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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) JOPS (Journal Of Pharmacy and Science) Jurnal Riset Kefarmasian Indonesia Archives Pharmacia Journal of Pharmaceutical Science and Herbal Technology Jurnal Novem Medika Farmasi
Auliah, Nielma
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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THE FORMULATION OF CREAM PREPARATIONS BLUSH ON OF ETANOL EXTRACT FROM MIANA PURPLE LEAVES (Coleus scutellarioides L.) AS BLUSHER Suryanita; Fitrahmia S, Nur; Auliah, Nielma; Bachri, Nurjannah
Journal of Pharmaceutical Science and Herbal Technology Vol. 9 No. 1 (2024): Journal of Pharmaceutical Science and Herbal Technology
Publisher : STIKES Nani Hasanuddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Anthocyanin is a chemical compound found in purple miana leaves and plays an important role in providing color. Purple miana leaf extract can be used as a natural coloring in blush on cream preparations. The aim of this research is to determine whether purple miana leaf extract (Coleus scutellarioides L) can be formulated in the form of a blush cream dosage form that is physically and chemically stable. The research method used was experimental research by making blush on preparation formulations with concentrations of 7.5%, 10% and 12.5% ​​and evaluating the preparations using physicochemical, irritation tests and hedonic tests. The research results showed that blush on formulations with concentrations of 7.5%, 10% and 12.5% ​​were physically and chemically stable and in the hedonic/preference test the most preferred formulation was the formulation with a concentration of 12.5%. The conclusion of this research is that the ethanol extract of purple miana leaves (Coleus Scutellarioides L) can be formulated in the form of a blush cream dosage form that is physically and chemically stable.
Efektivitas Antidiare Ekstrak Buah Terong Takokak (Solanum torvum) Terhadap Hewan Uji Mencit (Mus musculus) Diinduksi Dengan Minyak Jarak (Oleum ricini) Najamuddin, Mirfaidah; Auliah, Nielma; Iriani, Nova; wahyuni; yustisi, Andi juella; Karim, Suhrah Febrina; Junita, Nurfitria; SG, Noviatri
Jurnal Novem Medika Farmasi Vol. 1 No. 2: volume 1 Issue 2
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v1i2.611

Abstract

Ekstrak etanol buah terong Takokak (Solanum torvum) mengandung tannin yang berfungsi sebagai anti diare. Penelitian ini bertujuan untuk melihat efektivitas antidiare ekstrak buah terong takokak (Solanum torvum) terhadap hewan uji mencit (Mus musculus). Buah terong Takokak melewati proses maserasi, kemudian dibuat menjadi tiga dosis yaitu 15, 20, dan 25 mg/kg BB, dengan menggunakan minyak jarak (Oleum ricini) diinduksikan kepada 5 kelompok perlakuan hewan uji, dan diamati konsistensi feses dan bobot feses yang dihasilkan pada 4 jam perlakuan dibandingkan dengan loperamide 2 mg sebagai kontrol positif. Hasil yang diperoleh menunjukkan pada masing-masing kelompok ekstrak 15 mg/kgBB, 20 mg/kgBB, dan 25 mg/kgBB dengan kontrol negatif Na.CMC diperoleh hasil p< 0.05 hanya pada dosis 25 mg/kgBB dan kontrol positif loperamid, artinya memiliki kemampuan sebagai antidiare yang baik daripada kontrol negatif. Disimpulkan bahwa dosis 25 mg/kgBB merupakan dosis yang paling efektif sebagai antidiare.
Formulasi dan Uji Efektivitas Sediaan Lip cream dari Ekstrak Etanol Biji Buah Merah (Pandanus conoideus L) sebagai Pewarna Alami dengan Menggunakan Metode DPPH (1,1-Difenil-2-Pikrihidrazil) Primadani, Nur Baetty; Alyidrus, Rugayyah; Farid, Nurfiddin; Auliah, Nielma
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4173

