cell wall of MTB. This result indicated that UA could be one of the potential ligands for the development of new antituberculosis drugs.
Simple Method of 9,10-Anthraquinone Assay in Eleutherine americana (Aubl.) Merr. ex K. Heyne using High-Performance Liquid Chromatography Sophi Damayanti; Samuel Gunadi Tanusondjaja; Benny Permana; Rika Hartati; Dian Ayu Eka Pitaloka; Indra Wibowo
Indonesian Journal of Chemistry Vol 21, No 6 (2021)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.64701

Abstract

Eleutherine americana (E. americana) is a medicinal plant commonly found on the island of Borneo, Indonesia. This plant is known to have several biological activities. However, anthraquinone residues are generally present as contaminants. This study was aimed to develop a method of determining the levels of 9,10-anthraquinone in plant extracts and fractions using High Performance Liquid Chromatography (HPLC). The research aims to optimize the mobile phase, the system suitability test, and the system validation. The optimal mobile phase was acetonitrile:distilled water 1:1 v/v with a flow rate of 1.25 mL/min. The validation result shows that the linearity was obtained with a correlation coefficient (r) of 0.9995 and an r2 coefficient of 0.9991. The estimated limits for detection and quantification values were 0.178 and 0.594 µg/mL, respectively. In the intraday and inter-day accuracy test, the coefficient of variance for reference was 0.627 and 0.774, while the results for the sample were 2.966 and 2.658. The percentage recovery rate for reference was between 98.976–101.452%, and for the sample, the result was 89.191–94.667%. The average 9,10-anthraquinone content in the acetate fraction of E. americana plant was 9.799 µg/g ± 5.243.
Effectiveness of Cognitive-behavioral Therapy for Generalized-Anxiety Disorders in Adolescents: A Systematic Review Using PICO Framework Suryanto, Rajwa Dwifauza; Gaharani, Prodio Efa; Salsabila, Salma; Finola Aziz, Calista Sasikirana; Khaerani, Fitri Azlia; Athaya, Salsabila; Setyowati, Lulu Alya; Kartadikaria, Elisya; Djamaluddin, Muhammad Ilham; Soewahju, Renata Bella Aprilana; Pitaloka, Dian Ayu Eka
Pharmacology and Clinical Pharmacy Research Vol 10, No 2 (2025)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v10i2.53373

Abstract

A number of teenagers experience various levels of mental disorders, ranging from mild stress to Generalized Anxiety Disorder (GAD). According to the World Health Organization (WHO), approximately 264 million people suffer from anxiety disorders, including GAD, and this condition is a significant leading cause of suicide incidents, ranking sixth among serious mental health issues. From a societal perspective, Cognitive Behavioral Therapy (CBT) has the advantage of cost-effectiveness by minimizing the use of medications and enhancing productivity in education for adolescents receiving CBT. This study aims to conduct a systematic review of the existing literature on GAD in adolescents, using the PICO format method and formulating relevant research questions (RQ). Based on research that has been done, CBT has a relevant effect on some cases of GAD experienced by adolescents, although in some conditions CBT needs to be combined with antidepressants.
Evaluasi Kelengkapan Resep di Apotek X Kota Bandung Periode Februari 2025 Raptania, Callista Najla; Eka Pitaloka, Dian Ayu
Majalah Farmasetika Vol 10, No 3 (2025)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v10i3.64153

Abstract

Evaluasi kelengkapan resep merupakan salah satu pelayanan farmasi klinik untuk mencegah terjadinya medication error sehingga menjamin keamanan, efektivitas, dan rasionalitas terapi obat. Penelitian ini bertujuan untuk menilai kelengkapan resep berdasarkan aspek administratif, farmasetik, dan klinis di Apotek X Kota Bandung pada periode Februari 2025. Penelitiani ini menggunakan metode desktriptif observasional dengan pendekatan retrospektif terhadap 75 resep yang dianalisis berdasarkan kriteria kelengkapan resep dalam Peraturan Menteri Kesehatan No. 73 Tahun 2016. Hasil menunjukkan bahwa persentase aspek administratif untuk nama pasien, nama dokter, dan alamat dokter, serta tanggal penulisan resep sebesar 100%, sedangkan berat badan (41,33%) dan jenis kelamin (58,67%) masih sering diabaikan. Persentase aspek farmasetik untuk nama dan jumlah obat sebesar 100%, namun kekurangan ditemukan pada pencantuman bentuk (66,67%) dan kekuatan sediaan (96%). Persentase aspek klinis untuk aturan dan cara pakai obat tercantum pada seluruh resep, tidak ditemukan duplikasi obat, tetapi interaksi obat terjadi pada 74,67% resep, terutama pada pasien dengan polifarmasi. Berdasarkan hasil tersebut, diperlukan peningkatan kesadaran terkait pencantuman data yang lengkap serta mengoptimalkan peran Apoteker dalam pengkajian resep. Evaluasi secara sistematis diperlukan untuk meningkatkan mutu pelayanan kefarmasian serta menjamin keselamatan pasien.
The Role of Community Pharmacy Personnel in Tuberculosis Case Detection: A Narrative Review Carla Florencia; Ida Ayu Andri Parwitha; Dian Ayu Eka Pitaloka; Ivan Surya Pradipta
Jurnal Ilmiah Farmako Bahari Vol 17 No 2 (2026): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v17i2.42197

