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All Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Dentino: Jurnal Kedokteran Gigi Berkala Kedokteran The Indonesian Biomedical Journal SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Respirologi Indonesia YARSI Medical Journal Homeostasis: Jurnal Mahasiswa Pendidikan Dokter Borneo Journal of Pharmacy

Mashuri, Mashuri

Department Of Radiology, Faculty Of Medicine And Health Sciences, Universitas Lambung Mangkurat

Author-ID : 743225

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Kajian Stress Oksidatif Pada Bayi Prematur Setiawan, Bambang; Suhartono, Eko; Mashuri, Mashuri
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 5, No 1 (2005)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Preterm babies can be considered as a disease with an oxidative stress compo-nent. Beside that, in preterm babies found any disease which have causal link with the action of reactive oxygen species. Damaged which mediated by reactive oxygen species caused bay decreased of endogenous antioxidant defense. In the hospital preterm babies can expose by some source o oxidative stress, such blood transfusion, high concentration oxygen therapy, and parenteral nutrition feeding.Bayi prematur dapat dipertimbangkan sebagai penyakit akibat komponen stress oksidatif. Kerusakan yang ditimbulkan oleh Senyawa Oksigen Reaktif tersebut diperantarai oleh rendahnya sistem antioksidan endogen. Di samping itu, dalam perawatan di rumah sakit, bayi prematur sering terpajan berbagai kondisi yang merupakan sumber stress oksidatif. Kondisi tersebut dapat berupa transfusi darah, terapi oksigen konsentrasi tinggi, dan pemberian makan dengan nutrisi parenteral.

MODEL PEMBENTUKAN ADVANCED GLYCATION END PRODUCTS (AGES) DAN DEGRADASI TIROSIN AKIBAT REAKSI MAILLARD Suhartono, Eko; Setiawan, Bambang; Mashuri, Mashuri
Jurnal Kedokteran YARSI Vol 13, No 1 (2005): JANUARI - APRIL 2005
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jky.v13i1.1050

Maillard reaction or glycosylation reaction is a reaction between amine group and aldehyde group from glucose to form dicarbonyl compound and Advanced Glycation End Products (AGEs). The formation of AGEs have a role in diabetic complications. This work was conducted study the tyrosine degradation reaction model and the formation of AGEs caused by Maillard reaction. The research design was an experimental study with pre and posttest control group design with followed up posttest in 48 hours to 20 days. Two solutions, A and B were used; solution A was a mixture of BSA 30% + buffer phosphate pH 7 + aquadest, and solution B was BSA 30%+ buffer phosphate pH 7+ aquadest+ glucose. The degradation of tyrosine was measured by its absorbance at l=470 nm and the absorbance of AGEs formation at l=340 nm. Model of AGEs formation in solution A followed the equation of Y=0,0289X ? 0,01847 with correlation coefficient R2=0,9767, where as that in solution B followed equation of Y=0,6552X ? 1,5267 with correlation coefficient R2=0,9463. The tyrosine degradation model in solution A followed equation of Y=-0,1232X + 2,7166 with correlations coefficient R2=0,9175 where as that in solution B followed equation of Y=-0,03552X + 0,7762 with coefficient of correlation R2=0,9175. Negative value was observed in correlation between AGEs absorbance with tyrosine in solution A and B reflecting the formation of AGEs followed by tyrosine degradation

