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All Journal Diagnosa: Jurnal Ilmu Kesehatan dan Keperawatan Jurnal Ilmiah Dan Karya Mahasiswa Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Sains Farmasi dan Kesehatan
Ivan Charles S.Klau
Unknown Affiliation
Humanities Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Environmental Science Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Studi Fitokimia Dan Farmakologi Morinda Citrifolia Dalam Terapi Kanker: Artikel Review Maria Fransiska Silviani Derosari; Niken Rahmita Khairani; Safanda Tiara Fitri; Miya Hartini Nur Wakhid; Ewalde Yovita Bria; Magdalena Kasmin Belaon Lebuan; Aprilia Puji Astuti; Maulidiyah Cholifah; Agustinus Alfred Seran; Ivan Charles S.Klau; Arista Wahyu Ningsih
DIAGNOSA: Jurnal Ilmu Kesehatan dan Keperawatan Vol. 2 No. 1 (2024): Februari,: Jurnal Ilmu Kesehatan dan Keperawatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59581/diagnosa-widyakarya.v2i1.2227

Abstract

Morinda citrifolia (noni) is a plant that has attracted attention in research as a source of compounds with anti-cancer potential. The aim of this comprehensive understanding is to analyze various studies that have been carried out to investigate the ability of Morinda citrifolia in cancer therapy. The research method involved a qualitative literature study, where we collected ten research articles that had been conducted on various types of cancer cells and the compounds contained in Morinda citrifolia. Research results show that Morinda citrifolia contains a variety of compounds such as anthraquinones, scopoletin, quercetin, and others, which have shown promising anti-cancer activity. In addition, in-silico research also identifies compounds that have the potential to influence key molecular targets in cancer growth pathways. Research results show a variety of anticancer activities associated with these compounds, including their ability to inhibit cancer cell growth, induce apoptosis, reduce oxidative stress, and inhibit cancer cell movement. In several studies, compounds such as morindone, scopoletin, and quercetin have shown promising anticancer activity, especially in certain cancer cell models. In conclusion, Morinda citrifolia shows potential as a source of interesting anti-cancer compounds, and further research is expected to help better understand the potential benefits of this plant in cancer therapy. In this context, further clinical research is needed to validate the efficacy and safety of using Morinda citrifolia in cancer therapy in humans.
Artikel Review : Studi Fitokimia Dan Aktivitas Farmakologi Pada Tanaman Bidara (Ziziphus Mauritiana Lamk) Windi Tri Wahyuni; Fina Nikmatul Wasi’ah; Ismatun Maulidiyah; Elsa Saqila; Sirojul Eilma; Oktafia Damayanti; Brelianty Nevy; Silvi Novita; Agustinus Alfred Seran; Ivan Charles S.Klau; Arista Wahyu Ningsih
Jurnal Ilmiah Dan Karya Mahasiswa Vol. 2 No. 1 (2024): FEBRUARI : JURNAL ILMIAH DAN KARYA MAHASISWA
Publisher : Institut Teknologi dan Bisnis (ITB) Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54066/jikma.v2i1.1287

