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Widjaja, Tiyon
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Other

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COMPARATIVE TEST OF EFFECTIVENESS OF ALCOHOL MIXTURE BASE HAND SANITIZER WITH CHLORHEXIDINE MIXTURE BASE ON ESCHERICHIA COLI AND SHIGELLA SONNEI BACTERIA rahmi, eldiza puji; Farida Muti, Annisa; Pradana, Dhinga Luthfiyani; Valentino, Mikhael; Cahyadi, Salwa Nisrina; Andini, Putri; Ferdian, Muhamad; Widjaja, Tiyon; Razan Fachrudin, Brooklyn; Nabila, Annisa Hasna; Wandira, Salsabilla Puteri; Marliah Saputri, Sirly; Azzahra, Khayla Shifa; Kusumaningrum, Alfina Aprilia; Shabrina, Cut Laila Nur; Nurjannah, Rabbiah Putri
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 2 No 1 (2023): Vol.2 No.1 JUNE (2023)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i1.7013

Abstract

ABSTRACT Hand sanitizer is a hand cleanser which is easy and practical in use. Using hand sanitizer can be an alternative for washing hands if in condition without water and soap. Hand sanitizer is used to clean pathogens on hands. The ability to kill pathogens in hand sanitizers is due to the active substance content in them. In this research, the effectiveness of 2 hand sanitizers on the market was tested. The test aims to see the effect of the active substances in each preparation on the effectiveness of killing pathogens. Testing was carried out using the Kirby Bauer method and on 2 bacterial media, namely Escherichia coli and Shigella sonnei. Hand sanitizer 1 has a composition consisting of 70% ethyl alcohol and 0.5% chlorhexidine. Hand sanitizer 2 has a composition consisting of 55% ethyl alcohol and 18% isopropyl alcohol with a total of 73% alcohol. Based on observations, it was found that hand sanitizer 1 was more effective than hand sanitizer 2. The chlorhexidine content in hand sanitizer 1 increased its effectiveness in killing pathogens.
FORMULATION AND EVALUATION OF AMOXICILLIN TRIHYDRATE FAST DISINTEGRATING TABLET (FDT) USING SODIUM STARCH GLYCOLATE (SSG) AS SUPER DISINTEGRANT Widjaja, Tiyon; Hasna Nabila, Annisa; Qaanita, Nasya
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 3 No 2 (2024): Vol.3 No.2 DECEMBER (2024)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v3i2.9103

Abstract

This study was conducted to make a fast-disintegrating amoxicillin tablet formulation using a super disintegrant. Fast disintegrating tablets are tablets that quickly disintegrate after being placed in the mouth so that they can provide benefits for patients who have difficulty getting water or patients who have difficulty swallowing tablet drugs. Amoxicillin fast disintegrating tablet uses lactose monohydrate as filler, avicel pH 102 as binder, sodium starch glycolate as super disintegrant, stearic acid as lubricant, and aspartame as sweetener. The results of the granule evaluation showed that the fines produced from the particle distribution test were 4,56%. The tablet evaluation results showed that the tablets produced had a diameter of 0.6 0,0 cm with a thickness of 0,4 0,0 cm. The average weight of the tablets produced was 143,62 3,04 mg. The hardness of the tablets obtained was 3,962 ± 0,5678 kg with an average tablet friability of 0,63 ± 0,0028%. Tablet dissolution results showed that within 30 minutes tablet 1 dissolved as much as 116,21% and tablet 2 dissolved as much as 116,38%. The results of the disintegration time test showed that the tablets disintegrated for 44,44 ± 15,3957 seconds and the wetting time test was pored for 20 seconds. All evaluations carried out have met the predetermined acceptance requirements. Therefore, this FDT amoxicillin preparation formulation is declared as an optimal and effective formulation for use.
Co-Authors Azzahra, Khayla Shifa Cahyadi, Salwa Nisrina Farida Muti, Annisa Ferdian, Muhamad Hasna Nabila, Annisa Kusumaningrum, Alfina Aprilia Marliah Saputri, Sirly Nabila, Annisa Hasna Nurjannah, Rabbiah Putri Pradana, Dhinga Luthfiyani Putri Andini, Putri Qaanita, Nasya Rahmi, Eldiza Puji Razan Fachrudin, Brooklyn Shabrina, Cut Laila Nur Valentino, Mikhael Wandira, Salsabilla Puteri