Abstract

Formulation and Effectiveness Test of Lip Cream Preparations from Ethanol Extract of Red Fruit Seeds (Pandanus conoideus L) as A Natural Dye Using The DPPH (1,1-Diphenyl-2-Pikrihidrazil) Method. Red fruit seeds are botanical specimens that possess keratenoid chemicals, specifically b-carotene and a-carotene, which exhibit antioxidant properties. The objective of this study is to develop a stable Lipcream formulation and measure the IC50 value of the lipcream prepared from the ethanol extract of red fruit seeds (Pandanus conoideus L), which has antioxidant properties. An experimental research approach utilizing a solvent maceration technique with a solvent concentration of 96%. The obtained concentrated extract was subjected to rotation, followed by the fabrication of solutions with concentrations of 2%, 4%, and 6%, utilizing beeswax as a thickening agent. Kaolin is used as a texturizer. The emollients used are castor oil, cetyl alcohol, and dimethicon. Methyl paraben and propyl paraben are utilized as preservatives. Titanium dioxide serves as a pigment. The scent of vanilla. The preparation was evaluated by a cycling test consisting of 6 cycles over a period of 12 days. Organoleptic observations revealed a semi-solid texture, cream-like form, and a vanilla scent. The homogeneity test yielded consistent results, with pH measurements exceeding 0.05p, spreadability test results surpassing 0.05p, and adhesiveness test results meeting the specified standards. In addition to doing antioxidant testing, the DPPH method is employed using a UV-Vis spectrophotometer. The research findings indicate that the ethanol extract derived from red fruit seeds (Pandanus conoideus L) can be effectively made into a stable lip cream formulation, both in terms of its physical and chemical properties. The IC50 values obtained from the lip cream formulation including the ethanol extract of red fruit seeds (Pandanus conoideus L) were 59,496 ppm, 52,817 ppm, and 5,581 ppm, respectively. Formula 3 contains the most potent antioxidant value among all lip cream preparations.
Test the Antioxidant Effectiveness of Oyster Mushroom (Pleurotus ostreatus) Ethyl Acetate Fraction Cream Formula using FRAP (Ferric Reducing Antioxidant Power) and ABTS (2,2'-azino-bis (3-3) ethylbenzothiazoline-6-sulphonic acid) Methods) Nadjamuddin, Mirfaidah; Auliah, Nielma; Mulyadin; Tajuddin, Zakiah; Andriawan, Riki
Jurnal Penelitian Pendidikan IPA Vol 9 No 12 (2023): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i12.6118

Abstract

Antioxidants are compounds that can fight the influence of free radical molecules due to chemical reactions and metabolic events in the body. Phenolic compounds work to reduce the reaction of increasing the oxidation number, and are able to reduce highly reactive free radicals, lipid peroxidation processes, and metal oxides that can be obtained from oyster mushrooms. This study aims to make an antioxidant cream preparation and measure the IC50 value by conducting an antioxidant test of the ethyl acetate fraction of oyster mushroom (Pleurotus ostreotus) cream using FRAP (ferric reducing antioxidant power) and ABTS (2.2'-azino-bis (3-3) ethylbenzothiazoline-6-sulphonic acid) methods. The methods used are FRAP and ABTS where oyster mushrooms go through a liquid-liquid partition process and are made into cream preparations with formula concentrations of 2%, 4% and 6%, then their antioxidant activity is seen. The results of measuring three cream formulas obtained an IC50 value using the FRAP method of 110.12 bpj, and an IC50 value using the ABTS method of 84.61 bpj. The conclusion was that the IC50 value using the FRAP method (110.12 bpj) had medium category activity and the IC50 value using the ABTS method (84.61 bpj) had strong category activity.
Formulasi Dan Uji Aktivitas Antibakteri Sediaan Deodoran Spray Fraksi Etil Asetat Daun Jamblang (Syzygium Cumini) Terhadap Staphylococcus epidermidis Nurhikmah, Nurhikmah; SR, Muhammad Asri; Wahid, Hilmiati; Suryanita, Suryanita; Auliah, Nielma
Archives Pharmacia Vol 8, No 1 (2026): ARCHIVES PHARMACIA
Publisher : Lembaga Penerbitan Universitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47007/ap.v8i1.9874

