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All Journal International Journal of Public Health Science (IJPHS) Science and Technology Indonesia Majalah Farmaseutik Journal of Fisheries & Marine
zai, Khadijah
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Physics

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Kajian Pustaka Sintesis Nanopartikel Perak dari Berbagai Tanaman Nusantara dan Aplikasinya Sebagai Antibakteri Tri Nanda, Yogie Andika; zai, Khadijah
Majalah Farmaseutik Vol 19, No 3 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i3.85186

Abstract

Nanopartikel perak merupakan suatu partikel yang berukuran 1-100 nm. Nanopartikel perak memberikan potensi aplikasi yang luas. Dalam bidang kesehatan, nanopartikel perak telah digunakan sebagai agen antimikroba yang efektif untuk melawan infeksi bakteri. Proses sintesis nanopartikel perak umumnya menggunakan bahan kimia berbahaya dan merugikan lingkungan. Kajian ini bertujuan untuk menyajikan informasi terkait metode sintesis nanopartikel perak yang aman bagi manusia dan lingkungan melalui pendekatan biologis berbasis bahan alam (sintesis hijau) yang terdapat di Indonesia. Senyawa di dalam tanaman dapat berperan sebagai reduktor dalam sintesis nanopartikel perak. Berdasarkan kajian literatur yang telah dilakukan, disimpulkan bahwa ekstrak tanaman dapat digunakan sebagai bioreduktor untuk sintesis nanopartikel perak dan terbukti berpotensi sebagai antibakteri pada berbagai jenis bakteri.
POTENSI SUMBER DAYA ALAM INDONESIA SEBAGAI BAHAN BAKU ALTERNATIF PEMBUATAN CARBOXYMETHYLCELLULOSE – Natrium (CMC-Na) : review Nugraheni, Heka Mareta; Zai, Khadijah; Santosa, Djoko
Majalah Farmaseutik Vol 20, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v20i2.93539

Abstract

Carboxymethylcellulose – Natrium (CMC-Na) merupakan salah satu senyawa turunan dari selulosa yang memiliki berbagai kegunaan baik pada bidang farmasi, tekstile, konstruksi dan makanan. CMC-Na dapat diperoleh dari bahan alam yang mengandung selulosa seperti batang tumbuhan, kayu, daun, kulit buah, tangkai maupun serabut. Berdasarkan banyaknya kegunaan dan berlimpahnya bahan alam sebagai bahan utama pembuatan CMC-Na menjadikan banyaknya penelitian terkait sintesis CMC-Na. Review artikel ini bertujuan untuk membahas potensi bahan alam sebagai bahan baku dalam pembuatan CMC-Na. Pencarian arikel dilakukan secara online melalui Google Scholar dengan katakunci tertentu untuk mendapatkan informasi terbaru yang dipubikasi pada tahun 2013 sampai tahun 2022. Proses sintesis CMC-Na melalui beberapa tahapan, yaitu delignifikasi, bleaching, alkalisasi dan karboksimetilasi. Disisi lain, terdapat beberapa faktor yang perlu dilakukannya penelitian lebih lanjut, seperti proses ekstraksi selulosa, konsentrasi NaOH dan Natrium Monokloroasetat yang dgunakan, serta waktu dan suhu. Faktor-faktor tersebut berperan penting dalam mempengaruhi kualitas CMC-Na yang dihasilkan, sehingga penelitian lebih lanjut diperlukan untuk memastikan bahwa bahan alam yang tersedia melimpah di Indonesia dapat menghasilkan produk CMC-Na dengan kualitas yang baik.
Thermosensitive hydrogels as drug carriers for breast cancer treatment: a systematic review Ikhsanudin, Azis; Sulaiman, Teuku Nanda Saifullah; Zai, Khadijah; Sudarmanto, Bambang Sulistyo Ari
International Journal of Public Health Science (IJPHS) Vol 12, No 3: September 2023
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v12i3.22773