KORELASI PANJANG LENGAN BAWAH DAN TINGGI BADAN MAHASISWI SUKU BANJAR FAKULTAS KEDOKTERAN UNIVERSITAS LAMBUNG MANGKURAT Iwan Aflanie; Nurul Qomariah; Mashuri Mashuri
Berkala Kedokteran Vol 13, No 1 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Estimated height has an important role in identifying unknown bodies, incomplete, and the residual bone. Measurements in the long bones such as the forearm are better used to determine the height because it is the best result among the other members of the body size. The purpose of this study was to analyzed a correlation between the forearm length with the height of Banjar Tribe’s students of Medical Faculty of Lambung Mangkurat University and to obtain height estimation formula based on the forearm length in Banjar Tribe’ female. The research method is an analytical observation with cross sectional approach. The research subjects were taken by purposive sampling with samples of 52 people and were analyzed by Pearson correlation and linear regression analysis. The results of Pearson test showed that the value of p = 0,00 for the right and left arm with the value of r = 0.974 for the right arm and r = 0.972 for the left arm, which means there is a very strong relationship between the forearm length with height. It is concluded that there is a very strong correlation between the forearm length with students height of Banjar tribe Medical Faculty of Lambung Mangkurat University with height estimation formula Height = 63,838 + 3,693 x length of the right forearm and Height = 61,873 + 3,780 x left forearm length. Keywords: identification, height estimation, Banjar tribe’ female Abstrak: Memperkirakan tinggi badan mempunyai peranan penting dalam mengidentifikasi jenazah tidak dikenal, tidak lengkap, dan sisa tulang. Pengukuran pada tulang panjang seperti lengan bawah lebih baik digunakan untuk menentukan tinggi badan karena merupakan hasil terbaik diantara ukuran anggota tubuh yang lain. Penelitian ini bertujuan menganalisis korelasi antara panjang lengan bawah dengan tinggi badan dan mendapatkan formula estimasi tinggi badan berdasarkan panjang lengan bawah pada mahasiswi suku Banjar Fakultas Kedokteran Universitas Lambung Mangkurat. Metode penelitian adalah observasional analitik dengan pendekatan cross sectional. Pengambilan subjek penelitian dengan cara purposive sampling dengan jumlah sampel sebanyak 52 orang. Analisis yang digunakan dengan analisis korelasi Pearson. Hasil uji Pearson didapatkan nilai p = 0,00 untuk lengan kanan dan kiri. Hubungan antara panjang lengan bawah kanan dengan tinggi badan memiliki nilai r = 0,974, sedangkan hubungan antara panjang lengan bawah kiri dengan tinggi badan memiliki nilai r = 0,972. Kesimpulan penelitian ini adalah terdapat korelasi yang sangat kuat antara panjang lengan bawah dengan tinggi badan pada mahasiswi suku Banjar Fakultas Kedokteran Universitas Lambung Mangkurat dengan formula estimasi tinggi badan TB = 63,838 + 3,693 x panjang lengan bawah kanan dan TB = 61,873 + 3,780 x panjang lengan bawah kiri. Kata-kata kunci : identifikasi, estimasi tinggi badan, wanita suku Banjar

PERBEDAAN HASIL LABORATORIUM PENDERITA HEPATITIS B DAN C KRONIS DENGAN DERAJAT FIBROSIS HATI Nudyan Betharina; FX Hendriyono; Mashuri Mashuri
Berkala Kedokteran Vol 13, No 1 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Abstract: Hepatitis is a disorder of liver inflamation caused by many thing such as infections, metabolism disturbance, drugs, or alcohol. The most infection of hepatitis in Indonesia are Hepatitis B and C. This research purpose was to figure out the differences between laboratorium result SGOT, SGPT, albumin, and gama-GT with fibrosis stage used by USG to patients with chronic hepatitis B and C in RSUD Ulin Banjarmasin. This research design was analysis observation with cross sectional design. There were 5 samples by choosen with purposive sampling method. The result was found the value of SGOT was 217.75 U/L in Hepatitis B and in hepatitis C was 134 U/L (p= 0,356), the value of SGPT in hepatitis B was 175 U/L and in hepatitis C was 31 U/L (p= 0,609), and for albumin in hepatitis B was 3.29 g/dL and 3.1 g/dL in hepatitis C (p= 0,622). The statistic tests showed there was no differences in laboratorium results of hepatitis B and C with liver fibrosis stage. Keywords: Chronic hepatitis, Liver fibrosis, SGOT, SGPT, albumin. Abstrak: Penyakit hepatitis merupakan suatu kelainan berupa peradangan hati yang dapat disebabkan oleh banyak hal, antara lain infeksi, gangguan metabolisme, obat-obatan, atau alkohol. Infeksi hepatitis terbanyak di Indonesia adalah hepatitis B dan C. Penelitian ini bertujuan untuk mengetahui perbedaan antara hasil laboratorium SGOT, SGPT, albumin dan gama-GT dengan derajat fibrosis menggunakan pencitraan USG pada penderita hepatitis B dan C kronis di RSUD Ulin Banjarmasin. Rancangan penelitian berupa observasional analitik dengan pendekatan cross sectional. Sebanyak lima subjek dipilih menggunakan metode purposive sampling. Hasil penelitian didapatkan rerata kadar SGOT yang didapatkan 217.75 U/L pada hepatitis B dan pada hepatitis C 134 U/L (p = 0,356), rerata kadar SGPT pada hepatitis B 175 U/L dan pada hepatitis C 31 U/L (p = 0,609), rerata kadar albumin pada hepatitis B 3.29 g/dl dan 3.1 g/dl pada hepatitis C (p = 0,622). Hasil uji statistik menunjukkan tidak terdapat perbedaan hasil laboratorium penderita hepatitis B dan C kronis dengan derajat fibrosis hati. Kata-kata kunci: Hepatitis kronis, fibrosis hati, SGOT, SGPT, albumin.