Abstract

Masalah bau badan merupakan hal umum yang disebabkan oleh aktivitas bakteri pada tubuh, khususnya Staphylococcus epidermidis, dan dapat mengganggu kenyamanan. Deodoran adalah salah satu solusi untuk mengatasi masalah ini. Namun, sebagian besar deodoran di pasaran mengandung bahan kimia seperti aluminium, paraben, dan triclosan yang dapat menimbulkan risiko kesehatan. Oleh karena itu, diperlukan alternatif deodoran berbahan alami yang aman dan efektif, salah satunya dari daun jamblang (Syzygium cumini) yang diketahui mengandung senyawa flavonoid dengan potensi antimikroba. Penelitian ini bertujuan untuk mengetahui apakah fraksi etil asetat daun jamblang dapat diformulasikan menjadi sediaan deodoran spray yang stabil secara fisika dan kimia, serta untuk mengetahui konsentrasi yang efektif dalam menghambat pertumbuhan bakteri Staphylococcus epidermidis. Penelitian dilakukan secara eksperimental dengan empat formula (F0, FI, FII, dan FIII), yang kemudian dievaluasi stabilitas fisikokimianya serta diuji aktivitas antibakterinya menggunakan metode difusi cakram. Hasil menunjukkan bahwa semua formula stabil secara fisika dan kimia. Uji aktivitas antibakteri menunjukkan F0 tidak aktif, FI menghasilkan zona hambat 8,8 mm (sedang), FII sebesar 11,4 mm, dan FIII sebesar 13,88 mm (kuat). Berdasarkan hasil tersebut, dapat disimpulkan bahwa fraksi etil asetat daun jamblang dapat diformulasikan sebagai deodoran spray alami yang stabil dan memiliki aktivitas antibakteri terhadap Staphylococcus epidermidis.
UJI AKTIVITAS ANTIBAKTERI SEDIAAN SABUN CAIR MINYAK ATSIRI KULIT BUAH JERUK BALI (Citrus maxima) Yustisi, Andi Juaella; Wahyuningsih, Sri; Auliah, Nielma
Jurnal Riset Kefarmasian Indonesia Vol. 5 No. 2 (2023): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v5i2.355

Abstract

Pomelofruit (Citrus maxima) has several chemical compounds, one of which is essential oil, 6.68g of essential oil was found in the peel of the pomelofruit (Citrus maxima) which has an active compound, namely limonene (94.96%). The essential oil provided strong antibacterial activity against S. aureus isolates. The purpose of the study was to formulate the essential oil of pomelofruit peel (Citrus maxima) into liquid soap preparations that met physical stability and to test the antibacterial activity of liquid soap preparations of pomelofruit (Citrus maxima) peel essential oil against S. aureus bacteria. The method used in testing the stability of liquid soap preparations is cycling test and in the antibacterial activity test using the Disk diffusion method. The results obtained that the essential oil of pomelofruit peel (Citrus maxima) can be formulated in the form of liquid soap because it meets the physical stability test, namely before and after the cycling test and activity tests. antibacterial against S. aureus. at 1% concentration of 18.9mm (strong), 3% of 20.4mm (very strong), and 5% of 21.1mm (very strong). Based on this, the essential oil of pomelofruit peel (Citrus maxima) can be made into liquid soap preparations that meet the physical stability test and have antibacterial activity in very strong category at a concentration of 5% in inhibiting the growth of S. aureus bacteria.
PENGEMBANGAN FORMULASI EMULGEL FRAKSI n-HEKSAN DAUN MIANA (Coleus scutellarioides) SEBAGAI ANTIBAKTERI TERHADAP Propionibacterium acnes PENYEBAB JERAWAT (Acne vulgaris) Auliah, Nielma; Bachri, Nurjannah; SR, Muhammad Asri; Nurfatma, Nurfatma
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 1 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i1.431

Abstract

Acne (Acne vulgaris) is a condition where the skin experiences inflammation in the polysebaceous unit which is triggered by Propionibacterium acnes. Miana leaves (Coleus scutellarioides) contain alkaloid and terpenoid compounds which can act as antibacterials. This research aims to determine whether the n-hexane fraction of Miana leaves (C. scutellarioides) can be formulated in the form of a physically and chemically stable emulgel preparation, to determine whether the n-hexane fraction of Miana leaves (C. scutellarioides) has activity against P. acnes. as a cause of acne (A. vulgaris) and to determine the formula with an effective concentration in inhibiting the growth of P. acnes. This research is a form of laboratory experimentation. The n-Hexane fraction of miana leaves was obtained by fractionation. Antibacterial activity testing was carried out using the well method. The results obtained were physically and chemically stable emulgel formulas, namely F0 and F1. The inhibition zone of F1 is 16.46 mm (strong), F2 is 14.40 mm (strong), F3 is 16.78 mm (strong) and F0 has no antibacterial activity. The formula with a concentration of 12.5% was the most effective in inhibiting the growth of P. acnes, namely 16.78 mm. From the results of this research, it was found that the n-Hexane fraction of Miana leaves (C. scutellarioides) has strong antibacterial activity against P. acnes and can be formulated in the form of an emulgel dosage form.
UJI EFEK ANALGETIK EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus Lam.) TERHADAP MENCIT (Mus musculus) YANG DIINDUKSI ASAM ASETAT Auliah, Nielma; Lotuconsina, Ari Aprianto; Thalib, Muthmainnah
Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 2 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v1i2.24

