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The Correlation between Leukopenia and the Severity of Dengue Hemorrhagic Fever in Pediatric Patients Mulyadi, Angelina; Sukmana, Judya; Anindya, Pramita; Purwoko, Suliman
Journal La Medihealtico Vol. 5 No. 1 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i1.1079

Abstract

The aim of this study is to investigate the correlation between leukopenia and the severity of DHF in pediatric patients treated at RSPAL dr. Ramelan Surabaya from January 2021 to December 2022. This analytical observational study employed a cross-sectional design, involving 126 patient records from RSPAL dr. Ramelan Surabaya during the specified period. The sample selection was done using purposive sampling. The variables under investigation were leukopenia on days 2 to 5 and the DHF grade in patients aged 5 to 14 years. The statistical correlation test, Kendall's tau-b, indicated that there is no significant correlation between leukopenia and the severity of DHF in pediatric patients, with a p-value of 0.340, meaning p > α (with α = 0.05). The data revealed that out of the patients, 88 (69.8%) had Grade I, 16 (12.7%) had Grade II, 19 (15.1%) had Grade III, and 3 (2.4%) had Grade IV. Leukopenia occurred in 49 (73.1%) Grade I patients, 9 (13.4%) Grade II patients, 7 (10.4%) Grade III patients, and 2 (3%) Grade IV patients. In conclusion, this study found no significant correlation between leukopenia and the severity of DHF in pediatric patients treated at RSPAL dr. Ramelan Surabaya from January 2021 to December 2022.
DOSAGES ANALYSIS OF HYPERBARIC OXYGEN THERAPY TO IMPROVING COGNITIVE FUNCTION IN PATIENTS POST-TRAUMATIC BRAIN INJURY: A REVIEW Nuri, Almas; Edi, Djatiwidodo; Anindya, Pramita; Ilmawan, Moh. Fathi
MNJ (Malang Neurology Journal) Vol. 11 No. 1 (2025): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.01.24

Abstract

Background: Traumatic brain injury is a type of intracranial injury caused by a mechanical impact that causes anatomical and physiological damage to the brain. Globally, there are 50 million cases of traumatic brain injury each year that cause 10 million deaths and/or hospitalizations. Hyperbaric oxygen therapy is a therapy that uses 100% oxygen at pressures greater than 1 Atmosphere Absolute  (ATA) to increase tissue oxygenation and repair damaged tissue. This study was made to determine the effect of hyperbaric oxygen therapy on improving cognitive function in post-traumatic brain injury patients and the mechanisms underlying it. Objective: To determine the dose of hyperbaric oxygen therapy that can trigger improved cognitive function in post-traumatic brain injury patients, as well as the side effects. Methods: This research is descriptive research and uses the literature study method. In collecting data, using all journals with the search keywords "hyperbaric oxygen therapy" "traumatic brain injury" "hyperbaric oxygen therapy for TBI" "HBOT and TBI" "oxygen therapy and brain injury" published in 2017 - 2022 and indexed by Scimago Journal & Country Rank (SJR) and/or Science And Technology Index (SINTA) then new conclusions and descriptions are made. Results: After selecting 262 journals, ten journals met the inclusion and exclusion criteria. The ten journals stated that there was an effect of hyperbaric oxygen therapy on improving cognitive function in post-traumatic brain injury patients. assessment of improvement in cognitive function in the attached journal, assessed with different parameters. Conclusion: Hyperbaric oxygen therapy is a potential therapy to accelerate cognitive function improvement in post-traumatic brain injury patients.
Understanding the Determinants of Acute Otitis Media in Children Exposed to Tobacco Smoke: A Study from an Urban Indonesian Population Ekananda, Nabilla Firya; Rusli, Christina; Anindya, Pramita
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 6 No. 1 (2025): June
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

