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All Journal Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Martabe : Jurnal Pengabdian Kepada Masyarakat Eksakta : Berkala Ilmiah Bidang MIPA Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Penelitian Farmasi dan Herbal Jurnal Kesehatan Tambusai Jurnal EduHealth Borneo Journal of Pharmacy
Muchlisin, M. Artabah
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Journal : Pharma Xplore : Jurnal Sains dan Ilmu Farmasi

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PEMANFAATAN SENYAWA METABOLIT SEKUNDER KAWISTA (Limonia acidissima) UNTUK PENGELOLAAN DIABETES: TINJAUAN ANALISIS JEJARING FARMAKOLOGI Hentu, Dina Siti Rahma M.; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Astuti, Engrid Juni; Rafikayanti, Agustin
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 1 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i1.6964

Abstract

This study aims to explore the potential of secondary metabolite compounds from the kawista plant (Limonia acidissima) as antidiabetic agents through an in silico approach. We utilized pharmacological network analysis and analysis of the most important proteins to identify potential protein targets and signaling pathways involved in diabetes regulation. The analysis revealed that secondary metabolite compounds from kawista have the potential to affect various crucial aspects of glucose and lipid metabolism in the body, including through interactions with key proteins such as AKT1. These findings provide new insights into the development of additional therapies for diabetes treatment, and demonstrate the potential of in silico methods in accelerating the discovery and development of new drugs.
Co-Authors Ahmad Shobrun Jamil Almutahrihan, Irsan Fahmi Azka Khoirunnisa Bambang Tri Purwanto Bilgis Nurfatiyah, Rize Dina Siti Rahma M. Hentu Engrid Juni Astuti Hentu, Dina Siti Rahma M. Huda Prastyo, Miftahul Ikka Choirun Nisa, Vasda Irsan Fahmi Almuhtarihan Lena, Nour M. Helmi Pertiwi, Cinta Junaidi Putri Puspaweni, Hestining Rafikayanti, Agustin Rohmaturrizqi, Arvil Satriawan, Herland Siswandono, Siswandono Tri Widiandani Veda, Adella Infia Helga wahyuni, reni sri