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All Journal Jurnal Medik Veteriner Narra J
Wibowo, Syahputra
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Inhibition of B-cell activating factor activity using active compounds from Physalis angulata in the mechanism of nephrotic syndrome improvement: A computational approach Kardani, Astrid K.; Fitri, Loeki E.; Samsu , Nur; Subandiyah , Krisni; Endharti, Agustina T.; Nugrahenny, Dian; Wibowo, Syahputra
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.859

Abstract

Nephrotic syndrome, a multifaceted medical condition characterized by significant proteinuria, has recently prompted a reorientation of research efforts toward B-cell-mediated mechanisms. This shift underscores the pivotal role played by B-cells in its pathogenesis. The aim of this study was to explore potential therapeutic pathways, with specific attention given to compounds found in Physalis angulata, including withanolides, such as physalins, which constitute one of the five distinct withanolide subgroups identified in Physalis angulata. Furthermore, the study assessed the monoclonal antibody belimumab, designed to target B-cell activating factor (BAFF) and its associated receptors (TACI, BCMA, and BAFF-R). Various research techniques were employed, encompassing data mining, bioactivity analysis, Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) profiling, molecular modeling, and docking studies. Withanolide was demonstrated as a potential inhibitor for the protein BAFF, showing a binding energy of -7.1 kcal/mol. Physalin F emerged as the leading candidate inhibitor for the protein TACI, with a binding energy of -8.3 kcal/mol. Similarly, withanolide was identified as the top inhibitor candidate for the protein BCMA, exhibiting a binding energy of -7.0 kcal/mol. The most favorable interaction with BAFF-R was physalin F, which displayed a binding energy of -8.0 kcal/mol. Moreover, molecular dynamic simulation suggested that physalin F was able to maintain protein stability, hence being a good inhibitor candidate for BAFF-R and TACI proteins. The results of this investigation demonstrated substantial promise, indicating that these withanolides and withaphysalin A compounds derived from Physalis angulata offer alternative avenues for B-cell targeting. Consequently, this study presents opportunities for pioneering treatments in the management of nephrotic syndrome.
Trypanosoma evansi as a Major Cause of Animal Trypanosomiasis: A Comprehensive Review Warsito, Sunaryo Hadi; Khairullah, Aswin Rafif; Lamid, Mirni; Al-Arif, Mohammad Anam; Hermadi, Herry Agoes; Lokapirnasari, Widya Paramita; Kusala, Muhammad Khaliim Jati; Wibowo, Syahputra; Ayuti, Siti Rani; Wardhani, Bantari Wisynu Kusuma; Fauziah, Ima; Yanestria, Sheila Marty; Moses, Ikechukwu Benjamin; Prasetyo, Agung; Aryaloka, Suhita; Fauzia, Kartika Afrida; Ahmad, Riza Zainuddin; Kurniasih, Dea Anita Ariani
Jurnal Medik Veteriner Vol. 8 No. 2 (2025): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol8.iss2.2025.455-477

Abstract

Trypanosomiasis caused by Trypanosoma evansi is a major protozoan illness that affects animals worldwide. It is also referred to as “surra” and affects a variety if wild and domestic animals such as sheep, cattle, goats, dogs, buffaloes, pigs, elephants, amongst others. In preparing this review, relevant scientific articles were searched on PubMed, SCOPUS, and Web of Science databases using the keyword “Trypanosoma evansi AND animals”. T. evansi are carried by a vast number of hematophagous flies and are found in the extracellular and internal fluids of certain hosts. Trypanosomosis is mostly characterized by anemia, and the degree of anemia can typically be used as a gauge for the disease's severity. Trypanosomiasis compromises the host animal's immune system and its diagnosis is dependent on a number of factors such as thorough clinical examination, suitable sample collection, sample size, suitable diagnostic test performance, and logical interpretation of test results. The clinical manifestations of trypanosomiasis vary widely in both appearance and severity, ranging from neurological disturbances and skin plaques to vaginal enlargement. Hematophagous biting flies, including Tabanus, Haematopota, Glossina, Chrysops, Lyperosia, Stomoxys, and Hippobusca flies, contribute to the spread of trypanosomiasis. Four medications are primarily used to treat trypanosomiasis: quinapyramine, karetin, diminazene aceturate (Berenil), and melarsomine (cymelarsan). An efficient vaccination program is an additional technique for managing infectious diseases in addition to treatment. The most important step in curtailing the spread of trypanosomiasis caused by T. evansi is to stop its transmission by flies via physical and chemical methods.
Co-Authors Agung Prasetyo Al arif, Mohammad Anam Aryaloka, Suhita Ayuti, Siti Rani Dian Nugrahenny Endharti, Agustina T. Fauzia, Kartika Afrida Fauziah, Ima Herry Agoes Hermadi Kardani, Astrid K. Khairullah, Aswin Rafif Kurniasih, Dea Anita Ariani Kusala, Muhammad Khaliim Jati Loeki E. Fitri Mirni Lamid Moses, Ikechukwu Benjamin Riza Zainuddin Ahmad Samsu , Nur Sheila Marty Yanestria Subandiyah , Krisni Wardhani, Bantari Wisynu Kusuma Warsito, Sunaryo Hadi Widya Paramita Lokapirnasari