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DIFFERENCES IN DWI IMAGE INFORMATION WITH VARIATION IN B-VALUE IN MRI BRAIN CASES TUMOR Febriana, Chindi; Susanto, Fani; Fitriana, Lutfatul; Oviyanti, Pradana Nur
Medical Imaging and Radiation Protection Research Journal Vol 3 No 2 (2023): Medical Imaging and Radiation Protection Research (MIROR) Journal
Publisher : LPPM Universitas Awal Bros

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54973/miror.v3i2.358

Diffusion Weighted Imaging (DWI) is a sequence used in brain tumor cases to assess molecular movement (diffusion). DWI is influenced by the selection of the b-value parameter which results in differences in the generated signal. The aim of this study is to determine the differences in b-value variations of 500, 1000, 1500 s/mm2 in brain tumor cases and identify the most optimal variation. This study is a pre-experimental study conducted using a 1.5 Tesla Philips MRI machine at a private hospital in South Jakarta from March to April 2023. The sample consisted of twelve DWI MRI images with different b-value variations. Visual grading analysis was performed by three radiology specialists, and the data were analyzed using the Friedman test in SPSS. The results showed a significant difference in image information based on the use of different b-value variations, with a pvalue of 0.05 (2.36). The use of a b-value of 1000 s/mm had the highest mean rank in the basal ganglia, cerebellum, thalamus, pons, gray matter, and lesions. The difference in image information with b-value variations visualized different brain tumor representations due to increased noise with higher b-values and suboptimal image sharpness with lower b-values due to low signal intensity. The use of b-value variations of 500, 1000, 1500 s/mm2resulted in differences in anatomical image information in sequences DWI MRI brain axial of brain cases tumor due to differences in image noise and signal intensity, with a b-value of 1000 s/mm being the most optimal variation.

STUDI KUALITATIF: ANALISIS INFORMASI ANATOMI PADA VARIASI SLICE THICKNESS MSCT SCAN ORBITA DENGAN MEDIA KONTRAS POTONGAN AXIAL MPR Utami, Hernastiti Sedya; Azizah, Atika Nur; Maulana, Andi Muh.; Susanto, Fani; Oviyanti, Pradana Nur
Jurnal Kesehatan Vol 14, No 1 (2023)
Publisher : Sekolah Tinggi Ilmu Kesehatan (STIKes) Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38165/jk.v14i1.342

Struktur anatomi orbita sangat kompleks sehingga memerlukan detail yang baik pada msct scan untuk melihat patologi orbita. Salah satu parameter pada msct scan orbita untuk mengetahui keakuratan struktur anatomi orbita adalah ketebalan irisan. menurut literatur ketebalan irisan untuk orbital 2mm. Sedangkan literatur lain mengatakan 3-5 mm. Tujuan dari penelitian ini adalah untuk menganalisis informasi citra yang dihasilkan dengan variasi ketebalan irisan pada orbital ct scan.Metode penelitian ini menggunakan jenis penelitian kualitatif dengan studi eksperimen. Populasi dan sampel adalah 15 pasien dengan citra MSCT scan orbita dengan rekonstruksi ketebalan irisan media kontras potongan MPR aksial yaitu 1 mm, 2 mm dan 3 mm. Informasi citra yang dinilai adalah akurasi, kejelasan struktur dan jaringan pada citra ct scan orbita potongan MPR aksial meliputi anatomi tulang hidung, saraf optik, sinus etmoidalis, sinus sfenoid, tulang lakrimal, kornea, lensa, bola mata dan sklera. Pengambilan data dilakukan dengan cara observasi dan kuisioner kepada spesialis radiologi sebagai observer dan analisis data dilakukan dengan menggunakan SPPS uji Friedman test.Hasil dari penelitian ini yaitu terdapat perbedaan antara informasi citra pada variasi ketebalan irisan CT scan MPR aksial orbital dan ketebalan irisan yang dapat memberikan informasi anatomi yang optimal pada citra axial MSCT scan MPR orbital dengan media kontras yaitu 2 mm.Kata kunci : msct scan orbital; ketebalan irisanAbstract The anatomical structure of the orbit is so complex that it requires good detail on CT scan to see the pathology of the orbit. One of the parameters on the orbital ct scan to reveal the accuracy of the orbital anatomical structure is slice thickness. according to the slice thickness literature for orbital 2mm. Whereas other literature says 3-5 mm. the purpose of this study was to analyze the image information produced with slice thickness variations on ct scan orbitals. The method of this research is qualitative with a experiment study. Population and sample were 15 patients with orbital CT scan images with contrast media slice thickness reconstruction of axial MPR pieces that were 1 mm, 2 mm and 3 mm. Assessed image information is accuracy, clarity of structure and tissue on orbital ct scan images of axial MPR pieces including anatomy of nasal bone, optic nerve, ethmoidal sinus, sphenoid sinus, lacrimal bone, cornea, lens, globe and sclera.Data retrieval is done by observation radiologist and data analysis is carried out by SPSS Friedman test.The result of this research is there is a relationship between image information on slice thickness variations of axial MPR CT scans of orbital and slice thickness which can provide optimal anatomical image information on axial images of MPR CT scans of orbitals with contrast agent that is 2 mm.Keywords: orbital msct scan; slice thickness

