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ADIPOSE-DERIVED STEM CELL THERAPY ON NON-COMMUNICABLE DISEASE: A SYSTEMATIC REVIEW Tandarto, Kevin; Purwoko, Reza Yuridian; Oktarina, Caroline; Jonlean, Reganedgary; Irawan, Cosphiadi; Abdullah, Murdani; Pawitan , Jeanne Adiwinata
Journal of Stem Cell Research and Tissue Engineering Vol. 7 No. 1 (2023): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v7i1.40636

The increasing number of non-communicable diseases demands practical therapy innovations, including adipose-derived stem cell application. This study aimed to analyze the effectiveness of adipose stem cell therapy on non-communicable disease patients. The method used in this study was a systematic review according to PRISMA 2020 guidelines. The database search was done on PubMed, Google Scholar, Proquest, and the EBSCO host database between 2016 and 2021. ROBINS-I tool and RoB-2 were used to assess the risk of bias in the clinical trial study. The first literature search identified a total of 2615 articles. After exclusion for some reason, 6 articles were included in this systematic review study. A total of five studies were included in this study. Based on the risk of bias assessment of the included studies, it was found that all studies had a low risk of bias in all domains. This study showed that the efficacy of adipose-derived stem cell therapy was inconsistent; however, the results were promising. In addition, the results showed that adipose-derived stem cell therapy was safe without significant side effects. Further study was needed to identify therapeutic strategies based on Evidence-based Medicine (EBM).

Knowledge, attitude, and practice on antibiotic use in DKI Jakarta during COVID-19 pandemic Andini, Dheanita Nissrina; Gayatri, Anggi; Jonlean, Reganedgary
Indonesian Journal of Pharmacology and Therapy Vol 6 No 1 (2025)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.18822

Insufficient knowledge of antibiotic use among the general public could lead to antibiotic resistance. As the COVID-19 pandemic might encourage antibiotic self-medication, a study about recent knowledge, attitude, and practice (KAP) levels on antibiotic use during the COVID-19 pandemic needs to be carried out, including its possible associated factors. It is a cross-sectional study with 420 subjects living in DKI Jakarta and aged 18 or above. A validated KAPAQ questionnaire was used. Chi-square analysis was used to analyze the correlation between KAP levels and its possible associated factors. Most subjects’ score of KAP in antibiotic use were considered high. A statistically significant correlation between knowledge and attitude (p<0.001), knowledge and practice (p<0.001), and between attitude and practice (p<0.001) was found. A statistically significant correlation between gender and occupation fields with KAP (p<0.05), education level with knowledge (p<0.05), and history of self-medication with attitude and practice (p<0.05) were found. Age, marital status, and history of COVID-19 do not show any statistically significant correlation with KAP levels. In conclusion, most subjects have a high score of KAP in antibiotic use. All three variables also show significant correlations between each other while the sociodemographic factors that correlate significantly with KAP levels are gender, occupation field, education level, and history of self-medication with antibiotics.

The Association Between the Knowledge and Self-Medication Practices for Upper Respiratory Tract Infection (URTI) in the DKI Jakarta Population Nathanael, Kevin; Jonlean, Reganedgary; Gayatri, Anggi
Generics: Journal of Research in Pharmacy Vol 5, No 2 (2025): Generics : Journal of Research in Pharmacy Volume 5, Edisi 2, 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/genres.v5i2.26022

Most upper respiratory infections (URTIs) are caused by viruses and are self-limiting. It is one of the most frequent diseases to be treated with self-medication. Approriate self-medication practices will increase the safety of drug use. These practices need to be supported by a good level of knowledge. Therefore, this study was aimed to assess the association between level of knowledge and self-medication practices for URTIs in DKI Jakarta population. This cross-sectional study used an online questionnaire distributed around DKI Jakarta. The answers given by the subjects in the questionnaire will be used as our primary data, and the sample population was comprised of adult residents of DKI Jakarta. The questionnaire was developed by the study team and had been tested for validity and reliability before being used for data collection9. The questionnaire was divided into 3 parts, for collecting demographic data, self-medication patterns and level of knowledge regarding self-medication in URTIs. A Chi Square test was performed to analyze the association between level of knowledge and appropriateness of self-medication practices, with p value = 0.05. A total of 102 participants were analyzed at the end of this study. Information from peers tends to be the source of information for most participants, with 73.5% from friends and neighbors and 84.3% from family members. Only 21.6% of participants sought information from medical professionals. As many as 91.2% of participants took antibiotics to relieve their symptoms of URTI without prescription. Most subjects had an adequate level of knowledge (51%) and only a few subjects had a poor level of knowledge (4.9%). There was no significant association between the level of knowledge and the appropriateness of selecting drugs to treat fever, cough and rhinorrhea in this study. Most of the participants have an adequate level of knowledge on self-medication for URTI symptoms. However, there was no association between level of knowledge and the appropriateness of drug selection and the consumption of antibiotics without doctor prescription is still a common practice