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Abstract

Tobacco smoking is a pervasive global health challenge, with its by-product, secondhand smoke, negatively impacting health, especially in vulnerable populations such as children. In Indonesia, ear disorders, notably Acute Otitis Media (AOM), are common pediatric morbidities. AOM, an inflammation of the middle ear, is frequently linked to high smoking activity and, critically, exposure to tobacco smoke. This study aimed to elucidate the association between secondhand smoke exposure and AOM occurrence in children aged 0-5 years presenting at Dr. Ramelan Naval Hospital, Surabaya. Utilizing a cross-sectional observational design, data were collected from 74 eligible pediatric patients through questionnaires detailing their smoke exposure and corresponding AOM diagnoses. Spearman's correlation analysis revealed a statistically significant relationship between secondhand smoke exposure and AOM incidence (p<0.001), characterized by a moderate correlation coefficient (r=0.329). The findings underscore that a significant proportion of pediatric AOM cases at our institution are associated with moderate secondhand smoke exposure. This research concludes that secondhand smoke exposure is a significant risk factor for Acute Otitis Media, particularly among children aged 0-5 years, highlighting a critical need for public health interventions to reduce household smoke exposure and improve pediatric ear health outcomes.
Analysis Of Maternal Hygiene Practices And Sanitation Knowledge On Stunting Incidence In Children Under Five At Sepatan Health Center, Tangerang Regency Muhamarudin; Anindya, Pramita; Budipramana , Vicky Sumarki; Dagradi, Eric Mayo
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 6 No. 1 (2025): June
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

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Abstract

Stunting remains a significant global health challenge, profoundly impacting child growth and development, defined by a height-for-age z-score below -2 standard deviations of the WHO growth standards. Substandard sanitation and poor hygiene practices substantially elevate the risk of stunting, potentially by up to five-fold. Parental involvement, especially maternal knowledge and understanding of stunting, is crucial for its prevention. This study aimed to analyze the association between maternal hygiene practices, maternal sanitation knowledge, and stunting prevalence in toddlers. We conducted a cross-sectional, observational analytic study among mothers of stunted children aged 0-5 years within the working area of Puskesmas Sepatan, Tangerang Regency, Indonesia. A total of 63 respondents completed questionnaires assessing their hygiene behaviors and sanitation knowledge. Our findings indicate that most stunted toddlers had mothers with suboptimal hygiene practices, despite their sanitation knowledge generally being in the 'good' category. Spearman's correlation analysis revealed a significant association between maternal hygiene practices and stunting incidence (p=0.044), as well as between maternal sanitation knowledge and stunting incidence (p=0.000). This study concludes that both maternal hygiene practices and sanitation knowledge are significantly associated with stunting among toddlers in this Indonesian community, underscoring the critical need for targeted interventions focusing on behavioral change alongside educational initiatives to combat this pervasive public health issue.
Kaitan Antara Gangguan Perkembangan dan Perilaku Anak dengan Gut-Brain Axis Anindya, Pramita; Diarsvitri, Wienta
Surabaya Biomedical Journal Vol. 1 No. 2 (2022): Januari
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i2.21

Abstract

Tujuan Penelitian: Gangguan perkembangan dan perilaku pada anak merupakan masalah yang sering ditemukan, namun belum jelas mekanismenya. Penelitian ini bertujuan untuk membahas kaitan antara gangguan perkembangan dan perilaku pada anak dengan gut-brain axis. Metode : Penelitian literature review ini menggunakan 20 artikel dengan kriteria inklusi artikel yang dipublikasikan di jurnal nasional terakreditasi dan jurnal internasional antara tahun 2012-2021, berbahasa Indonesia atau Inggris, dan dapat diakses full text. Artikel didapatkan dari mesin pencari PubMed, Google Scholar dan Cochrane dengan beberapa kata kunci. Hasil : Konsep gut- brain axis berperan penting dalam pertahanan tubuh. Paradigma gut-brain axis merujuk pada adanya hubungan antara saluran cerna dan otak melalui mekanisme dua arah atau bidirectional, suatu alur homeostasis sistem saraf, hormonal dan sistem imun, yang jika salah satu bermasalah maka dapat menimbulkan ketidak seimbangan diantara ketiganya. Kesimpulan : Hasil penelitian mendukung keberadaan gut-brain axis, bahwa ada kaitan antara mikrobiota dalam saluran cerna dengan gangguan perkembangan dan perilaku pada anak. Konsekuensi jangka panjang dari gangguan dalam komposisi mikrobiota usus pada awal kehidupan mempengaruhi kondisi kesehatan di masa dewasa.