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FUCOIDAN NANOENCAPSULATION FROM BROWN ALGAE (Sargassum polycystum) AS A POTENTIAL MARINE IMMUNOMODULATORY AGENT Purwanto, Ungsari Rizki Eka; Ikasari, Endang Diyah; Bagiana, I Kadek; Kusmita, Lia; Trisnayanthi, Ni Nyoman Ayu Indah; Mudianta, I Wayan; Prasetijo, Rahmadi
Jurnal Ilmiah Farmako Bahari Vol 15, No 1 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i1.3207

The quest for better and more effective treatments has encouraged the search for therapies derived from natural sources to obtain effective immune therapy, considering that several pandemics have arisen caused by viruses. Developing fucoidan from brown algae in drug encapsulation as an immunomodulator could be more promising. This study aimed to produce nanoencapsulation loaded with fucoidan-purified extract from brown algae and to evaluate the influence of nanoencapsulation formulation on the immunomodulatory activity of fucoidan. Fucoidan was obtained from brown algae and extracted by hot aqueous, followed by ethanol purification. Nanoencapsulation of fucoidan purified extract was prepared using the ionic gelation method. The carbon clearance method was carried out for the immunomodulatory activity test of the nanoencapsulation of fucoidan purified extract. Nanoencapsulation of fucoidan purified extract with the optimum composition of maltodextrin 9.9% and S-TPP 0.1% (1:5) resulted in particle size of 715.4 nm, zeta potential -0.1 mV, pH 7.54, transmittance 97.54%+0.08, and entrapment efficiency 89.94%+0.17. The carbon clearance test showed that the nanoencapsulation of fucoidan was a strong immunostimulant with a phagocytosis index of 1.65. The development of nanoencapsulation could increase the phagocytosis index of fucoidan purified extracts from brown algae. Further molecular studies are needed to demonstrate the molecular activity of this preparation as an immunomodulator.

Optimization of HPMC and Glycerine in Essence of Sheet Mask Containing Centella asiatica (L.) Urb. Extract and Snail Mucus (Achatina fulica) as A Moisturizer Anjani Saskia Putri; Endang Diyah Ikasari; Ungsari Rizki Eka Purwanto
Journal of Food and Pharmaceutical Sciences Vol 12, No 2 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.9889

Various natural ingredients have been formulated as moisturizers in cosmetics, both from natural and animal raw material, especially Centella asiatica (L.) Urb. Extract and snail mucus (Achatina fulica). However, there is only a little research to determine the development of both material in one cosmetic preparation, namely sheet mask. The mask sleeve, which is a sheet mask applicator, will dry longer than other masks, therefore the penetration shown as a moisturizer is better. Gelling agents (such as hydroxypropyl methyl cellulose (HPMC)) and humectants (such as glycerinee) are important ingredients in sheet masks. This research aims to optimization HPMC and glycerine in a sheet masks Centella asiatica and snail mucus. Optimization of HPMC and glycerine with a ratio of 0.3–3% HPMC and glycerine was carried out using the Design Expert 10 with Simplex Lattice Design method. The responses from optimization of the preparation were pH, viscosity, absorption power and skin moisture. The optimum formula was obtained at a concentration of 0.589% HPMC and 2.711% glycerine with pH of 5.64 ±0.02; viscosity of 4581.8± 59.80 cPs, absorption power in scale of 4.6+0,55 , and skin moisture of 32.09%+3.21. The irritation test has a score of 0 or does not cause irritation.

OPTIMASI NATRIUM ALGINAT DAN MINYAK ATSIRI SEREH WANGI (Cymbopogon nardus) SEDIAAN PATCH TRANSDERMAL METOKLOPRAMID HIDROKLORIDA Pratiwi, Audena; Ikasari, Endang Diyah; Munisih, Siti
Media Farmasi Indonesia Vol. 14 No. 1 (2019): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (436.399 KB)