Abstract

Research has been carried out with the title "Test of the Analgetic Effect of Ethanol Extract of Jackfruit Leaves (Artocarpus heterophyllus Lam.) On Acetic Acid-induced Mice (mus musculus). Analgesics or painkillers are drugs that reduce or eliminate taste without losing consciousness. One of the traditional plants commonly used empirically is jackfruit leaves (Artocarpus heterophyllus Lam.). This study aims to determine the analgetic effect of ethanol extract of jackfruit leaves (Artocarpus heterophylus Lam.) At a dose of 100 mg / kgBB, 300 mg / kgBB and 600 mg / kgBW on acetic acid induced male mice (Mus musculus). This research is an experimental study and uses the chemical induction method. The results obtained in the form of% protection inhibition stretching ethanol extract of jackfruit leaves (Artocarpus heterophyllus Lam.) At a dose of 100mg / kgBB (28.79%); 300mg / kgBB (53.31%); 600mg / kgBB (60.70%). From the results of the research that has been done it can be concluded that the ethanol extract of jackfruit leaves (Artocarpus heterophyllus Lam.) Has the highest analgesic effect at a dose of 600mg / kgBW having a percentage of protection of 66.70%.
EVALUASI PENGGUNAAN ANTIBIOTIK DENGAN METODE GYSSENS PADA PASIEN PNEUMONIA DI RUMAH SAKIT BHAYANGKARA KUPANG PERIODE JULI – DESEMBER 2019 Yusuf, Muhammad; Auliah, Nielma; Sarambu, Hana Evangelista
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 2 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i2.243

Abstract

Pneumonia is a disease in Indonesia that has a high mortality rate in 2018. Pneumonia is an inflammation of the lungs caused by microorganisms (bacteria, viruses, fungi, parasites). Pneumonia caused by Mycobacterium tuberculosis is not included. While lung inflammation caused by non-microorganisms (chemicals, radiation, aspiration of toxic substances, drugs, etc.) is called pneumonitis. One of the treatment for pneumonia is antibiotics where the incidence of resistance in patients often occurs due to irrational use, therefore it needs to be monitored and evaluated by health workers. The purpose of this study was to determine the use of antibiotics in pneumonia patients at Bhayangkara Hospital Kupang with the Gyssens method according to the Minister of Health of the Republic of Indonesia No. 8 of 2015. The Gyssens method is an evaluation of the use of antibiotics to assess the accuracy of the use of antibiotics which includes the accuracy of indications, the accuracy of selection based on effectiveness, toxicity, price and spectrum, duration of administration, dose, interval, route and time of administration. The method used is non-experimental with a descriptive research design, the sample taken is 25 medical record data. The results of the research category 0 (precise and rational) were 84% or in other words the use of antibiotics was rational, category IVb (there were antibiotics that were less toxic) was 12% and in category IIb (inappropriate interval antibiotics) was 4%.
Co-Authors Alyidrus, Rugayyah Andi Juaella Yustisi Andriawan, Riki Farid, Nurfiddin Fitrahmia S, Nur G. Gunawan Iriani, Nova Junita, Nurfitria Karim, Suhrah Febrina Lotuconsina, Ari Aprianto Muhammad Yusuf Mulyadin Nadjamuddin, Mirfaidah Najamuddin, Mirfaidah Nurfatma, Nurfatma Nurhikmah Nurhikmah Nurjannah Bachri Primadani, Nur Baetty Sarambu, Hana Evangelista SG, Noviatri SR, Muhammad Asri Suryanita Suryanita, Suryanita Tajuddin, Zakiah Thalib, Muthmainnah Wahid, Hilmiati WAHYUNI yustisi, Andi juella