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All Journal Epsilon: Jurnal Matematika Murni dan Terapan Indonesian Journal of Chemistry Jurnal Medik Veteriner SRIWIJAYA JOURNAL OF MEDICINE Narra J
Wibowo, Syahputra
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Transportation Veterinary

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Inhibition of B-cell activating factor activity using active compounds from Physalis angulata in the mechanism of nephrotic syndrome improvement: A computational approach Kardani, Astrid K.; Fitri, Loeki E.; Samsu , Nur; Subandiyah , Krisni; Endharti, Agustina T.; Nugrahenny, Dian; Wibowo, Syahputra
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.859

Abstract

Nephrotic syndrome, a multifaceted medical condition characterized by significant proteinuria, has recently prompted a reorientation of research efforts toward B-cell-mediated mechanisms. This shift underscores the pivotal role played by B-cells in its pathogenesis. The aim of this study was to explore potential therapeutic pathways, with specific attention given to compounds found in Physalis angulata, including withanolides, such as physalins, which constitute one of the five distinct withanolide subgroups identified in Physalis angulata. Furthermore, the study assessed the monoclonal antibody belimumab, designed to target B-cell activating factor (BAFF) and its associated receptors (TACI, BCMA, and BAFF-R). Various research techniques were employed, encompassing data mining, bioactivity analysis, Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) profiling, molecular modeling, and docking studies. Withanolide was demonstrated as a potential inhibitor for the protein BAFF, showing a binding energy of -7.1 kcal/mol. Physalin F emerged as the leading candidate inhibitor for the protein TACI, with a binding energy of -8.3 kcal/mol. Similarly, withanolide was identified as the top inhibitor candidate for the protein BCMA, exhibiting a binding energy of -7.0 kcal/mol. The most favorable interaction with BAFF-R was physalin F, which displayed a binding energy of -8.0 kcal/mol. Moreover, molecular dynamic simulation suggested that physalin F was able to maintain protein stability, hence being a good inhibitor candidate for BAFF-R and TACI proteins. The results of this investigation demonstrated substantial promise, indicating that these withanolides and withaphysalin A compounds derived from Physalis angulata offer alternative avenues for B-cell targeting. Consequently, this study presents opportunities for pioneering treatments in the management of nephrotic syndrome.
Trypanosoma evansi as a Major Cause of Animal Trypanosomiasis: A Comprehensive Review Warsito, Sunaryo Hadi; Khairullah, Aswin Rafif; Lamid, Mirni; Al-Arif, Mohammad Anam; Hermadi, Herry Agoes; Lokapirnasari, Widya Paramita; Kusala, Muhammad Khaliim Jati; Wibowo, Syahputra; Ayuti, Siti Rani; Wardhani, Bantari Wisynu Kusuma; Fauziah, Ima; Yanestria, Sheila Marty; Moses, Ikechukwu Benjamin; Prasetyo, Agung; Aryaloka, Suhita; Fauzia, Kartika Afrida; Ahmad, Riza Zainuddin; Kurniasih, Dea Anita Ariani
Jurnal Medik Veteriner Vol. 8 No. 2 (2025): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol8.iss2.2025.455-477

Abstract

Trypanosomiasis caused by Trypanosoma evansi is a major protozoan illness that affects animals worldwide. It is also referred to as “surra” and affects a variety if wild and domestic animals such as sheep, cattle, goats, dogs, buffaloes, pigs, elephants, amongst others. In preparing this review, relevant scientific articles were searched on PubMed, SCOPUS, and Web of Science databases using the keyword “Trypanosoma evansi AND animals”. T. evansi are carried by a vast number of hematophagous flies and are found in the extracellular and internal fluids of certain hosts. Trypanosomosis is mostly characterized by anemia, and the degree of anemia can typically be used as a gauge for the disease's severity. Trypanosomiasis compromises the host animal's immune system and its diagnosis is dependent on a number of factors such as thorough clinical examination, suitable sample collection, sample size, suitable diagnostic test performance, and logical interpretation of test results. The clinical manifestations of trypanosomiasis vary widely in both appearance and severity, ranging from neurological disturbances and skin plaques to vaginal enlargement. Hematophagous biting flies, including Tabanus, Haematopota, Glossina, Chrysops, Lyperosia, Stomoxys, and Hippobusca flies, contribute to the spread of trypanosomiasis. Four medications are primarily used to treat trypanosomiasis: quinapyramine, karetin, diminazene aceturate (Berenil), and melarsomine (cymelarsan). An efficient vaccination program is an additional technique for managing infectious diseases in addition to treatment. The most important step in curtailing the spread of trypanosomiasis caused by T. evansi is to stop its transmission by flies via physical and chemical methods.
ANALISIS KOMPARATIF METODE DES HOLT’S DAN ARIMA TERHADAP PERAMALAN TINGKAT PENGANGGURAN DI PROVINSI KALIMANTAN SELATAN Oktaviani, Yeni Rahma; Sa'adah, Yalela; Wibowo, Syahputra; Abdurrahman, Saman
EPSILON: JURNAL MATEMATIKA MURNI DAN TERAPAN Vol 19, No 2 (2025)
Publisher : Mathematics Study Program, Faculty of Mathematics and Natural Sciences, Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/epsilon.v19i2.17155