Neuroimaging and Intravenous Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke beyond 4.5 Hours: A Systematic Review Ghifari, Muhammad Ramadhan; Deskianditya, Resa Budi; Oviyanti, Pradana Nur; Maatisya, Yuki Fitria; Putri, Vega Pratiwi
AKSONA Vol. 5 No. 1 (2025): JANUARY 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v5i1.62758

Highlight: Ischemic stroke is a major cause of disability and death globally, emphasizing the urgent need for timely and effective thrombolytic interventions within a narrow treatment window. Neuroimaging has the potential to extend the therapeutic window for IV rt-PA beyond 4.5 hours, allowing clinicians to identify patients with salvageable brain tissue for treatment. Extending the IV rt-PA treatment window with neuroimaging support can significantly improve outcomes in stroke patients, although careful risk assessment is crucial. ABSTRACT Introduction: Current guidelines suggest giving intravenous recombinant tissue plasminogen activator (rt-PA) within 4.5 hours after acute ischemic stroke onset or the time the patient was last-seen-well. Patients often arrive at the hospital after 4.5 hours, making thrombolysis treatment challenging. It is crucial to examine expanding this timeframe beyond 4.5 hours of onset or last-seen-well. Objective: This systematic review intended to examine the effectiveness and safety of IV rt-PA in patients presenting to the hospital beyond 4.5 hours of onset or last-seen-well. Methods: We searched PubMed, Scopus, and ScienceDirect for studies on acute ischemic stroke patients treated with IV rt-PA alteplase beyond 4.5 hours of onset or last-seen-well. Outcomes comprised the Modified Rankin Scale (mRS) score, intracranial hemorrhage (ICH), symptomatic ICH, and mortality. We assessed the risk of bias using Cochrane Risk of Bias Vol 2 and ROBINS-I. Results: Eleven randomized controlled trials and observational studies were selected. Most subjects were above 65 years, and their baseline mean or median NIHSS scores were 6–12. Seven studies had specific neuroimaging criteria for eligibility, such as DWI/FLAIR or T2WI mismatch, PWI/DWI mismatch, or CT/MR perfusion. In RCTs, alteplase group had 47.1% to 53.3% favourable results (mRS 0-1) compared to 41.3% to 48.3% in placebo/controls group and 23% to 85% in observational studies. Compared to the placebp/control group and onset within 4.5 hours, alteplase typically had better ourcomes. However, ICH, symptomatic ICH, and mortality were numerically higher, albeit not statistically significant. Conclusion: IV rt-PA alteplase can be given for up to 9-12 hours from onset or last-seen-well with neuroimaging evidence of salvageable tissue, such as the perfusion imaging RAPID criteria or DWI/FLAIR or T2WI mismatch, taking consideration of hemorrhage and mortality concerns.

Comparison of anatomical information of lumbar T2 TSE MRI images with nex variation between use and without sense Safitri, Ara Novita; Susanto, Fani; Rahardian, Arga Pratama; Oviyanti, Pradana Nur; Samudra, Alan
Science Midwifery Vol 13 No 1 (2025): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i1.1911

Due to the long scan time, patients often report pain and discomfort during lumbar MRI examination. NEX and SENSE are two parallel imaging parameters that affect scan time. However, the resulting image information is also affected by NEX and SENSE. Therefore, this study examines the information between NEX variations with and without SENSE on anatomical images and their relationship with scan time on lumbar T2 TSE MRI examinations. This study is quantitative and uses an experimental method. The sample in this study was 10 volunteers who would be given 6 treatments, namely NEX 1 variation without SENSE, NEX 1 with SENSE, NEX 2 without SENSE, NEX 2 with SENSE, NEX 3 without SENSE, and NEX 3 with SENSE on Lumbar T2 TSE MRI examinations in January 2025. Using the Visual Grading Analysis (VGA) method, two radiology specialist observers analyzed the image results. Then the Cohen's Kappa consistency test was carried out and the Friedman test was used to verify the questionnaire results statistically. This study shows that there is a significant difference in the value of image information between NEX 1 variations of vertebral body anatomy with and without SENSE. While in the anatomy of the Intervertebral Disc, Ligament, Spinal Cord, and Spinal Stenosis did not show a significant difference in each variation of NEX with and without SENSE. For scan time, with NEX variations using SENSE requires a shorter scan time compared to without the use of SENSE.

