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All Journal Indonesian Journal of Chemical Science Welfare: Jurnal Pengabdian Masyarakat
Alwia, Nisa
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Chemistry Environmental Science Physics Social Sciences

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Edukasi Pemanfaatan Buah dan Rempah Toga Sebagai Bahan Dasar Pembuatan Infused Water Untuk Detoksifikasi Tubuh di SMK N 2 Rangkas Bitung Maulana, Ilham; Ardillah, Destry; Irawan, Olgi; Gulo, Triss Ella Julita; Alwia, Nisa; Lubis, Martinasari
Welfare : Jurnal Pengabdian Masyarakat Vol. 1 No. 2 (2023): Welfare : June 2023
Publisher : Fakultas Ekonomi dan Bisnis Islam, IAIN Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30762/welfare.v1i2.539

Abstract

The problem of climate change is causing a decline in public health, so by paying attention to this as a government partner, the Pharmacy S1 Study Program Department has the responsibility to participate in educating the use of fruit, spices, and toga as body detoxification. Infused water is a drink consisting of water enriched with added flavors and nutrients from natural ingredients such as fruits, vegetables, and spices. The purpose of this activity is to provide education to the public on how to maintain health in the face of increased rainfall and extreme climate change by consuming infused water. The method used in this activity is to provide education about making infused water and distributing infused water products made by the service team to students of SMK N 2 Rangkas Bitung. The result of this service is that the students of SMK N 2 Rangkas Bitung know how to make infused water and are equipped with bottles and infused water products to practice directly.
Interaction Study of BCN OH ( Bicyclononyn ) and Pertuzumab in the Development of ADC ( Antibody Drug Conjugation ) Through Virtual Screening Alwia, Nisa; Aden Dhana Rizkita1; Tris Ella Julita Gulo; Nisa Sri Wahyuni; Risma Eka Putri Selay; Ayu Andini Rizki Lestari Rohman; Efriyana Oksal; Kumam Pinky Chanu; Asaduzzaman; Taufik Muhammad Faqih5
Indonesian Journal of Chemical Science Vol. 13 No. 2 (2024): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

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Abstract

ADC (Antibody Drug Conjugation) is a complex molecule consisting of antibodies designed as a targeted therapy to treat disease, or a biologically active cytotoxic drug. Docking simulations of the pertuzumab antibody with the BCN OH ligand were carried out to see the interactions and stable conjugates between the antibody and the ligand as a form of ADC development using three software, consisting of Discovery Studio, pymol and pyrex. The pymol application is used for the preparation of pertuzumab, namely removing residues and water and is used to combine the ligand with the antibody, while the use of Pyrex Autodocx Vina is to determine the conformation of the ligand in binding with the macromolecule. Discovery studio is used to realize the bond between the linker and antibody and see the interactions that occur. This research aims to determine the interaction of pertuzumab with BCN OH as a starting point for selecting a suitable ligand for the ADC product so that later the ADC will be more stable until the target of the simulations carried out is obtained by the results of interactions that occur between pertuzumab and the BCN OH molecule. After being realized in two dimensions, it can be seen that there are amino acid compounds that bind to BCN OH on side B:103, there is lysine, side B:40 proline, side B:38 Arginine, side B:85 Threonine, and on side B:415 there is Air molecules. In the docking process, the presence of lysine bonds is an important factor in looking at the interaction of compounds with their macromolecules, considering that lysine is one of the residues that will bind to the functional groups on the linker to produce ADC products.
Co-Authors Aden Dhana Rizkita1 Ardillah, Destry Asaduzzaman Ayu Andini Rizki Lestari Rohman Baety, Shelly Siti Nour Efriyana Oksal Gulo, Triss Ella Julita Hafidz, Muhammad Rafi Ilham Maulana Irawan, Olgi Kumam Pinky Chanu Lubis, Martinasari Risma Eka Putri Selay Rizkita, Aden Dhana Taufik Muhammad Faqih5 Tris Ella Julita Gulo Wahyuni, Nisa Sri