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All Journal INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Health Information : Jurnal Penelitian Molucca Medica Jurnal Pengabdian Masyarakat : Pemberdayaan, Inovasi dan Perubahan Pakem : Jurnal Pengabdian Kepada Masyarakat Jurnal Inovasi, Pemberdayaan dan Pengabdian Masyarakat Media Penelitian dan Pengembangan Kesehatan
Hasan, Fonnie Esther
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Fungsi Antioksidan dalam Menghambat Peroksidasi Lipid dan Meningkatkan Ketahanan Membran Eritrosit pada Penderita Diabetes Melitus Hasan, Fonnie Esther; Yunus, Reni
Health Information : Jurnal Penelitian Vol 15 No 2 (2023): Mei-Agustus
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36990/hijp.v15i2.901

Abstract

Diabetes melitus (DM) merupakan penyakit kronis yang berakar pada defisiensi insulin, menyebabkan gangguan metabolik dan komplikasi mikro- dan makrovaskular. Hiperglikemia pada DM memicu stres oksidatif dengan peningkatan produksi radikal bebas, merusak vaskular melalui aktivasi jalur diasilgliserol/protein kinase C dan peningkatan aktivitas polyol pathway. Dampak stres oksidatif termanifestasi dalam perubahan komposisi lipid pada membran eritrosit, meningkatkan resistensi aliran mikrovaskular, dan menghasilkan malondialdehyde (MDA) sebagai biomarker stres oksidatif. Sistem proteksi terhadap radikal bebas melibatkan enzim dan antioksidan non-enzimatik, yang bekerja bersama untuk menetralkan efek merusak radikal bebas. Pemahaman mendalam tentang interaksi ini membuka peluang untuk pengembangan strategi pencegahan dan penanganan komplikasi DM secara lebih efektif melalui penelitian lanjutan.
Immunomodulatory activity of kersen leaf extract (Muntingia calabura) on diabetic rats: analysis of immune response Hasan, Fonnie Esther; Yunus, Reni; Magdalena, Magdalena
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 6 No 2 (2024): Promising and valuable research towards diagnosis, prognosis and treatment of dis
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v6i2.5746

Abstract

The immune response to high blood glucose levels leads to an inflammatory response and also produces inflammation mediators. Immunomodulatory functions of Kersen (Muntingia calabura) need further enhancement to ensure that its benefits are more widely recognized by the public. This study aims to determine the immunomodulatory activity of Kersen leaf in inducing and modulating the immune response in diabetic rats. This study was an experimental laboratory with a pre-and post-test with a control group design. The subjects were 30 white rats (Rattus Novergicus Wistar Strain), were treated with extract M. calabura dose 1 (100 mg/kg bw/day), dose 2 (200 mg/kg bw/day), dose 3 (300 mg/kg bw/day). For clinical evaluation, three control groups were formed, including a Normal Control Group, a Diabetes Mellitus (DM) Positive Group, and a DM Positive Group treated with Anti-Diabetic Drugs. The highest amount of IFN-γ concentrations were found in the DM positive control group + antidiabetic drugs (710.3 ± 27.2 ng/mL).  The highest number of Nitrit Oxide (NO) concentration was found in the DM positive control group (103.7 ± 10.2 µmol/L). The highest average amount of pancreatic β cell regeneration was found in the normal control group.  The DM positive control group and the treatment group had a significant difference (p < 0.05) It means that there is a significant difference in the data of all treatment groups, or these three groups have anti-diabetic activity by repairing or preventing damage to the pancreas organ in DM rats. This study revealed that M. calabura possesses immunomodulatory activity, capable of inducing and modulating immune responses in diabetic rats.
Edukasi Efek Protektif dan Pemeriksaan Kadar High Density Lipoprotein Terhadap Perlemakan Hati Pada Masyarakat Desa Awila Kabupaten Konawe Utara Atmaja, Ratih Feraritra Danu; Orno, Theosobia Grace; Hasan, Fonnie Esther
Jurnal Inovasi, Pemberdayaan dan Pengabdian Masyarakat Vol 4 No 2 (2024): Juli- Desember
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36990/jippm.v4i2.1608