Abstract

Thermo-sensitive hydrogel is a drug delivery system in breast cancer therapy, where the influence of environmental temperature changes will affect the characteristics of the polymer base. This study aimed to determine the effectiveness of polymers in thermo-sensitive hydrogel bases as drug carriers in breast cancer therapy and compared them with traditional intravenous drug release. This study used a systematic literature review (SLR) using selected reporting items for systematic review and meta-analysis guidelines (PRISMA) (P), based on predetermined inclusion criteria, namely English article, thermos-sensitive hydrogel, breast cancer, and original article. An initial database search yielded 618 articles, PubMed (241), Scopus (364), and the Directory of Open Access Journals (DOAJ) (36). To maintain the quality of the data studied in this article, researchers used inclusion and exclusion criteria, where the exclusion criteria used were non-English languages, review articles, proceedings, communications, video articles, and not open access. After the article screening process, 11 articles were obtained which would then be summarized in data extraction. The conclusion of this study shows that the thermos-sensitive hydrogel drug delivery system has advantages in drug release, where the drug will be released continuously, but also has the disadvantage of uncontrolled drug release.
Development and Validation of the RP-HPLC Method for Dexamethasone Sodium Phosphate Determination in Nasal Chitosan Microsphere Preparations Desnita, Rise; Noviana, Eka; Zai, Khadijah; Sulaiman, Teuku Nanda Saifullah
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.165-172

Abstract

The purpose of this work was to provide a robust, sensitive, accurate, and straightforward analytical method for measuring dexamethasone sodium phosphate (DSP) in chitosan microspheres preparedn using the spray drying method. DSP was quantitatively analyzed using RP-HPLC with an ultraviolet detector at 254 nm, a mobile phase that contained a mixture of acetonitrile and 0.1% sodium dihydrogen phosphate monohydrate (50:50) operating isocratically at a flow rate of 1.0 mL/min, and a stationary phase that was a C18 PrincetonSPHER-100 C18-QB 100A HPLC Column (250 × 4.6 mm, 5 um). The ICH recommendations were followed in the validation of the analytical method. DSP had a retention duration of 2.899 minutes and a tailing factor of 0.827. The RP-HPLC method was linear (R = 0.9992) in the 15-60 ug/mL concentration range. The limits of quantitation (LOQ) and detection (LOD) were 4.425 ug/mL and 1.327 ug/mL, respectively. The relative standard deviations for the intra-day and inter-day precisions were 0.057-0.876% and 0.780-0.949%, respectively. The recovery percentages at 50, 100, and 200% concentration levels were within the 99.269-100.980% range. The validated method has been successfully applied to determine DSP entrapment efficiency in chitosan microspheres. A linear, sensitive, accurate, precise, and robust technique of determining DSP in chitosan microsphere preparations is offered by the established RP-HPLC method.
Effect of Ultrasonic Assisted Extraction with Ethanol for Removing Lipid on Catfish (Pangasius sp.) Skin as a Collagen Source and Its Characteristics Agustina, Maulida; Patmawati, Patmawati; Mubarok, Shofy; Sulmartiwi, Laksmi; Wulandari, Diah Anggraini; Zai, Khadijah; Siva, Raseetha; Pujiastuti, Dwi Yuli; Nirmala, Dwitha; Carattri Kusuma Werdani, Money; Moechthar, Oemar; Alwi Husein, Mohamad Akmal
Jurnal Ilmiah Perikanan dan Kelautan Vol. 16 No. 1 (2024): JURNAL ILMIAH PERIKANAN DAN KELAUTAN
Publisher : Faculty of Fisheries and Marine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jipk.v16i1.46061

Abstract

Abstract Fish skin is rich in collagen (80%-90%). However, catfish (Pangasius sp.) skin has a high lipid content, which can reduce the quality of collagen. Therefore, treatment is needed to remove the lipid using ultrasonic assisted extraction (UAE) with ethanol. Hence, the aim of the present study was to remove lipid content from catfish skin as a raw material for collagen by using UAE with different concentrations of ethanol (25, 50, and 75%). The research was conducted in three stages: removing impurities, collagen extraction, and characterization of collagen. The result exhibited that UAE-ethanol treatment was capable of removing up to 85.6% of lipid content, and the produced collagen had the potential to be utilized as an alternative source of collagen based on its properties. Highlight Research Ethanol could be used as extractor of lipid from catfish skin of Pangasius Ultrasonic assisted extraction could increase efficiency of lipid extraction from catfish skin. Fish skin of Pangasius sp. has a potential source for collagen. Collagen from skin of Pangasius sp. has a good characteristic with high protein content.
Co-Authors Alwi Husein, Mohamad Akmal Azis Ikhsanudin Carattri Kusuma Werdani, Money Djoko Santosa Dwi Yuli Pujiastuti Dwitha Nirmala Eka Noviana Maulida Agustina Mubarok, Shofy N. Juni Triastuti Nugraheni, Heka Mareta Oemar Moechthar Patmawati Patmawati, Patmawati Rise Desnita, Rise Siva, Raseetha Sudarmanto, B.S. Ari Sulaiman, Teuku Nanda Saifullah Tri Nanda, Yogie Andika Wulandari, Diah Anggraini