Abstract

Background: The Bidara plant (Ziziphus mauritiana Lam) is a plant that can be used as a traditional medicine for the treatment of various diseases. Apart from that, the Bidara plant is one type of plant that has the widest distribution and has high economic value. According to several research results, Bidara leaves contain many compounds found in Bidara plants, including saponins, flavonoids, tannins, alkaloids and phenols. Objective: This review journal aims to determine the compounds contained in each part of the Bidara plant and their pharmacological activity. Method: The method used in this article is the literature review method. Results: In this journal review article, there is discussion about Bidara (Ziziphus mauritiana Lam) especially on pharmacological activities such as antibacterial, antimicrobial, antidepressant, anticancer, antipyretic, analgesic, anti-inflammatory and antioxidant in parts of the Bidara plant. Conclusion: in several of these reviews it can be concluded that the part of the Bidara plant that contains many ingredients and has many benefits is the leaves.
Artikel Review Fitokimia : Efektivitas Refluks Sebagai Metode Ekstraksi Isafani, Nungki Hatit; Nailah Mutiara Wahid; Marscha Dwi Lestari; Ryan Satria Pranata; Meiva Shafa Herdini; M. Ilham Fannany; Helmalia Jelita Putri; Anisa Rachman; Nadya Tazkiyah Tsabitah; A’Yunil Hisbiyah; Ivan Charles S.Klau; Arista Wahyu Ningsih
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The reflux extraction method is a technique that uses a solvent at its boiling point for a certain time with a stable solvent volume, due to the presence of a reflux condenser. This method is generally used to extract coarse-textured and heat-resistant materials, because the process involves continuous heating. The main advantage of the reflux method is its ability to efficiently extract samples with coarse textures. This article discusses the effectiveness of reflux extraction by outlining its working principle, factors that influence extraction results, its advantages and disadvantages, applications to various phytochemical compounds, and also innovative developments of this method. In the reflux method, the solvent is heated to its boiling point and the solvent vapor formed is recondensed so that it can circulate repeatedly. This process allows for more efficient and stable extraction. Several factors that influence extraction results include the type of solvent, temperature, stirring speed, solvent, the ratio between the material and the surface area of ​​the material, and the length of the extraction time. Sari's research results showed that the galactomannan yield from coconut pulp using aquadest solvent reached 3.82%, higher than Zultiniar's research using methanol with a yield of 0.90%. This result is consistent with the research of Zulmi et al. who extracted galactomannan from palm fruit using aquadest solvent, while Tarigan who used ethanol obtained a lower yield.
Tinjauan Literatur: Efektivitas Maserasi sebagai Metode Ekstraksi Fitokimia Ningsih, Arista Wahyu; Jihan Fahiroh Nur Arifin; Retno Wulan Devitri; Rusdiana Tri Septiarini; Elvira Silvany Zahara; Vira Maulidya; Yasmine Eka Maulidya; Elly Eka Rahmawati; Zakkiya Sabila; Zahratul Humaidah; Ivan Charles S.Klau
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1927

Abstract

Extraction is a crucial stage in obtaining bioactive compounds from natural materials that have potential as medicinal, cosmetic, or nutraceutical ingredients. Among the various extraction methods available, maceration remains one of the most widely used techniques due to its simplicity, cost-effectiveness, and ability to maintain the stability of active compounds. The maceration process involves soaking powdered plant material in a suitable solvent at room temperature for a certain period, accompanied by periodic stirring to facilitate the diffusion of active compounds into the solvent. This method is particularly effective for extracting polar and semi-polar compounds such as flavonoids, phenolics, and essential oils that are sensitive to heat. The review shows that the effectiveness of maceration is influenced by several key factors, including the type and concentration of solvent, particle size of the material, duration of soaking, and stirring frequency. The use of ethanol with higher concentrations generally yields greater extract recovery and higher levels of active compounds. In addition, maceration is considered environmentally friendly because it requires no excessive heating and can employ safe, natural solvents. Therefore, despite the development of advanced extraction technologies, maceration remains a relevant, practical, and efficient method for phytochemical extraction, especially in laboratory research and small-scale herbal industries.          
Co-Authors Agustinus Alfred Seran Anisa Rachman Aprilia Puji Astuti Arista Wahyu Ningsih A’Yunil Hisbiyah Brelianty Nevy Elly Eka Rahmawati Elsa Saqila Elvira Silvany Zahara Ewalde Yovita Bria Fina Nikmatul Wasi’ah Helmalia Jelita Putri Isafani, Nungki Hatit Ismatun Maulidiyah Jihan Fahiroh Nur Arifin M. Ilham Fannany Magdalena Kasmin Belaon Lebuan Maria Fransiska Silviani Derosari Marscha Dwi Lestari Maulidiyah Cholifah Meiva Shafa Herdini Miya Hartini Nur Wakhid Nadya Tazkiyah Tsabitah Nailah Mutiara Wahid Niken Rahmita Khairani Oktafia Damayanti Retno Wulan Devitri Rusdiana Tri Septiarini Ryan Satria Pranata Safanda Tiara Fitri Silvi Novita Sirojul Eilma Vira Maulidya Windi Tri Wahyuni Yasmine Eka Maulidya Zahratul Humaidah Zakkiya Sabila