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All Journal Biofaal Journal Jurnal Anestesi: Jurnal Ilmu Kesehatan dan Kedokteran Tolis Mengabdi : Jurnal Pengabdian Kepada Masyarakat Pasapua Health Journal Medicor : Journal of Health Informatics and Health Policy
Nadira Pattimura
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Engineering Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Other

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Journal : Biofaal Journal

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POTENSI KULIT BATANG Cinnamomum burmannii Bl. DALAM MENCEGAH INFERTILITAS; KAJIAN TERHADAP BERAT TESTIS DAN JUMLAH SPERMATOZOA MENCIT (Mus musculus) MODEL DIABETES MELLITUS TIPE-1 Moniharapon, Mechiavel; Ukratalo, Abdul M; Pattimura, Nadira; Samson, Efraim; Pangemanan, Victory O
Biofaal Journal Vol 4 No 2 (2023): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v4i2pp108-117

Abstract

In individuals with diabetes mellitus, the increase in Reactive Oxygen Species (ROS) can damage the mitochondrial membrane, leading to the loss of potential mitochondrial membrane function in inducing apoptosis of sperm cells. Cinnamomum burmannii is a type of spice that contains antioxidants, thus capable of neutralizing free radicals and reducing oxidative stress caused by diabetes mellitus. Flavonoids also have an effect on increasing spermatogenesis. The aim of this research is to examine the role of methanol extract from Cinnamomum burmannii bark in increasing testis weight and spermatozoa count in type-1 diabetes mellitus mice (Mus musculus). The study employs a Completely Randomized Design (CRD) with five treatments and three replications. Twenty mice are divided into groups: K- (control), K+ mice injected with STZ without medication), P1 (dose of 200 mg/kg BW), P2 (dose of 400 mg/kg BW), and P3 (dose of 800 mg/kg BW). Before administering the Cinnamomum burmannii bark extract, blood sugar levels are measured in the K+, P1, P2, and P3 groups. If blood sugar levels have increased (>128 mg/dL), the P1, P2, and P3 groups are given the Cinnamomum burmannii bark extract according to the predetermined dosage. The treatment is carried out for 14 days. On the last day, surgery is performed to extract the testes and observe the spermatozoa count. The observation data on testis weight and spermatozoa count will be analyzed using ANOVA with SPSS 24.0. The results indicate that the administration of methanol extract from Cinnamomum burmannii bark significantly affects the increase in testis weight and spermatozoa count in type-1 diabetes mellitus mice. The increase in testis weight and spermatozoa count is proportional to the dosage given
Phytochemical and Bioactivity Study of Sargassum duplicatum as a Candidate Natural Biolarvicide Compound Pattimura, Nadira; Pattimura, Nastain Abubakar
Biofaal Journal Vol 6 No 2 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i2pp90-104

Abstract

Dengue hemorrhagic fever (DHF) is an endemic disease found in nearly all provinces of Indonesia. The occurrence of DHF is closely associated with climatic factors on spatial, temporal, and spatio-temporal scales. The search for new methods to eliminate the sources of dengue virus transmission is both urgent and essential. Sargassum duplicatum, a species of brown seaweed native to Indonesia, has been shown to possess potential antioxidant properties. This alga contains bioactive compounds, including steroids, alkaloids, phenols, flavonoids, saponins, and tannins, which are suspected to be toxic to insects. This study aimed to evaluate the larvicidal activity and determine the LC₅₀ and LC₉₀ values of ethanol extract from Sargassum duplicatum against the larvae of Aedes aegypti mosquitoes. A completely randomized design (CRD) was employed, consisting of five treatment groups with three replications each. A total of 300 third-instar Aedes aegypti larvae were introduced into treatment containers containing predetermined concentrations of Sargassum duplicatum ethanol extract, with each container holding 20 larvae. Observational data were analyzed using ANOVA and probit analysis. Phytochemical screening of the ethanol extract from Sargassum duplicatum confirmed the presence of flavonoids, saponins, tannins, and alkaloids. The extract demonstrated increased larval mortality in Aedes aegypti with increasing concentrations. A concentration of 75 ppm exhibited larvicidal efficacy comparable to that of 1% Abate. The LC₅₀ value of the ethanol extract was calculated to be 9.098 ppm, while the LC₉₀ value was 20.485 ppm.
Co-Authors Abdul M Ukratalo Basyarewan, Eko Saputra N Dodikrisno E Manery Efraim Samson, Efraim Handy Erwin Pier Leimena Ichsan, Muh. Nurhidayat La Eddy Loilatu, Muhammad Fitrah Makatita, Sakina Manery, Dodikrisno E Moniharapon, Mechiavel Nastain Abubakar Pattimura Pangemanan, Victory O Taufik Zuneldi Tihurua, Ma’syari Arfah Ukratalo, Abdul M Wakanno, Ferros Rozik Yushar A Embisa