Natrium alginat mempunyai sifat elastisitas yang baik dan dapat digunakan secara tunggal sebagai polimer. Minyak atsiri sereh wangi mengandung senyawa terpen yang dapat meningkatkan penyerapan perkutan obat hidrofilik maupun lipofilik. Tujuan penelitian ini adalah untuk megetahui pengaruh masing-masing dan interaksi penggunaan natrium alginat dan minyak atsiri sereh wangi (Cymbopogon nardus) pada karakteristik fisik patch transdermal metoklopramid hidroklorida, serta menentukan formula optimum patch transdermal metoklopramid hidroklorida. Patch dibuat dengan metode matriks. Perbandingan konsentrasi natrium alginat dan minyak atsiri sereh wangi ditentukan berdasarkan Design Expert 10.0.1 dengan metode Simplex Lattice Design secara berturut-turut adalah run 1 (6% : 3%), run 2 (7% : 2%), run 3 (4% : 5%), run 4 (4% : 5%), run 5 (6% : 3%), run 6 (5% : 4%), run 7 (8% : 1%), dan run 8 (8% : 1%). Formula yang terpilih sebagai formula optimum adalah formula dengan konsentrasi natrium alginat 6,412% dan minyak atsiri sereh wangi 2,59% dan menghasilkan rerata uji ketebalan 0,26 mm, ketahanan lipat 127 kali, Q360 93,45%, dan laju difusi 0,0029 mg/menit. Hasil uji dengan T-Test menunjukkan bahwa hasil semua pengujian yang diperoleh antara teoretis dengan hasil percobaan berbeda tidak signifikan (P>0.05).

OPTIMASI NATRIUM ALGINAT DAN MINYAK CENGKEH PADA FORMULASI PATCH TRANSDERMAL METOKLOPRAMID HIDROKLORIDA Rini, Arum Setyo; Ikasari, Endang Diyah; Munisih, Siti
Media Farmasi Indonesia Vol. 14 No. 1 (2019): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (424.267 KB)

Penelitian ini bertujuan untuk mengetahui pengaruh konsentrasi natrium alginat dan minyak cengkeh pada karakteristik fisik dan pelepasan obat dari patch transdermal metoklopramid hidroklorida (MTH), serta menentukan formula optimum perbandingan konsentrasi natrium alginat dan minyak cengkeh pada karakteristik fisik dan pelepasan obat dari patch transdermal MTH. Patch transdermal dibuat dengan metode solvent evaporation. Optimasi dilakukan dengan metode simplex lattice design dengan delapan run yaitu run 1 (7%A : 2%B), run 2 (5%A : 4%B), run 3 (8%A : 1%B), run 4 (4%A : 5%B), run 5 (6%A : 3%B), run 6 (4%A : 5%B), run 7 (6%A : 3%B), dan run 8 (8%A : 1%B). Komponen A merupakan konsentrasi natrium alginat dan komponen B adalah konsentrasi minyak cengkeh. Berdasarkan persamaan SLD dengan menggunakan program design expert 10.0.1 dapat diketahui bahwa penggunaan tunggal komponen natrium alginat meningkatkan ketebalan, ketahanan lipat, fluks dan Q360. Komponen minyak cengkeh secara tunggal meningkatkan ketebalan, fluks dan Q360, tetapi menurunkan ketahanan lipat. Interaksi kedua komponen menurunkan ketebalan, ketahanan lipat, fluks dan Q360. Formula optimum patch transdermal dengan kombinasi natrium alginat sebagai polimer matriks dan minyak cengkeh sebagai enhancer adalah pada proporsi 4,53% dan 4,47%. Hasil uji one sample t-test menunjukkan hasil teoritis dan percobaan berbeda tidak signifikan (P > 0,05).

OPTIMASI BASIS KRIM EKSTRAK ETANOL DAUN KAWISTA (Limonia acidissima L.) SEBAGAI ANTIBAKTERI Staphylococcus aureus Nugraheni, Christi Karina; Ikasari, Endang Diyah; Kusmita, Lia
Media Farmasi Indonesia Vol. 11 No. 1 (2016): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (285.561 KB)

