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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease Journal of Stem Cell Research and Tissue Engineering Indonesian Journal of Global Health research Indonesian Journal of Cancer The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Tandarto, Kevin
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Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Veterinary

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Plasmodium falciparum Breath Metabolomics (Breathomics) Analysis as a Non-Invasive Practical Method to Diagnose Malaria in Pediatric Ivan, Ignatius; Stella, Maureen Miracle; Tandarto, Kevin; Budiman, Fanny; Joprang, Freggy Spicano
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 1 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i1.24069

Abstract

Children under 5 years of age are particularly vulnerable to malaria. Malaria has caused 445,000 deaths worldwide. Currently, rapid diagnostic tests (RDTs) are the fastest method to diagnose malaria. However, there are limitations that exist such as low sensitivity in detecting infections with low parasitemia. Practical, non-invasive and high ability tests to detect parasite are needed to find specific biomarkers for P. falciparum infection to determine the potential of P. falciparum 4 thioether in breathomics analysis by GC-MS as a practical non-invasive method in diagnosing malaria in pediatrics. Literature reviews from Google Scholar and ProQuest were published no later than the last 5 years. The concept of breathomics is that the breath's volatile organic compounds (VOCs) profile is altered when the health condition changes. Breath samples from individuals infected with P. falciparum malaria were taken by exhalation. Through GC-MS analysis, it was found that 4 thioether compounds (allyl methyl sulfide (AMS), 1-methylthio-propane, (Z) -1-methylthio-1-propene and (E) -1-methylthio-1-propene) underwent a significant change in concentration during the infection. Based on experiments conducted on mice and humans, the breathomics method is known to be able to detect parasitemia levels up to <100 parasites/µL, has a sensitivity level of about 71% to 91% and a specificity of about 75% to 94%. The discovery of 4 thioether compounds by GC-MS is a strong indication of malaria, because it has the potential for high sensitivity and specificity, and the detection power exceeds the ability of RDTs.
Zoliflodacin, A Novel Antimirobial Agent Against neisseria Gonorhoeae: A Systematic Rreview of Quasi-Experimental Studies Matthew, Franklind; Stella, Maureen Miracle; Tandarto, Kevin; Regina, Regina
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 36 No. 1 (2024): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V36.1.2024.68-74

Abstract

Background: The gram-negative bacteria Neisseria gonorrhoeae is the source of the STI known as gonorrhea. N. gonorrhoeae can adapt well to humans as a host and become a pathogen with sophisticated mechanisms to avoid the innate immune response as well as suppress the adaptive immune response. Lately, zoliflodacin was shown to have antibacterial activity against N. gonorrhoeae. Purpose: The aim of this study is to evaluate the antibacterial activity of zoliflodacin against N. gonorrhoeae. Methods: We followed the PRISMA 2020 guidelines to systematically search and collect literature in the following databases: ProQuest, EBSCOhost, PubMed, ScienceDirect, Taylor&Francis, SAGE, JSTOR, and Wiley, without time limitation (until October 9th,  2022). Titles and abstracts were reviewed for relevance. The inclusion criteria were original article written in English that investigated the effects of zoliflodacin in patients with gonorrhea. From 177 studies, we retrieved five studies for this study, published between 2015 and 2021. Results: Zoliflodacin was highly active in vitro against N. gonorrhoeae isolates from European countries, China, Thailand, and South Africa, and also showed potent antimicrobial activity against multi-resistant N. gonorrhoeae isolates in South Korea. There were three different kinds of minimum inhibitory concentration (MIC) evaluated, with the following results: modal MIC (0.064-0.25 μg/mL), MIC50 (0.03-0.125 μg/mL), and MIC90 (0.06-0.25 μg/mL). There was no cross-resistance to antimicrobials currently or previously used for gonorrhea treatment. This MIC range could be used for further studies.
ADIPOSE-DERIVED STEM CELL THERAPY ON NON-COMMUNICABLE DISEASE: A SYSTEMATIC REVIEW Tandarto, Kevin; Purwoko, Reza Yuridian; Oktarina, Caroline; Jonlean, Reganedgary; Irawan, Cosphiadi; Abdullah, Murdani; Pawitan , Jeanne Adiwinata
Journal of Stem Cell Research and Tissue Engineering Vol. 7 No. 1 (2023): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v7i1.40636