The Association Between the Knowledge and Self-Medication Practices for Upper Respiratory Tract Infection (URTI) in the DKI Jakarta Population Nathanael, Kevin; Jonlean, Reganedgary; Gayatri, Anggi
Generics: Journal of Research in Pharmacy Vol 5, No 2 (2025): Generics : Journal of Research in Pharmacy Volume 5, Edisi 2, 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/genres.v5i2.26022

Most upper respiratory infections (URTIs) are caused by viruses and are self-limiting. It is one of the most frequent diseases to be treated with self-medication. Approriate self-medication practices will increase the safety of drug use. These practices need to be supported by a good level of knowledge. Therefore, this study was aimed to assess the association between level of knowledge and self-medication practices for URTIs in DKI Jakarta population. This cross-sectional study used an online questionnaire distributed around DKI Jakarta. The answers given by the subjects in the questionnaire will be used as our primary data, and the sample population was comprised of adult residents of DKI Jakarta. The questionnaire was developed by the study team and had been tested for validity and reliability before being used for data collection9. The questionnaire was divided into 3 parts, for collecting demographic data, self-medication patterns and level of knowledge regarding self-medication in URTIs. A Chi Square test was performed to analyze the association between level of knowledge and appropriateness of self-medication practices, with p value = 0.05. A total of 102 participants were analyzed at the end of this study. Information from peers tends to be the source of information for most participants, with 73.5% from friends and neighbors and 84.3% from family members. Only 21.6% of participants sought information from medical professionals. As many as 91.2% of participants took antibiotics to relieve their symptoms of URTI without prescription. Most subjects had an adequate level of knowledge (51%) and only a few subjects had a poor level of knowledge (4.9%). There was no significant association between the level of knowledge and the appropriateness of selecting drugs to treat fever, cough and rhinorrhea in this study. Most of the participants have an adequate level of knowledge on self-medication for URTI symptoms. However, there was no association between level of knowledge and the appropriateness of drug selection and the consumption of antibiotics without doctor prescription is still a common practice

Characteristics of pressure injuries among geriatric patients at an Indonesian tertiary hospital: a cross-sectional study Yusharyahya, Shannaz Nadia; Legiawati, Lili; Astriningrum, Rinadewi; Jonlean, Reganedgary; Andhira, Vega
Medical Journal of Indonesia Vol. 32 No. 3 (2023): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.237092

BACKGROUND Pressure injury develops due to sustained pressure at the bony prominence of the skin and tissues. Geriatric patients often have multiple comorbidities, predisposing them to pressure injury. Data on the characteristics of the geriatric with pressure injuries are still limited. This study aimed to report the characteristics of geriatric patients with pressure injuries admitted at a tertiary hospital in Indonesia. METHODS This cross-sectional study used medical records of geriatric patients admitted with all stages of pressure injuries consulted to the Department of Dermatology and Venereology at a tertiary hospital in Indonesia between January 2017 and April 2021. Pressure injuries were classified based on the 2019 National Pressure Injury Advisory Panel guideline. RESULTS 39 patients presented with varied pressure injury characteristics. The sacral region was the most reported site (36%), with stage 2 pressure injury being the most commonly found stage in the patients (74%). Interestingly, 22% of the patients had pressure injuries found on the atypical sites due to prolonged surgery or the pressure of medical devices. More than half of the patients used conventional dressings (51.3%). Immobility was found in 35.9% of the patients due to being bedridden. CONCLUSIONS No characteristics were found as a significant risk factor for pressure injury formation during or outside the admission period. However, a history of surgery might be related to pressure injury formation during admission.

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