SARIDaun kawista diketahui mengandung senyawa flavonoid, tannin, danalkaloid yang dapat menghambat pertumbuhan Staphylococcus aureus.Penggunaan emulgid dan parafin cair dalam sediaan krim sebagai emulgator danpelembut diharapkan mampu meningkatkan aktivitas antibakteri Staphylococcusaureus dan karakteristik fisik krim yang memenuhi syarat.Penelitian ini bertujuanuntuk mengetahui pengaruh dan menentukan formula optimal dengan komponenemulgid dan parafin cair dalam krim ekstrak etanol daun kawista (Limoniaacidissima L.) pada karakteristik fisik dan aktivitas antibakteri Staphylococcusaureus dengan metode Simplex Lattice Design. Ekstrak etanol daun kawistadidapatkan dengan cara remaserasi menggunakan pelarut etanol 70%. Ekstrakkental diuji aktivitas antibakteri Staphylococcus aureus dengan metode difusisumuran kemudian konsentrasi ekstrak yang optimal diformulasikan dalamsediaan krim. Berdasarkan Design Expert 9.0.6.2 Trial, didapatkan formulaoptimal dengan perbandingan konsentrasi emulgid dan parafin cair sebesar24,848%:5,152%. Hasil pengujian formula optimal didapatkan rerata diameterzona hambat bakteri 11,50 mm, daya sebar 6,49 cm, viskositas 4480 cps, dan pH5,46 dimana hasil tersebut berbeda tidak signifikan terhadap hasil prediksi DesignExpert 9.0.6.2 Trial.

Optimization of HPMC and Glycerine in Essence of Sheet Mask Containing Centella asiatica (L.) Urb. Extract and Snail Mucus (Achatina fulica) as A Moisturizer Anjani Saskia Putri; Endang Diyah Ikasari; Ungsari Rizki Eka Purwanto
Journal of Food and Pharmaceutical Sciences Vol 12, No 2 (2024): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.9889

Various natural ingredients have been formulated as moisturizers in cosmetics, both from natural and animal raw material, especially Centella asiatica (L.) Urb. Extract and snail mucus (Achatina fulica). However, there is only a little research to determine the development of both material in one cosmetic preparation, namely sheet mask. The mask sleeve, which is a sheet mask applicator, will dry longer than other masks, therefore the penetration shown as a moisturizer is better. Gelling agents (such as hydroxypropyl methyl cellulose (HPMC)) and humectants (such as glycerinee) are important ingredients in sheet masks. This research aims to optimization HPMC and glycerine in a sheet masks Centella asiatica and snail mucus. Optimization of HPMC and glycerine with a ratio of 0.3–3% HPMC and glycerine was carried out using the Design Expert 10 with Simplex Lattice Design method. The responses from optimization of the preparation were pH, viscosity, absorption power and skin moisture. The optimum formula was obtained at a concentration of 0.589% HPMC and 2.711% glycerine with pH of 5.64 ±0.02; viscosity of 4581.8± 59.80 cPs, absorption power in scale of 4.6+0,55 , and skin moisture of 32.09%+3.21. The irritation test has a score of 0 or does not cause irritation.

OPTIMIZATION SUSTAINED RELEASE TABLET FUCOIDAN PURIFIED EXTRACT FROM BROWN SEAWEED (Sargassum polycystum) AS IMMUNOMODULATOR Ikasari, Endang Diyah; Wulansari, Endang Dwi; Purwanto, Ungsari Rizki Eka
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1310

Fucoidan is a sulfate polysaccharide compound that is widespread in the sea, especially in brown algae. Previous fucoidan pharmacokinetics studies have shown that fucoidan nanoparticles have the effect of increasing the immunomodulatory ability of fucoidan, but fucoidan consumed orally has a half-life in plasma of about 3 hours so that to reduce the amount of fucoidan supplement use in a day, fucoidan can be formulated into sustained release tablet preparations. The purpose of this study was to determine the optimal composition of Na. Alginate and HPMC as polymers in sustained-release tablet preparations containing purified fucoidan from brown seaweed to produce tablets with characteristics that meet the compendial requirements of the Indonesian Pharmacopoeia and can maintain fucoidan release in plasma with only one consumption per day to improve user compliance. Fucoidan extraction from brown seaweed was carried out using hot extraction. Purified fucoidan tablets were prepared by the Simplex Lattice Design method using Design Expert version 10.1. The concentration of Na. Alginate and HPMC used as much as 2–5% with 8 formulas, which were then printed on a tablet printing tool. The optimum formula was tested as an immunomodulator in mice with parameters for lymph weight, phagocytosis index, and stimulant index. Optimum formula for Na. alginate: HPMC (3.252:3.748%) with flow speed 8.552 g/sec, compressibility 15,648%, hardness 3.726 kg, friability 0.044%, MC 3.296, Crushing time 21.34 minutes, Q15 34.608%, Q45 34.824%. The optimum formula for the immunomodulatory effect had a significant effect on the lymph weight of mice.

