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All Journal Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Chemistry Indonesian Journal of Chemical Research Jurnal Ilmiah Farmako Bahari
Mudianta, I Wayan
Dept of Analytical Chemistry, Ganesha Univ. of Education, Jl. Udayana No. 11 Singaraja, Bali 81116
Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Engineering Environmental Science Health Professions Medicine & Pharmacology

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FUCOIDAN NANOENCAPSULATION FROM BROWN ALGAE (Sargassum polycystum) AS A POTENTIAL MARINE IMMUNOMODULATORY AGENT Purwanto, Ungsari Rizki Eka; Ikasari, Endang Diyah; Bagiana, I Kadek; Kusmita, Lia; Trisnayanthi, Ni Nyoman Ayu Indah; Mudianta, I Wayan; Prasetijo, Rahmadi
Jurnal Ilmiah Farmako Bahari Vol 15, No 1 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i1.3207

Abstract

The quest for better and more effective treatments has encouraged the search for therapies derived from natural sources to obtain effective immune therapy, considering that several pandemics have arisen caused by viruses. Developing fucoidan from brown algae in drug encapsulation as an immunomodulator could be more promising. This study aimed to produce nanoencapsulation loaded with fucoidan-purified extract from brown algae and to evaluate the influence of nanoencapsulation formulation on the immunomodulatory activity of fucoidan. Fucoidan was obtained from brown algae and extracted by hot aqueous, followed by ethanol purification. Nanoencapsulation of fucoidan purified extract was prepared using the ionic gelation method. The carbon clearance method was carried out for the immunomodulatory activity test of the nanoencapsulation of fucoidan purified extract. Nanoencapsulation of fucoidan purified extract with the optimum composition of maltodextrin 9.9% and S-TPP 0.1% (1:5) resulted in particle size of 715.4 nm, zeta potential -0.1 mV, pH 7.54, transmittance 97.54%+0.08, and entrapment efficiency 89.94%+0.17. The carbon clearance test showed that the nanoencapsulation of fucoidan was a strong immunostimulant with a phagocytosis index of 1.65. The development of nanoencapsulation could increase the phagocytosis index of fucoidan purified extracts from brown algae. Further molecular studies are needed to demonstrate the molecular activity of this preparation as an immunomodulator.
Learning Innovation Together with Community: Inventing and Commercializing Slow-Release Organic Nano Fertilizer Pellets for Healthy and Sustainable Rice Agriculture Karyasa, I Wayan; Widana, Gede Agus Beni; Astawa, I Putu Gede Banu; Mudianta, I Wayan
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 10, No 4 (2024): December
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.100798

Abstract

The village of Jagaraga, located in the Sawan district of Buleleng Regency, Bali Province, had significant potential in both culture and agriculture, particularly in rice farming. More than half of the village’s land area was rice fields, and over two-thirds of the villagers were rice farmers. However, ensuring healthy soils and crops through effective fertilizer solutions remained a major challenge. The aim of the community development initiative was to empower the village farmers to become innovative through collaborative learning and by inventing and commercializing a slow-release nano fertilizer. A participatory action and learning approach was used to engage the rice farming community. The Subak Babakan farmer organization and the local rice milling enterprise, PB Suwela Amertha, were involved in the empowerment activities, which included information sessions, training, technology application, guidance, evaluation, and sustainability planning. As a result, four formulas of slow-release organic nano fertilizers in pellet form were successfully developed. Additionally, a four-helix partnership involving academicians, the farmer community, enterprises, and the government was established to build a business platform for commercializing the innovation. Through this collaboration, academicians and community farmers successfully learned to address the primary challenges in rice agriculture innovatively while promoting sustainable practices to maintain the health of the land and the well-being of the villagers.
Chemical Constituent and Antioxidant Activity of Clove (Syzygium aromaticum) Bud and Leaf Essential Oils from Bali Muderawan, I Wayan; Laksmi, Pande Putu Diah Suci; Mudianta, I Wayan; Martiningsih, Ni Wayan
Indonesian Journal of Chemical Research Vol 12 No 3 (2025): Edition for January 2025
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2025.12-mud

Abstract

Bali is one of clove (Syzygium aromaticum) producers in Indonesia. Clove essential oil is mainly produced from the leaves and flowers. Eugenol is the main component in the essential oil of clove. The objective of this research is to determine constituents and antioxidant activity of clove’s bud and leaf essential oils from Bali. The essential oils were isolated from clove’s bud and leaf samples by steam distillation with the yield of 12.90 and 2.63%. The constituents of the clove essential oils were analyzed by using gas chromatography-mass spectrometry (GC-MS). Thirty-six and twenty-nine constituents were identified based on GC-MS from the clove bud and leaf essential oils, respectively. Major classes of compounds are sesquiterpenes, phenyl propanoids, oxygenated sesquiterpenes, and esters. Different compositions in major constituents were found between both essential oils. Clove bud essential oil (CBEO) contained eugenol (65.29 %), trans-caryophyllene (20.06 %), and α-humulene (3.38 %). While, in clove’s leaf essential oil (CLEO), the composition was eugenol (64.47 %), trans-caryophyllene (27.19 %), and α-humulene (3.62 %). The clove essential oil and its main component show strong antioxidant activity. The antioxidant activity of CBEO, CLEO, and eugenol is 22.58, 29.19, and 17.53 μg/mL, respectively.
Co-Authors Astawa, I Putu Gede Banu Endang Diyah Ikasari Gede Agus Beni Widana I Kadek Bagiana I Wayan Karyasa I Wayan Muderawan Laksmi, Pande Putu Diah Suci Lia Kusmita Meigaria, Komang Mirah Ni Wayan Martiningsih Purwanto, Ungsari Rizki Eka Rahmadi Prasetijo Trisnayanthi, Ni Nyoman Ayu Indah