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All Journal Medicinus : Jurnal Kedokteran International Journal of Public Health Excellence (IJPHE) The International Journal of Medical Science and Health Research Indonesian Journal of Medical and Pharmaceutical Science
Nugroho, Fajar Prianto
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Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Vitamin K Supplementation for Reducing Cardiovascular Events in End-Stage Chronic Kidney Disease: A Systematic Review Liora, Kevin; Wiyono, Putri Dhiya Prameswari; Putra, Ananda; Alexander, Devin; Ramadhan, Afif; Oktavia, Anissya Rima; Larissa, Olivia; Nugroho, Fajar Prianto; Tjahyanto, Teddy
International Journal of Public Health Excellence (IJPHE) Vol. 4 No. 1 (2024): June-December
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v4i1.919

Abstract

This study was conducted to analyze the hSIL of Vitamin K Supplementation in Reducing Cardiovascular Events in End-Stage Chronic Kidney Disease: A Systematic Review. Cardiovascular disease (CVD) is the leading source of morbidity and mortality worldwide, and chronic kidney disease (CKD) is a major contributor to this matter. Kidney disease is estimated to affect over 850 million people worldwide. The present systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. We searched studies from electronic databases (PubMed Central, ScienceDirect, PLoS One, Google Scholar, Nature). Studies were considered eligible if they met the following criteria : (1) the study is a randomized controlled trial (RCT), (2) the study was published in the last 5 years (2018– 2022), (3) the study participants were adult patients with kidney disease from stage III to end-stage who were given vitamin K supplementation, (4) the study reported coronary artery calcium scores pre- and post- vitamin K supplementation, (5) the study was published in English. Risk of bias of each study was evaluated using Cochrane Risk of Bias (RoB) 2 tool. Data were descriptively examined and narratively reported. In conclusion, our results do not suggest that vitamin K supplementation may affect vascular calcification as measured by the CAC score. Up till now there is no treatment to reverse vascular calcification in ESKD patients. The current clinical practice should focus on prevention and retardation of its progression.
The Analysis Study of Hemolysis due to Blood Warming during Blood Transfusion : A Comprehensive Systematic Review Nugroho, Fajar Prianto; Indra, Muhammad
The International Journal of Medical Science and Health Research Vol. 5 No. 1 (2024): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/6zhjkj65

Abstract

Introduction: Over recent decades, blood transfusion practices have significantly evolved, particularly in trauma care, surgery, obstetrics, and intensive care settings. This systematic review explores the relationship between blood warming, pressure, and hemolysis, aiming to provide evidence-based guidelines for safe transfusion practices. Methods: This systematic review follows PRISMA 2020 guidelines. We include studies from 2004 to 2024, focusing on hemolysis rates related to blood warming, transfusion outcomes, and safety thresholds for warming temperatures and pressures. A search across PubMed, ScienceDirect, and Sagepub yielded studies meeting these criteria. Data extraction focused on study characteristics, warming techniques, hemolysis rates, and outcomes. Results: Most studies indicated that blood warmers effectively raise temperatures without significantly increasing hemolysis under controlled conditions. However, higher flow rates and temperatures above 37°C increase the risk of hemolysis. While current blood warming devices are generally safe, there is variability in their performance based on flow rates and clinical settings. Conclusion: Blood warming devices are effective tools for preventing hypothermia during transfusions but must be carefully used to avoid hemolysis. Further research is needed to optimize protocols for different clinical contexts and patient populations to ensure safe and effective transfusions
Hypoalbuminemia as a Predictor of Outcomes in Acute Myeloid Leukemia: A Systematic Review and Meta-Analysis Jacobs, Christin Yosefin; Nugroho, Fajar Prianto; Amelia, Sesa; Pannaausten, Davin; Almaszahra, Annisa Naufal; Prayogo, Andi Bagus; Jessica; Pranata, Jimmy Angga
Medicinus Vol. 14 No. 2 (2025): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v14i2.9548

Abstract

Background : In acute myeloid leukemia (AML), hypoalbuminemia has been observed at diagnosis and during treatment, often correlating with poor clinical outcomes such as reduced remission rates, increased treatment-related toxicity, and shorter overall survival (OS). This systematic review and meta-analysis aim to investigate the prognostic value of hypoalbuminemia in patients with AML. Methods : A comprehensive literature search was conducted across PubMed, EMBASE, and Scopus to identify relevant studies published up to January 5, 2025. The search strategy included a combination of Medical Subject Headings (MeSH) terms and keywords such as “hypoalbuminemia,” “acute myeloid leukemia,” “AML,” “serum albumin,” “prognosis,” and “outcomes.” Boolean operators (AND, OR) were applied to refine the search. Result : This systematic review and meta-analysis included 10 studies with a total sample size of 4,105 participants, of which 2,134 were male, comparing normal albumin levels to hypoalbuminemia across diverse populations. The meta-analysis comparing OS between AML patients with hypoalbuminemia and normal serum albumin levels shows a pooled HR of 1.08 (95% CI: 0.81–1.44). Conclusions : While this meta-analysis suggests a potential association between hypoalbuminemia and poorer OS and DFS in AML patients, the lack of statistical significance and high heterogeneity caution against definitive conclusions.
Pengaruh Konsumsi Metformin terhadap Kejadian Anemia pada Penderita Diabetes Melitus Tipe 2 Nugroho, Fajar Prianto; Wisnuwardhani, Ratih Wirapuspita
Indonesian Journal of Medical and Pharmaceutical Science Vol. 4 No. 1 (2025)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v4i1.377

Abstract

Background: Diabetes mellitus is a chronic situation which is indicated by blood sugar levels that is higher than normal values, encompassing two types: type 1 and type 2. Type  2, also known as non-insulin dependent type of diabetes mellitus, can be treated managed with oral  anti-diabetic drugs (OADs). Metformin is a routinely used medication for type 2 diabetes and  is associated with long-term vitamin B12 deficiency,potentially leading to anemia. This study aimed to study the impact on metformin usage on the occurrence of anemia in type 2 diabetes mellitus patients at the Clinic in region S. Methods: This research employed a quantitative observational analytical approach with a cross-sectional data collection. The sample consisted of 62 individuals with type 2 diabetes mellitus who were taking metformin and were registered in the PROLANIS program at the Clinic in region S. Venous blood samples were collected and analyzed in the laboratory.The Pearson test was used to analysed the data. Results: The findings of this study indicated that the distribution of blood hemoglobin levels within the normal range, with an average hemoglobin level of 12.6 grams/dL. The usage of metformin did not have an effect on blood hemoglobin levels. Conclusion: This study concluded that metformin usage does not impact hemoglobin levels in patiens with type 2 diabetes mellitus.
Co-Authors Afif Ramadhan, Afif Alexander, Devin Almaszahra, Annisa Naufal Amelia, Sesa Jacobs, Christin Yosefin Jessica Larissa, Olivia Liora, Kevin MUHAMMAD INDRA Oktavia, Anissya Rima Pannaausten, Davin Pranata, Jimmy Angga Prayogo, Andi Bagus Putra, Ananda Tjahyanto, Teddy Wisnuwardhani, Ratih Wirapuspita Wiyono, Putri Dhiya Prameswari