Abstract

The increasing number of non-communicable diseases demands practical therapy innovations, including adipose-derived stem cell application. This study aimed to analyze the effectiveness of adipose stem cell therapy on non-communicable disease patients. The method used in this study was a systematic review according to PRISMA 2020 guidelines. The database search was done on PubMed, Google Scholar, Proquest, and the EBSCO host database between 2016 and 2021. ROBINS-I tool and RoB-2 were used to assess the risk of bias in the clinical trial study. The first literature search identified a total of 2615 articles. After exclusion for some reason, 6 articles were included in this systematic review study. A total of five studies were included in this study. Based on the risk of bias assessment of the included studies, it was found that all studies had a low risk of bias in all domains. This study showed that the efficacy of adipose-derived stem cell therapy was inconsistent; however, the results were promising. In addition, the results showed that adipose-derived stem cell therapy was safe without significant side effects. Further study was needed to identify therapeutic strategies based on Evidence-based Medicine (EBM).
The Role of Gut Microbiota Dysbiosis as a Potential Factor in Early Diagnosis, Prognosis and Therapeutic Strategy of COVID-19 Patients Tandarto, Kevin; Suyandi, Kadek Ari; Chandrawati, Lily
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 3 (2023): VOLUME 24, NUMBER 3, December, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2432023242

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the most widespread global pandemic since the 1918 influenza pandemic. The consequences of the coronavirus disease 2019 (COVID-19) are devastating and become the current world major public health issue. Not only SARS-CoV-2 attack the respiratory system, but also can affect multiple organs. Clinical manifestation varies from asymptomatic to severe multiorgan dysfunctions. COVID-19 is typically associated with a set of comorbidities such as hypertension, diabetes, obesity, and/or advanced age, which significantly exacerbates the consequences of infection. During the early stages of the disease, SARS-CoV-2 can also cause gastrointestinal symptoms such as vomiting, diarrhea, or abdominal pain. Intestinal dysfunction alters intestinal microbes and increases inflammatory cytokines. As a result, diagnosing gastrointestinal symptoms that procede respiratory problems during COVID-19 infection may be required for better early diagnosis and treatment. Discovering the composition of the microbiota and its metabolic products in the context of COVID-19 can aid in the identification of novel disease biomarkers and therapeutic targets. In the context of COVID-19, elucidating changes to the microbiome as reliable biomarkers represents an overlooked piece of the disease puzzle that requires further investigation.
The Efficacy and Safety of Ixazomib for Newly Diagnosed Multiple Myeloma (NDMM) and Refractory or Relapsed Multiple Myeloma (RRMM): An Updated Systematic Review Lubis, Ainun Basyiroh; Santosa, Damai; Rizky, Daniel; Tandarto, Kevin; Kartiyani, Ika; Yunarvika, Vina; Ardini, Desta Nur Ewika; Setiawan, Budi; Pangarsa, Eko Adhi; Suharti, Catharina
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1241

Abstract

Background: Newly diagnosed multiple myeloma (NDMM) is a significant healthcare concern, comprising 1.8% of newly diagnosed cancers in the United States. Recent advancements in NDMM and refractory/relapsed multiple myeloma (RRMM) treatment, including novel agents like ixazomib, have improved patient outcomes. Ixazomib, an oral proteasome inhibitor, has shown promise in clinical trials, particularly in combination with lenalidomide and dexamethasone (IRd). This study aims to find the efficacy and safety profiles of ixazomib for NRMM and RRMM.Methods: We conducted a systematic literature review using Scopus, PubMed, Google Scholar, and ProQuest databases, focusing on randomized controlled trials (RCTs) evaluating ixazomib’s efficacy and safety in NDMM and RRMM treatment. Eligibility criteria included studies published within the last 3 years reporting data on ixazomib in NDMM and RRMM patients. Quality assessment utilized the Cochrane Risk of Bias tool for RCTs.Results: The review identified three studies from 2021–2023 demonstrating ixazomib’s efficacy and safety in MM treatment across various patient groups. Benefits included improved progression-free survival (PFS) in non-transplant NDMM, significant PFS advantage in relapsed/ refractory MM, and efficacy in transplant-ineligible NDMM induction regimens.Conclusion: Ixazomib emerges as a well-tolerated maintenance therapy offering significant PFS advantages in NDMM and RRMM, irrespective of age or frailty status. Future research, including multicenter studies, is warranted to further elucidate ixazomib’s role in MM management.
Association Between Coffee Consumption and Gastroesophageal Reflux Disease (GERD): A Cross-Sectional Analysis Hartoyo, Farrell ZR; Tandarto, Kevin; Sidharta, Veronika; Tenggara, Riki
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 1 (2022): VOLUME 23, NUMBER 1, April 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (451.43 KB) | DOI: 10.24871/231202211-16

