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All Journal Journal of Agromedicine and Medical Sciences Ahmad Dahlan Medical Journal
Awisarita, Wiwara
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Overview of Tuberculosis Epidemiology at PKU Muhammadiyah Bantul Hospital in 2021-2023 Sukirto, Novi; Yuniasih, Dewi; Prisilla, Elvina; Umam Kurniawan, Nurcholid; Budi Rahayu, Ana; Awisarita, Wiwara; Ariani, Rizka
Ahmad Dahlan Medical Journal Vol. 5 No. 1 (2024): May 2024
Publisher : Universitas Ahmad Dahlan

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Abstract

The number of tuberculosis cases reported in Bantul Regency in 2022 was 732 cases. Aims this study to determine the epidemiological picture of tuberculosis in PKU Muhammadiyah Bantul Hospital in 2023. Research method: The research method applied in this study was the analytical observational method. The design in this study was cross-sectional. Tuberculosis cases at PKU Muhammadiyah Bantul Hospital in 2021-2023 experienced fluctuations and based on gender, the most cases were 54% males, the most tuberculosis patients were in the age group of 55-64 years, 86% of patients resided in Bantul Regency, the classification of tuberculosis was more in pulmonary tuberculosis, namely 72%, based on the results of the thoracic examination, 68% were known to be positive for tuberculosis, 17% of tuberculosis patients were accompanied by diabetes mellitus and 2% of tuberculosis patients were confirmed HIV positive. The conclusion is Patients at PKU Muhammadiyah Bantul Hospital were more male than female. Most of the patients in the age group of 55-64 years, and resided in Bantul. The TB diagnosis is most pulmonary tuberculosis, with more positive thoracic examination results, fewer patients with diabetes mellitus, and fewer HIV-positive tuberculosis patients. Keywords: epidemiology, characteristics, tuberculosis
Utilization of Xpert MTB/RIF molecular test and Thorax Radiography as Tuberculosis Screening at PKU Muhammadiyah Bantul Hospital Prisila, Elvina; Sukirto, Novi Wijayanti; Umam Kurniawan, Nurcholid; Rahayu, Ana Budi; Yuniasih, Dewi; Wira Oktaviana, Ardyawati; Putri Nurulita, Febrianti; Sholikhah, Amanatus; Awisarita, Wiwara
Ahmad Dahlan Medical Journal Vol. 5 No. 1 (2024): May 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/admj.v5i1.10428

Abstract

Tuberculosis is a disease caused by the bacteria Mycobacterium tuberculosis, and approximately 25% of the global population is afflicted with this bacterium. In 2022,The objective of this study is to assess the effectiveness of the Xpert MTB/RIF Molecular Test and Thorax Radiography as diagnostic tools for tuberculosis at PKU Muhammadiyah Bantul Hospital. The research employed quantitative methodologies with a cross-sectional design. The majority of tuberculosis suspects at PKU Muhammadiyah Bantul Hospital were individuals aged 64 years or older, based on age group. In terms of gender, 498 individuals were male. According to the Xpert MTB/RIF molecular test, 89 individuals tested positive for tuberculosis. In contrast, the number of individuals who tested positive for tuberculosis through thorax photo examination was 184. The findings indicate that the majority of patients suspected of having Tuberculosis were males and were primarily in the age category of above 64 years old. Thorax photo radiography yielded a higher number of confirmed positive tuberculosis findings compared to the Xpert MTB/RIF molecular test, based on the evaluation of individuals suspected of having tuberculosis.
Computational Prediction of Antimalarial Potential of Eurycoma longifolia Phytochemicals Targeting Plasmodium falciparum Awisarita, Wiwara; Farid, Muhammad
Journal of Agromedicine and Medical Sciences Vol. 11 No. 3 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i3.53732

Abstract

Falciparum malaria, caused by Plasmodium falciparum, remains a major global health threat, complicated by the emergence of drug-resistant strains that undermine the efficacy of current artemisinin-based therapies. Eurycoma longifolia Jack (Pasak Bumi), a medicinal plant native to Southeast Asia, has long been used in traditional medicine for treating malaria and infectious diseases. With increasing resistance of Plasmodium falciparum to conventional drugs, the search for novel antimalarial agents is crucial. This study aimed to predicted the antimalarial potential of bioactive compounds from E. longifolia through a computational approach targeting Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH). Ten phytochemicals were selected and their 3D structures were prepared using PyRx and Open Babel. Molecular docking simulations were conducted using AutoDock Vina, with artemisinin as a control. Docking validation achieved an RMSD of 0.823 Å, confirming protocol reliability. Among the tested ligands, syringic acid showed the highest binding affinity -6.7 kcal/mol, followed by scopoletin -6.6, and fraxidin -6.4, with key interactions involving residues His185, Val532, and Phe188. Toxicological predictions indicated variability, with 1,1′-biphenyl-3,3′-dicarboxylic acid exhibiting the highest acute toxicity. Despite no compound surpassing the native ligand's binding energy -7.9 kcal/mol, several exhibited promising interactions and favorable safety profiles. This study highlights E. longifolia as a promising source of phytochemicals for antimalarial drug discovery. Further experimental studies and molecular dynamics simulations are recommended to validate these findings and optimize compound efficacy.
Co-Authors Ariani, Rizka Budi Rahayu, Ana Muhammad Farid Prisila, Elvina Prisilla, Elvina Putri Nurulita, Febrianti Rahayu, Ana Budi Sholikhah, Amanatus Sukirto, Novi Sukirto, Novi Wijayanti Umam Kurniawan, Nurcholid Wira Okta Viana Yuniasih, Dewi