Analysis Pediatric Brain Anatomy and Motion Artifacts Between T2 TSE And T2 TSE Fast Blade Sagittal MRI 3T Rahmayanti LS, Umi; Utami , Hernastiti Sedya; Rahardian, Arga Pratama; Syafi'ie, Mochamad; Oviyanti, Pradana Nur
Eduvest - Journal of Universal Studies Vol. 5 No. 8 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i8.50966

Pediatric brain MRI is vulnerable to patients’ movement due to discomfort, resulting in anxiety, and may increase artifact susceptibility. Sedation is used to keep them calm during the MRI examination but it does not affect pulsation and flow artifacts. Fast acquisition technique and motion insensitive are required. Routine protocols of T2 sagittal pediatric brain MRI uses TSE sequences, but artifacts often appear on the image. BLADE fast imaging sequences are used with a pulse of MRI sequences, one of which is TSE with T2W. This research compared the image information of T2 TSE and T2 TSE fast BLADE sequences in pediatric brain MRI. It is a quantitative study with an experimental approach. The sample in this study was all pediatric Brain MRI examinations ≤5 years with the use of T2 TSE and T2 TSE fast BLADE sequences as many as 32 patients. Assessment of MRI image information was performed by 3 observers through visual grading analysis of sagittal brain anatomy image information and motion artifact, the data were analyzed using the Wilcoxon signed Rank Test. The results of the p-value statistical test showed that T2 TSE fast BLADE is significantly superior (p < 0.05) compared to T2 TSE in visualizing the overall anatomy and minimizing artifacts, image sharpness, lesion detection and diagnostic reliability of sagittal pediatric brain MRI. The conclusion T2 TSE fast BLADE sequence can be recommended in pediatric brain MRI examination because BLADE can eliminate all motion artifacts and produce optimal image information.

DIFFERENCES IN DWI IMAGE INFORMATION WITH VARIATION IN B-VALUE IN MRI BRAIN CASES TUMOR Febriana, Chindi; Susanto, Fani; Fitriana, Lutfatul; Oviyanti, Pradana Nur
Medical Imaging and Radiation Protection Research Journal Vol 3 No 2 (2023): Medical Imaging and Radiation Protection Research (MIROR) Journal
Publisher : LPPM Universitas Awal Bros

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54973/miror.v3i2.358

Diffusion Weighted Imaging (DWI) is a sequence used in brain tumor cases to assess molecular movement (diffusion). DWI is influenced by the selection of the b-value parameter which results in differences in the generated signal. The aim of this study is to determine the differences in b-value variations of 500, 1000, 1500 s/mm2 in brain tumor cases and identify the most optimal variation. This study is a pre-experimental study conducted using a 1.5 Tesla Philips MRI machine at a private hospital in South Jakarta from March to April 2023. The sample consisted of twelve DWI MRI images with different b-value variations. Visual grading analysis was performed by three radiology specialists, and the data were analyzed using the Friedman test in SPSS. The results showed a significant difference in image information based on the use of different b-value variations, with a pvalue of 0.05 (2.36). The use of a b-value of 1000 s/mm had the highest mean rank in the basal ganglia, cerebellum, thalamus, pons, gray matter, and lesions. The difference in image information with b-value variations visualized different brain tumor representations due to increased noise with higher b-values and suboptimal image sharpness with lower b-values due to low signal intensity. The use of b-value variations of 500, 1000, 1500 s/mm2resulted in differences in anatomical image information in sequences DWI MRI brain axial of brain cases tumor due to differences in image noise and signal intensity, with a b-value of 1000 s/mm being the most optimal variation.

Comparison of Agatston Score Calculation Between the Syngo.Via Automated Method and the Manual Method in Non-Contrast Cardiac CT Muaziz, Agil Abdul; Utami, Hernastiti Sedya; Oviyanti, Pradana Nur; Supriyadi, Supriyadi; Nugraha, Fathur Rahman
Jurnal Health Sains Vol. 7 No. 4 (2026): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v7i4.2826

In clinical practice, the Agatston Score can be calculated manually or automatically using post-processing software such as Syngo.Via; However, the difference in absolute values between these methods can affect clinical interpretation. The study aimed to compare measurements of the Agatston Score obtained using the Syngo.Via automated method and manual calculations on non-contrast cardiac CT, with an emphasis on measurement differences, suitability, and reliability. A quantitative observational analytical study was conducted using retrospective no-contrast cardiac CT data from 20 subjects. The Agatston score is calculated automatically using Syngo.Via and manually using the Weasis software on the same image dataset. The difference in measurement was analyzed descriptively and tested for normality. Statistical differences were evaluated using the Wilcoxon Signed Rank Test, suitability was evaluated using Bland–Altman analysis, and reliability was evaluated using the Intraclass Correlation Coefficient (ICC) with a two-way mixed effect model and absolute suitability. Results showed that a difference between the method was not normally distributed and a statistically significant difference in the Agatston score was observed (p < 0.05). The Bland–Altman analysis showed that most of the differences were distributed around the zero line with a few outliers, while the ICC analysis revealed a very high reliability between the two methods (ICC = 1,000). In conclusion, the automatic and manual measurement of the Agatston Score showed excellent reliability and good agreement despite the statistically significant differences in absolute values, suggesting that the two methods could be compared.

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