Abstract

Tuberculosis (TB) continues to pose a global health challenge, mainly due to low case detection rates in high-burden countries like Indonesia. Community pharmacies (CP), the health facilities most commonly visited by individuals experiencing tuberculosis symptoms, play an essential role in early detection and referral to health facilities. This narrative review examines the role of community pharmacists in TB case detection through pharmacy-based interventions in developing countries with high TB burden. The following databases were used to identify articles that met the inclusion and exclusion criteria: PubMed and Scopus. Based on three eligible studies from India, Pakistan, and Cambodia, pharmacy-based TB case detection programs were associated with increased case detection and referral of presumptive TB cases. The included studies reported that structured interventions, including pharmacist training, referral systems, monitoring, and public-private collaboration, may support TB case detection in high-burden settings. However, several barriers were identified, including uncertainty about referral pathways, financial constraints, and concerns about service quality at referral facilities. Given the limited evidence from only three studies, these findings should be interpreted cautiously, and further research is needed to assess the effectiveness and sustainability of pharmacy-based TB case-detection programs. CP engagement may contribute to TB case detection when reinforced by well-defined, structured referral pathways and integration with public-private TB control initiatives.
NON-TUBERCULOUS MYCOBACTERIA RESEARCH IN INDONESIA (2015–2025): GLOBAL COLLABORATION AND THEMATIC TRENDS: Non-Tuberculous Mycobacteria (NTM) di Indonesia (2015–2025): Kolaborasi Global dan Tren Tematik Dian Ayu Eka Pitaloka; Hilman Maulana Praja; Rizanty Amalia; Sharifah Shakirah Syed Omar; Ikhwan Yuda Kusuma; Shota Nakamura
Jurnal Berkala Epidemiologi Vol. 14 No. 3 (2026): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V14I32026.228-237

Abstract

Background: Non-tuberculous Mycobacteria (NTM) infections are an emerging public health challenge in Indonesia, where overlapping clinical presentations may cause misdiagnosis as tuberculosis (TB), inappropriate treatment, and challenges in TB control. Purpose: To provide the first bibliometric mapping of Indonesian NTM research (2015–2025), assessing productivity, impact, thematic evolution, and research gaps relevant to national diagnostic and surveillance policy. Methods: A systematic search of the Web of Science Core Collection (January 2015–December 2025) combined NTM, atypical mycobacteria, major species, and Indonesia. Following PRISMA-guided screening, 25 primary research articles were analyzed. Total publications (TP), total citations (TC), and H-index were analyzed using VOSviewer (v.1.6.20) and Microsoft Excel to map publication trends, collaboration, and keyword networks. Results: Output increased from fewer than one article annually in 2015–2017, rising from 2018 and peaking at seven articles in 2023, reflecting increased focus on molecular identification. International Journal of Mycobacteriology was the most prolific journal, while Scientific Reports and BMC Microbiology had the highest citation impact (ACP 21 and 9.5, respectively). Japan dominated international collaboration, while Universitas Airlangga led domestic contributions. Five thematic clusters emerged: TB-related infections and assay sensitivity; sputum-based molecular assays; NTM species and susceptibility; diagnosis and disease differentiation; and pulmonary TB with Mycobacterium avium complex features. Conclusion: Indonesian NTM research is shifting toward advanced diagnostics and resistance monitoring, yet remains dependent on international collaboration, underscoring the need for a National NTM Research Consortium to harmonize diagnostic standards and strengthen domestic research capacity.
Reducing Stockouts and Improving Inventory Performance of Category a Cardiovascular Drugs Through Kraljic Matrix and MMSL in Pharmacy in Indonesia Iqbal Sujida Ramadhan Ramadhan; Dian Ayu Eka Pitaloka; Angga Prawira Kautsar
Eduvest - Journal of Universal Studies Vol. 6 No. 9 (2026): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v6i9.53344

Abstract

Cardiovascular medicines require continuous availability because treatment interruptions may compromise chronic disease management. However, community pharmacies often experience stockouts, supply uncertainty, and inefficient inventory investment. This study aimed to evaluate the effectiveness of integrating the Kraljic Matrix and Minimum–Maximum Stock Level (MMSL) methods in improving the inventory performance of category A cardiovascular medicines at a community pharmacy in Bandung, Indonesia. A quasi-experimental pre–post design without a control group was applied using retrospective data from August–December 2025 and prospective data from January–May 2026. Thirty category A medicines were classified using the Kraljic Matrix, followed by quadrant-specific procurement strategies and MMSL calculations. Performance was assessed through stockout incidents, stockout duration, stockout losses, average inventory value, and Inventory Turnover Ratio (ITOR), with differences tested using the Wilcoxon signed-rank test. Stockout incidents decreased from 31 to 8, while median stockout duration and losses declined from four days and IDR 106,546 to zero. Median ITOR increased from 0.99 to 1.17, although average inventory value increased due to additional safety stock requirements. All indicators showed significant changes with large effect sizes. The integrated approach effectively reduced stockouts and improved inventory utilization, supporting risk-based procurement strategies for cardiovascular medicines in community pharmacies while maintaining treatment continuity and operational resilience.
Co-Authors Aluicia Anita Artarini Angga Prawira Kautsar Athaya, Salsabila Carla Florencia Djamaluddin, Muhammad Ilham Elin Yulinah Sukandar Finola Aziz, Calista Sasikirana Gaharani, Prodio Efa Hilman Maulana Praja Ida Ayu Andri Parwitha Ikhwan Yuda Kusuma Indra Wibowo Iqbal Sujida Ramadhan Ramadhan Ivan Surya Pradipta Kartadikaria, Elisya Khaerani, Fitri Azlia Permana, Benny Raptania, Callista Najla Rika Hartati Rizanty Amalia Salsabila, Salma Samuel Gunadi Tanusondjaja Setyowati, Lulu Alya Sharifah Shakirah Syed Omar Shota Nakamura Soewahju, Renata Bella Aprilana Sophi Damayanti Suryanto, Rajwa Dwifauza