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Syamsu Hidayat, Muhammad Zaenuri
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Medicine & Pharmacology

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PERBANDINGAN KLORAMFENIKOL, ERITROMISIN DAN FORMALIN DENGAN BERBAGAI DOSIS TERHADAP PENGHAMBATAN PERTUMBUHAN Clostridium perfringens Peramiarti, IDSAP; Syamsu Hidayat, Muhammad Zaenuri
Medical and Health Journal Vol 4 No 1 (2024): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2024.4.1.12735

Abstract

Death is the cessation of function of the circulatory system and respiratory system, or brain stem death has occurred. Decomposition is natural process that occur shortly after death. The main bacteria involved in the decomposition process is Clostridium perfringens. The process of decomposition sometimes need to be inhibited by the preservation bodies. Preserving the corpse is a medical procedure for the provision of certain chemicals such as formalin or can used a broad spectrum antibiotic chloramphenicol and erytromicine. This study aims to test the effectiveness of various doses of chloramphenicol, erytromicine and formaline in inhibiting the growth of Clostridium perfringens. This was an experimental study with post test only and contol group design. The treatment of various doses of chloramphenicol 0,25 µg/ml, 0,5 µg/ml, 1 µg/ml, 2 µg/ml, and 4 µg/ml; Erythromycin doses were 0,2 µg/mL, 0,4 µg/mL, 0,8 µg/mL, 1,6 µg/mL, and 3,2 µg/mL and formalin was given at 2%, 4%, 6%, 8%, and 10% in liquid medium Nutrient Broth. Incubated for 24 hours at 37 ° C, and then planted in agar plate wiith spread plate method to determine the growth of bacteria. Bacterial growth was calculated by colony counter, then the percentage inhibition was determined. Data were analyzed using parametric tests One Way Annova and Post Hoc Test. The effective concentration was determined by Minimum Inhibitory Concentration 50 (MIC50). Data were analyzed using One Way Annova test, showed p value=0,009 (p<0,05) which meant that there were significant difference between the number of colony inhibition with number of doses given to C. perfringens, and the results of Post Hoc Test concentration of formaldehyde 10% and 8% had the lowest number of colonies or has the ability to inhibit the growth of c. perfringens bacteria most of 80% and 63%, so it can be said to be effective concentration (MIC50) at 8% formalin treatment with inhibition of growth of 63%.
IMMUNE THROMBOCYTOPENIC PURPURA INDUCED BY VARICELLA ZOSTER IN AN 8-YEAR-OLD GIRL: A CASE REPORT Praditina, Wening Gelar; Hapsari, Ariadne Tiara; Syamsu Hidayat, Muhammad Zaenuri; Bunga, Bunga; Tamia, Afra Bryges
Medical and Health Journal Vol 4 No 2 (2025): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.4.2.14942

Abstract

Varicella Zoster Virus (VZV) can trigger various complications, one of which is Immune Thrombocytopenic Purpura (ITP), although this occurrence is rare. ITP is a bleeding disorder caused by excessive platelet destruction due to autoantibodies. This case report presents an 8-year-old female child who developed varicella accompanied by severe thrombocytopenia. Initially, the patient experienced prodromal symptoms including fever, followed by the appearance of vesicular skin lesions that spread centrifugally. Laboratory tests revealed thrombocytopenia, supporting the diagnosis of ITP. The management included antiviral therapy with acyclovir, platelet transfusion, and corticosteroid therapy to reduce inflammation. Although ITP triggered by varicella is rare, prompt and appropriate management is essential to prevent life-threatening complications.
Gambaran Histopatologi Jaringan Paru Tikus (Rattus norvegicus) Pada Beberapa Keadaan Tenggelam di Air Tawar Savitri, Annisa; Syamsu Hidayat, Muhammad Zaenuri; Rahmawati, Indah; Pratidina, Rr. Wening Gelar
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.14846

Abstract

Background: Drowning remains a significant cause of mortality, with complex pathophysiological mechanisms that are often challenging to diagnose. Histopathological examination of the lung is one of the tests that supports the diagnosis of the cause of death and manner of death in drowning cases. Objective: This study aims to analyze the histopathological features of rat lungs drowned in freshwater under conscious, unconscious, and post-mortem conditions. Methods: A descriptive experimental study by dividing the rats into three conditions; conscious, unconscious and post-mortem drowning. The lung tissues collected from the drowned rats, processed, stained with hematoxylin eosin and observed under the microscope. The results stated in descriptive form and scores. Results: In Group 1, alveolar edema (score 2), hemorrhage (score 4), inflammatory cell infiltration (score 2.2), and alveolar thickening (score 2.4) were observed. Group 2 exhibited a similar histopathological pattern to Group 1. Group 3 showed mild alveolar edema (score 1), massive hemorrhage (score 4), extensive inflammatory cell infiltration (score 4), and severe alveolar thickening (score 3). Conclusion: Histopathology of lung tissue of rats that drowned alive showed moderate alveolar edema, massive hemorrhage, moderate inflammatory cell infiltration and moderate alveolar thickening. Rats that drowned unconsciously showed moderate alveolar edema, massive hemorrhage, moderate inflammatory cell infiltration and moderate alveolar thickening. Rats that drowned after death showed minimal alveolar edema, massive hemorrhage, massive inflammatory cell infiltration and severe alveolar thickening.
Co-Authors Annisa Savitri, Annisa Ariadne Tiara Hapsari Bunga, Bunga Indah Rahmawati Peramiarti, IDSAP Praditina, Wening Gelar Pratidina, Rr. Wening Gelar Tamia, Afra Bryges