Abstract

Low high density lipoprotein level is one of the dyslipidemia conditions that can increase the risk of non-alcoholic fatty liver. Public knowledge about the different functions of fat components, especially HDL, is important to reduce the incidence of fatty liver including other complications such as metabolic syndrome and cardiovascular-related diseases. This activity aims to educate the public about the function of HDL as well as determine the HDL levels of each individual. This activity involved a team of lecturers, students of Poltekkes Kemenkes Kendari, media and 40 community members of Awila Village, Molawe District, North Konawe Regency as participants. This activity includes education, interactive discussions and checking community HDL levels. From the results of the activity, the post-education post-test results increased to 65% from 45% in the pre-test. The HDL level check showed that 55% of the participants had low HDL levels. Educational activities regarding the protective function and food sources high in HDL still need to be done in the community to improve the mindset related to fat and increase public awareness of the complications caused by the disease.
Upaya Pencegahan Penyakit Jantung Koroner Melalui Kegiatan Deteksi Dini Dislipidemia Pada Siswa Kelas XII SMA Negeri 1 Soropia Usman, Julianti Isma Sari; Hasan, Fonnie Esther; Fauzi, Ahmad Zil; Hasan, Aswiro
Jurnal Pengabdian Masyarakat: Pemberdayaan, Inovasi dan Perubahan Vol 5, No 1 (2025): JPM: Pemberdayaan, Inovasi dan Perubahan
Publisher : Penerbit Widina, Widina Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59818/jpm.v5i1.937

Abstract

Dyslipidemia is a condition where the level of fat in the blood exceeds the normal level allowed in the body, therefore routine screening is important for early detection and can prevent or delay death. Screening for lipid disorders in young adults may indicate risk for future cardiovascular events. For screening dyslipidemia in high school adolescents. Implementation of community service is carried out by conducting assessments and permits for carrying out activities at SMA Negeri 1 Soropia, providing education about dyslipidemia and carrying out lipid profile checks and measuring blood pressure in class XII students of SMA Negeri 1 Soropia. Class XII students consisted of 24 boys (56%) and 19 girls (44%). From the results of early detection of dyslipidemia, it was found that 2 teenagers (5%) had symptoms of dyslipidemia and 41 people (95%) were normal and the results of blood pressure measurements were 21 people (48%) had normal blood pressure, 11 people (26%) had hypertension and 11 hypotensive people (26%). Early detection of dyslipidemia in class XII students provides an initial understanding of their health condition and encourages healthy lifestyle changes.ABSTRAKDislipidemia ialah kondisi dimana kadar lemak dalam darah melebihi kadar normal yang diperbolehkan di dalam tubuh, untuk itu skrining rutin penting untuk deteksi dini dan dapat mencegah atau menunda kematian. Skrining gangguan lipid pada dewasa muda dapat mengindikasikan risiko kejadian kardiovaskular di masa depan. Sebagai skrining dislipidemia pada remaja SMA. Pelaksanaan pengabdian kepada masyarakat dilakukan dengan penjajakan dan perizinan untuk pelaksanaan kegiatan di SMA Negeri 1 Soropia, memberikan edukasi mengenai dislipidemia serta melakukan pemeriksaan profil lipid dan pengukuran tekanan darah pada Siswa kelas XII SMA Negeri 1 Soropia. Siswa kelas XII yang terdiri dari 24 orang laki-laki (56%) dan 19 orang perempuan (44%). Dari hasil deteksi dini dislipidemia ditemukan 2 orang remaja (5%) dengan gejala dislipidemia dan 41 orang (95%) normal dan hasil pengukuran tekanan darah sebanyak 21 orang (48%) memiliki tekanan darah normal, hipertensi 11 orang (26%) dan 11 orang hipotensi (26%). Deteksi dini dislipidemia pada siswa kelas XII memberikan pemahaman awal mengenai kondisi kesehatan mereka dan mendorong perubahan gaya hidup sehat.
EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura) MENINGKATKAN KETAHANAN MEMBRAN ERITROSIT TIKUS YANG DIPERLAKUKAN DIABETES MELLITUS Hasan, Fonnie Esther; Gobel, Sri Yunanci Van; Magdalena, Magdalena; Fristiohady, Adryan; Yunus, Reni
Media Penelitian dan Pengembangan Kesehatan Vol. 33 No. 2 (2023): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v33i2.1843

