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All Journal The Indonesian Biomedical Journal Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Public Health Risk Assesment Journal JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Maulana, Syafiq
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Religion Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Medicine & Pharmacology Public Health Social Sciences Veterinary

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Efikasi dan Keamanan Penggunaan Terapi Kombinasi Broadly Neutralizing Monoclonal Antibodies (bNAbs) untuk Menekan Kadar Viremia pada Pasien HIV-1: Sebuah Tinjauan Literatur Maulana, Syafiq
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 11 No 1 (2024): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 11.1 (2024)
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v11i2.796

Abstract

Background: Human Immunodeficiency Virus type 1 (HIV-1) remains a global health challenge with persistently high infection and mortality rates. Current antiretroviral therapy has not been able to completely eliminate the virus, highlighting the need for long-term alternative treatment strategies. The combination of broadly neutralizing antibodies (bNAbs) has emerged as a promising approach to suppress viremia and improve long-term control of HIV-1. Methods: This literature review was conducted by searching scientific articles in the PubMed and ScienceDirect databases using specific keywords related to bNAbs and HIV-1. Article selection was based on predefined inclusion and exclusion criteria, resulting in seven clinical trial articles for further analysis. Discussion: Current evidence shows that combination bNAbs offer improved efficacy and safety in addressing the genetic diversity of HIV-1 and preventing the emergence of resistance. The use of double, triple, and quadruple bNAb combinations has been shown to broaden viral neutralization and optimize long-term plasma viremia control. Favorable safety profiles in clinical trials support the potential of bNAbs as a promising long-term therapeutic candidate. However, most included studies had limited sample sizes and did not assess the long-term effects of the therapy. Conclusion: Combination bNAb therapy has the potential to become an effective and sustainable strategy in the management of HIV-1. Larger-scale studies are needed to strengthen clinical evidence and optimize its implementation.   Keywords: HIV-1, bNAbs combinations, virology, therapy
Expression of Plasma miRNA-133a is Significantly Lower in Acute Coronary Syndrome (ACS) than in Healthy/Non-ACS Subjects Rachmawati, Ermin; Sargowo, Djanggan; Saputra, Indra Wahyu; Riskiyah, Riskiyah; Handirosiyanto, Ikhwan; Hakim, Arief Rachman; Ismail, Mahrus; Tarsadi, Tarsadi; Maulana, Syafiq; Ahdi, Iwal Reza; Puspitasari, Alvina; Wardhani, Syanindita Puspa
The Indonesian Biomedical Journal Vol 16, No 5 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i5.3243

Abstract

BACKGROUND: The current biomarker diagnostic modality for acute coronary syndrome (ACS), cardiac troponin, has several limitations. Emerging studies showed that micro-RNA (miR)-133a was released from infarcted heart to circulation, yet the diagnostic value of miR-133a in ACS demonstrated a conflicting result. Therefore, this study was conducted to investigate the potency of plasma miR-133a as a biomarker candidate of ACS.METHODS: This was a case-controlled study, involving ACS and control subjects. The sociodemographic and clinical characteristics were assessed through medical records. A final of 39 ACS and 31 control subjects (consist of healthy and non-ACS subjects) passed the selection procedure by demonstrating a high purity of RNA. miR-133a from ACS and control subjects were detected by quantitative polymerase chain reaction (qPCR). Expression of miR-133a was evaluated for sensitivity and specificity as an ACS biomarker diagnostic using the receiver operating characteristic (ROC) curve.RESULTS: Plasma miR-133a expression was stably found in ACS subjects. The plasma miR-133a level was lower in ACS than in control subjects. miR-133a effectively distinguished ACS subjects from healthy subjects (AUC=0.911) and exhibited high diagnostic performance, with a sensitivity of 87.1% and specificity of 100% at a cut-off value of 44.035. In an extended model including both control subjects (healthy and non-ACS with comorbid conditions), miR-133a maintained diagnostic significance (AUC=0.874), showing sensitivity of 76.9% and specificity of 100% at a cut-off value of 11.69.CONCLUSION: Plasma miR-133a is significantly lower and effectively distinguishes ACS patients from both healthy individuals and non-ACS individuals with comorbid, with a cut-off value of 11.69. Therefore, plasma miR-133a is suggested to be a good candidate for diagnostic biomarkers of ACS.KEYWORDS: circulating miRNA, miRNA-133a, acute coronary syndrome, diagnostic biomarker
IMPLEMENTATION OF TAHFIZH AND TAFAQQUH FIDDIEN ASSIGNMENTS AT SMPIQU ALBAHJAH AZZAINIYAH BATAM Maulana, Syafiq; Mujahidin, Endin; Handrianto, Budi
Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Vol. 7 No. 3 (2023): SEPTEMBER
Publisher : LPPM Univ. Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/abdidos.v7i3.1938