Abstract

Background: Gastroesophageal reflux disease (GERD) is a condition in which stomach contents flow back into the esophagus, leading to various symptoms and complications. In Indonesia, the prevalence of GERD has been reported at 57.6%. Coffee consumption is often suspected to be closely linked to the occurrence of GERD. This study aims to determine the association between coffee consumption and the incidence of GERD.Methods: This study used a cross-sectional approach to conduct observational analytical research. The sample included individuals aged 18 to 65 years residing in Jakarta, selected using a consecutive sampling method. Data were collected using the Indonesian version of the Gastroesophageal Reflux Disease Questionnaire (GERD-Q). To assess the association between coffee consumption and GERD, the Chi-square test of independence was applied.Results: Out of 105 respondents, 26 were identified as having GERD. Among those, 84.6% reported consuming coffee at moderate to high frequencies, while 15.3% consumed little to no coffee. The Chi-square test of independence revealed a statistically significant association between coffee consumption and GERD among Jakarta residents aged 18 to 65 years (p = 0.006).Conclusion: There is a significant association between coffee consumption and the incidence of gastroesophageal reflux disease (GERD) among Jakarta residents aged 18 to 65 years.
The Role of Vitamin D in Enchancing Immune System and Preventing Stunting in Pediatric Patients: Literature Review Soleh, Mohamad; Atmalia, Khafifah Puja; Zulfa, Citra Kharisma; Irfan, Muhammad; Tandarto, Kevin
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6040

Abstract

The problem of stunting in Indonesia is a problem that has become a national concern. Stunting is caused by a lack of macro and micro nutrients. Vitamin D is one of the micronutrients that is important for growth in pediatric patients.Objectives of the studyo determine and examine the relationship between vitamin D and the immune system and prevention of stunting in pediatric patientsMethods: Literature searches were obtained through reference sources from Google Scholar, PubMed, Proquest, EBSCOhost. Inclusion criteria for the literature review were original articles, published in Indonesian and English, and receiving vitamin D therapy. A review of the literature highlights the crucial role of vitamin D in bone metabolism, growth, and immune system regulation, particularly in children. These functions contribute to the prevention of stunting. During pregnancy, vitamin D is essential for immune modulation in the fetus-mother interaction, making it a key regulatory factor. Its non-classical roles include acting as a strong immunomodulator by enhancing antibacterial defenses and regulating T-lymphocytes to reduce inflammation and promote immune tolerance. In the decidua, vitamin D supports innate immunity by enhancing infection response while preventing excessive immune-related inflammation. Current research has explored its potential in reducing the risk of infectious diseases like tuberculosis and in modulating autoimmune conditions. Vitamin D influences immune function beyond its direct role in the primary innate response. Early prevention of stunting requires sufficient intake of both macronutrients and micronutrients. Micronutrients, particularly vitamin D, play a vital role in bone metabolism and contribute to strengthening the body's defense mechanisms, helping to reduce the risk of infectious diseases in children.
Co-Authors Ardini, Desta Nur Ewika Atmalia, Khafifah Puja Budi Setiawan Budiman, Fanny Catharina Suharti Chandrawati, Lily Cosphiadi Irawan Hartoyo, Farrell ZR Ivan, Ignatius Jonlean, Reganedgary Joprang, Freggy Spicano Kartiyani, Ika Lubis, Ainun Basyiroh Matthew, Franklind Muhammad Irfan Murdani Abdullah Oktarina, Caroline Pangarsa, Eko Adhi Pawitan , Jeanne Adiwinata Purwoko, Reza Yuridian Regina Regina Riki Tenggara Rizky, Daniel Santosa, Damai Sidharta, Veronika Soleh, Mohamad Stella, Maureen Miracle Suyandi, Kadek Ari Yunarvika, Vina Zulfa, Citra Kharisma