Pembuatan Olahan Kopi Sehat dengan Bahan Dasar Bunga Krisan dan Biji Salak (Kopi “Laris”) Ikasari, Endang Diyah
Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Vol 8, No 1 (2025): Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstormin
Publisher : Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/japhb.v8i1.7829

Latar belakang diadakannya pengabdian tersebut adalah petani bunga krisan dan petani salak di daerah Bandungan adalah pemanfaatan bunga krisan yang tidak dimanfaatkan sebangai bunga hias serta peningkatan limbah salak yang terdiri dari kulit dan biji salak. Hal ini yang menggugah kelompok pengabdian kami dengan tujuan meningkatkan pengetahuan tentang pembuatan/pemanfaatan limbah agar menjadi hasil olahan yang dapat dijual. Metode yang dilakukan adalah melakukan penyuluhan dan pelatihan pengolahan limbah biji salak dan bunga krisan, melalui kelompok Kelompok Wanita Tani (KWT) Sido Makmur, Bandungan. Kegiatan dihadiri oleh 22 orang peserta, selain pembuatan juga dilaksanakan dengan penyuluhan mengenai khasiat limbah biji salak dan bunga krisan sebagai antioksidan sehingga dapat meningkatkan nilai jualnya. Tim pengabdian memperkenalkan metode pengolahan limbah biji salak dan bunga krisan hingga menjadi produk kopi secara langsung kepada kelompok kader. Tingkat pemahaman peserta diperoleh dengan memberikan soal yang sama sebelum penyuluhan dilakukan (pre test) dan setelah penyuluhan (post test). Dari total peserta diperoleh peningkatan pemahaman sebesar 54,54% .

Pharmaceutical Grade Microcrystalline Cellulose from Corn Husk (Zea mays L.): Fabrication and Characterization Cahyani, Intan Martha; Ikasari, Endang Diyah; Tadlkirotulladlat, Novi; Anggraini, Novita Sindy
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21516

Corn is a plant that grows easily in tropical climates. Corn production in Indonesia reaches 25.18 tons, the use of which in society is still limited to corn kernels as food, while other parts of the corn plant are waste. Corn husks are an abundant natural waste and contain 44.08% cellulose, so they can potentially be a source of pharmaceutical excipients, namely microcrystalline cellulose (MCC). This research aims to isolate and characterize MCC from pharmaceutical grade corn husks with commercial MCC as a comparator. The two methods of making MCC are delignification using 2% NaOH at 80-90°C 4 h. Hydrolysis using variations in HCl concentrations, namely 2 N, 4 N, and 6 N, at a temperature of 80°C 4 h. The research results obtained cellulose content in α-cellulose and MCC of corn husks with 3 consecutive treatments of 74.02%, 84.48%, 86.55%, and 84.44%. The result of the analysis test of FTIR, SEM, XRD, and PSA instruments indicate that corn husk MCC has characteristics of commercial MCC as a standard. The resulting corn husk MCC has physicochemical characteristics according to standards that can be used as a pharmaceutical excipient.

Optimization Of Sodium Croscarmellose And Sodium Starch Glycolate In Orally Disintegrating Tablets (Odt) Acetosal Endang Diyah Ikasari
Media Farmasi Indonesia Vol. 20 No. 1 (2025): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v20i1.289

Acetosal is a drug that is included in the NSAID class which has anticoagulant properties. Acetosal has low bioavailability due to first-pass effect metabolism, so it is formulated in ODT form to increase the bioavailability of acetosal. This research aims to determine the effect of croscarmellose sodium and sodium starch glycolate concentrations as superdisintegrants on the physical characteristics of acetosal ODT and to determine the concentrations of croscarmellose sodium and sodium starch glycolate as superdisintegrants that produce acetosal ODT with optimum physical characteristics. The ratio formula for CCS and SSG obtained from design expert 10.0.1 using the simplex lattice design method, namely FI (0:6); FII (3:3); FIII (6:0); FIV (4.5:1.5); FV (6:0); FVI (0:6); FVII (3:3); FVIII (1.5:4.5). Based on the research results, the optimum ODT formula for acetosal was obtained with a concentration of CCS 1.232% and SSG glycolate of 4.768%. The optimum formula test results obtained a flow rate of 19.706 grams/second, MC 2.574%, compressibility 24.00%, hardness 3.70 kg, friability 0.668%, disintegration time 40.574 seconds, wetting time 46.002 seconds, and dissolution 95.142%. Based on the t-test between theoretical and experimental results, the results show that the results are not significantly different so they are said to be valid.

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