Abstract

SMPIQU Albahjah Azzainiyah Batam School has one of the leading programs as a local content by implementing the Tahfidz and Tafakkuh Programs Each class must be able to participate in tahfidz and Tafakkuh activities held and assigned by the school. This observation aims to: (1) Know the implementation of tahfizh and Tafakkuh programs and (2) as a step for planning that can be carried out properly to achieve maximum results in the future. Where the development of students in the Albahjah Azzainiyah hut aims to instill the values of piety, independence, discipline, responsibility, simplicity, and skills to realize the vision, mission, goals, and targets of the school. The implementation of the assignment of Tahfidz and Tafaqquh fiddien is an observation of teacher activities to improve their role in education, especially character education at SMPIQU Azzainiyah Batam. The analysis used is observation and field participation. The subject of this study was a supervisor and teacher at SMPIQU AAlbahjah Azzainiyah Batam. While the object of this study is the Implementation of Tahfidz and Tafakuh Fiddin Assignments at SMPIQU Albahjah Azzainiyah Batam. Data observation is carried out by selecting the data obtained and then collected for analysis and conclusions. This research uses a qualitative approach, with a case study approach at SMPIQU Azzainiyah Batam. Data was obtained in this study through observation, interviews, and documentation studies. Based on the data obtained, researchers use descriptive analysis, namely by describing or describing what are the findings in the field related to the implementation of the Qur'an tahfidz and tafakkuh programs at SMPIQU Azzainiyah Batam
Diagnostic accuracy of loop-mediated isothermal amplification (LAMP) assays for dengue virus detection in serum: A systematic review and meta-analysis Maulana, Syafiq; Fatoni, Fatahillah Tsabit
Public Health Risk Assesment Journal Vol. 3 No. 2: January (2026)
Publisher : Institute for Advanced Science, Social, and Sustainable Future

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61511/phraj.v3i2.2026.2247

Abstract

Background: Rapid and accurate diagnosis of dengue virus (DENV) infection remains a challenge in endemic areas. Current gold standard methods have several limitations and are often unsuitable for resource-limited settings. Loop-mediated isothermal amplification (LAMP) offers a rapid, cost-effective, and field-adaptable alternative. This meta-analysis aimed to evaluate the diagnostic accuracy of LAMP for detecting DENV infection in human serum samples. Methods: A comprehensive literature search was conducted in PubMed, Scopus, Taylor & Francis, and Wiley databases up to July 2025. Pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were calculated to assess the diagnostic performance of LAMP. Meta-DiSC 1.4 was used for analysis, and methodological quality was evaluated using the QUADAS-2 tool. Meta-regression was performed to explore potential sources of heterogeneity. Findings: Five studies involving 807 samples were included in this meta-analysis. The pooled meta-analysis results were as follows: sensitivity 0.83 (95% CI: 0.80–0.85), specificity 0.95 (95% CI: 0.91–0.98), PLR 14.31 (95% CI: 7.82–26.20), NLR 0.15 (95% CI: 0.07–0.31), and DOR 103.30 (95% CI: 23.13–461.42). The summary of AUC was 0.9633, indicating good diagnostic accuracy. Meta-regression showed no significant effect of study design, sample size, geographic region, cross-reactivity testing, or reference standard on diagnostic accuracy. Conclusion: LAMP provides a highly accurate and reliable method for DENV detection in human serum, suitable for both clinical and field use. Its routine implementation may improve dengue outbreak management and surveillance in endemic areas. Novelty/Originality of this article: This is the first meta-analysis to comprehensively evaluate the diagnostic accuracy of LAMP for DENV detection in human serum. By synthesizing evidence from multiple studies, it provides stronger statistical power than individual reports and highlights the robustness of LAMP across diverse settings.
Co-Authors Ahdi, Iwal Reza Arief Rachman Hakim Budi Handrianto Djanggan Sargowo Endin Mujahidin Ermin Rachmawati Fatoni, Fatahillah Tsabit Handirosiyanto, Ikhwan Ismail, Mahrus Puspitasari, Alvina riskiyah, Riskiyah - Saputra, Indra Wahyu Tarsadi, Tarsadi Wardhani, Syanindita Puspa