The Role of Ceftazidime as a Photosensitizer in Human Erythrocytes Through Oxidative Stress Mechanism Mashuri Mashuri; Mustofa Ruhullah; Bayu Diertama Putera; Vicky Pramudinta Mega; Fadillah Alma Putra; Eko Suhartono
The Indonesian Biomedical Journal Vol 10, No 2 (2018)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v10i2.355

BACKGROUND: Ceftazidime was known to cause photosensitization reactions. However, how it plays the role remained unclear. In our study, we aim to investigate the photosensitization effect of ceftazidime in erythrocytes via oxidative stress.METHODS: Samples were divided into six different groups: negative control group, positive control group and four experimental groups with 10%, 20%, 30%, and 40% ceftazidime, respectively. The positive control and experimental groups were exposed to ultraviolet (UV)-light for 2 hours. Superoxide radical, malondialdehyde (MDA), carbonyl compounds (CC) and methemoglobin (Met-Hb) levels were then measured.RESULTS: The results showed a significant increased of superoxide radical, MDA, CC and Met-Hb levels in all experimental groups compared to both negative or positive control groups (p< 0.05).CONCLUSION: In conclusion, our study confirmed the role of ceftazidime as a photosensitizer in erythrocytes via the oxidative stress mechanisms.KEYWORDS: ceftazidime, oxidative stress, photosensitizer, photosensitization.

Perbedaan Skor Nasional dan Internasional dalam Mendiagnosis Pasien dengan Apendisitis Akut di RSUD Ulin Banjarmasin Ovimillia Anindia Tasya; Agung Ary Wibowo; Ida Yuliana; Winardi Budiwinata; Mashuri Mashuri
Homeostasis Vol 5, No 2 (2022)
Publisher : Homeostasis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (249.002 KB)

Abstract: Appendicitis is a disease caused by a blockage in the appendix. In 2009 it was found that at least 596,132 people in Indonesia had acute appendicitis. The diagnosis of appendicitis can be seen based on clinical manifestations, physical examination, and supporting examinations. Scoring is the fastest tool for predicting the diagnosis of acute appendicitis. This study will show whether there are differences in Alvarado scores, modified Alvarado scores, and Kalesaran scores in diagnosing acute appendicitis patients. With an analytical observational study, 66 samples from purposive sampling were processed through a retrospective cross-sectional approach. The inclusion criteria determined were patients aged 18-65 years and patients with physical examination of fever, epigastric diffuse pain, anorexia, nausea and vomiting, lower right tenderness, loose tenderness, Rovsing Sign, Psoas Sign, cough sign, leukocytosis, and displacement neutrophils to the left. With the exclusion criteria of patients with other infections and patients with incomplete data in the morning report. 44% were patients aged 18-25, and 9% were 56-65 years. 63% experienced by men and 38% by women. The most common manifestation was tenderness in the right lower quadrant while the least was fever with a total of 24 people. Data analysis using logistic regression showed P > 0.05 with the conclusion that there was no significant difference between Alvarado, modified Alvarado, and Kalesaran scores in diagnosing acute appendicitis patients. Keywords: acute appendicitis, Alvarado score, modified Alvarado score, Kalesaran Abstrak: Apendisitis merupakan penyakit yang disebabkan oleh sumbatan pada apendiks. Pada 2009 didapatkan setidaknya 596.132 orang di Indonesia mengalami apendisitis akut. Diagnosis apendisitis dapat dilihat berdasarkan manifestasi klinis, pemeriksaan fisik, serta pemeriksaan penunjang. Skoring menjadi alat paling cepat untuk memprediksi diagnosis apendisitis akut. Penelitian ini akan menunjukkan apakah terdapat perbedaan skor Alvarado, skor Alvarado termodifikasi, dan Skor Kalesaran dalam mendiagnosis pasien apendisitis akut. Dengan penelitian observasional analitik, 66 sampel dari purposive sampling diolah melalui pendekatan retrospective cross-sectional. Kriteria inklusi yang ditentukan adalah pasien dengan umur 18-65 tahun dan pasien dengan pemeriksaan fisik demam, nyeri baur epigaster, anoreksia, mual muntah, nyeri tekan kanan bawah, nyeri tekan lepas, Rovsing Sign, Psoas Sign, cough sign, leukositosis, serta perpindahan neutrofil ke kiri. Dengan kriteria eksklusi pasien yang mengalami infeksi lain serta pasien dengan data tidak lengkap pada morning report. 44% merupakan pasien dengan umur 18-25, dan 9% pada 56-65 tahun. 63% dialami oleh laki-laki dan 38% oleh perempuan.manifestasi paling banyak ditemukan adalah nyeri tekan pada kuadran kanan bawah sedangkan paling sedikit adalah demam dengan jumlah 24 orang. Analisis data menggunakan regresi logistik menunjukkan P > 0,05 dengan kesimpulan bahwa tidak ada perbedaan yang signifikan antara skor Alvarado, Alvarado termodifikasi, dan Kalesaran dalam mendiagnosis pasien apendisitis akut. Kata-kata kunci: apendisitis akut, skor Alvarado, skor Alvarado termodifikasi, Kalesaran