Abstract

The condition of Diabetes Mellitus (DM) due to hyperglycaemia can induce free radicals and decreased oxidant defence system, chronic hyperglycaemia will result in increased production of free radicals resulting in oxidative stress. The aim of this study was determine the oxidant activity of Kersen Leaf Extract in increasing the resistance of erythrocyte membranes in rats treated with diabetes mellitus by measuring the activity of Malondialdehyde (MDA) and measuring the percentage of erythrocyte cells that are hemolyzed. This study was conducted in vivo by examining the antioxidant activity of Muntingia calabura L. by measuring the levels of MDA and membrane resistance in diabetic rats. This study used animal model Rattus Norvegicus Wistar strain, total of 30 rats was divided into six groups with 5 rats in each group, which are negative control group, positive control group, positive control was added standard drug group, and diabetic rats. Kersen (Muntingia calabura L.) leaves extract reduced Malondialdehyde (MDA) levels of erythrocytes in diabetic rats at an optimum dose of 400 mg/kg of weight per day with a mean MDA value of 4.91 ± 2.1 µmol/ml. In addition, can reduce the amount of hemolysis of erythrocytes in diabetic rats at an optimum dose of 400 mg/kg of weight per day, and can reduce the number of abnormal erythrocytes in rats treated with diabetes mellitus with an optimum dose of 400 mg/kg bw/day with a mean haemolysis value of 33.34 ± 4.04%. Kersen (Muntingia calabura L) leaf extract increases the resistance of erythrocyte of diabetic rat’s.
PROFIL PENANDA FUNGSI HATI PADA PASIEN TUBERKULOSIS DI KOTA KENDARI Fauzi, Ahmad Zil; Yunus, Reni; Hasan, Fonnie Esther; Sari, Julianti Isma
Molucca Medica Vol 17 No 2 (2024): VOLUME 17, NOMOR 2, OKTOBER 2024
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/molmed.2024.v17.i2.124

Abstract

Tuberkulosis adalah penyakit pernapasan akut yang disebabkan oleh Mycobacterium tuberculosis yang dapat berdampak pada fungsi pernapasan. Penanganan penyakit tuberkulosis adalah dengan kepatuhan minum obat, akan tetapi masih ditemukan adanya kasus Multidrugs Resistensi Antibiotik yang diketahui dapat memberikan efek samping salah satunya hepatotoksik. Tujuan penelitian ini adalah untuk melakukan pemeriksaan penanda fungsi hati pada pasien tuberkulosis di Kota Kendari diantaranya bilirubin total, Serum Glutamic Oxaloacetic Tranaminase (SGOT) dan Serum Glutamic Piruvic Tranaminase (SGPT) dengan metode fotometri. Jenis penelitian ini adalah penelitian deskriptif kuantitaif dengan pendekatan cross sectional. Teknik sampling yang digunakan adalah purposive sampling, sesuai dengan kriteria sampel yang telah ditetapkan. Hasil penelitian menunjukkan terdapat 58 dari 60 subjek (97%) memiliki kadar bilirubin normal dengan rerata 0,41 mg/dl, 54 dari 60 subjek (90%) memiliki kadar SGOT normal dengan rerata kadar SGOT sebesar 21 IU/L dan 55 orang dari 60 subjek (92%) memiliki kadar SGPT normal dengan rerata kadar SGPT sebesar 17 IU/L.
SKRINING ANEMIA MELALUI PEMERIKSAAN LABORATORIUM PADA MASYARAKAT PESISIR DESA MEKAR KECAMATAN SOROPIA Sari, Julianti Isma; Orno, Theosobia Grace; Hasan, Fonnie Esther
PAKEM : Jurnal Pengabdian Kepada Masyarakat Vol 3 No 1 (2023): Pakem : Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/pakem.3.1.7-12

Abstract

Anemia was detected from laboratory tests with hemoglobin, hematocrit and erythrocyte levels below the reference value. Anemia can be detected with Point of Care Testing method using and is effective for conducting examinations in areas with a relatively small number of health facilities. The type of method used is analytic observation. This community service aims to screen for anemia by knowing hemoglobin and hematocrit levels. The results of the examination showed that from 50 respondents, the average hemoglobin level had a result below the reference value of 12.0 – 17.0 g/dl and the hematocrit value having a result below the reference value of 37-48%. The average hemoglobin value for men is 12.0 g/dl and for women is 11.9 g/dl. The average hematocrit value for both men and women is 35%. %. With anemia screening conducted, the public can find out hemoglobin and hematocrit levels as an effort to prevent anemia
Co-Authors Atmaja, Ratih Feraritra Danu Fauzi, Ahmad Zil Fristiohady, Adryan Gobel, Sri Yunanci Van Hasan, Aswiro Magdalena Magdalena Reni Yunus, Reni Sari, Julianti Isma Theosobia Grace Orno Usman, Julianti Isma Sari