Abstract

Unemployment is crucial issue in South Kalimantan Province as it contribute to increased poverty and the slowing down of regional economic growth. Therefore, reliable forecasting method is needed to support the government in formulating strategic policies. This study aims to compare and identify a representative time series forecasting model for the TPT in South Kalimantan Province. This research compares the performance of the DES Holt 1-parameter, 2 parameter, and ARIMA (1,1,0) models using 19 years of semi-annual unemployment rate data (2005-2024). The models applied parameter optimization for  and , obtained by trial and error and by using R Studio, while accuracy was evaluated using MAPE. The research results show that the DES Holt-2parameter model with optimal parameters  and . Demonstrated better statistical performance compared to the DES Holt 1-parameter and ARIMA (1,1,0) models because it yielded the smallest MAPE error value of 4,66. However, the ARIMA (1,1,0) models is superior because it is more capable of capturing dynamic trend changes in the region, whether the changes are short-term of long-lasting, and can better reflect socioeconomic structural changes. The contribution of this research is to provide a scientific basis and a more superior and representative forecasting model, namely ARIMA (1,1,0), for the South Kalimantan Provincial government in formulating policies for job creation, improving labor productivity, and strengthening the regional economy in a sustainable manner.
A Novel Multiepitope Vaccine for Jembrana Disease: Immunoinformatics, Structural Analysis, Molecular Docking, and Molecular Dynamics Fatimah, Fatimah; Wibowo, Syahputra; Sari, Dini Wahyu Kartika; Pratiwi, Rarastoeti; Kusumawati, Asmarani
Indonesian Journal of Chemistry Vol 26, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.110759

Abstract

Jembrana disease, caused by the Jembrana virus, leads to high mortality (30%) and abortion (49%) in cattle, making vaccination essential. In this study, a multiepitope vaccine was designed using immunogenic TM and CA proteins. Predicted cytotoxic T lymphocyte, helper T lymphocyte, and linear B-cell epitopes were linked with flexible linkers, and the 50S L7/L12 ribosomal protein was added as a TLR4 agonist. In silico analysis confirmed the construct as non-allergenic, antigenic, and thermostable (aliphatic index 85.44), with 94.2% of residues in favored Ramachandran regions. Docking analysis revealed strong binding to TLR4 (−66 kcal/mol), and molecular dynamics simulations validated the structural stability. Immune simulations revealed increased antigen and antibody levels (IgM early, IgG1/IgG2 after day 15), progressive CD4+ T-helper expansion, transient CD8+ T-cell peaks, elevated IFN-γ and IL-2, and strong dendritic cell activation through MHC I and II pathways. These findings indicate the vaccine effectively stimulates humoral and cellular responses, supporting its potential as a promising candidate against the Jembrana virus.
Computational Insights into the Dual Inhibition of PfATP6 and PfCRT by Bioactive Compounds from Spatholobus littoralis Hassk. Wahyuningtias, Dita Sheilla Putri; Putra, Oktavian Arya; Turnip, Laurens Frestasya A.; Ananda, Putu Desy Sagita; Wibowo, Syahputra; Wisynu Kusuma Wardhani, Bantari
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.362

Abstract

The current study examined the antimalarial activity of bioactive compounds extracted from Spatholobus littoralis Hassk. (bajakah wood) by an in-silico approach targeting the Plasmodium falciparum PfCRT and PfATP6 receptors. A total of forty-six phytochemicals were subjected to screening, resulting in the selection of six compounds based on bioactivity prediction, ADMET profiling, and molecular docking analyses.  Ramachandran plots were used to check the accuracy of the model, which showed that the protein structures were reliable.  Milbemycin A4-oxime exhibited the most significant binding affinity (−9.6 kcal/mol for PfCRT and −9.9 kcal/mol for PfATP6). These findings are comparable to or slightly better than those observed for artemisinin in this in silico model. These findings are preliminary and require further experiment. The molecule exhibited persistent interactions and favorable pharmacokinetic properties, indicating its potential use as a multitarget inhibitor.  Quercetin and 8-O-methylretusin had significant efficacy.  These results underscore the potential of S. littoralis metabolites, especially Milbemycin A4-oxime, as candidates for antimalarial drug development; however, additional in vitro and in vivo validation is necessary to establish efficacy and safety.
Co-Authors Agung Prasetyo Al arif, Mohammad Anam Ananda, Putu Desy Sagita Aryaloka, Suhita Asmarani Kusumawati Ayuti, Siti Rani Dian Nugrahenny Endharti, Agustina T. fatimah Fatimah Fauzia, Kartika Afrida Fauziah, Ima Herry Agoes Hermadi Kardani, Astrid K. Khairullah, Aswin Rafif Kurniasih, Dea Anita Ariani Kusala, Muhammad Khaliim Jati Loeki E. Fitri Mirni Lamid Moses, Ikechukwu Benjamin Oktaviani, Yeni Rahma Putra, Oktavian Arya Rarastoeti Pratiwi Riza Zainuddin Ahmad Sa'adah, Yalela Saman Abdurrahman Samsu , Nur Sari, Dini Wahyu Kartika Sheila Marty Yanestria Subandiyah , Krisni Turnip, Laurens Frestasya A. Wahyuningtias, Dita Sheilla Putri Wardhani, Bantari Wisynu Kusuma Warsito, Sunaryo Hadi Widya Paramita Lokapirnasari Wisynu Kusuma Wardhani, Bantari