Profil Pasien Karsinoma Hepatoseluler yang Menjalani Terapi Transarterial Chemoembolization (TACE) di RSUD Ulin Banjarmasin Periode 2016-2018 Muhammad Abdullah Mujahid Fadillah; Mashuri Mashuri; Triawanti Triawanti; Nina Mulyani; Azma Rosida
Homeostasis Vol 5, No 1 (2022)
Publisher : Homeostasis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.329 KB)

Abstract: Hepatocellular Carcinoma (HCC) is a malignant tumor attacks hepatocytes. 5.4% of all malignancies in the world caused by HCC. Transarterial chemoembolization (TACE) has been shown to be effective in controlling tumor development and prolonging survival time. This study aims to determine the profile of HCC patients who were given TACE action at Ulin Hospital Banjarmasin for the 2016-2018 period. descriptive research method using medical record data. The results of the study obtained 29 HCC patients, 62% were aged >50 years; 65,5% gender male; 79,3% Child-Pugh B classification; 62% had liver cirrhosis as a predisposition; 65,5% abdominal pain was the most frequent complaint; 86.2% had radiological imaging; 79,3% ECOG performance value was 2, and 93.1% of patients had no thrombus in the portal vein. Conclusion: HCC patients who were given TACE therapy were the most at the age of >50 years and male gender, Child-Pugh B was the most, the most predisposition to liver disease was liver cirrhosis, the most frequent complaint the feeling is abdominal pain, most radiology imaging there is a typical imaging, the highest ECOG performance value is 2, and most patients do not have a thrombus in the portal vein or inferior vena cava. Keywords: Hepatocellular Carcinoma, TACE, liver cirrhosis Abstrak: Karsinoma Hepatoseluler (KHS) merupakan tumor ganas yang menyerang hepatosit. KHS menyebabkan 5,4% dari keganasan di dunia. Transarterial chemoembolization (TACE) efektif mengendalikan perkembangan tumor dan memperpanjang waktu hidup pada KHS. Penelitian bertujuan mengetahui profil pasien KHS yang mendapat TACE di RSUD Ulin Banjarmasin periode 2016-2018. Metode penelitian deskriptif, menggunakan data rekam medik. Hasil didapatkan 29 pasien KHS, 62% berumur >50 tahun; 65,5% laki-laki; 79,3% klasifikasi child-pugh B ; 62% memiliki sirosis hati sebagai predisposisi; 65,5% nyeri perut menjadi keluhan tersering; 86,2% memiliki gambaran khas radiologi; 79,3% nilai ECOG performance 2, dan 93,1% pasien tidak terdapat trombus pada vena porta. Kesimpulan: pasien KHS yang diberi terapi TACE adalah usia >50 tahun dan laki-laki paling banyak, klasifikasi child-pugh B terbanyak, predisposisi penyakit hati tersering sirosis hati, keluhan tersering nyeri perut, gambaran radiologi terbanyak terdapat gambaran khas, terbanyak nilai ECOG performance 2, dan kebanyakan pasien tidak terdapat trombus di vena porta/vena cava inferior. Kata Kunci: karsinoma hepatoseluler, TACE, sirosis hati

HUBUNGAN DIAMETER APENDIKS BERDASARKAN USG DENGAN SKOR ALVARADO PADA APENDISITIS AKUT Fikra Safa Advancya Iman; Agung Ary Wibowo; Ida Yuliana; Winardi Budiwanata; Mashuri Mashuri
Homeostasis Vol 5, No 3 (2022)
Publisher : Homeostasis

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Appendicitis is the most common cause of acute abdomen and the most common surgical emergency. Signs and symptoms that are not always clear in every patient make it difficult to establish a diagnosis. This study aims to determine the relationship of the Alvarado score with the size of the diameter of the appendix based on ultrasound which can help in diagnosing cases of appendicitis. This research is an analytic observational study with a retrospective cohort study approach with a total sample of 52 people who have complied with the specified criteria and were selected by non-probability sampling technique. The data used for this study were the Alvarado score and the size of the diameter of the appendix based on the patient's ultrasound taken from secondary data. The Pearson correlation test conducted has shown a negative relationship between the Alvarado score and the size of the appendix diameter based on ultrasound with a p-value is 0,078>0.05. Based on this study, it can be concluded that there is no corellation between the size of the appendix diameter based on ultrasound and the Alvarado score in appendicitis patients of RSUD Ulin Banjarmasin

