Article Per Year (5 Year)
p-Index From 2021 - 2026
1.835
P-Index
This Author published in this journals
All Journal Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas JRST (Jurnal Riset Sains dan Teknologi) Martabe : Jurnal Pengabdian Kepada Masyarakat Eksakta : Berkala Ilmiah Bidang MIPA Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Penelitian Farmasi dan Herbal Jurnal Kesehatan Tambusai Jurnal EduHealth Borneo Journal of Pharmacy
Muchlisin, M. Artabah
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

Published : 12 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 12 Documents
Search

 1   2 
PENDAMPINGAN FORMULASI DAN USAHA DETERJEN CAIR LAUNDRY Chasanah, Uswatun; Muchlisin, M. Artabah
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 5, No 3 (2022): Martabe : Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v5i3.979-984

Abstract

Pandemi Covid 19 bukan hanya berpengaruh pada kesehatan, namun juga pada aspek sosial dan ekonimi. Adanya kebijakan Pemberlakukan Pembatasan Kegiatan Masyarakat (PPKM) pada masa Pandemi Covid 19 mengakibatkan pertumbuhan ekonomi menurun, daya beli masyarakat semakin lemah, dan angka kemiskinan semakin tinggi. Telah dilakukan Program Pengabdian kepada Masyarakat berupa kegiatan pendampingan formulasi dan pemasaran detergen cair laundry kepada Mitra adalah kelompok PKK Rt 04. Rw 09 kelurahan Sisir, kota Batu yang diwakili oleh seksi usaha. Tujuan dari kegiatan ini adalah untuk meningkatkan ketrampilan dan pemberdayaan ekonomi masyarakat. Metode dari kegiatan adalah dengan cara ceramah tentang teori formulasi deterjen cair laundry, setelah itu dilanjutkan dengan pelatihan / praktek  pembuatan deterjen cair laundry sampai diperoleh formula yang layak jual. Karena seksi usaha dalam kesehariannya berprofesi sebagai pedagang offline dan online, sehingga untuk pemasaran hasil produksi bukan menjadi masalah. Hasil dari kegiatan ini adalah masyarakat sekitar bisa mendapatkan produk deterjen cair laundry dengan harga ekonomis, sedangkan bagi personal seksi usaha, mereka mendapat tambahan sumber penghasilan. Tambahan lagi ada pemasukan kas untuk PKK.
Discovery of Novel GLUT4 Inhibitors from Kawista (Limonia Acidissima L.) Bioactive Compounds Through in Silico Approaches Muchlisin, M. Artabah; Astuti, Engrid Juni; Cahyani, Aura Lintang Ayu; Andita, Felia Rahma Cahya; Abdillah, Nur Islami Vikri; Inayah, Aghnia Fuadatul; Fakih, Taufik Muhammad
JRST (Jurnal Riset Sains dan Teknologi) Volume 10 No. 1, March 2026: JRST
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/jrst.v10i1.28366

Abstract

GLUT4 (Glucose Transporter Type 4) is a key regulator of glucose homeostasis in muscle and adipose tissues. Although inhibition of GLUT4 may exacerbate hyperglycemia in diabetes, it represents a potential therapeutic strategy in cancer by limiting glucose uptake in cells reliant on aerobic glycolysis (the Warburg effect). Natural secondary metabolites are promising candidates for modulating GLUT4 activity. This study aimed to identify potential GLUT4 inhibitors from bioactive compounds of Limonia acidissima (kawista) using in silico approaches. Secondary metabolites of kawista were screened for ADMET properties and oral bioavailability. Molecular docking was performed against the cryo-EM structure of GLUT4 (PDB ID: 7WSM), followed by 200 ns molecular dynamics simulations for the top-ranked ligands. Structural stability was evaluated using RMSD, RMSF, radius of gyration (Rg), and solvent-accessible surface area (SASA). Binding free energies were calculated using the MM-PBSA method. Docking analysis showed that the native ligand cytochalasin B exhibited strong binding affinity (−9.13 kcal/mol, Ki 202.26 nM). Among 43 kawista metabolites, stigmasterol (−8.6 kcal/mol, Ki 494.04 nM) and lupeol (−7.91 kcal/mol, Ki 1.58 μM) demonstrated the most favorable binding affinities. Molecular dynamics simulations revealed stable protein–ligand complexes, with RMSD values ranging from 2.0 to 3.5 Å. RMSF analysis indicated stable key binding residues (Gln298, Gln299, Asn304, Gly400, Trp428, and Asn427), except for Trp404, which showed higher fluctuation in the lupeol complex. Rg and SASA values remained relatively constant, indicating compact and stable complexes. MM-PBSA analysis confirmed that stigmasterol exhibited the most favorable binding free energy, closely comparable to cytochalasin B. These findings suggest that stigmasterol and lupeol from Limonia acidissima are promising GLUT4 inhibitors, with stigmasterol demonstrating the most stable interaction and favorable binding profile. This study highlights the potential of kawista-derived metabolites as lead compounds for further development of GLUT4-targeted anticancer agents.
Co-Authors Abdillah, Nur Islami Vikri Ahmad Shobrun Jamil Almutahrihan, Irsan Fahmi Andita, Felia Rahma Cahya Azka Khoirunnisa Bambang Tri Purwanto Bilgis Nurfatiyah, Rize Cahyani, Aura Lintang Ayu Dina Siti Rahma M. Hentu Engrid Juni Astuti Hentu, Dina Siti Rahma M. Huda Prastyo, Miftahul Ikka Choirun Nisa, Vasda Inayah, Aghnia Fuadatul Irsan Fahmi Almuhtarihan Lena, Nour M. Helmi Pertiwi, Cinta Junaidi Putri Puspaweni, Hestining Rafikayanti, Agustin Rohmaturrizqi, Arvil Satriawan, Herland Siswandono, Siswandono Taufik Muhammad Fakih Tri Widiandani Uswatun Chasanah Veda, Adella Infia Helga wahyuni, reni sri