The Correlations Between Clinical Characteristics and Inflammation Markers with Chest X-rays in COVID-19 Patients at Ulin Hospital Muhammad Nor; Ira Nurrasyidah; Mashuri Mashuri
Jurnal Respirologi Indonesia Vol 43, No 4 (2023)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v43i4.407

Background: Chest x-ray is one of the parameters used to estimate the severity and prognosis of COVID-19. Arterial oxygen saturation (SaO2), partial pressure of arterial oxygen (PaO2), and respiratory index (PaO/FiO2) can also predict the disease severity. Other parameters, like inflammation markers, have also been used as predictors for prognosis. Based on those considerations, this study aimed to examine their connection and find their correlation.Methods: This was an analytic observational retrospective study. The samples were moderate-critical COVID-19 patients in Ulin General Hospital Banjarmasin from July to December 2021 who met the inclusion and exclusion criteria. Statistical tests were used to see the relationship between clinical characteristics and inflammation markers with chest X-rays using various scoring systems (Brixia, sRALE, and modified Soetomo score).Results: The total number of subjects was 67. The data analysis found that the severity of the disease had a significant relationship with the severity of the chest x-ray (P<0.001). The PF ratio also had a significant negative correlation (P<0.001) with the severity of the chest x-ray. For inflammation markers, NLR, CRP, and LDH significantly correlated with a chest x-ray. The patient's outcome was also associated with a chest X-ray (P<0.015).Conclusion: There were significant correlations between clinical characteristics and inflammation markers on the chest X-ray severity, and sRALE was a better scoring system to assess chest X-ray severity than other scoring systems.

STUDI IN SILICO INTERAKSI KOBALT DAN MERKURI TERHADAP PROTEIN PADA KEJADIAN DIABETES MELITUS Aranda, Viren Lolita; Suhartono, Eko; Fujiati, Fujiati; Mashuri, Mashuri; Setiawan, Bambang
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11473

The coal mining industry in South Kalimantan can cause heavy metal waste pollution in the aquatic environment if not managed wisely. Cobalt and mercury are heavy metals that can cause disruption of glucose homeostasis which can lead to diabetes mellitus. The toxicity of cobalt and mercury occurs as a result of interactions with proteins associated with diabetes mellitus, namely insulin receptors, PPARγ, protein kinase b and c-reactive protein. This study aims to determine the interaction of heavy metals cobalt and mercury on insulin receptors, PPARγ, protein kinase b and c-reactive protein with PDB ID: 2HR7, 1PRG, 3E87, 1GNH taken from the Protein Data Bank and using the molecular docking website MIB2: Metal Ion-Binding site prediction and modeling server. Docking results were visualized using the Chimera ver 1.16 application. Based on the docking results, it was found that the interaction between cobalt and mercury with insulin receptors, PPARγ, protein kinase b and c-reactive protein. Cobalt has the highest potential to bind to insulin receptors. While mercury has the highest potential to bind to protein kinase b. Mercury binds more strongly to insulin receptors, PPARγ, protein kinase b and c-reactive protein than cobalt. This interaction causes changes in protein conformation that have the potential to inactivate protein function.

Co-Authors Agung Ary Wibowo Agung Ary Wibowo Aranda, Viren Lolita Azma Rosida Bambang Setiawan Bayu Diertama Putera Dona Marisa Eko Suhartono Fadillah Alma Putra Fikra Safa Advancya Iman Fujiati ., Fujiati FX Hendriyono Gusti Muhammad Perdana Putera Hapsari Lintang Sekartaji Husna Dharma Putera Ida Yuliana Ida Yuliana Ira Nurrasyidah Iskandar Iskandar Iwan Aflanie Lisda Hayatie Muhammad Abdullah Mujahid Fadillah Muhammad Nor Mustofa Ruhullah Muthmainah, Noor Nia Kania Nina Mulyani Noor Muthmainah Nudyan Betharina Nurul Qomariah Ovimillia Anindia Tasya Ristaniah Rose Effendy Setiawan, Bambang Syaifullah Akbar Pradito Triawanti Triawanti Vicky Pramudinta Mega Winardi Budiwanata Winardi Budiwinata Yosef Dwi Cahyadi Salan Zairin Noor

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